{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:19Z","timestamp":1791928699294,"version":"4.3.4"},"reference-count":53,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"13","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,11,5]]},"DOI":"10.1167\/iovs.18-24914","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T12:02:23Z","timestamp":1541505743000},"page":"5312","source":"Crossref","is-referenced-by-count":10,"title":["An iTRAQ-Based Quantitative Proteomic Analysis of Plasma Proteins in Preterm Newborns With Retinopathy of Prematurity"],"prefix":"10.1167","volume":"59","author":[{"given":"Magdalena","family":"Zasada","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Suski","sequence":"additional","affiliation":[{"name":"Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Bokiniec","sequence":"additional","affiliation":[{"name":"Neonatal and Intensive Care Department, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Szwarc-Duma","sequence":"additional","affiliation":[{"name":"Neonatal and Intensive Care Department, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Katarzyna","family":"Borszewska-Kornacka","sequence":"additional","affiliation":[{"name":"Neonatal and Intensive Care Department, Medical University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zef","family":"Madej","sequence":"additional","affiliation":[{"name":"Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Bujak-Gizycka","sequence":"additional","affiliation":[{"name":"Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Madetko-Talowska","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"Revhaug","sequence":"additional","affiliation":[{"name":"Department of Pediatric Research, Oslo University Hospital, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars O.","family":"Baumbusch","sequence":"additional","affiliation":[{"name":"Department of Pediatric Research, Oslo University Hospital, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola D.","family":"Saugstad","sequence":"additional","affiliation":[{"name":"Department of Pediatric Research, Oslo University Hospital, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek J\u00f3zef","family":"Pietrzyk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemko","family":"Kwinta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-13-5312-b01","doi-asserted-by":"crossref","unstructured":"Saigal S, Doyle LW. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet. 2008; 371: 261\u2013269.","DOI":"10.1016\/S0140-6736(08)60136-1"},{"key":"i1552-5783-59-13-5312-b02","doi-asserted-by":"crossref","unstructured":"Hartnett ME, Penn JS. Mechanisms and management of retinopathy of prematurity. N Engl J Med. 2012; 367: 2515\u20132526.","DOI":"10.1056\/NEJMra1208129"},{"key":"i1552-5783-59-13-5312-b03","doi-asserted-by":"crossref","unstructured":"Fulton AB, Hansen RM, Moskowitz A, Akula JD. The neurovascular retina in retinopathy of prematurity. Prog Retin Eye Res. 2009; 28: 452\u2013482.","DOI":"10.1016\/j.preteyeres.2009.06.003"},{"key":"i1552-5783-59-13-5312-b04","doi-asserted-by":"crossref","unstructured":"Yang CS, Wang AG, Sung CS, Hsu WM, Lee FL, Lee SM. Long-term visual outcomes of laser-treated threshold retinopathy of prematurity: a study of refractive status at 7 years. Eye (Lond). 2010; 24: 14\u201320.","DOI":"10.1038\/eye.2009.63"},{"key":"i1552-5783-59-13-5312-b05","doi-asserted-by":"crossref","unstructured":"Hansen RM, Harris ME, Moskowitz A, Fulton AB. Deactivation of the rod response in retinopathy of prematurity. Doc Ophthalmol. 2010; 121: 29\u201335.","DOI":"10.1007\/s10633-010-9228-z"},{"key":"i1552-5783-59-13-5312-b06","doi-asserted-by":"crossref","unstructured":"Repka MX. Ophthalmological problems of the premature infant. Ment Retard Dev Disabil Res Rev. 2002; 8: 249\u2013257.","DOI":"10.1002\/mrdd.10045"},{"key":"i1552-5783-59-13-5312-b07","doi-asserted-by":"crossref","unstructured":"Chen TC, Tsai TH, Shih YF, et al. Long-term evaluation of refractive status and optical components in eyes of children born prematurely. Invest Ophthalmol Vis Sci. 2010; 51: 6140\u20136148.","DOI":"10.1167\/iovs.10-5234"},{"key":"i1552-5783-59-13-5312-b08","doi-asserted-by":"crossref","unstructured":"VanderVeen DK, Bremer DL, Fellows RR, et al. Prevalence and course of strabismus through age 6 years in participants of the Early Treatment for Retinopathy of Prematurity randomized trial. J AAPOS. 2011; 15: 536\u2013540.","DOI":"10.1016\/j.jaapos.2011.07.017"},{"key":"i1552-5783-59-13-5312-b09","doi-asserted-by":"crossref","unstructured":"Hellstr\u00f6m A, Smith LE, Dammann O. Retinopathy of prematurity. Lancet. 2013; 382: 1445\u20131457.","DOI":"10.1016\/S0140-6736(13)60178-6"},{"key":"i1552-5783-59-13-5312-b10","doi-asserted-by":"crossref","unstructured":"Smith LE, Hard AL, Hellstr\u00f6m A. The biology of retinopathy of prematurity: how knowledge of pathogenesis guides treatment. Clin Perinatol. 2013; 40: 201\u2013214.","DOI":"10.1016\/j.clp.2013.02.002"},{"key":"i1552-5783-59-13-5312-b11","doi-asserted-by":"crossref","unstructured":"Lynch AM, Wagner BD, Mandava N, et al. The relationship of novel plasma proteins in the early neonatal period with retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2016; 57: 5076\u20135082.","DOI":"10.1167\/iovs.16-19653"},{"key":"i1552-5783-59-13-5312-b12","doi-asserted-by":"crossref","unstructured":"Sugioka K, Saito A, Kusaka S, Kuniyoshi K, Shimomura Y. Identification of vitreous proteins in retinopathy of prematurity. Biochem Biophys Res Commun. 2017; 488: 483\u2013488.","DOI":"10.1016\/j.bbrc.2017.05.067"},{"key":"i1552-5783-59-13-5312-b13","doi-asserted-by":"crossref","unstructured":"Suski M, Bokiniec R, Szwarc-Duma M, et al. Plasma proteome changes in cord blood samples from preterm infants [published online ahead of print June 18, 2018]. J Perinatol. https:\/\/doi.org\/10.1038\/s41372-018-0150-7.","DOI":"10.1038\/s41372-018-0150-7"},{"key":"i1552-5783-59-13-5312-b14","doi-asserted-by":"crossref","unstructured":"Suski M, Bokiniec R, Szwarc-Duma M, et al. Prospective plasma proteome changes in preterm infants with different gestational ages. Pediatr Res. 2018; 84: 104\u2013111.","DOI":"10.1038\/s41390-018-0003-2"},{"key":"i1552-5783-59-13-5312-b15","doi-asserted-by":"crossref","unstructured":"Kwinta P, Bokiniec R, Bik-Multanowski M, et al. Comparison of whole genome expression profile between preterm and full-term newborns. Ginekol Pol. 2017; 88: 434\u2013441.","DOI":"10.5603\/GP.a2017.0080"},{"key":"i1552-5783-59-13-5312-b16","doi-asserted-by":"crossref","unstructured":"Reynolds JD, Dobson V, Quinn GE, et al. Evidence-based screening criteria for retinopathy of prematurity: natural history data from the CRYO-ROP and LIGHT-ROP studies. Arch Ophthalmol. 2002; 120: 1470\u20131476.","DOI":"10.1001\/archopht.120.11.1470"},{"key":"i1552-5783-59-13-5312-b17","doi-asserted-by":"crossref","unstructured":"International Committee for the Classification of Retinopathy of Prematurity. The International Classification of Retinopathy of Prematurity revisited. Arch Ophthalmol. 2005; 123: 991\u2013999.","DOI":"10.1001\/archopht.123.7.991"},{"key":"i1552-5783-59-13-5312-b18","doi-asserted-by":"crossref","unstructured":"Candiano G, Dimuccio V, Bruschi M, et al. Combinatorial peptide ligand libraries for urine proteome analysis: investigation of different elution systems. Electrophoresis. 2009; 30: 2405\u20132411.","DOI":"10.1002\/elps.200800762"},{"key":"i1552-5783-59-13-5312-b19","doi-asserted-by":"crossref","unstructured":"Fasoli E, Farinazzo A, Sun CJ, et al. Interaction among proteins and peptide libraries in proteome analysis: pH involvement for a larger capture of species. J Proteomics. 2010; 73: 733\u2013742.","DOI":"10.1016\/j.jprot.2009.10.008"},{"key":"i1552-5783-59-13-5312-b20","doi-asserted-by":"crossref","unstructured":"Gallardo \u00d3, Ovelleiro D, Gay M, Carrascal M, Abian J. A collection of open source applications for mass spectrometry data mining. Proteomics. 2014; 14: 2275\u20132279.","DOI":"10.1002\/pmic.201400124"},{"key":"i1552-5783-59-13-5312-b21","doi-asserted-by":"crossref","unstructured":"Craig R, Beavis RC. TANDEM: matching proteins with tandem mass spectra. Bioinformatics. 2004; 20: 1466\u20131467.","DOI":"10.1093\/bioinformatics\/bth092"},{"key":"i1552-5783-59-13-5312-b22","doi-asserted-by":"crossref","unstructured":"Eng JK, Jahan TA, Hoopmann MR. Comet: an open-source MS\/MS sequence database search tool. Proteomics. 2013; 13: 22\u201324.","DOI":"10.1002\/pmic.201200439"},{"key":"i1552-5783-59-13-5312-b23","doi-asserted-by":"crossref","unstructured":"Shteynberg D, Deutsch EW, Lam H, et al. iProphet: multi-level integrative analysis of shotgun proteomic data improves peptide and protein identification rates and error estimates. Mol Cell Proteomics. 2011; 10: M111.007690.","DOI":"10.1074\/mcp.M111.007690"},{"key":"i1552-5783-59-13-5312-b24","doi-asserted-by":"crossref","unstructured":"Deutsch EW, Mendoza L, Shteynberg D, et al. A guided tour of the Trans-Proteomic Pipeline. Proteomics. 2010; 10: 1150\u20131159.","DOI":"10.1002\/pmic.200900375"},{"key":"i1552-5783-59-13-5312-b25","doi-asserted-by":"crossref","unstructured":"Reiter L, Claassen M, Schrimpf SP, et al. Protein identification false discovery rates for very large proteomics data sets generated by tandem mass spectrometry. Mol Cell Proteomics. 2009; 8: 2405\u20132417.","DOI":"10.1074\/mcp.M900317-MCP200"},{"key":"i1552-5783-59-13-5312-b26","doi-asserted-by":"crossref","unstructured":"Cox J, Mann M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol. 2008; 26: 1367\u20131372.","DOI":"10.1038\/nbt.1511"},{"key":"i1552-5783-59-13-5312-b27","doi-asserted-by":"crossref","unstructured":"Taverner T, Karpievitch YV, Polpitiya AD, et al. DanteR: an extensible R-based tool for quantitative analysis of -omics data. Bioinformatics. 2012; 28: 2404\u20132406.","DOI":"10.1093\/bioinformatics\/bts449"},{"key":"i1552-5783-59-13-5312-b28","unstructured":"Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. 6th ed. Philadelphia: Elsevier; 2010: 272\u2013288."},{"key":"i1552-5783-59-13-5312-b29","doi-asserted-by":"crossref","unstructured":"Clark SJ, Bishop PN. The eye as a complement dysregulation hotspot. Semin Immunopathol. 2018; 40: 65\u201374.","DOI":"10.1007\/s00281-017-0649-6"},{"key":"i1552-5783-59-13-5312-b30","doi-asserted-by":"crossref","unstructured":"Mohlin C, Sandholm K, Kvanta A, Ekdahl KN, Johansson K. A model to study complement involvement in experimental retinal degeneration. Ups J Med Sci. 2018; 123: 28\u201342.","DOI":"10.1080\/03009734.2018.1431744"},{"key":"i1552-5783-59-13-5312-b31","doi-asserted-by":"crossref","unstructured":"Lu CH, Lin ST, Chou HC, Lee YR, Chan HL. Proteomic analysis of retinopathy-related plasma biomarkers in diabetic patients. Arch Biochem Biophys. 2013; 529: 146\u2013156.","DOI":"10.1016\/j.abb.2012.11.004"},{"key":"i1552-5783-59-13-5312-b32","unstructured":"Zhou L, Liu X, Koh SK, Li X, Beuerman RW. Quantitative proteomic analysis of retina in oxygen-induced retinopathy mice using iTRAQ with 2D NanoLC-nanoESI-MS\/MS. J Integr Omics. 2011; 1: 226\u2013235."},{"key":"i1552-5783-59-13-5312-b33","doi-asserted-by":"crossref","unstructured":"Gao BB, Chen X, Timothy N, Aiello LP, Feener EP. Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy. J Proteome Res. 2008; 7: 2516\u20132525.","DOI":"10.1021\/pr800112g"},{"key":"i1552-5783-59-13-5312-b34","doi-asserted-by":"crossref","unstructured":"Rathi S, Jalali S, Patnaik S, et al. Abnormal complement activation and inflammation in the pathogenesis of retinopathy of prematurity. Front Immunol. 2017; 8: 1868.","DOI":"10.3389\/fimmu.2017.01868"},{"key":"i1552-5783-59-13-5312-b35","doi-asserted-by":"crossref","unstructured":"Langer HF, Chung KJ, Orlova VV, et al. Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. Blood. 2010; 116: 4395\u20134403.","DOI":"10.1182\/blood-2010-01-261503"},{"key":"i1552-5783-59-13-5312-b36","doi-asserted-by":"crossref","unstructured":"Davalos D, Akassoglou K. Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol. 2012; 34: 43\u201362.","DOI":"10.1007\/s00281-011-0290-8"},{"key":"i1552-5783-59-13-5312-b37","doi-asserted-by":"crossref","unstructured":"Lee J, Dammann O. Perinatal infection, inflammation, and retinopathy of prematurity. Semin Fetal Neonatal Med. 2012; 17: 26\u201329.","DOI":"10.1016\/j.siny.2011.08.007"},{"key":"i1552-5783-59-13-5312-b38","doi-asserted-by":"crossref","unstructured":"Chen M, Citil A, McCabe F, et al. Infection, oxygen, and immaturity: interacting risk factors for retinopathy of prematurity. Neonatology. 2011; 99: 125\u2013132.","DOI":"10.1159\/000312821"},{"key":"i1552-5783-59-13-5312-b39","doi-asserted-by":"crossref","unstructured":"Sood BG, Madan A, Saha S, et al. Perinatal systemic inflammatory response syndrome and retinopathy of prematurity. Pediatr Res. 2010; 67: 394\u2013400.","DOI":"10.1203\/PDR.0b013e3181d01a36"},{"key":"i1552-5783-59-13-5312-b40","doi-asserted-by":"crossref","unstructured":"Dammann O. Inflammation and retinopathy of prematurity. Acta Paediatr. 2010; 99: 975\u2013977.","DOI":"10.1111\/j.1651-2227.2010.01836.x"},{"key":"i1552-5783-59-13-5312-b41","doi-asserted-by":"crossref","unstructured":"Dammann O, Brinkhaus MJ, Bartels DB, et al. Immaturity, perinatal inflammation, and retinopathy of prematurity: a multi-hit hypothesis. Early Hum Dev. 2009; 85: 325\u2013329.","DOI":"10.1016\/j.earlhumdev.2008.12.010"},{"key":"i1552-5783-59-13-5312-b42","doi-asserted-by":"crossref","unstructured":"Christensen RD, Baer VL, Lambert DK, Henry E, Ilstrup SJ, Bennett ST. Reference intervals for common coagulation tests of preterm infants (CME). Transfusion. 2014; 54: 627\u2013632.","DOI":"10.1111\/trf.12322"},{"key":"i1552-5783-59-13-5312-b43","doi-asserted-by":"crossref","unstructured":"Mitra S, Aune D, Speer CP, Saugstad OD. Chorioamnionitis as a risk factor for retinopathy of prematurity: a systematic review and meta-analysis. Neonatology. 2014; 105: 189\u2013199.","DOI":"10.1159\/000357556"},{"key":"i1552-5783-59-13-5312-b44","doi-asserted-by":"crossref","unstructured":"Lajko M, Cardona HJ, Taylor JM, Shah RS, Farrow KN, Fawzi AA. Hyperoxia-induced proliferative retinopathy: early interruption of retinal vascular development with severe and irreversible neurovascular disruption. PLoS One. 2016; 11: e0166886.","DOI":"10.1371\/journal.pone.0166886"},{"key":"i1552-5783-59-13-5312-b45","doi-asserted-by":"crossref","unstructured":"Asakawa H, Tokunaga K, Kawakami F. Elevation of fibrinogen and thrombin-antithrombin III complex levels of type 2 diabetes mellitus patients with retinopathy and nephropathy. J Diabetes Complications. 2000; 14: 121\u2013126.","DOI":"10.1016\/S1056-8727(00)00075-1"},{"key":"i1552-5783-59-13-5312-b46","unstructured":"Mahendra JV, Kumar SD, Anuradha TS, Talikoti P, Nagaraj RS, Vishali V. Plasma fibrinogen in type 2 diabetic patients with metabolic syndrome and its relation with ischemic heart disease (IHD) and retinopathy. J Clin Diagn Res. 2015; 9: BC18\u2013BC21."},{"key":"i1552-5783-59-13-5312-b47","doi-asserted-by":"crossref","unstructured":"Sarangi R, Padhi S, Mohapatra S, et al. Serum high sensitivity C-reactive protein, nitric oxide metabolites, plasma fibrinogen, and lipid parameters in Indian type 2 diabetic males. Diabetes Metab Syndr. 2012; 6: 9\u201314.","DOI":"10.1016\/j.dsx.2012.05.015"},{"key":"i1552-5783-59-13-5312-b48","doi-asserted-by":"crossref","unstructured":"Koss MJ, Hoffmann J, Nguyen N, et al. Proteomics of vitreous humor of patients with exudative age-related macular degeneration. PLoS One. 2014; 9: e96895.","DOI":"10.1371\/journal.pone.0096895"},{"key":"i1552-5783-59-13-5312-b49","doi-asserted-by":"crossref","unstructured":"Klingel R, Fassbender C, Fischer I, et al. Rheopheresis for age-related macular degeneration: a novel indication for therapeutic apheresis in ophthalmology. Ther Apher. 2002; 6: 271\u2013281.","DOI":"10.1046\/j.1526-0968.2002.00418.x"},{"key":"i1552-5783-59-13-5312-b50","unstructured":"Weizmann Institute of Science and LifeMap Sciences. Complement C3 on GeneCards - The Human Gene Database. Available at: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=C3&keywords=complement,c3. Accessed May 12, 2018."},{"key":"i1552-5783-59-13-5312-b51","unstructured":"Weizmann Institute of Science and LifeMap Sciences. Fibrinogen Alpha Chain on GeneCards - The Human Gene Database. Available at: https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=FGA&keywords=fibrinogen. Accessed May 12, 2018."},{"key":"i1552-5783-59-13-5312-b52","doi-asserted-by":"crossref","unstructured":"Hoppe G, Lee TJ, Yoon S, et al. Inducing a visceral organ to protect a peripheral capillary bed: stabilizing hepatic HIF-1a prevents oxygen-induced retinopathy. Am J Pathol. 2014; 184: 1890\u20131899.","DOI":"10.1016\/j.ajpath.2014.02.017"},{"key":"i1552-5783-59-13-5312-b53","doi-asserted-by":"crossref","unstructured":"Hoppe G, Yoon S, Gopalan B, et al. Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity. Proc Natl Acad Sci U S A. 2016; 113: E2516\u2013E2525.","DOI":"10.1073\/pnas.1523005113"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2712980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:59Z","timestamp":1791927059000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-24914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,5]]},"references-count":53,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-24914","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,5]]}}}