{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:11Z","timestamp":1791928691800,"version":"4.3.4"},"reference-count":30,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,7,16]]},"DOI":"10.1167\/iovs.18-2476","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T17:48:40Z","timestamp":1532108920000},"page":"3543","source":"Crossref","is-referenced-by-count":13,"title":["Activation of the EGF Receptor by Histamine Receptor Subtypes Stimulates Mucin Secretion in Conjunctival Goblet Cells"],"prefix":"10.1167","volume":"59","author":[{"given":"Min","family":"He","sequence":"first","affiliation":[{"name":"Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States"},{"name":"Department of Ophthalmology, The Second Hospital of Shanxi Medical University, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit","family":"Lippestad","sequence":"additional","affiliation":[{"name":"Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States"},{"name":"Faculty of Medicine, University of Oslo, Oslo, Norway"},{"name":"Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayu","family":"Li","sequence":"additional","affiliation":[{"name":"Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin R.","family":"Hodges","sequence":"additional","affiliation":[{"name":"Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor P.","family":"Utheim","sequence":"additional","affiliation":[{"name":"Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States"},{"name":"Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway"},{"name":"Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlene A.","family":"Dartt","sequence":"additional","affiliation":[{"name":"Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-8-3543-b01","doi-asserted-by":"crossref","unstructured":"Ablamowicz AF, Nichols JJ. Ocular surface membrane-associated mucins. Ocul Surf. 2016; 14: 331\u2013341.","DOI":"10.1016\/j.jtos.2016.03.003"},{"key":"i1552-5783-59-8-3543-b02","doi-asserted-by":"crossref","unstructured":"Dartt DA, Masli S. Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation. Curr Opin Allergy Clin Immunol. 2014; 14: 464\u2013470.","DOI":"10.1097\/ACI.0000000000000098"},{"key":"i1552-5783-59-8-3543-b03","doi-asserted-by":"crossref","unstructured":"Leonardi A, Castegnaro A, Valerio AL, et al. Epidemiology of allergic conjunctivitis: clinical appearance and treatment patterns in a population-based study. Curr Opin Allergy Clin Immunol. 2015; 15: 482\u2013488.","DOI":"10.1097\/ACI.0000000000000204"},{"key":"i1552-5783-59-8-3543-b04","doi-asserted-by":"crossref","unstructured":"Patel DS, Arunakirinathan M, Stuart A, et al. Allergic eye disease. BMJ. 2017; 359:j4706.","DOI":"10.1136\/bmj.j4706"},{"key":"i1552-5783-59-8-3543-b05","doi-asserted-by":"crossref","unstructured":"Hayashi D, Li D, Hayashi C, et al. Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion. Invest Ophthalmol Vis Sci. 2012; 53: 2993\u20133003.","DOI":"10.1167\/iovs.11-8748"},{"key":"i1552-5783-59-8-3543-b06","doi-asserted-by":"crossref","unstructured":"Dartt DA, Hodges RR, Li D, et al. Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. J Immunol. 2011; 186: 4455\u20134466.","DOI":"10.4049\/jimmunol.1000833"},{"key":"i1552-5783-59-8-3543-b07","doi-asserted-by":"crossref","unstructured":"Li D, Carozza RB, Shatos MA, et al. Effect of histamine on Ca(2+)-dependent signaling pathways in rat conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2012; 53: 6928\u20136938.","DOI":"10.1167\/iovs.12-10163"},{"key":"i1552-5783-59-8-3543-b08","doi-asserted-by":"crossref","unstructured":"Hodges RR, Li D, Shatos MA, et al. Lipoxin A4 activates ALX\/FPR2 receptor to regulate conjunctival goblet cell secretion. Mucosal Immunol. 2017; 10: 46\u201357.","DOI":"10.1038\/mi.2016.33"},{"key":"i1552-5783-59-8-3543-b09","doi-asserted-by":"crossref","unstructured":"Hodges RR, Li D, Shatos MA, et al. Lipoxin A4 counter-regulates histamine-stimulated glycoconjugate secretion in conjunctival goblet cells. Sci Rep. 2016; 6: 36124.","DOI":"10.1038\/srep36124"},{"key":"i1552-5783-59-8-3543-b10","doi-asserted-by":"crossref","unstructured":"Li D, Hodges RR, Jiao J, et al. Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. Mucosal Immunol. 2013; 6: 1119\u20131130.","DOI":"10.1038\/mi.2013.7"},{"key":"i1552-5783-59-8-3543-b11","doi-asserted-by":"crossref","unstructured":"Prenzel N, Fischer OM, Streit S, et al. The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr Relat Cancer. 2001; 8: 11\u201331.","DOI":"10.1677\/erc.0.0080011"},{"key":"i1552-5783-59-8-3543-b12","doi-asserted-by":"crossref","unstructured":"Lee DC, Sunnarborg SW, Hinkle CL, et al. TACE\/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. Ann N Y Acad Sci. 2003; 995: 22\u201338.","DOI":"10.1111\/j.1749-6632.2003.tb03207.x"},{"key":"i1552-5783-59-8-3543-b13","doi-asserted-by":"crossref","unstructured":"Sahin U, Weskamp G, Kelly K, et al. Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol. 2004; 164: 769\u2013779.","DOI":"10.1083\/jcb.200307137"},{"key":"i1552-5783-59-8-3543-b14","doi-asserted-by":"crossref","unstructured":"Gu J, Chen L, Shatos MA, et al. Presence of EGF growth factor ligands and their effects on cultured rat conjunctival goblet cell proliferation. Exp Eye Res. 2008; 86: 322\u2013334.","DOI":"10.1016\/j.exer.2007.11.004"},{"key":"i1552-5783-59-8-3543-b15","doi-asserted-by":"crossref","unstructured":"Hodges RR, Bair JA, Carozza RB, et al. Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion. Exp Eye Res. 2012; 103: 99\u2013113.","DOI":"10.1016\/j.exer.2012.08.010"},{"key":"i1552-5783-59-8-3543-b16","doi-asserted-by":"crossref","unstructured":"Shatos MA, Gu J, Hodges RR, et al. ERK\/p44p42 mitogen-activated protein kinase mediates EGF-stimulated proliferation of conjunctival goblet cells in culture. Invest Ophthalmol Vis Sci. 2008; 49: 3351\u20133359.","DOI":"10.1167\/iovs.08-1677"},{"key":"i1552-5783-59-8-3543-b17","doi-asserted-by":"crossref","unstructured":"Li D, Shatos MA, Hodges RR, et al. Role of PKCalpha activation of Src, PI-3K\/AKT, and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2013; 54: 5661\u20135674.","DOI":"10.1167\/iovs.13-12473"},{"key":"i1552-5783-59-8-3543-b18","doi-asserted-by":"crossref","unstructured":"Erle DJ, Sheppard D. The cell biology of asthma. J Cell Biol. 2014; 205: 621\u2013631.","DOI":"10.1083\/jcb.201401050"},{"key":"i1552-5783-59-8-3543-b19","doi-asserted-by":"crossref","unstructured":"Hirota N, Risse PA, Novali M, et al. Histamine may induce airway remodeling through release of epidermal growth factor receptor ligands from bronchial epithelial cells. FASEB J. 2012; 26: 1704\u20131716.","DOI":"10.1096\/fj.11-197061"},{"key":"i1552-5783-59-8-3543-b20","doi-asserted-by":"crossref","unstructured":"Matovinovic E, Solberg O, Shusterman D. Epidermal growth factor receptor\u2014but not histamine receptor\u2014is upregulated in seasonal allergic rhinitis. Allergy. 2003; 58: 472\u2013475.","DOI":"10.1034\/j.1398-9995.2003.00156.x"},{"key":"i1552-5783-59-8-3543-b21","doi-asserted-by":"crossref","unstructured":"Abu El-Asrar AM, Al-Mansouri S, Tabbara KF, et al. Immunopathogenesis of conjunctival remodelling in vernal keratoconjunctivitis. Eye (Lond). 2006; 20: 71\u201379.","DOI":"10.1038\/sj.eye.6701811"},{"key":"i1552-5783-59-8-3543-b22","doi-asserted-by":"crossref","unstructured":"Lippestad M, Hodges RR, Utheim TP, et al. Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca(2+) in cultured rat conjunctival goblet cells. Exp Eye Res. 2018; 173: 64\u201372.","DOI":"10.1016\/j.exer.2018.04.015"},{"key":"i1552-5783-59-8-3543-b23","doi-asserted-by":"crossref","unstructured":"Lippestad M, Hodges RR, Utheim TP, et al. Resolvin D1 increases mucin secretion in cultured rat conjunctival goblet cells via multiple signaling pathways. Invest Ophthalmol Vis Sci. 2017; 58: 4530\u20134544.","DOI":"10.1167\/iovs.17-21914"},{"key":"i1552-5783-59-8-3543-b24","unstructured":"Shatos MA, Rios JD, Tepavcevic V, et al. Isolation, characterization, and propagation of rat conjunctival goblet cells in vitro. Invest Ophthalmol Vis Sci. 2001; 42: 1455\u20131464."},{"key":"i1552-5783-59-8-3543-b25","doi-asserted-by":"crossref","unstructured":"Horikawa Y, Shatos MA, Hodges RR, et al. Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells. Invest Ophthalmol Vis Sci. 2003; 44: 2535\u20132544.","DOI":"10.1167\/iovs.02-1117"},{"key":"i1552-5783-59-8-3543-b26","doi-asserted-by":"crossref","unstructured":"Chen L, Hodges RR, Funaki C, et al. Effects of alpha1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells. Am J Physiol Cell Physiol. 2006; 291: C946\u2013C956.","DOI":"10.1152\/ajpcell.00014.2006"},{"key":"i1552-5783-59-8-3543-b27","doi-asserted-by":"crossref","unstructured":"Rivera-Ramirez N, Montejo-Lopez W, Lopez-Mendez MC, et al. Histamine H3 receptor activation stimulates calcium mobilization in a subpopulation of rat striatal neurons in primary culture, but not in synaptosomes. Neurochem Int. 2016; 101: 38\u201347.","DOI":"10.1016\/j.neuint.2016.10.005"},{"key":"i1552-5783-59-8-3543-b28","doi-asserted-by":"crossref","unstructured":"Sadek B, Stark H. Cherry-picked ligands at histamine receptor subtypes. Neuropharmacology. 2016; 106: 56\u201373.","DOI":"10.1016\/j.neuropharm.2015.11.005"},{"key":"i1552-5783-59-8-3543-b29","doi-asserted-by":"crossref","unstructured":"Schneider EH, Seifert R. The histamine H4-receptor and the central and peripheral nervous system: a critical analysis of the literature. Neuropharmacology. 2016; 106: 116\u2013128.","DOI":"10.1016\/j.neuropharm.2015.05.004"},{"key":"i1552-5783-59-8-3543-b30","doi-asserted-by":"crossref","unstructured":"Kanno H, Horikawa Y, Hodges RR, et al. Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion. Am J Physiol Cell Physiol. 2003; 284: C988\u2013C998.","DOI":"10.1152\/ajpcell.00582.2001"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2688306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:55Z","timestamp":1791927055000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-2476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,16]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,7,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-2476","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,16]]}}}