{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:04Z","timestamp":1791928684235,"version":"4.3.4"},"reference-count":43,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"11","license":[{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,9,14]]},"DOI":"10.1167\/iovs.18-25038","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T08:33:29Z","timestamp":1537259609000},"page":"4614","source":"Crossref","is-referenced-by-count":63,"title":["Microvascular Changes in Peripapillary and Optic Nerve Head Tissues After Trabeculectomy in Primary Open-Angle Glaucoma"],"prefix":"10.1167","volume":"59","author":[{"given":"Ji-Ah","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl J. A.","family":"Girard","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, National University of Singapore, Singapore"},{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Martial","family":"Mari","sequence":"additional","affiliation":[{"name":"GePaSud, Universit\u00e9 de la Polyn\u00e9sie Fran\u00e7aise, Tahiti, French Polynesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-11-4614-b01","doi-asserted-by":"crossref","unstructured":"Gordon MO, Beiser JA, Brandt JD, et al. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002; 120: 714\u2013720; discussion 829\u2013730.","DOI":"10.1001\/archopht.120.6.714"},{"key":"i1552-5783-59-11-4614-b02","doi-asserted-by":"crossref","unstructured":"Kass MA, Heuer DK, Higginbotham EJ, et al. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002; 120: 701\u2013713; discussion 829\u2013730.","DOI":"10.1001\/archopht.120.6.701"},{"key":"i1552-5783-59-11-4614-b03","doi-asserted-by":"crossref","unstructured":"The AGIS Investigators. The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. Am J Ophthalmol. 2000; 130: 429\u2013440.","DOI":"10.1016\/S0002-9394(00)00538-9"},{"key":"i1552-5783-59-11-4614-b04","doi-asserted-by":"crossref","unstructured":"Leske MC, Heijl A, Hussein M, et al. Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthalmol. 2003; 121: 48\u201356.","DOI":"10.1001\/archopht.121.1.48"},{"key":"i1552-5783-59-11-4614-b05","unstructured":"Quigley H, Anderson DR. The dynamics and location of axonal transport blockade by acute intraocular pressure elevation in primate optic nerve. Invest Ophthalmol. 1976; 15: 606\u2013616."},{"key":"i1552-5783-59-11-4614-b06","doi-asserted-by":"crossref","unstructured":"Quigley HA, Addicks EM, Green WR, Maumenee AE. Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage. Arch Ophthalmol. 1981; 99: 635\u2013649.","DOI":"10.1001\/archopht.1981.03930010635009"},{"key":"i1552-5783-59-11-4614-b07","unstructured":"Gaasterland D, Tanishima T, Kuwabara T. Axoplasmic flow during chronic experimental glaucoma. 1. Light and electron microscopic studies of the monkey optic nervehead during development of glaucomatous cupping. Invest Ophthalmol Vis Sci. 1978; 17: 838\u2013846."},{"key":"i1552-5783-59-11-4614-b08","doi-asserted-by":"crossref","unstructured":"Lee EJ, Kim TW, Weinreb RN. Reversal of lamina cribrosa displacement and thickness after trabeculectomy in glaucoma. Ophthalmology. 2012; 119: 1359\u20131366.","DOI":"10.1016\/j.ophtha.2012.01.034"},{"key":"i1552-5783-59-11-4614-b09","doi-asserted-by":"crossref","unstructured":"Lee SH, Yu DA, Kim TW, Lee EJ, Girard MJ, Mari JM. Reduction of the lamina cribrosa curvature after trabeculectomy in glaucoma. Invest Ophthalmol Vis Sci. 2016; 57: 5006\u20135014.","DOI":"10.1167\/iovs.15-18982"},{"key":"i1552-5783-59-11-4614-b10","doi-asserted-by":"crossref","unstructured":"Lee EJ, Kim TW. Lamina cribrosa reversal after trabeculectomy and the rate of progressive retinal nerve fiber layer thinning. Ophthalmology. 2015; 122: 2234\u20132242.","DOI":"10.1016\/j.ophtha.2015.07.020"},{"key":"i1552-5783-59-11-4614-b11","doi-asserted-by":"crossref","unstructured":"Burgoyne CF, Downs JC, Bellezza AJ, Suh JK, Hart RT. The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Prog Retin Eye Res. 2005; 24: 39\u201373.","DOI":"10.1016\/j.preteyeres.2004.06.001"},{"key":"i1552-5783-59-11-4614-b12","doi-asserted-by":"crossref","unstructured":"Shin JW, Sung KR, Uhm KB, et al. Peripapillary microvascular improvement and lamina cribrosa depth reduction after trabeculectomy in primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2017; 58: 5993\u20135999.","DOI":"10.1167\/iovs.17-22787"},{"key":"i1552-5783-59-11-4614-b13","doi-asserted-by":"crossref","unstructured":"Hollo G. Influence of large intraocular pressure reduction on peripapillary OCT vessel density in ocular hypertensive and glaucoma eyes. J Glaucoma. 2017; 26: e7\u2013e10.","DOI":"10.1097\/IJG.0000000000000527"},{"key":"i1552-5783-59-11-4614-b14","doi-asserted-by":"crossref","unstructured":"Ghasemi Falavarjani K, Al-Sheikh M, Akil H, Sadda SR. Image artefacts in swept-source optical coherence tomography angiography. Br J Ophthalmol. 2017; 101: 564\u2013568.","DOI":"10.1136\/bjophthalmol-2016-309104"},{"key":"i1552-5783-59-11-4614-b15","doi-asserted-by":"crossref","unstructured":"Sauvola J, Seppanen T, Haapakoski S, Pietikainen M. Adaptive document binarization. In: Proceedings of the Fourth International Conference on Document Analysis and Recognition. Ulm, Germany: IEEE; 1997: 147\u2013152.","DOI":"10.1109\/ICDAR.1997.619831"},{"key":"i1552-5783-59-11-4614-b16","unstructured":"Niblack W. An Introduction to Digital Image Processing. Birkeroed, Denmark: Strandberg Publishing Company; 1986."},{"key":"i1552-5783-59-11-4614-b17","doi-asserted-by":"crossref","unstructured":"Lee SH, Kim TW, Lee EJ, Girard MJ, Mari JM. Diagnostic power of lamina cribrosa depth and curvature in glaucoma. Invest Ophthalmol Vis Sci. 2017; 58: 755\u2013762.","DOI":"10.1167\/iovs.16-20802"},{"key":"i1552-5783-59-11-4614-b18","doi-asserted-by":"crossref","unstructured":"Girard MJ, Strouthidis NG, Ethier CR, Mari JM. Shadow removal and contrast enhancement in optical coherence tomography images of the human optic nerve head. Invest Ophthalmol Vis Sci. 2011; 52: 7738\u20137748.","DOI":"10.1167\/iovs.10-6925"},{"key":"i1552-5783-59-11-4614-b19","doi-asserted-by":"crossref","unstructured":"Mari JM, Strouthidis NG, Park SC, Girard MJ. Enhancement of lamina cribrosa visibility in optical coherence tomography images using adaptive compensation. Invest Ophthalmol Vis Sci. 2013; 54: 2238\u20132247.","DOI":"10.1167\/iovs.12-11327"},{"key":"i1552-5783-59-11-4614-b20","doi-asserted-by":"crossref","unstructured":"Toris CB, Gelfman C, Whitlock A, Sponsel WE, Rowe-Rendleman CL. Making basic science studies in glaucoma more clinically relevant: the need for a consensus. J Ocul Pharmacol Ther. 2017; 33: 501\u2013518.","DOI":"10.1089\/jop.2017.0001"},{"key":"i1552-5783-59-11-4614-b21","doi-asserted-by":"crossref","unstructured":"Kuerten D, Fuest M, Koch EC, Remky A, Plange N. Long term effect of trabeculectomy on retrobulbar haemodynamics in glaucoma. Ophthalmic Physiol Opt. 2015; 35: 194\u2013200.","DOI":"10.1111\/opo.12188"},{"key":"i1552-5783-59-11-4614-b22","doi-asserted-by":"crossref","unstructured":"Januleviciene I, Siaudvytyte L, Diliene V, Barsauskaite R, Siesky B, Harris A. Effect of trabeculectomy on ocular hemodynamic parameters in pseudoexfoliative and primary open-angle glaucoma patients. J Glaucoma. 2015; 24: e52\u2013e56.","DOI":"10.1097\/IJG.0000000000000055"},{"key":"i1552-5783-59-11-4614-b23","doi-asserted-by":"crossref","unstructured":"Trible JR, Sergott RC, Spaeth GL, et al. Trabeculectomy is associated with retrobulbar hemodynamic changes. A color Doppler analysis. Ophthalmology. 1994; 101: 340\u2013351.","DOI":"10.1016\/S0161-6420(13)31332-3"},{"key":"i1552-5783-59-11-4614-b24","doi-asserted-by":"crossref","unstructured":"Berisha F, Schmetterer K, Vass C, et al. Effect of trabeculectomy on ocular blood flow. Br J Ophthalmol. 2005; 89: 185\u2013188.","DOI":"10.1136\/bjo.2004.048173"},{"key":"i1552-5783-59-11-4614-b25","doi-asserted-by":"crossref","unstructured":"Poinoosawmy D, Indar A, Bunce C, Garway-Heath DF, Hitchings RA. Effect of treatment by medicine or surgery on intraocular pressure and pulsatile ocular blood flow in normal-pressure glaucoma. Graefes Arch Clin Exp Ophthalmol. 2002; 240: 721\u2013726.","DOI":"10.1007\/s00417-002-0504-9"},{"key":"i1552-5783-59-11-4614-b26","doi-asserted-by":"crossref","unstructured":"Mackenzie PJ, Cioffi GA. Vascular anatomy of the optic nerve head. Can J Ophthalmol. 2008; 43: 308\u2013312.","DOI":"10.3129\/i08-042"},{"key":"i1552-5783-59-11-4614-b27","doi-asserted-by":"crossref","unstructured":"Hayreh SS. Blood supply of the optic nerve head and its role in optic atrophy, glaucoma, and oedema of the optic disc. Br J Ophthalmol. 1969; 53: 721\u2013748.","DOI":"10.1136\/bjo.53.11.721"},{"key":"i1552-5783-59-11-4614-b28","doi-asserted-by":"crossref","unstructured":"Lee EJ, Kim TW, Weinreb RN, Kim H. Reversal of lamina cribrosa displacement after intraocular pressure reduction in open-angle glaucoma. Ophthalmology. 2013; 120: 553\u2013559.","DOI":"10.1016\/j.ophtha.2012.08.047"},{"key":"i1552-5783-59-11-4614-b29","doi-asserted-by":"crossref","unstructured":"Zhi Z, Cepurna WO, Johnson EC, Morrison JC, Wang RK. Impact of intraocular pressure on changes of blood flow in the retina, choroid, and optic nerve head in rats investigated by optical microangiography. Biomed Opt Express. 2012; 3: 2220\u20132233.","DOI":"10.1364\/BOE.3.002220"},{"key":"i1552-5783-59-11-4614-b30","doi-asserted-by":"crossref","unstructured":"Best M, Blumenthal M, Galin MA, Toyofuku H. Fluorescein angiography during induced ocular hypertension in glaucoma. Br J Ophthalmol. 1972; 56: 6\u201312.","DOI":"10.1136\/bjo.56.1.6"},{"key":"i1552-5783-59-11-4614-b31","doi-asserted-by":"crossref","unstructured":"Lee EJ, Kim TW, Kim M, Kim H. Influence of lamina cribrosa thickness and depth on the rate of progressive retinal nerve fiber layer thinning. Ophthalmology. 2015; 122: 721\u2013729.","DOI":"10.1016\/j.ophtha.2014.10.007"},{"key":"i1552-5783-59-11-4614-b32","doi-asserted-by":"crossref","unstructured":"Furlanetto RL, Park SC, Damle UJ, et al. Posterior displacement of the lamina cribrosa in glaucoma: in vivo interindividual and intereye comparisons. Invest Ophthalmol Vis Sci. 2013; 54: 4836\u20134842.","DOI":"10.1167\/iovs.12-11530"},{"key":"i1552-5783-59-11-4614-b33","doi-asserted-by":"crossref","unstructured":"Yang H, He L, Gardiner SK, et al. Age-related differences in longitudinal structural change by spectral-domain optical coherence tomography in early experimental glaucoma. Invest Ophthalmol Vis Sci. 2014; 55: 6409\u20136420.","DOI":"10.1167\/iovs.14-14156"},{"key":"i1552-5783-59-11-4614-b34","doi-asserted-by":"crossref","unstructured":"Rhodes LA, Huisingh C, Johnstone J, et al. Peripapillary choroidal thickness variation with age and race in normal eyes. Invest Ophthalmol Vis Sci. 2015; 56: 1872\u20131879.","DOI":"10.1167\/iovs.14-16179"},{"key":"i1552-5783-59-11-4614-b35","doi-asserted-by":"crossref","unstructured":"Saeedi O, Pillar A, Jefferys J, Arora K, Friedman D, Quigley H. Change in choroidal thickness and axial length with change in intraocular pressure after trabeculectomy. Br J Ophthalmol. 2014; 98: 976\u2013979.","DOI":"10.1136\/bjophthalmol-2013-304433"},{"key":"i1552-5783-59-11-4614-b36","doi-asserted-by":"crossref","unstructured":"Levitzky M, Henkind P. Angioarchitecture of the optic nerve. II. Lamina cribrosa. Am J Ophthalmol. 1969; 68: 986\u2013996.","DOI":"10.1016\/0002-9394(69)93438-2"},{"key":"i1552-5783-59-11-4614-b37","doi-asserted-by":"crossref","unstructured":"Tokayer J, Jia Y, Dhalla AH, Huang D. Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Biomed Opt Express. 2013; 4: 1909\u20131924.","DOI":"10.1364\/BOE.4.001909"},{"key":"i1552-5783-59-11-4614-b38","doi-asserted-by":"crossref","unstructured":"Pechauer AD, Jia Y, Liu L, Gao SS, Jiang C, Huang D. Optical coherence tomography angiography of peripapillary retinal blood flow response to hyperoxia. Invest Ophthalmol Vis Sci. 2015; 56: 3287\u20133291.","DOI":"10.1167\/iovs.15-16655"},{"key":"i1552-5783-59-11-4614-b39","doi-asserted-by":"crossref","unstructured":"Huang D, Jia Y, Gao SS, Lumbroso B, Rispoli M. Optical coherence tomography angiography using the Optovue device. Dev Ophthalmol. 2016; 56: 6\u201312.","DOI":"10.1159\/000442770"},{"key":"i1552-5783-59-11-4614-b40","doi-asserted-by":"crossref","unstructured":"Jia Y, Morrison JC, Tokayer J, et al. Quantitative OCT angiography of optic nerve head blood flow. Biomed Opt Express. 2012; 3: 3127\u20133137.","DOI":"10.1364\/BOE.3.003127"},{"key":"i1552-5783-59-11-4614-b41","doi-asserted-by":"crossref","unstructured":"Jia Y, Bailey ST, Hwang TS, et al. Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye. Proc Natl Acad Sci U S A. 2015; 112: E2395\u2013E2402.","DOI":"10.1073\/pnas.1500185112"},{"key":"i1552-5783-59-11-4614-b42","doi-asserted-by":"crossref","unstructured":"Spaide RF, Fujimoto JG, Waheed NK. Image artifacts in optical coherence tomography angiography. Retina. 2015; 35: 2163\u20132180.","DOI":"10.1097\/IAE.0000000000000765"},{"key":"i1552-5783-59-11-4614-b43","doi-asserted-by":"crossref","unstructured":"Akagi T, Iida Y, Nakanishi H, et al. Microvascular density in glaucomatous eyes with hemifield visual field defects: an optical coherence tomography angiography study. Am J Ophthalmol. 2016; 168: 237\u2013249.","DOI":"10.1016\/j.ajo.2016.06.009"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2702941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:57Z","timestamp":1791927057000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-25038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,14]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,9,4]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-25038","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9,14]]}}}