{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:17Z","timestamp":1791928697926,"version":"4.3.4"},"reference-count":43,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"DOI":"10.1167\/iovs.18-24968","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T12:13:00Z","timestamp":1546431180000},"page":"16","source":"Crossref","is-referenced-by-count":61,"title":["MiR-34c Participates in Diabetic Corneal Neuropathy Via Regulation of Autophagy"],"prefix":"10.1167","volume":"60","author":[{"given":"Jianzhang","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Fujian Medical University Union Hospital, Fu Zhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XinYing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Fujian Medical University Union Hospital, Fu Zhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Fujian Medical University Union Hospital, Fu Zhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","published-online":{"date-parts":[[2019,1,2]]},"reference":[{"key":"i1552-5783-60-1-16-b01","doi-asserted-by":"crossref","unstructured":"Obrosova IG. Diabetes and the peripheral nerve. Biochim Biophys Acta. 2009; 1792: 931\u2013940.","DOI":"10.1016\/j.bbadis.2008.11.005"},{"key":"i1552-5783-60-1-16-b02","doi-asserted-by":"crossref","unstructured":"Jeric M, Vuica A, Boric M. Diabetes mellitus affects activity of calcium\/ calmodulin-dependent protein kinase II alpha in rat trigeminal ganglia. J Chem Neuroanat. 2015; 64: 12\u201319.","DOI":"10.1016\/j.jchemneu.2015.02.003"},{"key":"i1552-5783-60-1-16-b03","unstructured":"Beckers HJ, Klooster J, Vrensen GF, Lamers WP. Ultrastructural identification of trigeminal nerve endings in the rat cornea and iris. Invest Ophthalmol Vis Sci. 1992; 33: 1979\u20131986."},{"key":"i1552-5783-60-1-16-b04","unstructured":"De Leeuw AM, Chan KY. Corneal nerve regeneration. Correlation between morphology and restoration of sensitivity. Invest Ophthalmol Vis Sci. 1989; 30: 1980\u20131990."},{"key":"i1552-5783-60-1-16-b05","doi-asserted-by":"crossref","unstructured":"Nones CF, Reis RC, Jesus CH, Veronez DA, Cunha JM, Chichorro JG. Orofacial sensory changes after streptozotocin-induced diabetes in rats. Brain Res. 2013; 1501: 56\u201367.","DOI":"10.1016\/j.brainres.2013.01.002"},{"key":"i1552-5783-60-1-16-b06","unstructured":"Zhang Z, Xie L, Dong X. Morphological and functional studies on nerve regeneration after corneal nerve injuries [in Chinese]. Zhonghua Yan Ke Za Zhi. 1994; 30: 301\u2013304."},{"key":"i1552-5783-60-1-16-b07","doi-asserted-by":"crossref","unstructured":"Abdelkader H, Patel DV, McGhee C, et al. New therapeutic approaches in the treatment of diabetic keratopathy: a review J Clin Experiment Ophthalmol. 2012; 39: 259\u2013270.","DOI":"10.1111\/j.1442-9071.2010.02435.x"},{"key":"i1552-5783-60-1-16-b08","doi-asserted-by":"crossref","unstructured":"Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol. 2010; 12: 823\u2013830.","DOI":"10.1038\/ncb0910-823"},{"key":"i1552-5783-60-1-16-b09","doi-asserted-by":"crossref","unstructured":"Kang R, Zeh HJ, Lotze MT, Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 2011; 18: 571\u2013580.","DOI":"10.1038\/cdd.2010.191"},{"key":"i1552-5783-60-1-16-b10","doi-asserted-by":"crossref","unstructured":"Fang L, Zhou Y, Cao H, et al. Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury. PLoS One. 2013; 8: e60546.","DOI":"10.1371\/journal.pone.0060546"},{"key":"i1552-5783-60-1-16-b11","doi-asserted-by":"crossref","unstructured":"Chandrasekaran K, Anjaneyulu M, Inoue T, et al. Mitochondrial transcription factor A regulation of mitochondrial degeneration in experimental diabetic neuropathy. Am J Physiol Endocrinol Metab. 2015; 309: E132\u2013141.","DOI":"10.1152\/ajpendo.00620.2014"},{"key":"i1552-5783-60-1-16-b12","doi-asserted-by":"crossref","unstructured":"Martorell-Riera A, Segarra-Mondejar M, Munoz JP, et al. Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death. EMBO J. 2014; 33: 2388\u20132407.","DOI":"10.15252\/embj.201488327"},{"key":"i1552-5783-60-1-16-b13","doi-asserted-by":"crossref","unstructured":"Besirli CG, Chinskey ND, Zheng QD, et al. Autophagy activation in the injured photoreceptor inhibits fas-mediated apoptosis. Invest Ophthalmol Vis Sci. 2011; 52: 4193\u20134199.","DOI":"10.1167\/iovs.10-7090"},{"key":"i1552-5783-60-1-16-b14","doi-asserted-by":"crossref","unstructured":"Gao FB. Posttranscriptional control of neuronal development by miRNA networks. Trends Neurosci. 2008; 31: 20\u201326.","DOI":"10.1016\/j.tins.2007.10.004"},{"key":"i1552-5783-60-1-16-b15","doi-asserted-by":"crossref","unstructured":"Brodersen P, Voinnet O. Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol. 2009; 10: 141\u2013148.","DOI":"10.1038\/nrm2619"},{"key":"i1552-5783-60-1-16-b16","doi-asserted-by":"crossref","unstructured":"Panwalkar P, Moiyadi A, Goel A, et al. MiR-206, a cerebellum enriched miRNA is downregulated in all medulloblastoma subgroups and its overexpression is necessary for growth inhibition of medulloblastoma cells. J Mol Neurosci. 2015; 56: 673\u2013680.","DOI":"10.1007\/s12031-015-0548-z"},{"key":"i1552-5783-60-1-16-b17","doi-asserted-by":"crossref","unstructured":"Prajapati P, Sripada L, Singh K, Bhatelia K, Singh R. TNF-alpha regulates miRNA targeting mitochondrial complex-I and induces cell death in dopaminergic cells. Biochim Biophys Acta. 2015; 1852: 451\u2013461.","DOI":"10.1016\/j.bbadis.2014.11.019"},{"key":"i1552-5783-60-1-16-b18","doi-asserted-by":"crossref","unstructured":"Sinirlioglu ZA, Coskunpinar E, Akbas F. miRNA and mRNA expression profiling in rat brain following alcohol dependence and withdrawal. Cell Mol Biol (Noisy-le-grand). 2017; 63: 49\u201356.","DOI":"10.14715\/cmb\/2017.63.2.7"},{"key":"i1552-5783-60-1-16-b19","doi-asserted-by":"crossref","unstructured":"Kara M, Kaplan M, Bozgeyik I, et al. MTUS1 tumor suppressor and its miRNA regulators in fibroadenoma and breast cancer. Gene. 2016; 587: 173\u2013177.","DOI":"10.1016\/j.gene.2016.05.006"},{"key":"i1552-5783-60-1-16-b20","doi-asserted-by":"crossref","unstructured":"Lafferty-Whyte K, Cairney CJ, Jamieson NB, Oien KA, Keith WN. Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms. Biochim Biophys Acta. 2009; 1792: 341\u2013352.","DOI":"10.1016\/j.bbadis.2009.02.003"},{"key":"i1552-5783-60-1-16-b21","doi-asserted-by":"crossref","unstructured":"He L, He X, Lim LP, et al. A microRNA component of the p53 tumour suppressor network. Nature. 2007; 447: 1130\u20131134.","DOI":"10.1038\/nature05939"},{"key":"i1552-5783-60-1-16-b22","doi-asserted-by":"crossref","unstructured":"Zhao T, Li J, Chen AF. MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. Am J Physiol Endocrinol Metab. 2010; 299: E110\u2013E116.","DOI":"10.1152\/ajpendo.00192.2010"},{"key":"i1552-5783-60-1-16-b23","doi-asserted-by":"crossref","unstructured":"Wang X, Liu P, Zhu H, et al. miR-34a, a microRNA upregulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res Bull. 2009; 80: 268\u2013273.","DOI":"10.1016\/j.brainresbull.2009.08.006"},{"key":"i1552-5783-60-1-16-b24","doi-asserted-by":"crossref","unstructured":"Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB. Role of Bcl-2 family proteins in a non-apoptotic programmed celldeath dependent on autophagy genes. Nat Cell Biol. 2006; 6: 1221\u20131228.","DOI":"10.1038\/ncb1192"},{"key":"i1552-5783-60-1-16-b25","doi-asserted-by":"crossref","unstructured":"Yang J, Chen D, He Y, et al. MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9. Age (Dordr) 2013; 35: 11\u201322.","DOI":"10.1007\/s11357-011-9324-3"},{"key":"i1552-5783-60-1-16-b26","doi-asserted-by":"crossref","unstructured":"Malin SA, Davis BM, Molliver DC. Production of dissociated sensory neuron cultures and considerations for their use in studying neuronal function and plasticity. Nat Protoc. 2007; 2: 152\u2013160.","DOI":"10.1038\/nprot.2006.461"},{"key":"i1552-5783-60-1-16-b27","doi-asserted-by":"crossref","unstructured":"Li Z, Burns AR, Han L, Rumbaut, RE, Smith CW. IL-17 and VEGF are necessary for efficient corneal nerve regeneration. Am J Pathol. 2011; 178: 1106\u20131116.","DOI":"10.1016\/j.ajpath.2010.12.001"},{"key":"i1552-5783-60-1-16-b28","doi-asserted-by":"crossref","unstructured":"Guaiquil VH, Karagianni N, Fukuoka S, Alegre G, Rosenblatt MI. VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions. Proc Natl Acad Sci U S A. 2014; 111: 17272\u201317277.","DOI":"10.1073\/pnas.1407227111"},{"key":"i1552-5783-60-1-16-b29","doi-asserted-by":"crossref","unstructured":"Byun YS, Kang B, Yoo YS, Joo CK. Poly(ADP-Ribose) polymerase inhibition improves corneal epithelial innervation and wound healing in diabetic rats. Invest Ophthalmol Vis Sci. 2015; 56: 1948\u20131955.","DOI":"10.1167\/iovs.14-16259"},{"key":"i1552-5783-60-1-16-b30","doi-asserted-by":"crossref","unstructured":"Gao J, Wang Y, Zhao X, Chen P, Xie L. MicroRNA-204-5p-mediated regulation of SIRT1 contributes to the delay of epithelial cell cycle traversal in diabetic corneas. Invest Ophthalmol Vis Sci. 2015; 56: 1493\u2013150.","DOI":"10.1167\/iovs.14-15913"},{"key":"i1552-5783-60-1-16-b31","doi-asserted-by":"crossref","unstructured":"Joglekar MV, Januszewski AS, Jenkins AJ, Hardikar AA. Circulating microRNA biomarkers of diabetic retinopathy. Diabetes. 2016; 65: 1.22\u201324.","DOI":"10.2337\/dbi15-0028"},{"key":"i1552-5783-60-1-16-b32","doi-asserted-by":"crossref","unstructured":"Bhatwadekar A, Yan D, Stepps Y, et al. miR-92a corrects CD34+ cell dysfunction in diabetes by modulating core circadian genes involved in progenitor differentiation. Diabetes. 2015; 64: 4226\u20134237.","DOI":"10.2337\/db15-0521"},{"key":"i1552-5783-60-1-16-b33","doi-asserted-by":"crossref","unstructured":"Wang Z, Yin B, Wang B, Ma Z, Liu W, Lv G. MicroRNA-210 promotes proliferation and invasion of peripheral nerve sheath tumor cells targeting EFNA3. Oncol Res. 2013; 21: 145\u2013154.","DOI":"10.3727\/096504013X13841340689573"},{"key":"i1552-5783-60-1-16-b34","doi-asserted-by":"crossref","unstructured":"Li S, Wang X, Gu Y, et al. Let-7 microRNAs regenerate peripheral nerve regeneration by targeting nerve growth factor. Mol Ther. 2015; 23: 423\u2013433.","DOI":"10.1038\/mt.2014.220"},{"key":"i1552-5783-60-1-16-b35","doi-asserted-by":"crossref","unstructured":"Bikbova G, Oshitari T, Tawada A, Yamamoto S. Corneal changes in diabetes mellitus. Curr Diabetes Rev. 2012; 8: 294\u2013302.","DOI":"10.2174\/157339912800840479"},{"key":"i1552-5783-60-1-16-b36","doi-asserted-by":"crossref","unstructured":"Jeganathan VS, Wang JJ, Wong TY. Ocular associations of diabetes other than diabetic retinopathy. Diabetes Care. 2008; 31: 1905\u20131912.","DOI":"10.2337\/dc08-0342"},{"key":"i1552-5783-60-1-16-b37","doi-asserted-by":"crossref","unstructured":"Carloni S, Girelli S, Scopa C, et al. Activation of autophagy and Akt\/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia. Autophagy. 2010; 6: 366\u2013377.","DOI":"10.4161\/auto.6.3.11261"},{"key":"i1552-5783-60-1-16-b38","doi-asserted-by":"crossref","unstructured":"Carloni S, Albertini MC, Galluzzi L, et al. Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia-ischemia: role of protein synthesis and autophagic pathways. Exp Neurol. 2014; 255: 103\u2013112.","DOI":"10.1016\/j.expneurol.2014.03.002"},{"key":"i1552-5783-60-1-16-b39","doi-asserted-by":"crossref","unstructured":"Balduini W, Carloni S, Buonocore G. Autophagy in hypoxiaischemia induced brain injury. J Matern Fetal Neonatal Med. 2012; 25: 30\u201340.","DOI":"10.3109\/14767058.2012.663176"},{"key":"i1552-5783-60-1-16-b40","doi-asserted-by":"crossref","unstructured":"Kosacka J, Nowicki M, Bl\u00fcher M. et al. Increased autophagy in peripheral nerves may protect Wistar Ottawa Karlsburg W rats against neuropathy. Exp Neurol. 2013; 250: 125\u2013135.","DOI":"10.1016\/j.expneurol.2013.09.017"},{"key":"i1552-5783-60-1-16-b41","doi-asserted-by":"crossref","unstructured":"Shi G, Shi J, Liu K et al. Increased miR-195 aggravates neuropathic pain by inhibiting autophagy following peripheral nerve injury. Glia. 2013; 61: 504\u2013512.","DOI":"10.1002\/glia.22451"},{"key":"i1552-5783-60-1-16-b42","doi-asserted-by":"crossref","unstructured":"Yao J, Tao ZF, Li CP, et al. Regulation of autophagy by high glucose in human retinal pigment epithelium. Cell Physiol Biochem. 2014; 33: 107\u2013116.","DOI":"10.1159\/000356654"},{"key":"i1552-5783-60-1-16-b43","doi-asserted-by":"crossref","unstructured":"Mizushima N. Methods for monitoring autophagy using GFP-LC3 transgenic mice. Methods Enzymol. 2009; 452: 13\u201323.","DOI":"10.1016\/S0076-6879(08)03602-1"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2720150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:03Z","timestamp":1791927063000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-24968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,2]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-24968","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1,2]]}}}