{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:05:49Z","timestamp":1793066749246,"version":"4.5.0"},"reference-count":36,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2019,1,29]]},"DOI":"10.1167\/iovs.18-24813","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T05:39:34Z","timestamp":1548826774000},"page":"420","source":"Crossref","is-referenced-by-count":85,"title":["Disruption of Intestinal Homeostasis and Intestinal Microbiota During Experimental Autoimmune Uveitis"],"prefix":"10.1167","volume":"60","author":[{"given":"Cathleen","family":"Janowitz","sequence":"first","affiliation":[{"name":"Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko K.","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Metea","sequence":"additional","affiliation":[{"name":"Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Gligor","sequence":"additional","affiliation":[{"name":"Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Yu","sequence":"additional","affiliation":[{"name":"Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Karstens","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States"},{"name":"Division of Arthritis and Rheumatic Diseases, Department of Medicine, Oregon Health & Science University, Portland, Oregon, United States"},{"name":"Devers Eye Institute, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Asquith","sequence":"additional","affiliation":[{"name":"Division of Arthritis and Rheumatic Diseases, Department of Medicine, Oregon Health & Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe","family":"Lin","sequence":"additional","affiliation":[{"name":"Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-60-1-420-b01","doi-asserted-by":"crossref","unstructured":"Carter JD. Reactive arthritis: defined etiologies, emerging pathophysiology, and unresolved treatment. Infect Dis Clin North Am. 2006; 20: 827\u2013847.","DOI":"10.1016\/j.idc.2006.09.004"},{"key":"i1552-5783-60-1-420-b02","doi-asserted-by":"crossref","unstructured":"Costello ME, Ciccia F, Willner D, et al. Brief report: intestinal dysbiosis in ankylosing spondylitis. Arthritis Rheumatol. 2015; 67: 686\u2013691.","DOI":"10.1002\/art.38967"},{"key":"i1552-5783-60-1-420-b03","doi-asserted-by":"crossref","unstructured":"Miyake S, Kim S, Suda W, et al. Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to clostridia xiva and iv clusters. PLoS One, 2015; 10: e0137429.","DOI":"10.1371\/journal.pone.0137429"},{"key":"i1552-5783-60-1-420-b04","doi-asserted-by":"crossref","unstructured":"Rosenbaum JT, Lin P, Asquith M. The microbiome, HLA, and the pathogenesis of uveitis. Jpn J Ophthalmol, 2016; 60: 1\u20136.","DOI":"10.1007\/s10384-015-0416-y"},{"key":"i1552-5783-60-1-420-b05","doi-asserted-by":"crossref","unstructured":"Nouri M, Bredberg A, Westrom B, Lavasani S. Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cells. PLoS One. 2014; 9: e106335.","DOI":"10.1371\/journal.pone.0106335"},{"key":"i1552-5783-60-1-420-b06","doi-asserted-by":"crossref","unstructured":"Horai R, Sen HN, Caspi RR. Commensal microbiota as a potential trigger of autoimmune uveitis. Expert Rev Clin Immunol. 2017; 13: 291\u2013293.","DOI":"10.1080\/1744666X.2017.1288098"},{"key":"i1552-5783-60-1-420-b07","doi-asserted-by":"crossref","unstructured":"Horai R, Zarate-Blades CR, Dillenburg-Pilla P, et al. Microbiota-dependent activation of an autoreactive t cell receptor provokes autoimmunity in an immunologically privileged site. Immunity. 2015; 43: 343\u2013353.","DOI":"10.1016\/j.immuni.2015.07.014"},{"key":"i1552-5783-60-1-420-b08","doi-asserted-by":"crossref","unstructured":"Honda K, Littman DR. The microbiota in adaptive immune homeostasis and disease. Nature. 2016; 535: 75\u201384.","DOI":"10.1038\/nature18848"},{"key":"i1552-5783-60-1-420-b09","doi-asserted-by":"crossref","unstructured":"Ivanov, II, Atarashi K, Manel N, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 2009; 139: 485\u2013498.","DOI":"10.1016\/j.cell.2009.09.033"},{"key":"i1552-5783-60-1-420-b10","doi-asserted-by":"crossref","unstructured":"Tan TG, Sefik E, Geva-Zatorsky N, et al. Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice. Proc Natl Acad Sci U S A. 2016; 113: E8141\u2013E8150.","DOI":"10.1073\/pnas.1617460113"},{"key":"i1552-5783-60-1-420-b11","doi-asserted-by":"crossref","unstructured":"Wu HJ, Ivanov II, Darce J, et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity. 2010; 32: 815\u2013827.","DOI":"10.1016\/j.immuni.2010.06.001"},{"key":"i1552-5783-60-1-420-b12","doi-asserted-by":"crossref","unstructured":"Atarashi K, Tanoue T, Shima T, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science. 2011; 331: 337\u2013341.","DOI":"10.1126\/science.1198469"},{"key":"i1552-5783-60-1-420-b13","doi-asserted-by":"crossref","unstructured":"Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A. 2010; 107: 12204\u201312209.","DOI":"10.1073\/pnas.0909122107"},{"key":"i1552-5783-60-1-420-b14","doi-asserted-by":"crossref","unstructured":"Nakamura YK, Metea C, Karstens L, et al. Gut microbial alterations associated with protection from autoimmune uveitis. Invest Ophthalmol Vis Sci. 2016; 57: 3747\u20133758.","DOI":"10.1167\/iovs.16-19733"},{"key":"i1552-5783-60-1-420-b15","unstructured":"Agarwal RK, Caspi RR. Rodent models of experimental autoimmune uveitis. Methods Mol Med. 2004; 102: 395\u2013419."},{"key":"i1552-5783-60-1-420-b16","doi-asserted-by":"crossref","unstructured":"Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012; 9: 671\u2013675.","DOI":"10.1038\/nmeth.2089"},{"key":"i1552-5783-60-1-420-b17","doi-asserted-by":"crossref","unstructured":"Flahou B, Deun KV, Pasmans F, et al. The local immune response of mice after Helicobacter suis infection: strain differences and distinction with Helicobacter pylori. Vet Res. 2012; 43: 75.","DOI":"10.1186\/1297-9716-43-75"},{"key":"i1552-5783-60-1-420-b18","doi-asserted-by":"crossref","unstructured":"Matsushita T, Yanaba K, Bouaziz JD, Fujimoto M, Tedder TF. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest. 2008; 118: 3420\u20133430.","DOI":"10.1172\/JCI36030"},{"key":"i1552-5783-60-1-420-b19","doi-asserted-by":"crossref","unstructured":"Wainwright DA, Sengupta S, Han Y, Ulasov IV, Lesniak MS. The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma. PLoS One. 2010; 5: e15390.","DOI":"10.1371\/journal.pone.0015390"},{"key":"i1552-5783-60-1-420-b20","doi-asserted-by":"crossref","unstructured":"Cani PD, Possemiers S, Van de Wiele T, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut. 2009; 58: 1091\u20131103.","DOI":"10.1136\/gut.2008.165886"},{"key":"i1552-5783-60-1-420-b21","doi-asserted-by":"crossref","unstructured":"Gilbert JA, Meyer F, Jansson J, et al. The Earth Microbiome Project: Meeting report of the \u201c1 EMP meeting on sample selection and acquisition\u201d at Argonne National Laboratory October 6 2010. Stand Genomic Sci. 2010; 3: 249\u2013253.","DOI":"10.4056\/aigs.1443528"},{"key":"i1552-5783-60-1-420-b22","doi-asserted-by":"crossref","unstructured":"Caporaso JG, Kuczynski J, Stombaugh J, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010; 7: 335\u2013336.","DOI":"10.1038\/nmeth.f.303"},{"key":"i1552-5783-60-1-420-b23","doi-asserted-by":"crossref","unstructured":"Edgar RC. Search and clustering orders of magnitude faster than BLAST. Bioinformatics. 2010; 26: 2460\u20132461.","DOI":"10.1093\/bioinformatics\/btq461"},{"key":"i1552-5783-60-1-420-b24","doi-asserted-by":"crossref","unstructured":"Segata N, Izard J, Waldron L, et al. Metagenomic biomarker discovery and explanation. Genome Biol. 2011; 12: R60.","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"i1552-5783-60-1-420-b25","doi-asserted-by":"crossref","unstructured":"Burke JP, Mulsow JJ, O'Keane C, Docherty NG, Watson RW, O'Connell PR. Fibrogenesis in Crohn's disease. Am J Gastroenterol. 2007; 102: 439\u2013448.","DOI":"10.1111\/j.1572-0241.2006.01010.x"},{"key":"i1552-5783-60-1-420-b26","doi-asserted-by":"crossref","unstructured":"MacDonald TT, Spencer J. The role of activated T cells in transformed intestinal mucosa. Digestion. 1990; 46 (suppl 2): 290\u2013296.","DOI":"10.1159\/000200399"},{"key":"i1552-5783-60-1-420-b27","doi-asserted-by":"crossref","unstructured":"Zeitz M, Ullrich R, Schneider T, Kewenig S, Hohloch K, Riecken EO. HIV\/SIV enteropathy. Ann N Y Acad Sci. 1998; 859: 139\u2013148.","DOI":"10.1111\/j.1749-6632.1998.tb11118.x"},{"key":"i1552-5783-60-1-420-b28","doi-asserted-by":"crossref","unstructured":"Nakamura YK, Janowitz C, Metea C, et al. Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine. Sci Rep. 2017; 7: 11745.","DOI":"10.1038\/s41598-017-12163-3"},{"key":"i1552-5783-60-1-420-b29","doi-asserted-by":"crossref","unstructured":"Miele L, Valenza V, La Torre G, et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology. 2009; 49: 1877\u20131887.","DOI":"10.1002\/hep.22848"},{"key":"i1552-5783-60-1-420-b30","doi-asserted-by":"crossref","unstructured":"Moschen AR, Gerner RR, Wang J, et al. Lipocalin 2 protects from inflammation and tumorigenesis associated with gut microbiota alterations. Cell Host Microbe. 2016; 19: 455\u2013469.","DOI":"10.1016\/j.chom.2016.03.007"},{"key":"i1552-5783-60-1-420-b31","doi-asserted-by":"crossref","unstructured":"Wozniak KL, Hole CR, Yano J, Fidel PL Jr, Wormley FL Jr. Characterization of IL-22 and antimicrobial peptide production in mice protected against pulmonary Cryptococcus neoformans infection. Microbiology. 2014; 160: 1440\u20131452.","DOI":"10.1099\/mic.0.073445-0"},{"key":"i1552-5783-60-1-420-b32","doi-asserted-by":"crossref","unstructured":"Lugering N, Stoll R, Kucharzik T, et al. Immunohistochemical distribution and serum levels of the Ca(2+)-binding proteins MRP8, MRP14 and their heterodimeric form MRP8\/14 in Crohn's disease. Digestion. 1995; 56: 406\u2013414.","DOI":"10.1159\/000201267"},{"key":"i1552-5783-60-1-420-b33","doi-asserted-by":"crossref","unstructured":"Rodenburg W, Keijer J, Kramer E, et al. Salmonella induces prominent gene expression in the rat colon. BMC Microbiol. 2007; 7: 84.","DOI":"10.1186\/1471-2180-7-84"},{"key":"i1552-5783-60-1-420-b34","doi-asserted-by":"crossref","unstructured":"Pavlidis P, Gulati S, Dubois P, et al. Early change in faecal calprotectin predicts primary non-response to anti-TNFalpha therapy in Crohn's disease. Scand J Gastroenterol. 2016; 51: 1447\u20131452.","DOI":"10.1080\/00365521.2016.1205128"},{"key":"i1552-5783-60-1-420-b35","doi-asserted-by":"crossref","unstructured":"Chassaing B, Srinivasan G, Delgado MA, Young AN, Gewirtz AT, Vijay-Kumar M. Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PLoS One. 2012; 7: e44328.","DOI":"10.1371\/journal.pone.0044328"},{"key":"i1552-5783-60-1-420-b36","doi-asserted-by":"crossref","unstructured":"Thorsvik S, Damas JK, Granlund AV, et al. Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease. J Gastroenterol Hepatol. 2017; 32: 128\u2013135.","DOI":"10.1111\/jgh.13598"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2723290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:10Z","timestamp":1791927070000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-24813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,29]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-24813","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1,29]]}}}