{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:19Z","timestamp":1791928699981,"version":"4.3.4"},"reference-count":68,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2019,3,29]]},"DOI":"10.1167\/iovs.18-25583","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T11:36:23Z","timestamp":1553859383000},"page":"1254","source":"Crossref","is-referenced-by-count":26,"title":["Rapamycin Rescues Endoplasmic Reticulum Stress\u2013Induced Dry Eye Syndrome in Mice"],"prefix":"10.1167","volume":"60","author":[{"given":"Bum-Joo","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Sun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joo","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Samsung Medical Center, Sungkyukwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Young","family":"Hyon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-60-4-1254-b01","doi-asserted-by":"crossref","unstructured":"Brauer L, Kindler C, Jager K, et al. Detection of surfactant proteins A and D in human tear fluid and the human lacrimal system. Invest Ophthalmol Vis Sci. 2007; 48: 3945\u20133953.","DOI":"10.1167\/iovs.07-0201"},{"key":"i1552-5783-60-4-1254-b02","doi-asserted-by":"crossref","unstructured":"Dogru M, Suleyman A. Serum 25-hydroxyvitamin D3 levels in children with allergic or nonallergic rhinitis. Int J Pediatr Otorhinolaryngol. 2016; 80: 39\u201342.","DOI":"10.1016\/j.ijporl.2015.11.013"},{"key":"i1552-5783-60-4-1254-b03","doi-asserted-by":"crossref","unstructured":"Dana MR, Hamrah P. Role of immunity and inflammation in corneal and ocular surface disease associated with dry eye. Adv Exp Med Biol. 2002; 506: 729\u2013738.","DOI":"10.1007\/978-1-4615-0717-8_103"},{"key":"i1552-5783-60-4-1254-b04","doi-asserted-by":"crossref","unstructured":"Yoon SY, Bae SH, Shin YJ, et al. Low serum 25-hydroxyvitamin D Levels are associated with dry eye syndrome. PLoS One. 2016; 11: e0147847.","DOI":"10.1371\/journal.pone.0147847"},{"key":"i1552-5783-60-4-1254-b05","doi-asserted-by":"crossref","unstructured":"Seo Y, Ji YW, Lee SM, et al. Activation of HIF-1alpha (hypoxia inducible factor-1alpha) prevents dry eye-induced acinar cell death in the lacrimal gland. Cell Death Dis. 2014; 5: e1309.","DOI":"10.1038\/cddis.2014.260"},{"key":"i1552-5783-60-4-1254-b06","doi-asserted-by":"crossref","unstructured":"Coursey TG, Tukler Henriksson J, Barbosa FL, de Paiva CS, Pflugfelder SC. Interferon-gamma-induced unfolded protein response in conjunctival goblet cells as a cause of mucin deficiency in Sjogren syndrome. Am J Pathol. 2016; 186: 1547\u20131558.","DOI":"10.1016\/j.ajpath.2016.02.004"},{"key":"i1552-5783-60-4-1254-b07","doi-asserted-by":"crossref","unstructured":"Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 2010; 140: 900\u2013917.","DOI":"10.1016\/j.cell.2010.02.034"},{"key":"i1552-5783-60-4-1254-b08","doi-asserted-by":"crossref","unstructured":"Minamino T, Komuro I, Kitakaze M. Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease. Circ Res. 2010; 107: 1071\u20131082.","DOI":"10.1161\/CIRCRESAHA.110.227819"},{"key":"i1552-5783-60-4-1254-b09","doi-asserted-by":"crossref","unstructured":"Wu J, Kaufman RJ. From acute ER stress to physiological roles of the unfolded protein response. Cell Death Differ. 2006; 13: 374\u2013384.","DOI":"10.1038\/sj.cdd.4401840"},{"key":"i1552-5783-60-4-1254-b10","doi-asserted-by":"crossref","unstructured":"Boyce M, Yuan J. Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ. 2006; 13: 363\u2013373.","DOI":"10.1038\/sj.cdd.4401817"},{"key":"i1552-5783-60-4-1254-b11","doi-asserted-by":"crossref","unstructured":"Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 2007; 8: 519\u2013529.","DOI":"10.1038\/nrm2199"},{"key":"i1552-5783-60-4-1254-b12","doi-asserted-by":"crossref","unstructured":"Luoma PV. Elimination of endoplasmic reticulum stress and cardiovascular, type 2 diabetic, and other metabolic diseases. Ann Med. 2013; 45: 194\u2013202.","DOI":"10.3109\/07853890.2012.700116"},{"key":"i1552-5783-60-4-1254-b13","doi-asserted-by":"crossref","unstructured":"Nashine S, Cohen P, Chwa M, et al. Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. Cell Death Dis. 2017; 8: e2951.","DOI":"10.1038\/cddis.2017.348"},{"key":"i1552-5783-60-4-1254-b14","doi-asserted-by":"crossref","unstructured":"Baban B, Liu JY, Abdelsayed R, Mozaffari MS. Reciprocal relation between GADD153 and Del-1 in regulation of salivary gland inflammation in Sjogren syndrome. Exp Mol Pathol. 2013; 95: 288\u2013297.","DOI":"10.1016\/j.yexmp.2013.09.002"},{"key":"i1552-5783-60-4-1254-b15","doi-asserted-by":"crossref","unstructured":"Hodges RR, Dartt DA. Regulatory pathways in lacrimal gland epithelium. Int Rev Cytol. 2003; 231: 129\u2013196.","DOI":"10.1016\/S0074-7696(03)31004-6"},{"key":"i1552-5783-60-4-1254-b16","doi-asserted-by":"crossref","unstructured":"Dartt DA. Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases. Prog Retin Eye Res. 2009; 28: 155\u2013177.","DOI":"10.1016\/j.preteyeres.2009.04.003"},{"key":"i1552-5783-60-4-1254-b17","doi-asserted-by":"crossref","unstructured":"Rocha EM, Alves M, Rios JD, Dartt DA. The aging lacrimal gland: changes in structure and function. Ocul Surf. 2008; 6: 162\u2013174.","DOI":"10.1016\/S1542-0124(12)70177-5"},{"key":"i1552-5783-60-4-1254-b18","doi-asserted-by":"crossref","unstructured":"Radovancevic B, El-Sabrout R, Thomas C, Radovancevic R, Frazier OH, Van Buren C. Rapamycin reduces rejection in heart transplant recipients. Transplant Proc. 2001; 33: 3221\u20133222.","DOI":"10.1016\/S0041-1345(01)02370-3"},{"key":"i1552-5783-60-4-1254-b19","doi-asserted-by":"crossref","unstructured":"Zhu J, Hua X, Li D, Zhang J, Xia Q. Rapamycin attenuates mouse liver ischemia and reperfusion injury by inhibiting endoplasmic reticulum stress. Transplant Proc. 2015; 47: 1646\u20131652.","DOI":"10.1016\/j.transproceed.2015.05.013"},{"key":"i1552-5783-60-4-1254-b20","doi-asserted-by":"crossref","unstructured":"Shin YJ, Hyon JY, Choi WS, et al. Chemical injury-induced corneal opacity and neovascularization reduced by rapamycin via TGF-beta1\/ERK pathways regulation. Invest Ophthalmol Vis Sci. 2013; 54: 4452\u20134458.","DOI":"10.1167\/iovs.13-11684"},{"key":"i1552-5783-60-4-1254-b21","doi-asserted-by":"crossref","unstructured":"Hongyok T, Chae JJ, Shin YJ, Na D, Li L, Chuck RS. Effect of chitosan-N-acetylcysteine conjugate in a mouse model of botulinum toxin B-induced dry eye. Arch Ophthalmol. 2009; 127: 525\u2013532.","DOI":"10.1001\/archophthalmol.2009.52"},{"key":"i1552-5783-60-4-1254-b22","doi-asserted-by":"crossref","unstructured":"Suwan-apichon O, Rizen M, Rangsin R, et al. Botulinum toxin B-induced mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2006; 47: 133\u2013139.","DOI":"10.1167\/iovs.05-0380"},{"key":"i1552-5783-60-4-1254-b23","doi-asserted-by":"crossref","unstructured":"Nakamura S, Shibuya M, Saito Y, et al. Protective effect of D-beta-hydroxybutyrate on corneal epithelia in dry eye conditions through suppression of apoptosis. Invest Ophthalmol Vis Sci. 2003; 44: 4682\u20134688.","DOI":"10.1167\/iovs.03-0198"},{"key":"i1552-5783-60-4-1254-b24","doi-asserted-by":"crossref","unstructured":"Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004; 78: 409\u2013416.","DOI":"10.1016\/j.exer.2003.09.003"},{"key":"i1552-5783-60-4-1254-b25","doi-asserted-by":"crossref","unstructured":"Ward SK, Wakamatsu TH, Dogru M, et al. The role of oxidative stress and inflammation in conjunctivochalasis. Invest Ophthalmol Vis Sci. 2010; 51: 1994\u20132002.","DOI":"10.1167\/iovs.09-4130"},{"key":"i1552-5783-60-4-1254-b26","unstructured":"Wang P, Sheng M, Li B, Jiang Y, Chen Y. High osmotic pressure increases reactive oxygen species generation in rabbit corneal epithelial cells by endoplasmic reticulum. Am J Transl Res. 2016; 8: 860\u2013870."},{"key":"i1552-5783-60-4-1254-b27","doi-asserted-by":"crossref","unstructured":"Nair S, Xu C, Shen G, et al. Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL\/6J mice. Toxicol Lett. 2007; 168: 21\u201339.","DOI":"10.1016\/j.toxlet.2006.10.012"},{"key":"i1552-5783-60-4-1254-b28","doi-asserted-by":"crossref","unstructured":"Stevenson W, Chauhan SK, Dana R. Dry eye disease: an immune-mediated ocular surface disorder. Arch Ophthalmol. 2012; 130: 90\u2013100.","DOI":"10.1001\/archophthalmol.2011.364"},{"key":"i1552-5783-60-4-1254-b29","doi-asserted-by":"crossref","unstructured":"Savini G, Prabhawasat P, Kojima T, Grueterich M, Espana E, Goto E. The challenge of dry eye diagnosis. Clin Ophthalmol. 2008; 2: 31\u201355.","DOI":"10.2147\/OPTH.S1496"},{"key":"i1552-5783-60-4-1254-b30","doi-asserted-by":"crossref","unstructured":"Jonsson MV, Delaleu N, Brokstad KA, Berggreen E, Skarstein K. Impaired salivary gland function in NOD mice: association with changes in cytokine profile but not with histopathologic changes in the salivary gland. Arthritis Rheum. 2006; 54: 2300\u20132305.","DOI":"10.1002\/art.21945"},{"key":"i1552-5783-60-4-1254-b31","doi-asserted-by":"crossref","unstructured":"Zinszner H, Kuroda M, Wang X, et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 1998; 12: 982\u2013995.","DOI":"10.1101\/gad.12.7.982"},{"key":"i1552-5783-60-4-1254-b32","doi-asserted-by":"crossref","unstructured":"Iwawaki T, Akai R, Kohno K, Miura M. A transgenic mouse model for monitoring endoplasmic reticulum stress. Nat Med. 2004; 10: 98\u2013102.","DOI":"10.1038\/nm970"},{"key":"i1552-5783-60-4-1254-b33","doi-asserted-by":"crossref","unstructured":"Wang H, Wang X, Ke ZJ, et al. Tunicamycin-induced unfolded protein response in the developing mouse brain. Toxicol Appl Pharmacol. 2015; 283: 157\u2013167.","DOI":"10.1016\/j.taap.2014.12.019"},{"key":"i1552-5783-60-4-1254-b34","doi-asserted-by":"crossref","unstructured":"Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P. Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol. 2013; 5: a013169.","DOI":"10.1101\/cshperspect.a013169"},{"key":"i1552-5783-60-4-1254-b35","doi-asserted-by":"crossref","unstructured":"Malhotra JD, Kaufman RJ. ER stress and its functional link to mitochondria: role in cell survival and death. Cold Spring Harb Perspect Biol. 2011; 3: a004424.","DOI":"10.1101\/cshperspect.a004424"},{"key":"i1552-5783-60-4-1254-b36","doi-asserted-by":"crossref","unstructured":"Pallepati P, Averill-Bates DA. Activation of ER stress and apoptosis by hydrogen peroxide in HeLa cells: protective role of mild heat preconditioning at 40 degrees C. Biochim Biophys Acta. 2011; 1813: 1987\u20131999.","DOI":"10.1016\/j.bbamcr.2011.07.021"},{"key":"i1552-5783-60-4-1254-b37","doi-asserted-by":"crossref","unstructured":"Sano R, Reed JC. ER stress-induced cell death mechanisms. Biochim Biophys Acta. 2013; 1833: 3460\u20133470.","DOI":"10.1016\/j.bbamcr.2013.06.028"},{"key":"i1552-5783-60-4-1254-b38","doi-asserted-by":"crossref","unstructured":"Choi SK, Lim M, Byeon SH, Lee YH. Inhibition of endoplasmic reticulum stress improves coronary artery function in the spontaneously hypertensive rats. Sci Rep. 2016; 6: 31925.","DOI":"10.1038\/srep31925"},{"key":"i1552-5783-60-4-1254-b39","doi-asserted-by":"crossref","unstructured":"Zeng L, Zampetaki A, Margariti A, et al. Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow. Proc Natl Acad Sci U S A. 2009; 106: 8326\u20138331.","DOI":"10.1073\/pnas.0903197106"},{"key":"i1552-5783-60-4-1254-b40","doi-asserted-by":"crossref","unstructured":"Marciniak SJ, Yun CY, Oyadomari S, et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 2004; 18: 3066\u20133077.","DOI":"10.1101\/gad.1250704"},{"key":"i1552-5783-60-4-1254-b41","doi-asserted-by":"crossref","unstructured":"Li D, Wang C, Yao Y, et al. mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type. FASEB J. 2016; 30: 3388\u20133399.","DOI":"10.1096\/fj.201600495R"},{"key":"i1552-5783-60-4-1254-b42","doi-asserted-by":"crossref","unstructured":"Dong G, Liu Y, Zhang L, Huang S, Ding HF, Dong Z. mTOR contributes to ER stress and associated apoptosis in renal tubular cells. Am J Physiol Renal Physiol. 2015; 308: F267\u2013274.","DOI":"10.1152\/ajprenal.00629.2014"},{"key":"i1552-5783-60-4-1254-b43","doi-asserted-by":"crossref","unstructured":"Newman PJ. The role of PECAM-1 in vascular cell biology. Ann N Y Acad Sci. 1994; 714: 165\u2013174.","DOI":"10.1111\/j.1749-6632.1994.tb12041.x"},{"key":"i1552-5783-60-4-1254-b44","doi-asserted-by":"crossref","unstructured":"Benavides OM, Petsche JJ, Moise KJ Jr, Johnson A, Jacot JG. Evaluation of endothelial cells differentiated from amniotic fluid-derived stem cells. Tissue Eng Part A. 2012; 18: 1123\u20131131.","DOI":"10.1089\/ten.tea.2011.0392"},{"key":"i1552-5783-60-4-1254-b45","doi-asserted-by":"crossref","unstructured":"Leach RM, Treacher DF. Oxygen transport-2. Tissue hypoxia. BMJ. 1998; 317: 1370\u20131373.","DOI":"10.1136\/bmj.317.7169.1370"},{"key":"i1552-5783-60-4-1254-b46","unstructured":"Ziello JE, Jovin IS, Huang Y. Hypoxia-inducible factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia. Yale J Biol Med. 2007; 80: 51\u201360."},{"key":"i1552-5783-60-4-1254-b47","doi-asserted-by":"crossref","unstructured":"Krock BL, Skuli N, Simon MC. Hypoxia-induced angiogenesis: good and evil. Genes Cancer. 2011; 2: 1117\u20131133.","DOI":"10.1177\/1947601911423654"},{"key":"i1552-5783-60-4-1254-b48","doi-asserted-by":"crossref","unstructured":"Galan M, Kassan M, Kadowitz PJ, Trebak M, Belmadani S, Matrougui K. Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction. Biochim Biophys Acta. 2014; 1843: 1063\u20131075.","DOI":"10.1016\/j.bbamcr.2014.02.009"},{"key":"i1552-5783-60-4-1254-b49","doi-asserted-by":"crossref","unstructured":"Humar R, Kiefer FN, Berns H, Resink TJ, Battegay EJ. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J. 2002; 16: 771\u2013780.","DOI":"10.1096\/fj.01-0658com"},{"key":"i1552-5783-60-4-1254-b50","doi-asserted-by":"crossref","unstructured":"Tanida I, Ueno T, Kominami E. LC3 and autophagy. Methods Mol Biol. 2008; 445: 77\u201388.","DOI":"10.1007\/978-1-59745-157-4_4"},{"key":"i1552-5783-60-4-1254-b51","doi-asserted-by":"crossref","unstructured":"Binet F, Sapieha P. ER stress and angiogenesis. Cell Metab. 2015; 22: 560\u2013575.","DOI":"10.1016\/j.cmet.2015.07.010"},{"key":"i1552-5783-60-4-1254-b52","doi-asserted-by":"crossref","unstructured":"Yoon YM, Lee JH, Yun SP, et al. Tauroursodeoxycholic acid reduces ER stress by regulating of Akt-dependent cellular prion protein. Sci Rep. 2016; 6: 39838.","DOI":"10.1038\/srep39838"},{"key":"i1552-5783-60-4-1254-b53","doi-asserted-by":"crossref","unstructured":"Sekiguchi Y, Zhang J, Patterson S, et al. Rapamycin inhibits transforming growth factor beta-induced peritoneal angiogenesis by blocking the secondary hypoxic response. J Cell Mol Med. 2012; 16: 1934\u20131945.","DOI":"10.1111\/j.1582-4934.2011.01493.x"},{"key":"i1552-5783-60-4-1254-b54","doi-asserted-by":"crossref","unstructured":"El Annan J, Chauhan SK, Ecoiffier T, Zhang Q, Saban DR, Dana R. Characterization of effector T cells in dry eye disease. Invest Ophthalmol Vis Sci. 2009; 50: 3802\u20133807.","DOI":"10.1167\/iovs.08-2417"},{"key":"i1552-5783-60-4-1254-b55","doi-asserted-by":"crossref","unstructured":"Iwasaki A. The importance of CD11b+ dendritic cells in CD4+ T cell activation in vivo: with help from interleukin 1. J Exp Med. 2003; 198: 185\u2013190.","DOI":"10.1084\/jem.20030737"},{"key":"i1552-5783-60-4-1254-b56","doi-asserted-by":"crossref","unstructured":"Sprague AH, Khalil RA. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol. 2009; 78: 539\u2013552.","DOI":"10.1016\/j.bcp.2009.04.029"},{"key":"i1552-5783-60-4-1254-b57","doi-asserted-by":"crossref","unstructured":"Komura T, Sakai Y, Honda M, Takamura T, Wada T, Kaneko S. ER stress induced impaired TLR signaling and macrophage differentiation of human monocytes. Cell Immunol. 2013; 282: 44\u201352.","DOI":"10.1016\/j.cellimm.2013.04.006"},{"key":"i1552-5783-60-4-1254-b58","doi-asserted-by":"crossref","unstructured":"Kaser A, Lee AH, Franke A, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008; 134: 743\u2013756.","DOI":"10.1016\/j.cell.2008.07.021"},{"key":"i1552-5783-60-4-1254-b59","doi-asserted-by":"crossref","unstructured":"Rao J, Yue S, Fu Y, et al. ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury. Am J Transplant. 2014; 14: 1552\u20131561.","DOI":"10.1111\/ajt.12711"},{"key":"i1552-5783-60-4-1254-b60","doi-asserted-by":"crossref","unstructured":"Martinon F, Chen X, Lee AH, Glimcher LH. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol. 2010; 11: 411\u2013418.","DOI":"10.1038\/ni.1857"},{"key":"i1552-5783-60-4-1254-b61","doi-asserted-by":"crossref","unstructured":"Jiang YJ, Lee CL, Wang Q, et al. Establishment of an orthotopic pancreatic cancer mouse model: cells suspended and injected in Matrigel. World J Gastroenterol. 2014; 20: 9476\u20139485.","DOI":"10.3748\/wjg.v20.i28.9476"},{"key":"i1552-5783-60-4-1254-b62","doi-asserted-by":"crossref","unstructured":"Shashidharamurthy R, Hennigar RA, Fuchs S, Palaniswami P, Sherman M, Selvaraj P. Extravasations and emigration of neutrophils to the inflammatory site depend on the interaction of immune-complex with Fcgamma receptors and can be effectively blocked by decoy Fcgamma receptors. Blood. 2008; 111: 894\u2013904.","DOI":"10.1182\/blood-2007-04-085944"},{"key":"i1552-5783-60-4-1254-b63","doi-asserted-by":"crossref","unstructured":"Jovicic N, Jeftic I, Jovanovic I, et al. Differential immunometabolic phenotype in Th1 and Th2 dominant mouse strains in response to high-fat feeding. PLoS One. 2015; 10: e0134089.","DOI":"10.1371\/journal.pone.0134089"},{"key":"i1552-5783-60-4-1254-b64","doi-asserted-by":"crossref","unstructured":"Boldizsar F, Tarjanyi O, Nemeth P, Mikecz K, Glant TT. Th1\/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB\/c, but not in MHC-matched, arthritis-resistant DBA\/2 mice. Int Immunol. 2009; 21: 511\u2013522.","DOI":"10.1093\/intimm\/dxp018"},{"key":"i1552-5783-60-4-1254-b65","doi-asserted-by":"crossref","unstructured":"Hrincius ER, Liedmann S, Finkelstein D, et al. Acute lung injury results from innate sensing of viruses by an ER stress pathway. Cell Rep. 2015; 11: 1591\u20131603.","DOI":"10.1016\/j.celrep.2015.05.012"},{"key":"i1552-5783-60-4-1254-b66","doi-asserted-by":"crossref","unstructured":"Tang Y, Li J, Gao C, et al. Hepatoprotective effect of quercetin on endoplasmic reticulum stress and inflammation after intense exercise in mice through phosphoinositide 3-kinase and nuclear factor-kappa B. Oxid Med Cell Longev. 2016; 2016: 8696587.","DOI":"10.1155\/2016\/8696587"},{"key":"i1552-5783-60-4-1254-b67","doi-asserted-by":"crossref","unstructured":"Casero RA Jr, Porter CW, Bernacki RJ. Activity of tunicamycin against Trypanosoma brucei in vitro and in vivo. Antimicrob Agents Chemother. 1982; 22: 1008\u20131011.","DOI":"10.1128\/AAC.22.6.1008"},{"key":"i1552-5783-60-4-1254-b68","doi-asserted-by":"crossref","unstructured":"Cai X, Chen L, McGinnis JF. Correlation of ER stress and retinal degeneration in tubby mice. Exp Eye Res. 2015; 140: 130\u2013138.","DOI":"10.1016\/j.exer.2015.08.022"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2729848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:02Z","timestamp":1791927062000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-25583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,29]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-25583","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3,29]]}}}