{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:15Z","timestamp":1791928695895,"version":"4.3.4"},"reference-count":63,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:00:00Z","timestamp":1536019200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,9,4]]},"DOI":"10.1167\/iovs.18-24621","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T11:44:25Z","timestamp":1536320665000},"page":"4392","source":"Crossref","is-referenced-by-count":66,"title":["Neuroprotective Effects of FGF2 and Minocycline in Two Animal Models of Inherited Retinal Degeneration"],"prefix":"10.1167","volume":"59","author":[{"given":"Johnny","family":"Di Pierdomenico","sequence":"first","affiliation":[{"name":"Departamento de Oftalmolog\u00eda, Facultad de Medicina, Universidad de Murcia and Instituto Murciano de Investigaci\u00f3n Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Scholz","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Javier","family":"Valiente-Soriano","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmolog\u00eda, Facultad de Medicina, Universidad de Murcia and Instituto Murciano de Investigaci\u00f3n Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"S\u00e1nchez-Migall\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmolog\u00eda, Facultad de Medicina, Universidad de Murcia and Instituto Murciano de Investigaci\u00f3n Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Vidal-Sanz","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmolog\u00eda, Facultad de Medicina, Universidad de Murcia and Instituto Murciano de Investigaci\u00f3n Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Langmann","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Agudo-Barriuso","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmolog\u00eda, Facultad de Medicina, Universidad de Murcia and Instituto Murciano de Investigaci\u00f3n Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Garc\u00eda-Ayuso","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmolog\u00eda, Facultad de Medicina, Universidad de Murcia and Instituto Murciano de Investigaci\u00f3n Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Paz","family":"Villegas-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Oftalmolog\u00eda, Facultad de Medicina, Universidad de Murcia and Instituto Murciano de Investigaci\u00f3n Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-11-4392-b01","doi-asserted-by":"crossref","unstructured":"Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet. 2006; 368: 1795\u20131809.","DOI":"10.1016\/S0140-6736(06)69740-7"},{"key":"i1552-5783-59-11-4392-b02","doi-asserted-by":"crossref","unstructured":"Swaroop A, Sieving PA. The golden era of ocular disease gene discovery: race to the finish. Clin Genet. 2013; 84: 99\u2013101.","DOI":"10.1111\/cge.12204"},{"key":"i1552-5783-59-11-4392-b03","doi-asserted-by":"crossref","unstructured":"van Soest S, Westerveld A, de Jong PT, Bleeker-Wagemakers EM, Bergen AA. Retinitis pigmentosa: defined from a molecular point of view. Surv Ophthalmol. 1999; 43: 321\u2013334.","DOI":"10.1016\/S0039-6257(98)00046-0"},{"key":"i1552-5783-59-11-4392-b04","unstructured":"LaVail MM. Analysis of neurological mutants with inherited retinal degeneration. Friedenwald lecture. Invest Ophthalmol Vis Sci. 1981; 21: 638\u2013657."},{"key":"i1552-5783-59-11-4392-b05","doi-asserted-by":"crossref","unstructured":"Slijkerman RW, Song F, Astuti GD, et al. The pros and cons of vertebrate animal models for functional and therapeutic research on inherited retinal dystrophies. Prog Retin Eye Res. 2015; 48: 137\u2013159.","DOI":"10.1016\/j.preteyeres.2015.04.004"},{"key":"i1552-5783-59-11-4392-b06","doi-asserted-by":"crossref","unstructured":"Veleri S, Lazar CH, Chang B, et al. Biology and therapy of inherited retinal degenerative disease: insights from mouse models. Dis Model Mech. 2015; 8: 109\u2013129.","DOI":"10.1242\/dmm.017913"},{"key":"i1552-5783-59-11-4392-b07","doi-asserted-by":"crossref","unstructured":"LaVail MM, Yasumura D, Matthes MT, et al. Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy. Proc Natl Acad Sci U S A. 2000; 97: 11488\u201311493.","DOI":"10.1073\/pnas.210319397"},{"key":"i1552-5783-59-11-4392-b08","doi-asserted-by":"crossref","unstructured":"Lewin AS, Drenser KA, Hauswirth WW, et al. Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa. Nat Med. 1998; 4: 967\u2013971.","DOI":"10.1038\/nm0898-967"},{"key":"i1552-5783-59-11-4392-b09","unstructured":"Machida S, Kondo M, Jamison JA, et al. P23H rhodopsin transgenic rat: correlation of retinal function with histopathology. Invest Ophthalmol Vis Sci. 2000; 41: 3200\u20133209."},{"key":"i1552-5783-59-11-4392-b10","doi-asserted-by":"crossref","unstructured":"Steinberg RH. Survival factors in retinal degenerations. Curr Opin Neurobiol. 1994; 4: 515\u2013524.","DOI":"10.1016\/0959-4388(94)90052-3"},{"key":"i1552-5783-59-11-4392-b11","doi-asserted-by":"crossref","unstructured":"Garcia-Ayuso D, Ortin-Martinez A, Jimenez-Lopez M, et al. Changes in the photoreceptor mosaic of P23H-1 rats during retinal degeneration: implications for rod-cone dependent survival. Invest Ophthalmol Vis Sci. 2013; 54: 5888\u20135900.","DOI":"10.1167\/iovs.13-12643"},{"key":"i1552-5783-59-11-4392-b12","doi-asserted-by":"crossref","unstructured":"Duncan JL, LaVail MM, Yasumura D, et al. An RCS-like retinal dystrophy phenotype in mer knockout mice. Invest Ophthalmol Vis Sci. 2003; 44: 826\u2013838.","DOI":"10.1167\/iovs.02-0438"},{"key":"i1552-5783-59-11-4392-b13","doi-asserted-by":"crossref","unstructured":"Parinot C, Nandrot EF. A comprehensive review of mutations in the MERTK proto-oncogene. Adv Exp Med Biol. 2016; 854: 259\u2013265.","DOI":"10.1007\/978-3-319-17121-0_35"},{"key":"i1552-5783-59-11-4392-b14","doi-asserted-by":"crossref","unstructured":"Terubayashi H, Murabe Y, Fujisawa H, Itoi M, Ibata Y. Enzymhistochemical identification of microglial cells in the rat retina: light and electron microscopic studies. Exp Eye Res. 1984; 39: 595\u2013603.","DOI":"10.1016\/0014-4835(84)90059-9"},{"key":"i1552-5783-59-11-4392-b15","doi-asserted-by":"crossref","unstructured":"Boya J, Calvo J, Carbonell AL. Appearance of microglial cells in the postnatal rat retina. Arch Histol Jpn. 1987; 50: 223\u2013228.","DOI":"10.1679\/aohc.50.223"},{"key":"i1552-5783-59-11-4392-b16","doi-asserted-by":"crossref","unstructured":"Ashwell KW, Hollander H, Streit W, Stone J. The appearance and distribution of microglia in the developing retina of the rat. Vis Neurosci. 1989; 2: 437\u2013448.","DOI":"10.1017\/S0952523800012335"},{"key":"i1552-5783-59-11-4392-b17","doi-asserted-by":"crossref","unstructured":"Thanos S. Sick photoreceptors attract activated microglia from the ganglion cell layer: a model to study the inflammatory cascades in rats with inherited retinal dystrophy. Brain Res. 1992; 588: 21\u201328.","DOI":"10.1016\/0006-8993(92)91340-K"},{"key":"i1552-5783-59-11-4392-b18","doi-asserted-by":"crossref","unstructured":"Salvador-Silva M, Vidal-Sanz M, Villegas-Perez MP. Microglial cells in the retina of Carassius auratus: effects of optic nerve crush. J Comp Neurol. 2000; 417: 431\u2013447.","DOI":"10.1002\/(SICI)1096-9861(20000221)417:4<431::AID-CNE4>3.0.CO;2-G"},{"key":"i1552-5783-59-11-4392-b19","doi-asserted-by":"crossref","unstructured":"Sobrado-Calvo P, Vidal-Sanz M, Villegas-Perez MP. Rat retinal microglial cells under normal conditions, after optic nerve section, and after optic nerve section and intravitreal injection of trophic factors or macrophage inhibitory factor. J Comp Neurol. 2007; 501: 866\u2013878.","DOI":"10.1002\/cne.21279"},{"key":"i1552-5783-59-11-4392-b20","doi-asserted-by":"crossref","unstructured":"de Hoz R, Gallego BI, Ramirez AI, et al. Rod-like microglia are restricted to eyes with laser-induced ocular hypertension but absent from the microglial changes in the contralateral untreated eye. PLoS One. 2013; 8: e83733.","DOI":"10.1371\/journal.pone.0083733"},{"key":"i1552-5783-59-11-4392-b21","doi-asserted-by":"crossref","unstructured":"de Hoz R, Ramirez AI, Gonzalez-Martin R, et al. Bilateral early activation of retinal microglial cells in a mouse model of unilateral laser-induced experimental ocular hypertension. Exp Eye Res. 2018; 171: 12\u201329.","DOI":"10.1016\/j.exer.2018.03.006"},{"key":"i1552-5783-59-11-4392-b22","doi-asserted-by":"crossref","unstructured":"Rojas B, Gallego BI, Ramirez AI, et al. Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers. J Neuroinflammation. 2014; 11: 133.","DOI":"10.1186\/1742-2094-11-133"},{"key":"i1552-5783-59-11-4392-b23","doi-asserted-by":"crossref","unstructured":"Gallego BI, Salazar JJ, de Hoz R, et al. IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma. J Neuroinflammation. 2012; 9: 92.","DOI":"10.1186\/1742-2094-9-92"},{"key":"i1552-5783-59-11-4392-b24","doi-asserted-by":"crossref","unstructured":"Gupta N, Brown KE, Milam AH. Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration. Exp Eye Res. 2003; 76: 463\u2013471.","DOI":"10.1016\/S0014-4835(02)00332-9"},{"key":"i1552-5783-59-11-4392-b25","doi-asserted-by":"crossref","unstructured":"Langmann T. Microglia activation in retinal degeneration. J Leukoc Biol. 2007; 81: 1345\u20131351.","DOI":"10.1189\/jlb.0207114"},{"key":"i1552-5783-59-11-4392-b26","doi-asserted-by":"crossref","unstructured":"Zhao L, Zabel MK, Wang X, et al. Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration. EMBO Mol Med. 2015; 7: 1179\u20131197.","DOI":"10.15252\/emmm.201505298"},{"key":"i1552-5783-59-11-4392-b27","doi-asserted-by":"crossref","unstructured":"Di Pierdomenico J, Garcia-Ayuso D, Pinilla I, et al. Early events in retinal degeneration caused by rhodopsin mutation or pigment epithelium malfunction: differences and similarities. Front Neuroanat. 2017; 11: 14.","DOI":"10.3389\/fnana.2017.00014"},{"key":"i1552-5783-59-11-4392-b28","doi-asserted-by":"crossref","unstructured":"Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature. 1990; 347: 83\u201386.","DOI":"10.1038\/347083a0"},{"key":"i1552-5783-59-11-4392-b29","doi-asserted-by":"crossref","unstructured":"Green ES, Rendahl KG, Zhou S, et al. Two animal models of retinal degeneration are rescued by recombinant adeno-associated virus-mediated production of FGF-5 and FGF-18. Mol Ther. 2001; 3: 507\u2013515.","DOI":"10.1006\/mthe.2001.0289"},{"key":"i1552-5783-59-11-4392-b30","doi-asserted-by":"crossref","unstructured":"Miyazaki M, Ikeda Y, Yonemitsu Y, et al. Simian lentiviral vector-mediated retinal gene transfer of pigment epithelium-derived factor protects retinal degeneration and electrical defect in Royal College of Surgeons rats. Gene Ther. 2003; 10: 1503\u20131511.","DOI":"10.1038\/sj.gt.3302028"},{"key":"i1552-5783-59-11-4392-b31","doi-asserted-by":"crossref","unstructured":"Buch PK, MacLaren RE, Duran Y, et al. In contrast to AAV-mediated Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy in rodent models of retinal degeneration. Mol Ther. 2006; 14: 700\u2013709.","DOI":"10.1016\/j.ymthe.2006.05.019"},{"key":"i1552-5783-59-11-4392-b32","doi-asserted-by":"crossref","unstructured":"Ortin-Martinez A, Valiente-Soriano FJ, Garcia-Ayuso D, et al. A novel in vivo model of focal light emitting diode-induced cone-photoreceptor phototoxicity: neuroprotection afforded by brimonidine, BDNF, PEDF or bFGF. PLoS One. 2014; 9: e113798.","DOI":"10.1371\/journal.pone.0113798"},{"key":"i1552-5783-59-11-4392-b33","doi-asserted-by":"crossref","unstructured":"Scholz R, Sobotka M, Caramoy A, et al. Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration. J Neuroinflammation. 2015; 12: 209.","DOI":"10.1186\/s12974-015-0431-4"},{"key":"i1552-5783-59-11-4392-b34","doi-asserted-by":"crossref","unstructured":"Wu DC, Jackson-Lewis V, Vila M, Tieu K, et al. Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 2002; 22: 1763\u20131771.","DOI":"10.1523\/JNEUROSCI.22-05-01763.2002"},{"key":"i1552-5783-59-11-4392-b35","doi-asserted-by":"crossref","unstructured":"Peng B, Xiao J, Wang K, So KF, Tipoe GL, Lin B. Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa. J Neurosci. 2014; 34: 8139\u20138150.","DOI":"10.1523\/JNEUROSCI.5200-13.2014"},{"key":"i1552-5783-59-11-4392-b36","doi-asserted-by":"crossref","unstructured":"Perry J, Du J, Kjeldbye H, Gouras P. The effects of bFGF on RCS rat eyes. Curr Eye Res. 1995; 14: 585\u2013592.","DOI":"10.3109\/02713689508998406"},{"key":"i1552-5783-59-11-4392-b37","doi-asserted-by":"crossref","unstructured":"LaVail MM, Unoki K, Yasumura D, Matthes MT, Yancopoulos GD, Steinberg RH. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Natl Acad Sci U S A. 1992; 89: 11249\u201311253.","DOI":"10.1073\/pnas.89.23.11249"},{"key":"i1552-5783-59-11-4392-b38","unstructured":"Cao W, Tombran-Tink J, Elias R, Sezate S, Mrazek D, McGinnis JF. In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor. Invest Ophthalmol Vis Sci. 2001; 42: 1646\u20131652."},{"key":"i1552-5783-59-11-4392-b39","doi-asserted-by":"crossref","unstructured":"Di Pierdomenico J, Garcia-Ayuso D, Jimenez-Lopez M, et al. Different ipsi- and contralateral glial responses to anti-VEGF and triamcinolone intravitreal injections in rats. Invest Ophthalmol Vis Sci. 2016; 57: 3533\u20133544.","DOI":"10.1167\/iovs.16-19618"},{"key":"i1552-5783-59-11-4392-b40","doi-asserted-by":"crossref","unstructured":"Garcia-Ayuso D, Salinas-Navarro M, Agudo M, et al. Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retina. Exp Eye Res. 2010; 91: 800\u2013810.","DOI":"10.1016\/j.exer.2010.10.003"},{"key":"i1552-5783-59-11-4392-b41","doi-asserted-by":"crossref","unstructured":"Garcia-Ayuso D, Di Pierdomenico J, Hadj-Said W, et al. Taurine depletion causes ipRGC loss and increases light-induced photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2018; 59: 1396\u20131409.","DOI":"10.1167\/iovs.17-23258"},{"key":"i1552-5783-59-11-4392-b42","doi-asserted-by":"crossref","unstructured":"Sahni JN, Angi M, Irigoyen C, et al. Therapeutic challenges to retinitis pigmentosa: from neuroprotection to gene therapy. Curr Genomics. 2011; 12: 276\u2013284.","DOI":"10.2174\/138920211795860062"},{"key":"i1552-5783-59-11-4392-b43","doi-asserted-by":"crossref","unstructured":"Garcia-Ayuso D, Di Pierdomenico J, Esquiva G, et al. Inherited photoreceptor degeneration causes the death of melanopsin-positive retinal ganglion cells and increases their coexpression of Brn3a. Invest Ophthalmol Vis Sci. 2015; 56: 4592\u20134604.","DOI":"10.1167\/iovs.15-16808"},{"key":"i1552-5783-59-11-4392-b44","doi-asserted-by":"crossref","unstructured":"Jones BW, Pfeiffer RL, Ferrell WD, et al. Retinal remodeling in human retinitis pigmentosa. Exp Eye Res. 2016; 150: 149\u2013165.","DOI":"10.1016\/j.exer.2016.03.018"},{"key":"i1552-5783-59-11-4392-b45","doi-asserted-by":"crossref","unstructured":"Marc RE, Jones BW. Retinal remodeling in inherited photoreceptor degenerations. Mol Neurobiol. 2003; 28: 139\u2013147.","DOI":"10.1385\/MN:28:2:139"},{"key":"i1552-5783-59-11-4392-b46","doi-asserted-by":"crossref","unstructured":"Kolomeyer AM, Zarbin MA. Trophic factors in the pathogenesis and therapy for retinal degenerative diseases. Surv Ophthalmol. 2014; 59: 134\u2013165.","DOI":"10.1016\/j.survophthal.2013.09.004"},{"key":"i1552-5783-59-11-4392-b47","doi-asserted-by":"crossref","unstructured":"Buch PK, MacLaren RE, Ali RR. Neuroprotective gene therapy for the treatment of inherited retinal degeneration. Curr Gene Ther. 2007; 7: 434\u2013445.","DOI":"10.2174\/156652307782793531"},{"key":"i1552-5783-59-11-4392-b48","doi-asserted-by":"crossref","unstructured":"Liang FQ, Dejneka NS, Cohen DR, et al. AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse. Mol Ther. 2001; 3: 241\u2013248.","DOI":"10.1006\/mthe.2000.0252"},{"key":"i1552-5783-59-11-4392-b49","unstructured":"Akimoto M, Miyatake S, Kogishi J, et al. Adenovirally expressed basic fibroblast growth factor rescues photoreceptor cells in RCS rats. Invest Ophthalmol Vis Sci. 1999; 40: 273\u2013279."},{"key":"i1552-5783-59-11-4392-b50","doi-asserted-by":"crossref","unstructured":"Neuner-Jehle M, Berghe LV, Bonnel S, et al. Ocular cell transfection with the human basic fibroblast growth factor gene delays photoreceptor cell degeneration in RCS rats. Hum Gene Ther. 2000; 11: 1875\u20131890.","DOI":"10.1089\/10430340050129495"},{"key":"i1552-5783-59-11-4392-b51","doi-asserted-by":"crossref","unstructured":"Sakai T, Kuno N, Takamatsu F, et al. Prolonged protective effect of basic fibroblast growth factor-impregnated nanoparticles in royal college of surgeons rats. Invest Ophthalmol Vis Sci. 2007; 48: 3381\u20133387.","DOI":"10.1167\/iovs.06-1242"},{"key":"i1552-5783-59-11-4392-b52","doi-asserted-by":"crossref","unstructured":"Arroba AI, Alvarez-Lindo N, van Rooijen N, de la Rosa EJ. Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2011; 52: 9124\u20139130.","DOI":"10.1167\/iovs.11-7736"},{"key":"i1552-5783-59-11-4392-b53","doi-asserted-by":"crossref","unstructured":"Guadagni V, Novelli E, Piano I, Gargini C, Strettoi E. Pharmacological approaches to retinitis pigmentosa: a laboratory perspective. Prog Retin Eye Res. 2015; 48: 62\u201381.","DOI":"10.1016\/j.preteyeres.2015.06.005"},{"key":"i1552-5783-59-11-4392-b54","doi-asserted-by":"crossref","unstructured":"Lai AY, Todd KG. Differential regulation of trophic and proinflammatory microglial effectors is dependent on severity of neuronal injury. Glia. 2008; 56: 259\u2013270.","DOI":"10.1002\/glia.20610"},{"key":"i1552-5783-59-11-4392-b55","doi-asserted-by":"crossref","unstructured":"Narayan DS, Wood JP, Chidlow G, Casson RJ. A review of the mechanisms of cone degeneration in retinitis pigmentosa. Acta Ophthalmol. 2016; 94: 748\u2013754.","DOI":"10.1111\/aos.13141"},{"key":"i1552-5783-59-11-4392-b56","doi-asserted-by":"crossref","unstructured":"Cai Z, Yan Y, Wang Y. Minocycline alleviates beta-amyloid protein and tau pathology via restraining neuroinflammation induced by diabetic metabolic disorder. Clin Interv Aging. 2013; 8: 1089\u20131095.","DOI":"10.2147\/CIA.S46536"},{"key":"i1552-5783-59-11-4392-b57","doi-asserted-by":"crossref","unstructured":"Kumar A, Chaudhary T, Mishra J. Minocycline modulates neuroprotective effect of hesperidin against quinolinic acid induced Huntington's disease like symptoms in rats: behavioral, biochemical, cellular and histological evidences. Eur J Pharmacol. 2013; 720: 16\u201328.","DOI":"10.1016\/j.ejphar.2013.10.057"},{"key":"i1552-5783-59-11-4392-b58","doi-asserted-by":"crossref","unstructured":"Ferretti MT, Allard S, Partridge V, Ducatenzeiler A, Cuello AC. Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology. J Neuroinflammation. 2012; 9: 62.","DOI":"10.1186\/1742-2094-9-62"},{"key":"i1552-5783-59-11-4392-b59","doi-asserted-by":"crossref","unstructured":"Hashemi-Monfared A, Firouzi M, Bahrami Z, Zahednasab H, Harirchian MH. Minocycline decreases CD36 and increases CD44 in LPS-induced microglia. J Neuroimmunol. 2018; 317: 95\u201399.","DOI":"10.1016\/j.jneuroim.2018.01.010"},{"key":"i1552-5783-59-11-4392-b60","doi-asserted-by":"crossref","unstructured":"Wang AL, Yu AC, Lau LT, et al. Minocycline inhibits LPS-induced retinal microglia activation. Neurochem Int. 2005; 47: 152\u2013158.","DOI":"10.1016\/j.neuint.2005.04.018"},{"key":"i1552-5783-59-11-4392-b61","doi-asserted-by":"crossref","unstructured":"Gargini C, Terzibasi E, Mazzoni F, Strettoi E. Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study. J Comp Neurol. 2007; 500: 222\u2013238.","DOI":"10.1002\/cne.21144"},{"key":"i1552-5783-59-11-4392-b62","unstructured":"Yang LP, Li Y, Zhu XA, Tso MO. Minocycline delayed photoreceptor death in rds mice through iNOS-dependent mechanism. Mol Vis. 2007; 13: 1073\u20131082."},{"key":"i1552-5783-59-11-4392-b63","doi-asserted-by":"crossref","unstructured":"Bosco A, Inman DM, Steele MR, et al. Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA\/2J mouse model of glaucoma. Invest Ophthalmol Vis Sci. 2008; 49: 1437\u20131446.","DOI":"10.1167\/iovs.07-1337"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2701839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:57Z","timestamp":1791927057000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-24621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,4]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,9,4]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-24621","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9,4]]}}}