{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:37Z","timestamp":1791928717208,"version":"4.3.4"},"reference-count":64,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2019,2,11]]},"DOI":"10.1167\/iovs.18-25257","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T18:30:51Z","timestamp":1549909851000},"page":"634","source":"Crossref","is-referenced-by-count":22,"title":["MMP Inhibition Preserves Integrin Ligation and FAK Activation to Induce Survival and Regeneration in RGCs Following Optic Nerve Damage"],"prefix":"10.1167","volume":"60","author":[{"given":"Philippe M.","family":"D'Onofrio","sequence":"first","affiliation":[{"name":"Division of Anatomy, Department of Surgery, University of Toronto, Toronto, Ontario, Canada"},{"name":"Rehabilitation Science Institute, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza P.","family":"Shabanzadeh","sequence":"additional","affiliation":[{"name":"Division of Anatomy, Department of Surgery, University of Toronto, Toronto, Ontario, Canada"},{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Anatomy, Department of Surgery, University of Toronto, Toronto, Ontario, Canada"},{"name":"Rehabilitation Science Institute, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"B\u00e4hr","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medicine G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo D.","family":"Koeberle","sequence":"additional","affiliation":[{"name":"Division of Anatomy, Department of Surgery, University of Toronto, Toronto, Ontario, Canada"},{"name":"Rehabilitation Science Institute, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-60-2-634-b01","doi-asserted-by":"crossref","unstructured":"Shao L, Yu S, Ji W, Li H, Gao Y. The contribution of necroptosis in neurodegenerative diseases. Neurochem Res. 2017; 42: 2117\u20132126.","DOI":"10.1007\/s11064-017-2249-1"},{"key":"i1552-5783-60-2-634-b02","doi-asserted-by":"crossref","unstructured":"Caccamo A, Branca C, Piras IS, et al. Necroptosis activation in Alzheimer's disease. Nat Neurosci. 2017; 20: 1236\u20131246.","DOI":"10.1038\/nn.4608"},{"key":"i1552-5783-60-2-634-b03","doi-asserted-by":"crossref","unstructured":"Teng XX, Chen W, Liu Z, et al. NLRP3 Inflammasome is involved in Q-VD-OPH induced necroptosis following cerebral ischemia-reperfusion injury. Neurochem Res. 2018; 43: 1200\u20131209.","DOI":"10.1007\/s11064-018-2537-4"},{"key":"i1552-5783-60-2-634-b04","doi-asserted-by":"crossref","unstructured":"Santos AR, Corredor RG, Obeso BA, et al. \u00df1 integrin-focal adhesion kinase (FAK) signaling modulates retinal ganglion cell (RGC) survival. PLoS One. 2012; 7: e48332.","DOI":"10.1371\/journal.pone.0048332"},{"key":"i1552-5783-60-2-634-b05","doi-asserted-by":"crossref","unstructured":"Yong VW. Metalloproteinases: mediators of pathology and regeneration in the CNS. Nat Rev Neurosci. 2005; 6: 931\u2013944:","DOI":"10.1038\/nrn1807"},{"key":"i1552-5783-60-2-634-b06","doi-asserted-by":"crossref","unstructured":"Stupack DG. Integrins as a distinct subtype of dependence receptors. Cell Death Differ. 2005; 12: 1021\u20131030.","DOI":"10.1038\/sj.cdd.4401658"},{"key":"i1552-5783-60-2-634-b07","doi-asserted-by":"crossref","unstructured":"Stupack DG, Puente XS, Boutsaboualoy S, Storgard CM, Cheresh DA. Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol. 2001; 155: 459\u2013470.","DOI":"10.1083\/jcb.200106070"},{"key":"i1552-5783-60-2-634-b08","unstructured":"Einer SG, Elner VM. The integrin superfamily and the eye. Invest Ophthalmol Vis Sci. 1996; 37: 696\u2013701."},{"key":"i1552-5783-60-2-634-b09","doi-asserted-by":"crossref","unstructured":"Bonfoco E, Chen W, Paul R, Cheresh D, Cooper NR. \u00df1 integrin antagonism on adherent, differentiated human neuroblastoma cells triggers an apoptotic signaling pathway. Neuroscience. 2000; 30: 1145\u20131152.","DOI":"10.1016\/S0306-4522(00)00429-2"},{"key":"i1552-5783-60-2-634-b10","doi-asserted-by":"crossref","unstructured":"Vos CM, Sjulson L, Nath A, et al. Cytotoxicity by matrix metalloprotease-1 in organotypic spinal cord and dissociated neuronal cultures. Exp Neurol. 2000; 163: 324\u2013330.","DOI":"10.1006\/exnr.2000.7388"},{"key":"i1552-5783-60-2-634-b11","doi-asserted-by":"crossref","unstructured":"Leu ST, Jacques SA, Wingerd KL, et al. Integrin alpha4beta1 function is required for cell survival in developing retina. Dev Biol. 2004; 276: 416\u2013430.","DOI":"10.1016\/j.ydbio.2004.09.003"},{"key":"i1552-5783-60-2-634-b12","doi-asserted-by":"crossref","unstructured":"Galileo DS, Majors J, Horwitz AF, Sanes JR. Retrovirally introduced antisense integrin RNA inhibits neuroblast migration in vivo. Neuron. 1992; 9: 1117\u20131131.","DOI":"10.1016\/0896-6273(92)90070-T"},{"key":"i1552-5783-60-2-634-b13","doi-asserted-by":"crossref","unstructured":"Zhang Z, Galileo DS. Retroviral transfer of antisense integrin alpha6 or alpha8 sequences results in laminar redistribution or clonal cell death in developing brain. J Neurosci. 1998; 18: 6928\u20136938.","DOI":"10.1523\/JNEUROSCI.18-17-06928.1998"},{"key":"i1552-5783-60-2-634-b14","doi-asserted-by":"crossref","unstructured":"Korsching S. The neurotrophic factor concept: a reexamination. J Neurosci. 1993; 13: 2739\u20132748.","DOI":"10.1523\/JNEUROSCI.13-07-02739.1993"},{"key":"i1552-5783-60-2-634-b15","doi-asserted-by":"crossref","unstructured":"Zhang X, Cheng M, Chintala SK. Optic nerve ligation leads to astrocyte-associated matrix metalloproteinase-9 induction in the mouse retina. Neurosci Lett. 2004; 356: 140\u2013144.","DOI":"10.1016\/j.neulet.2003.10.084"},{"key":"i1552-5783-60-2-634-b16","doi-asserted-by":"crossref","unstructured":"Zhang X, Cheng M, Chintala SK. Kainic acid-mediated upregulation of matrix metalloproteinase-9 promotes retinal degeneration. Invest Ophthalmol Vis Sci. 2004; 45: 2374\u20132383.","DOI":"10.1167\/iovs.03-1239"},{"key":"i1552-5783-60-2-634-b17","doi-asserted-by":"crossref","unstructured":"Zhang X, Sakamoto T, Hata Y, et al. Expression of matrix metalloproteinases and their inhibitors in experimental retinal ischemia-reperfusion injury in rats. Exp Eye Res. 2002; 74: 577\u2013584.","DOI":"10.1006\/exer.2001.1152"},{"key":"i1552-5783-60-2-634-b18","doi-asserted-by":"crossref","unstructured":"Meredith JE, Fazeli B, Schwartz MA. The extracellular matrix as a cell survival factor. Mol Biol Cell. 1993; 4: 953\u2013961.","DOI":"10.1091\/mbc.4.9.953"},{"key":"i1552-5783-60-2-634-b19","doi-asserted-by":"crossref","unstructured":"Koeberle PD, B\u00e4hr M. The upregulation of GLAST-1 is an indirect antiapoptotic mechanism of GDNF and neurturin in the adult CNS. Cell Death Differ. 2008; 15: 471\u2013483.","DOI":"10.1038\/sj.cdd.4402281"},{"key":"i1552-5783-60-2-634-b20","doi-asserted-by":"crossref","unstructured":"Zhou Y, Pernet V, Hauswirth WW, Di Polo A. Activation of the extracellular signal-regulated kinase 1\/2 pathway by AAV gene transfer protects retinal ganglion cells in glaucoma. Mol Ther. 2005; 12: 402\u2013412.","DOI":"10.1016\/j.ymthe.2005.04.004"},{"key":"i1552-5783-60-2-634-b21","unstructured":"Magharious MM, Sardet C, Pag\u00e8s G, L'Allemain G, Brunet A, Pouyss\u00e9gur J. Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts. Invest Ophthalmol Vis Sci. 2011; 17: 50\u201383."},{"key":"i1552-5783-60-2-634-b22","doi-asserted-by":"crossref","unstructured":"Monnier PP, D'Onofrio PM, Magharious M, et al. Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells. J Neurosci. 2011; 31: 10494\u201310505.","DOI":"10.1523\/JNEUROSCI.0148-11.2011"},{"key":"i1552-5783-60-2-634-b23","doi-asserted-by":"crossref","unstructured":"Magharious MM, D'Onofrio PM, Koeberle PD. Optic nerve transection: a model of adult neuron apoptosis in the central nervous system. J Vis Exp. 2011; 51: 2241.","DOI":"10.3791\/2241"},{"key":"i1552-5783-60-2-634-b24","doi-asserted-by":"crossref","unstructured":"Koeberle PD, Ball AK. Effects of GDNF on retinal ganglion cell survival following axotomy. Vision Res. 1998; 38: 1505\u20131515.","DOI":"10.1016\/S0042-6989(97)00364-7"},{"key":"i1552-5783-60-2-634-b25","doi-asserted-by":"crossref","unstructured":"Misantone LJ, Gershenbaum M, Murray M. Viability of retinal ganglion cells after optic nerve crush in adult rats. J Neurocytol. 1984; 13: 449\u2013465.","DOI":"10.1007\/BF01148334"},{"key":"i1552-5783-60-2-634-b26","doi-asserted-by":"crossref","unstructured":"Magharious MM, D'Onofrio PM, Koeberle PD. Methods for experimental manipulations after optic nerve transection in the mammalian CNS. J Vis Exp. 2011; 51: 2261.","DOI":"10.3791\/2261"},{"key":"i1552-5783-60-2-634-b27","doi-asserted-by":"crossref","unstructured":"Mansour-Robaey S, Clarke DB, Wang YC, Bray GM, Aguayo AJ. Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc Natl Acad Sci U S A. 1994; 91: 1632\u20131636.","DOI":"10.1073\/pnas.91.5.1632"},{"key":"i1552-5783-60-2-634-b28","doi-asserted-by":"crossref","unstructured":"Koeberle PD, Wang Y, Schlichter LC. Kv1.1 and Kv1.3 channels contribute to the degeneration of retinal ganglion cells after optic nerve transection in vivo. Cell Death Differ. 2010; 17: 134\u2013144.","DOI":"10.1038\/cdd.2009.113"},{"key":"i1552-5783-60-2-634-b29","unstructured":"Su Y, Wang F, Zhao S, et al. Axonal regeneration after optic nerve crush in Nogo-A\/B\/C knockout mice. Mol Vis. 2008; 14: 268\u2013273."},{"key":"i1552-5783-60-2-634-b30","doi-asserted-by":"crossref","unstructured":"Mathalone N, Lahat N, Rahat MA, Bahar-Shany K, Oron Y, Geyer O. The involvement of matrix metalloproteinases 2 and 9 in rat retinal ischemia. Graefes Arch Clin Exp Ophthalmol. 2007; 245: 725\u2013732.","DOI":"10.1007\/s00417-006-0362-y"},{"key":"i1552-5783-60-2-634-b31","doi-asserted-by":"crossref","unstructured":"Romanic AM, White RF, Arleth AJ, Ohlstein EH, Barone FC. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke. 1998; 29: 1020\u20131030.","DOI":"10.1161\/01.STR.29.5.1020"},{"key":"i1552-5783-60-2-634-b32","doi-asserted-by":"crossref","unstructured":"Li J, Lahat N, Rahat MA, Bahar-Shany K, Oron Y, Geyer O. Macrophage metalloelastase (MMP-12) deficiency mitigates retinal inflammation and pathological angiogenesis in ischemic retinopathy. PLoS One. 2012; 7: e52699.","DOI":"10.1371\/journal.pone.0052699"},{"key":"i1552-5783-60-2-634-b33","doi-asserted-by":"crossref","unstructured":"Santos ARC, Corredor RG, Obeso BA, et al. \u00df1 Integrin-focal adhesion kinase (FAK) signaling modulates retinal ganglion cell (RGC) survival. PLoS One. 2012; 7: e48332.","DOI":"10.1371\/journal.pone.0048332"},{"key":"i1552-5783-60-2-634-b34","doi-asserted-by":"crossref","unstructured":"Gu Z, Cui J, Brown S, et al. A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J Neurosci. 2005; 25: 6401\u20136408.","DOI":"10.1523\/JNEUROSCI.1563-05.2005"},{"key":"i1552-5783-60-2-634-b35","doi-asserted-by":"crossref","unstructured":"Wen LP, Fahrni JA, Troie S, Guan JL, Orth K, Rosen GD. Cleavage of focal adhesion kinase by caspases during apoptosis. J Biol Chem. 1997; 272: 26056\u201326061.","DOI":"10.1074\/jbc.272.41.26056"},{"key":"i1552-5783-60-2-634-b36","doi-asserted-by":"crossref","unstructured":"Ruoslahti E. RGD and other recognition sequences for integrins. Annu Rev Cell Dev Biol. 1996; 12: 697\u2013715.","DOI":"10.1146\/annurev.cellbio.12.1.697"},{"key":"i1552-5783-60-2-634-b37","doi-asserted-by":"crossref","unstructured":"Kapp TG, Rechenmacher F, Neubauer S, et al. A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins. Sci Rep. 2017; 7: 39805.","DOI":"10.1038\/srep39805"},{"key":"i1552-5783-60-2-634-b38","doi-asserted-by":"crossref","unstructured":"Danhier F, Le Breton A, Pr\u00e9at V. RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis. Mol Pharm. 2012; 9: 2961\u20132973.","DOI":"10.1021\/mp3002733"},{"key":"i1552-5783-60-2-634-b39","doi-asserted-by":"crossref","unstructured":"Allen CM, Sharman WM, La Madeleine C, van Lier JE, Weber JM. Attenuation of photodynamically induced apoptosis by an RGD containing peptide. Photochem Photobiol Sci. 2002; 1: 246\u2013254.","DOI":"10.1039\/b109979e"},{"key":"i1552-5783-60-2-634-b40","doi-asserted-by":"crossref","unstructured":"Puente LG, Ostergaard HL. Beta 1\/beta 3 integrin ligation is uncoupled from ERK1\/ERK2 activation in cytotoxic T lymphocytes. J Leukoc Biol. 2003; 73: 391\u2013398.","DOI":"10.1189\/jlb.0402199"},{"key":"i1552-5783-60-2-634-b41","doi-asserted-by":"crossref","unstructured":"Kikkawa Y, Hozumi K, Katagiri F, Nomizu M, Kleinman HK, Koblinski JE. Laminin-111-derived peptides and cancer laminin-111-derived peptides and cancer. Cell Adh Migr. 2013; 7: 150\u2013159.","DOI":"10.4161\/cam.22827"},{"key":"i1552-5783-60-2-634-b42","doi-asserted-by":"crossref","unstructured":"Sieg DJ, Kauck CR, Ilic D, et al. FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol. 2000; 2: 249\u2013256.","DOI":"10.1038\/35010517"},{"key":"i1552-5783-60-2-634-b43","doi-asserted-by":"crossref","unstructured":"Raivich G, Makwana M. The making of successful axonal regeneration: Genes, molecules and signal transduction pathways. Brain Res Rev. 2007; 53: 287\u2013311.","DOI":"10.1016\/j.brainresrev.2006.09.005"},{"key":"i1552-5783-60-2-634-b44","doi-asserted-by":"crossref","unstructured":"Fournier AE, Takizawa BT, Strittmatter SM. Rho kinase inhibition enhances axonal regeneration in the injured CNS. J Neurosci. 2003; 23: 1416\u20131423.","DOI":"10.1523\/JNEUROSCI.23-04-01416.2003"},{"key":"i1552-5783-60-2-634-b45","doi-asserted-by":"crossref","unstructured":"Watanabe K, Ueno M, Kamiya D, et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol. 2007; 25: 681\u2013686.","DOI":"10.1038\/nbt1310"},{"key":"i1552-5783-60-2-634-b46","doi-asserted-by":"crossref","unstructured":"Guo L, Moss SE, Alexander RA, Ali RR, Fitzke FW, Cordeiro MF. Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix. Invest Ophthalmol Vis Sci. 2005; 46: 175\u2013182.","DOI":"10.1167\/iovs.04-0832"},{"key":"i1552-5783-60-2-634-b47","doi-asserted-by":"crossref","unstructured":"Zhang X, Cheng M, Chintala SK. Kainic acid-mediated upregulation of matrix metalloproteinase-9 promotes retinal degeneration. Invest Ophthalmol Vis Sci. 2004; 45: 2374\u20132383.","DOI":"10.1167\/iovs.03-1239"},{"key":"i1552-5783-60-2-634-b48","doi-asserted-by":"crossref","unstructured":"Chintala SK, Zhang X, Austin JS, Fini ME. Deficiency in matrix metalloproteinase gelatinase B (MMP-9) protects against retinal ganglion cell death after optic nerve ligation. J Biol Chem. 2002; 277: 47461\u201347468.","DOI":"10.1074\/jbc.M204824200"},{"key":"i1552-5783-60-2-634-b49","doi-asserted-by":"crossref","unstructured":"Hu T, You Q, Chen D, et al. Inhibiting matrix metalloproteinase 3 ameliorates neuronal loss in the ganglion cell layer of rats in retinal ischemia\/reperfusion. Neurochem Res. 2016; 41: 1107\u20131118.","DOI":"10.1007\/s11064-015-1800-1"},{"key":"i1552-5783-60-2-634-b50","doi-asserted-by":"crossref","unstructured":"Xie Y, Mustafa A, Yerzhan A, et al. Nuclear matrix metalloproteinases: functions resemble the evolution from the intracellular to the extracellular compartment. Cell Death Discov. 2017; 3: 17036.","DOI":"10.1038\/cddiscovery.2017.36"},{"key":"i1552-5783-60-2-634-b51","doi-asserted-by":"crossref","unstructured":"Shan X, Tomlinson L, Yang Q, Colognato H. Distinct requirements for extracellular and intracellular MMP12 in the development of the adult V-SVZ neural stem cell niche. Stem Cell Reports. 2018; 10: 984\u2013999.","DOI":"10.1016\/j.stemcr.2018.01.038"},{"key":"i1552-5783-60-2-634-b52","doi-asserted-by":"crossref","unstructured":"Limb GA, Daniels JT, Pleass R, Charteris DG, Luthert PJ, Khaw PT. Differential expression of matrix metalloproteinases 2 and 9 by glial M\u00fcller cells: response to soluble and extracellular matrix-bound tumor necrosis factor-alpha. Am J Pathol. 2002; 160: 1847\u20131855.","DOI":"10.1016\/S0002-9440(10)61131-5"},{"key":"i1552-5783-60-2-634-b53","doi-asserted-by":"crossref","unstructured":"Vecino E, Heller JP, Veiga-Crespo P, Martin KR, Fawcett JW. Influence of extracellular matrix components on the expression of integrins and regeneration of adult retinal ganglion cells. PLoS One. 2015; 10: e0125250.","DOI":"10.1371\/journal.pone.0125250"},{"key":"i1552-5783-60-2-634-b54","doi-asserted-by":"crossref","unstructured":"Nishiuchi R, Takagi J, Hayashi M, et al. Ligand-binding specificities of laminin-binding integrins: A comprehensive survey of laminin\u2013integrin interactions using recombinant a3\u00df1, a6\u00df1, a7\u00df1 and a6\u00df4 integrins. Matrix Biol. 2006; 25: 189\u2013197.","DOI":"10.1016\/j.matbio.2005.12.001"},{"key":"i1552-5783-60-2-634-b55","doi-asserted-by":"crossref","unstructured":"Villegas-P\u00e9rez MP, Vidal-Sanz M, Bray GM, Aguayo AJ. Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats. J Neurosci. 1988; 8: 265\u2013280.","DOI":"10.1523\/JNEUROSCI.08-01-00265.1988"},{"key":"i1552-5783-60-2-634-b56","doi-asserted-by":"crossref","unstructured":"Boateng SY, Lateef SS, Mosley W, Hartman TJ, Hanley L, Russell B. RGD and YIGSR synthetic peptides facilitate cellular adhesion identical to that of laminin and fibronectin but alter the physiology of neonatal cardiac myocytes. Am J Physiol Cell Physiol. 2005; 288: C30\u2013C38.","DOI":"10.1152\/ajpcell.00199.2004"},{"key":"i1552-5783-60-2-634-b57","unstructured":"Nomizu M, Yamamura K, Kleinman HK, Yamada Y. Multimeric forms of Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide enhance the inhibition of tumor growth and metastasis. Cancer Res. 1993; 53: 3459\u20133461."},{"key":"i1552-5783-60-2-634-b58","doi-asserted-by":"crossref","unstructured":"Hauck CR, Hsia DA, Schlaepfer DD. Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cells. J Biol Chem. 2000; 275: 41092\u201341099.","DOI":"10.1074\/jbc.M005450200"},{"key":"i1552-5783-60-2-634-b59","doi-asserted-by":"crossref","unstructured":"Hunger-Glaser I, Fan RS, Perez-Salazar E, Rozengurt E. PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser-910: dissociation from Tyr-397 phosphorylation and requirement for ERK activation. J Cell Physiol. 2004; 200: 213\u2013222.","DOI":"10.1002\/jcp.20018"},{"key":"i1552-5783-60-2-634-b60","doi-asserted-by":"crossref","unstructured":"Mattson MP, Camandola S. NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest. 2001; 107: 247\u2013254.","DOI":"10.1172\/JCI11916"},{"key":"i1552-5783-60-2-634-b61","doi-asserted-by":"crossref","unstructured":"Wachter T, Sprick M, Hausmann D, et al. cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes. J Biol Chem. 2004; 279: 52824\u201352834.","DOI":"10.1074\/jbc.M409554200"},{"key":"i1552-5783-60-2-634-b62","doi-asserted-by":"crossref","unstructured":"Gervais FG, Thornberry NA, Ruffolo SC, Nicholson DW, Roy S. Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide. J Biol Chem. 1998; 272: 17102\u201317108.","DOI":"10.1074\/jbc.273.27.17102"},{"key":"i1552-5783-60-2-634-b63","doi-asserted-by":"crossref","unstructured":"Tucker BA, Rahimtula M, Mearow KM. Src and FAK are key early signalling intermediates required for neurite growth in NGF-responsive adult DRG neurons. Cell Signal. 2008; 20: 241\u2013257.","DOI":"10.1016\/j.cellsig.2007.10.014"},{"key":"i1552-5783-60-2-634-b64","doi-asserted-by":"crossref","unstructured":"McKerracher L, David S, Jackson DL, Kottis V, Dunn RJ, Braun PE. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron. 1994; 13: 805\u2013811.","DOI":"10.1016\/0896-6273(94)90247-X"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2725036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:12Z","timestamp":1791927072000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-25257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,11]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-25257","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2,11]]}}}