{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:30Z","timestamp":1791928710964,"version":"4.3.4"},"reference-count":60,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"DOI":"10.1167\/iovs.18-25535","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T12:12:43Z","timestamp":1546431163000},"page":"41","source":"Crossref","is-referenced-by-count":36,"title":["Noninvasive Assessment of Corneal Crosslinking With Phase-Decorrelation Optical Coherence Tomography"],"prefix":"10.1167","volume":"60","author":[{"given":"Brecken J.","family":"Blackburn","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Ford","sequence":"additional","affiliation":[{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius","family":"de Stefano","sequence":"additional","affiliation":[{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States"},{"name":"Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"William J.","family":"Dupps","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States"},{"name":"Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States"},{"name":"Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Rollins","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","published-online":{"date-parts":[[2019,1,2]]},"reference":[{"key":"i1552-5783-60-1-41-b01","doi-asserted-by":"crossref","unstructured":"Kymes SM, Walline JJ, Zadnik K, Sterling J, Gordon MO. Changes in the quality-of-life of people with keratoconus. Am J Ophthalmol. 2008; 145: 611\u2013617.","DOI":"10.1016\/j.ajo.2007.11.017"},{"key":"i1552-5783-60-1-41-b02","doi-asserted-by":"crossref","unstructured":"Sarezky D, Orlin SE, Pan W, VanderBeek BL. Trends in corneal transplantation in keratoconus. Cornea. 2017; 36: 131\u2013137.","DOI":"10.1097\/ICO.0000000000001083"},{"key":"i1552-5783-60-1-41-b03","doi-asserted-by":"crossref","unstructured":"Godefrooij DA, de Wit GA, Uiterwaal CS, Imhof SM, Wisse RP. Age-specific incidence and prevalence of keratoconus: a nationwide registration study. Am J Ophthalmol. 2017; 175: 169\u2013172.","DOI":"10.1016\/j.ajo.2016.12.015"},{"key":"i1552-5783-60-1-41-b04","doi-asserted-by":"crossref","unstructured":"Karolak JA, Gajecka M. Genomic strategies to understand causes of keratoconus. Mol Genet Genomics. 2017; 292: 251\u2013269.","DOI":"10.1007\/s00438-016-1283-z"},{"key":"i1552-5783-60-1-41-b05","doi-asserted-by":"crossref","unstructured":"Randleman JB, Russell B, Ward MA, Thompson KP, Stulting RD. Risk factors and prognosis for corneal ectasia after LASIK. Ophthalmology. 2003; 110: 267\u2013275.","DOI":"10.1016\/S0161-6420(02)01727-X"},{"key":"i1552-5783-60-1-41-b06","doi-asserted-by":"crossref","unstructured":"Rad AS, Jabbarvand M, Saifi N. Progressive keratectasia after laser in situ keratomileusis. J Refract Surg. 2004; 20 (suppl 5): S718\u2013S722.","DOI":"10.3928\/1081-597X-20040903-18"},{"key":"i1552-5783-60-1-41-b07","doi-asserted-by":"crossref","unstructured":"Pallikaris IG, Kymionis GD, Astyrakakis NI. Corneal ectasia induced by laser in situ keratomileusis. J Cataract Refract Surg. 2001; 27: 1796\u20131802.","DOI":"10.1016\/S0886-3350(01)01090-2"},{"key":"i1552-5783-60-1-41-b08","doi-asserted-by":"crossref","unstructured":"Binder PS, Trattler WB. Evaluation of a risk factor scoring system for corneal ectasia after LASIK in eyes with normal topography. J Refract Surg. 2010; 26: 241\u2013250.","DOI":"10.3928\/1081597X-20100212-02"},{"key":"i1552-5783-60-1-41-b09","doi-asserted-by":"crossref","unstructured":"Roy AS, Dupps WJ Jr. Effects of altered corneal stiffness on native and postoperative LASIK corneal biomechanical behavior: a whole-eye finite element analysis. J Refract Surg. 2009; 25: 875\u2013887.","DOI":"10.3928\/1081597X-20090917-09"},{"key":"i1552-5783-60-1-41-b10","doi-asserted-by":"crossref","unstructured":"Roberts CJ, Dupps WJ Jr. Biomechanics of corneal ectasia and biomechanical treatments. J Cataract Refract Surg. 2014; 40: 991\u2013998.","DOI":"10.1016\/j.jcrs.2014.04.013"},{"key":"i1552-5783-60-1-41-b11","doi-asserted-by":"crossref","unstructured":"Roy AS, Dupps WJ Jr. Patient-specific computational modeling of keratoconus progression and differential responses to collagen cross-linking. Invest Ophthalmol Vis Sci. 2011; 52: 9174\u20139187.","DOI":"10.1167\/iovs.11-7395"},{"key":"i1552-5783-60-1-41-b12","doi-asserted-by":"crossref","unstructured":"Gefen A, Shalom R, Elad D, Mandel Y. Biomechanical analysis of the keratoconic cornea. J Mech Behav Biomed Mater. 2009; 2: 224\u2013236.","DOI":"10.1016\/j.jmbbm.2008.07.002"},{"key":"i1552-5783-60-1-41-b13","doi-asserted-by":"crossref","unstructured":"Hong CW, Sinha-Roy A, Schoenfield L, McMahon JT, Dupps WJ Jr. Collagenase-mediated tissue modeling of corneal ectasia and collagen cross-linking treatments. Invest Ophthalmol Vis Sci. 2012; 53: 2321\u20132327.","DOI":"10.1167\/iovs.11-9327"},{"key":"i1552-5783-60-1-41-b14","doi-asserted-by":"crossref","unstructured":"Nash IS, Greene PR, Foster CS. Comparison of mechanical properties of keratoconus and normal corneas. Exp Eye Res. 1982; 35: 413\u2013424.","DOI":"10.1016\/0014-4835(82)90040-9"},{"key":"i1552-5783-60-1-41-b15","doi-asserted-by":"crossref","unstructured":"Andreassen TT, Simonsen AH, Oxlund H. Biomechanical properties of keratoconus and normal corneas. Exp Eye Res. 1980; 31: 435\u2013441.","DOI":"10.1016\/S0014-4835(80)80027-3"},{"key":"i1552-5783-60-1-41-b16","doi-asserted-by":"crossref","unstructured":"Ford MR, Dupps WJ Jr, Rollins AM, Roy AS, Hu Z. Method for optical coherence elastography of the cornea. J Biomed Opt. 2011; 16: 16005.","DOI":"10.1117\/1.3526701"},{"key":"i1552-5783-60-1-41-b17","doi-asserted-by":"crossref","unstructured":"Akca BI, Chang EW, Kling S, et al. Observation of sound-induced corneal vibrational modes by optical coherence tomography. Biomed Opt Express. 2015; 6: 3313\u20133319.","DOI":"10.1364\/BOE.6.003313"},{"key":"i1552-5783-60-1-41-b18","doi-asserted-by":"crossref","unstructured":"Ambrozinski L, Song S, Yoon SJ, et al. Acoustic micro-tapping for non-contact 4D imaging of tissue elasticity. Sci Rep. 2016; 6: 38967.","DOI":"10.1038\/srep38967"},{"key":"i1552-5783-60-1-41-b19","doi-asserted-by":"crossref","unstructured":"Manapuram RK, Aglyamov SR, Monediado FM, et al. In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography. J Biomed Opt. 2012; 17: 100501.","DOI":"10.1117\/1.JBO.17.10.100501"},{"key":"i1552-5783-60-1-41-b20","doi-asserted-by":"crossref","unstructured":"Singh M, Li J, Han Z, et al. Investigating elastic anisotropy of the porcine cornea as a function of intraocular pressure with optical coherence elastography. J Refract Surg. 2016; 32: 562\u2013567.","DOI":"10.3928\/1081597X-20160520-01"},{"key":"i1552-5783-60-1-41-b21","doi-asserted-by":"crossref","unstructured":"Scarcelli G, Pineda R, Yun SH. Brillouin optical microscopy for corneal biomechanics. Invest Ophthalmol Vis Sci. 2012; 53: 185\u2013190.","DOI":"10.1167\/iovs.11-8281"},{"key":"i1552-5783-60-1-41-b22","doi-asserted-by":"crossref","unstructured":"Scarcelli G, Besner S, Pineda R, Yun SH. Biomechanical characterization of keratoconus corneas ex vivo with Brillouin microscopy. Invest Ophthalmol Vis Sci. 2014; 55: 4490\u20134495.","DOI":"10.1167\/iovs.14-14450"},{"key":"i1552-5783-60-1-41-b23","doi-asserted-by":"crossref","unstructured":"Luce DA. Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg. 2005; 31: 156\u2013162.","DOI":"10.1016\/j.jcrs.2004.10.044"},{"key":"i1552-5783-60-1-41-b24","doi-asserted-by":"crossref","unstructured":"Valbon BF, Ambrosio R Jr, Fontes BM, Alves MR. Effects of age on corneal deformation by non-contact tonometry integrated with an ultra-high-speed (UHS) Scheimpflug camera. Arq Bras Oftalmol. 2013; 76: 229\u2013232.","DOI":"10.1590\/S0004-27492013000400008"},{"key":"i1552-5783-60-1-41-b25","doi-asserted-by":"crossref","unstructured":"Huseynova T, Waring GO IV, Roberts C, Krueger RR, Tomita M. Corneal biomechanics as a function of intraocular pressure and pachymetry by dynamic infrared signal and Scheimpflug imaging analysis in normal eyes. Am J Ophthalmol. 2014; 157: 885\u2013893.","DOI":"10.1016\/j.ajo.2013.12.024"},{"key":"i1552-5783-60-1-41-b26","doi-asserted-by":"crossref","unstructured":"Kling S, Marcos S. Contributing factors to corneal deformation in air puff measurements. Invest Ophthalmol Vis Sci. 2013; 54: 5078\u20135085.","DOI":"10.1167\/iovs.13-12509"},{"key":"i1552-5783-60-1-41-b27","doi-asserted-by":"crossref","unstructured":"Fontes BM, Ambrosio R Jr, Velarde GC, Nose W. Ocular response analyzer measurements in keratoconus with normal central corneal thickness compared with matched normal control eyes. J Refract Surg. 2011; 27: 209\u2013215.","DOI":"10.3928\/1081597X-20100415-02"},{"key":"i1552-5783-60-1-41-b28","doi-asserted-by":"crossref","unstructured":"Saad A, Lteif Y, Azan E, Gatinel D. Biomechanical properties of keratoconus suspect eyes. Invest Ophthalmol Vis Sci. 2010; 51: 2912\u20132916.","DOI":"10.1167\/iovs.09-4304"},{"key":"i1552-5783-60-1-41-b29","doi-asserted-by":"crossref","unstructured":"Hu Z, Rollins AM. Fourier domain optical coherence tomography with a linear-in-wavenumber spectrometer. Opt Lett. 2007; 32: 3525\u20133527.","DOI":"10.1364\/OL.32.003525"},{"key":"i1552-5783-60-1-41-b30","doi-asserted-by":"crossref","unstructured":"Chu B. Dynamic light scattering. In: Borsali R, Pecora R, eds. Soft Matter Characterization. Dordrecht, Netherlands: Springer; 2008: 335\u2013372.","DOI":"10.1007\/978-1-4020-4465-6_7"},{"key":"i1552-5783-60-1-41-b31","doi-asserted-by":"crossref","unstructured":"Chu B. Laser light scattering. Annu Rev Phys Chem. 1970; 21: 145\u2013174.","DOI":"10.1146\/annurev.pc.21.100170.001045"},{"key":"i1552-5783-60-1-41-b32","doi-asserted-by":"crossref","unstructured":"Einstein A. On the motion of small particles suspended in liquids at rest required by the molecular-kinetic theory of heat. Ann Phys. 1905; 17: 549\u2013560.","DOI":"10.1002\/andp.19053220806"},{"key":"i1552-5783-60-1-41-b33","doi-asserted-by":"crossref","unstructured":"Boas DA, Bizheva KK, Siegel AM. Using dynamic low-coherence interferometry to image Brownian motion within highly scattering media. Opt Lett. 1998; 23: 319\u2013321.","DOI":"10.1364\/OL.23.000319"},{"key":"i1552-5783-60-1-41-b34","doi-asserted-by":"crossref","unstructured":"Kalkman J, Sprik R, van Leeuwen TG. Path-length-resolved diffusive particle dynamics in spectral-domain optical coherence tomography. Phys Rev Lett. 2010; 105: 198302.","DOI":"10.1103\/PhysRevLett.105.198302"},{"key":"i1552-5783-60-1-41-b35","doi-asserted-by":"crossref","unstructured":"Lee J, Wu W, Jiang JY, Zhu B, Boas DA. Dynamic light scattering optical coherence tomography. Opt Express. 2012; 20: 22262\u201322277.","DOI":"10.1364\/OE.20.022262"},{"key":"i1552-5783-60-1-41-b36","doi-asserted-by":"crossref","unstructured":"Chhetri RK, Kozek KA, Johnston-Peck AC, Tracy JB, Oldenburg AL. Imaging three-dimensional rotational diffusion of plasmon resonant gold nanorods using polarization-sensitive optical coherence tomography. Phys Rev E. 2011; 83: 40903.","DOI":"10.1103\/PhysRevE.83.040903"},{"key":"i1552-5783-60-1-41-b37","doi-asserted-by":"crossref","unstructured":"Blackmon RL, Sandhu R, Chapman BS, et al. Imaging extracellular matrix remodeling in vitro by diffusion-sensitive optical coherence tomography. Biophys J. 2016; 110: 1858\u20131868.","DOI":"10.1016\/j.bpj.2016.03.014"},{"key":"i1552-5783-60-1-41-b38","doi-asserted-by":"crossref","unstructured":"Nolte DD, An R, Turek J, Jeong K. Holographic tissue dynamics spectroscopy. J Biomed Opt. 2011; 16: 87004.","DOI":"10.1117\/1.3615970"},{"key":"i1552-5783-60-1-41-b39","doi-asserted-by":"crossref","unstructured":"Joo C, Evans CL, Stepinac T, Hasan T, de Boer JF. Diffusive and directional intracellular dynamics measured by field-based dynamic light scattering. Opt Express. 2010; 18: 2858\u20132871.","DOI":"10.1364\/OE.18.002858"},{"key":"i1552-5783-60-1-41-b40","doi-asserted-by":"crossref","unstructured":"Lo WCY, Uribe-Patarroyo N, Nam AS, Villiger M, Vakoc BJ, Bouma BE. Laser thermal therapy monitoring using complex differential variance in optical coherence tomography. J Biophotonics. 2017; 10: 84\u201391.","DOI":"10.1002\/jbio.201600072"},{"key":"i1552-5783-60-1-41-b41","doi-asserted-by":"crossref","unstructured":"Hayes S, Kamma-Lorger CS, Boote C, et al. The effect of riboflavin\/UVA collagen cross-linking therapy on the structure and hydrodynamic behaviour of the ungulate and rabbit corneal stroma. PLoS One. 2013; 8: e52860.","DOI":"10.1371\/journal.pone.0052860"},{"key":"i1552-5783-60-1-41-b42","doi-asserted-by":"crossref","unstructured":"Abass A, Hayes S, White N, Sorensen T, Meek KM. Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution. J R Soc Interface. 2015; 12: 20140717.","DOI":"10.1098\/rsif.2014.0717"},{"key":"i1552-5783-60-1-41-b43","doi-asserted-by":"crossref","unstructured":"Morishige N, Shin-Gyou-Uchi R, Azumi H, et al. Quantitative analysis of collagen lamellae in the normal and keratoconic human cornea by second harmonic generation imaging microscopy. Invest Ophthalmol Vis Sci. 2014; 55: 8377\u20138385.","DOI":"10.1167\/iovs.14-15348"},{"key":"i1552-5783-60-1-41-b44","doi-asserted-by":"crossref","unstructured":"Meek KM, Tuft SJ, Huang Y, et al. Changes in collagen orientation and distribution in keratoconus corneas. Invest Ophthalmol Vis Sci. 2005; 46: 1948\u20131956.","DOI":"10.1167\/iovs.04-1253"},{"key":"i1552-5783-60-1-41-b45","doi-asserted-by":"crossref","unstructured":"Sardar DK, Swanland GY, Yow RM, Thomas RJ, Tsin ATC. Optical properties of ocular tissues in the near infrared region. Lasers Med Sci. 2007; 22: 46\u201352.","DOI":"10.1007\/s10103-006-0421-y"},{"key":"i1552-5783-60-1-41-b46","doi-asserted-by":"crossref","unstructured":"Wollensak G, Spoerl E, Seiler T. Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003; 135: 620\u2013627.","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"i1552-5783-60-1-41-b47","doi-asserted-by":"crossref","unstructured":"Webb JN, Su JP, Scarcelli G. Mechanical outcome of accelerated corneal crosslinking evaluated by Brillouin microscopy. J Cataract Refract Surg. 2017; 43: 1458\u20131463.","DOI":"10.1016\/j.jcrs.2017.07.037"},{"key":"i1552-5783-60-1-41-b48","doi-asserted-by":"crossref","unstructured":"Cheng N-S. Formula for the viscosity of a glycerol-water mixture. Ind Eng Chem Res. 2008; 47: 3285\u20133288.","DOI":"10.1021\/ie071349z"},{"key":"i1552-5783-60-1-41-b49","unstructured":"Hatami-Marbini H, Rahimi A. Interrelation of hydration, collagen cross-linking treatment, and biomechanical properties of the cornea. Curr Eye Res. 2016; 41: 616\u2013622."},{"key":"i1552-5783-60-1-41-b50","doi-asserted-by":"crossref","unstructured":"Ford MR, Sinha Roy A, Rollins AM, Dupps WJ Jr. Serial biomechanical comparison of edematous, normal, and collagen crosslinked human donor corneas using optical coherence elastography. J Cataract Refract Surg. 2014; 40: 1041\u20131047.","DOI":"10.1016\/j.jcrs.2014.03.017"},{"key":"i1552-5783-60-1-41-b51","doi-asserted-by":"crossref","unstructured":"Vantipalli S, Li J, Singh M, Aglyamov SR, Larin KV, Twa MD. Effects of thickness on corneal biomechanical properties using optical coherence elastography. Optom Vis Sci. 2018; 95: 299\u2013308.","DOI":"10.1097\/OPX.0000000000001193"},{"key":"i1552-5783-60-1-41-b52","doi-asserted-by":"crossref","unstructured":"Xia D, Zhang S, Hjortdal J\u00d8, et al. Hydrated human corneal stroma revealed by quantitative dynamic atomic force microscopy at nanoscale. ACS Nano. 2014; 8: 6873\u20136882.","DOI":"10.1021\/nn5015837"},{"key":"i1552-5783-60-1-41-b53","doi-asserted-by":"crossref","unstructured":"Shao P, Seiler TG, Eltony AM, et al. Effects of corneal hydration on brillouin microscopy in vivo. Invest Ophthalmol Vis Sci. 2018; 59: 3020\u20133027.","DOI":"10.1167\/iovs.18-24228"},{"key":"i1552-5783-60-1-41-b54","doi-asserted-by":"crossref","unstructured":"Dias J, Ziebarth NM. Impact of hydration media on ex vivo corneal elasticity measurements. Eye Contact Lens. 2015; 41: 281.","DOI":"10.1097\/ICL.0000000000000119"},{"key":"i1552-5783-60-1-41-b55","doi-asserted-by":"crossref","unstructured":"Kling S, Marcos S. Effect of hydration state and storage media on corneal biomechanical response from in vitro inflation tests. J Refract Surg. 2013; 29: 490\u2013497.","DOI":"10.3928\/1081597X-20130617-08"},{"key":"i1552-5783-60-1-41-b56","doi-asserted-by":"crossref","unstructured":"Kymionis GD, Grentzelos MA, Plaka AD, et al. Correlation of the corneal collagen cross-linking demarcation line using confocal microscopy and anterior segment optical coherence tomography in keratoconic patients. Am J Ophthalmol. 2014; 157: 110\u2013115.","DOI":"10.1016\/j.ajo.2013.09.010"},{"key":"i1552-5783-60-1-41-b57","doi-asserted-by":"crossref","unstructured":"Carvalho LA, Prado M, Cunha RH, et al. Keratoconus prediction using a finite element model of the cornea with local biomechanical properties. Arq Bras Oftalmol. 2009; 72: 139\u2013145.","DOI":"10.1590\/S0004-27492009000200002"},{"key":"i1552-5783-60-1-41-b58","doi-asserted-by":"crossref","unstructured":"Braaf B, Donner S, Nam AS, Bouma BE, Vakoc BJ. Complex differential variance angiography with noise-bias correction for optical coherence tomography of the retina. Biomed Opt Express. 2018; 9: 486\u2013506.","DOI":"10.1364\/BOE.9.000486"},{"key":"i1552-5783-60-1-41-b59","doi-asserted-by":"crossref","unstructured":"Singh M, Han Z, Li J, et al. Quantifying the effects of hydration on corneal stiffness with noncontact optical coherence elastography. J Cataract Refract Surg. 2018; 44: 1023\u20131031.","DOI":"10.1016\/j.jcrs.2018.03.036"},{"key":"i1552-5783-60-1-41-b60","doi-asserted-by":"crossref","unstructured":"Chan CC, Hodge C, Sutton G. External analysis of the Randleman Ectasia Risk Factor Score System: a review of 36 cases of post LASIK ectasia. Clin Exp Ophthalmol. 2010; 38: 335\u2013340.","DOI":"10.1111\/j.1442-9071.2010.02251.x"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2720153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:09Z","timestamp":1791927069000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-25535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,2]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-25535","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1,2]]}}}