{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:09Z","timestamp":1791928689624,"version":"4.3.4"},"reference-count":43,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2018,10,25]]},"DOI":"10.1167\/iovs.18-25046","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T18:13:01Z","timestamp":1540491181000},"page":"5127","source":"Crossref","is-referenced-by-count":18,"title":["Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model,\n                    <i>rnv3<\/i>\n                    , Is Dependent on the\n                    <i>\n                      Crb1\n                      <sup>rd8<\/sup>\n                    <\/i>\n                    Allele"],"prefix":"10.1167","volume":"59","author":[{"given":"Bo","family":"Chang","sequence":"first","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"FitzMaurice","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieping","family":"Wang","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin E.","family":"Low","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Wiles","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patsy M.","family":"Nishina","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-59-12-5127-b01","doi-asserted-by":"crossref","unstructured":"Folkman J, Shing Y. Angiogenesis. J Biol Chem. 1992; 267: 10931\u201310934.","DOI":"10.1016\/S0021-9258(19)49853-0"},{"key":"i1552-5783-59-12-5127-b02","doi-asserted-by":"crossref","unstructured":"Campochiaro PA. Molecular pathogenesis of retinal and choroidal vascular diseases. Prog Retin Eye Res. 2015; 49: 67\u201381.","DOI":"10.1016\/j.preteyeres.2015.06.002"},{"key":"i1552-5783-59-12-5127-b03","doi-asserted-by":"crossref","unstructured":"Saint-Geniez M, D'Amore PA. Development and pathology of the hyaloid, choroidal and retinal vasculature. Int J Dev Biol. 2004; 48: 1045\u20131058.","DOI":"10.1387\/ijdb.041895ms"},{"key":"i1552-5783-59-12-5127-b04","doi-asserted-by":"crossref","unstructured":"Hartnett ME. Pathophysiology and mechanisms of severe retinopathy of prematurity. Ophthalmology. 2015; 122: 200\u2013210.","DOI":"10.1016\/j.ophtha.2014.07.050"},{"key":"i1552-5783-59-12-5127-b05","doi-asserted-by":"crossref","unstructured":"Heckenlively JR, Hawes NL, Friedlander M, et al. Mouse model of subretinal neovascularization with choroidal anastomosis. Retina. 2003; 23: 518\u2013522.","DOI":"10.1097\/00006982-200308000-00012"},{"key":"i1552-5783-59-12-5127-b06","doi-asserted-by":"crossref","unstructured":"Johnson KR, Gagnon LH, Chang B. A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice. Mamm Genome. 2016; 27: 200\u2013212.","DOI":"10.1007\/s00335-016-9632-0"},{"key":"i1552-5783-59-12-5127-b07","doi-asserted-by":"crossref","unstructured":"Nagai N, Lundh von Leithner P, Izumi-Nagai K, et al. Spontaneous CNV in a novel mutant mouse is associated with early VEGF-A-driven angiogenesis and latest age focal edema, neural cell loss, and dysfunction. Invest Ophthalmol Vis Sci. 2014; 55: 3709\u20133719.","DOI":"10.1167\/iovs.14-13989"},{"key":"i1552-5783-59-12-5127-b08","doi-asserted-by":"crossref","unstructured":"Hasegawa E, Sweigard H, Husain D, et al. Characterization of a spontaneous retinal neovascular mouse model. PLoS One. 2014; 9: e106507.","DOI":"10.1371\/journal.pone.0106507"},{"key":"i1552-5783-59-12-5127-b09","doi-asserted-by":"crossref","unstructured":"Hua J, Guerin KI, Chen J, et al. Resveratrol inhibits pathologic retinal neovascularization in Vldlr-\/- mice. Invest Ophthalmol Vis Sci. 2011; 52: 2809\u20132816.","DOI":"10.1167\/iovs.10-6496"},{"key":"i1552-5783-59-12-5127-b10","doi-asserted-by":"crossref","unstructured":"Dorrell MI, Aguilar E, Jacobson R, et al. Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress. J Clin Invest. 2009; 119: 611\u2013623.","DOI":"10.1172\/JCI35977"},{"key":"i1552-5783-59-12-5127-b11","doi-asserted-by":"crossref","unstructured":"Kyosseva SV, Chen L, Seal S, McGinnis JF. Nanoceria inhibit expression of genes associated with inflammation and angiogenesis in the retina of Vldlr null mice. Exp Eye Res. 2013; 116: 63\u201374.","DOI":"10.1016\/j.exer.2013.08.003"},{"key":"i1552-5783-59-12-5127-b12","doi-asserted-by":"crossref","unstructured":"Joyal JS, Sun Y, Gantner ML, et al. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016; 22: 439\u2013445.","DOI":"10.1038\/nm.4059"},{"key":"i1552-5783-59-12-5127-b13","doi-asserted-by":"crossref","unstructured":"Hu W, Jiang A, Liang J, et al. Expression of VLDLR in the retina and evolution of subretinal neovascularization in the knockout mouse model's retinal angiomatous proliferation. Invest Ophthalmol Vis Sci. 2008; 49: 407\u2013415.","DOI":"10.1167\/iovs.07-0870"},{"key":"i1552-5783-59-12-5127-b14","doi-asserted-by":"crossref","unstructured":"Liu CH, Wang Z, Sun Y, Chen J. Animal models of ocular angiogenesis: from development to pathologies. FASEB J. 2017; 31: 4665\u20134681.","DOI":"10.1096\/fj.201700336R"},{"key":"i1552-5783-59-12-5127-b15","unstructured":"Hawes NL, Smith RS, Chang B, et al. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis. 1999; 5: 22."},{"key":"i1552-5783-59-12-5127-b16","doi-asserted-by":"crossref","unstructured":"Chang B, Hawes NL, Pardue MT, et al. Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene. Vision Res. 2007; 47: 624\u2013633.","DOI":"10.1016\/j.visres.2006.11.020"},{"key":"i1552-5783-59-12-5127-b17","doi-asserted-by":"crossref","unstructured":"Truett GE, Heeger P, Mynatt RL, et al. Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT). Biotechniques. 2000; 29: 52\u201354.","DOI":"10.2144\/00291bm09"},{"key":"i1552-5783-59-12-5127-b18","doi-asserted-by":"crossref","unstructured":"Taylor BA, Navin A, Phillips SJ. PCR-amplification of simple sequence repeat variants from pooled DNA samples for rapidly mapping new mutations of the mouse. Genomics. 1994; 21: 626\u2013632.","DOI":"10.1006\/geno.1994.1323"},{"key":"i1552-5783-59-12-5127-b19","doi-asserted-by":"crossref","unstructured":"Fairfield H, Gilbert GJ, Barter M, et al. Mutation discovery in mice by whole exome sequencing. Genome Biol. 2011; 12: R86.","DOI":"10.1186\/gb-2011-12-9-r86"},{"key":"i1552-5783-59-12-5127-b20","doi-asserted-by":"crossref","unstructured":"Mehalow AK, Kameya S, Smith RS, et al. CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina. Hum Mol Genet. 2003; 12: 2179\u20132189.","DOI":"10.1093\/hmg\/ddg232"},{"key":"i1552-5783-59-12-5127-b21","doi-asserted-by":"crossref","unstructured":"Low BE, Krebs MP, Joung JK, et al. Correction of the Crb1rd8 allele and retinal phenotype in C57BL\/6N mice via TALEN-mediated homology-directed repair. Invest Ophthalmol Vis Sci. 2014; 55: 387\u2013395.","DOI":"10.1167\/iovs.13-13278"},{"key":"i1552-5783-59-12-5127-b22","doi-asserted-by":"crossref","unstructured":"Luhmann UF, Carvalho LS, Holthaus SM, et al. The severity of retinal pathology in homozygous Crb1rd8\/rd8 mice is dependent on additional genetic factors. Hum Mol Genet. 2015; 24: 128\u2013141.","DOI":"10.1093\/hmg\/ddu424"},{"key":"i1552-5783-59-12-5127-b23","doi-asserted-by":"crossref","unstructured":"Chang B, Hurd R, Wang J, Nishina P. Survey of common eye diseases in laboratory mouse strains. Invest Ophthalmol Vis Sci. 2013; 54: 4974\u2013481.","DOI":"10.1167\/iovs.13-12289"},{"key":"i1552-5783-59-12-5127-b24","doi-asserted-by":"crossref","unstructured":"Mattapallil MJ, Wawrousek EF, Chan CC, et al. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL\/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci. 2012; 53: 2921\u20132927.","DOI":"10.1167\/iovs.12-9662"},{"key":"i1552-5783-59-12-5127-b25","doi-asserted-by":"crossref","unstructured":"Nagai N, Ju M, Izumi-Nagai K, et al. Novel CCR3 Antagonists are effective mono- and combination inhibitors of choroidal neovascular growth and vascular permeability. Am J Pathol. 2015; 185: 2534\u20132549.","DOI":"10.1016\/j.ajpath.2015.04.029"},{"key":"i1552-5783-59-12-5127-b26","doi-asserted-by":"crossref","unstructured":"Foxton R, Osborne A, Martin KR, Ng YS, Shima DT. Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism. Cell Death Dis. 2016; 7: e2212.","DOI":"10.1038\/cddis.2016.110"},{"key":"i1552-5783-59-12-5127-b27","doi-asserted-by":"crossref","unstructured":"Paneghetti L, Ng YS. A novel endothelial-derived anti-inflammatory activity significantly inhibits spontaneous choroidal neovascularisation in a mouse model. Vasc Cell. 2016; 8: 2.","DOI":"10.1186\/s13221-016-0036-4"},{"key":"i1552-5783-59-12-5127-b28","doi-asserted-by":"crossref","unstructured":"van de Pavert SA, Sanz AS, Aartsen WM, et al. Crb1 is a determinant of retinal apical M\u00fcller glia cell features. Glia. 2007; 55: 1486\u20131497.","DOI":"10.1002\/glia.20561"},{"key":"i1552-5783-59-12-5127-b29","doi-asserted-by":"crossref","unstructured":"van Rossum AG, Aartsen WM, Meuleman J, et al. Pals1\/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells. Hum Mol Genet. 2006; 15: 2659\u20132672.","DOI":"10.1093\/hmg\/ddl194"},{"key":"i1552-5783-59-12-5127-b30","doi-asserted-by":"crossref","unstructured":"Zhao M, Andrieu-Soler C, Kowalczuk L, et al. A new CRB1 rat mutation links M\u00fcller glial cells to retinal telangiectasia. J Neurosci. 2015; 35: 6093\u20136106.","DOI":"10.1523\/JNEUROSCI.3412-14.2015"},{"key":"i1552-5783-59-12-5127-b31","doi-asserted-by":"crossref","unstructured":"Khan KN, Robson A, Mahroo OAR, et al. A clinical and molecular characterisation of CRB1-associated maculopathy. Eur J Hum Genet. 2018; 5: 687\u2013694.","DOI":"10.1038\/s41431-017-0082-2"},{"key":"i1552-5783-59-12-5127-b32","doi-asserted-by":"crossref","unstructured":"Henderson RH, Mackay DS, Li Z, et al. Phenotypic variability in patients with retinal dystrophies due to mutations in CRB1. Br J Ophthalmol. 2011; 95: 811\u2013817.","DOI":"10.1136\/bjo.2010.186882"},{"key":"i1552-5783-59-12-5127-b33","doi-asserted-by":"crossref","unstructured":"Baird AM, Lucas JA, Berg LJ. A profound deficiency in thymic progenitor cells in mice lacking Jak3. J Immunol. 2000; 165: 3680\u20133688.","DOI":"10.4049\/jimmunol.165.7.3680"},{"key":"i1552-5783-59-12-5127-b34","doi-asserted-by":"crossref","unstructured":"Thomis DC, Berg LJ. Peripheral expression of Jak3 is required to maintain T lymphocyte function. J Exp Med. 1997; 185: 197\u2013206.","DOI":"10.1084\/jem.185.2.197"},{"key":"i1552-5783-59-12-5127-b35","doi-asserted-by":"crossref","unstructured":"Grossman WJ, Verbsky JW, Yang L, et al. Dysregulated myelopoiesis in mice lacking Jak3. Blood. 1999; 94: 932\u2013939.","DOI":"10.1182\/blood.V94.3.932.415k30_932_939"},{"key":"i1552-5783-59-12-5127-b36","doi-asserted-by":"crossref","unstructured":"Yamaoka K, Min B, Zhou YJ, Paul WE, O'shea JJ. Jak3 negatively regulates dendritic-cell cytokine production and survival. Blood. 2005; 106: 3227\u20133233.","DOI":"10.1182\/blood-2005-02-0769"},{"key":"i1552-5783-59-12-5127-b37","doi-asserted-by":"crossref","unstructured":"Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science. 1995; 270: 794\u2013797.","DOI":"10.1126\/science.270.5237.794"},{"key":"i1552-5783-59-12-5127-b38","doi-asserted-by":"crossref","unstructured":"Soldevila G, Licona I, Salgado A, et al. Impaired chemokine-induced migration during T-cell development in the absence of Jak 3. Immunology. 2004; 112: 191\u2013200.","DOI":"10.1111\/j.1365-2567.2004.01863.x"},{"key":"i1552-5783-59-12-5127-b39","doi-asserted-by":"crossref","unstructured":"Park SY, Saijo K, Takahashi T, et al. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity. 1995; 3: 771\u2013782.","DOI":"10.1016\/1074-7613(95)90066-7"},{"key":"i1552-5783-59-12-5127-b40","doi-asserted-by":"crossref","unstructured":"Casanova JL, Holland SM, Notarangelo LD. Inborn errors of human JAKs and STATs. Immunity. 2012; 36: 515\u2013528.","DOI":"10.1016\/j.immuni.2012.03.016"},{"key":"i1552-5783-59-12-5127-b41","doi-asserted-by":"crossref","unstructured":"Jouanguy E, Gineau L, Cottineau J, et al. Inborn errors of the development of human natural killer cells. Curr Opin Allergy Clin Immunol. 2013; 13: 589\u2013595.","DOI":"10.1097\/ACI.0000000000000011"},{"key":"i1552-5783-59-12-5127-b42","doi-asserted-by":"crossref","unstructured":"Lange C, Thiersch M, Samardzija M, et al. LIF-dependent JAK3 activation is not essential for retinal degeneration. J Neurochem. 2010; 113: 1210\u20131220.","DOI":"10.1111\/j.1471-4159.2010.06686.x"},{"key":"i1552-5783-59-12-5127-b43","doi-asserted-by":"crossref","unstructured":"He X, Sun D, Chen S, Xu H. Activation of liver X receptor delayed the retinal degeneration of rd1 mice through modulation of the immunological function of glia. Oncotarget. 2017; 8: 32068\u201332082.","DOI":"10.18632\/oncotarget.16643"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2711341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:58Z","timestamp":1791927058000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-25046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,25]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,10,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-25046","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10,25]]}}}