{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:19Z","timestamp":1791928699947,"version":"4.3.4"},"reference-count":185,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2019,3,22]]},"DOI":"10.1167\/iovs.18-25922","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T16:30:34Z","timestamp":1553272234000},"page":"1105","source":"Crossref","is-referenced-by-count":48,"title":["Association of Gene Polymorphisms With Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis"],"prefix":"10.1167","volume":"60","author":[{"given":"Min","family":"Chen","sequence":"first","affiliation":[{"name":"Eye Center, the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Yu","sequence":"additional","affiliation":[{"name":"Eye Center, the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[{"name":"Eye Center, the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ma","sequence":"additional","affiliation":[{"name":"Eye Center, the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Center, the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Center, the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Gu","sequence":"additional","affiliation":[{"name":"Eye Center, the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye Center, the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-60-4-1105-b01","doi-asserted-by":"crossref","unstructured":"Kapetanakis VV, Chan MP, Foster PJ, et al. Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis. Br J Ophthalmol. 2016; 100: 86\u201393.","DOI":"10.1136\/bjophthalmol-2015-307223"},{"key":"i1552-5783-60-4-1105-b02","doi-asserted-by":"crossref","unstructured":"Bourne RR, Taylor HR, Flaxman SR, et al. Number of people blind or visually impaired by glaucoma worldwide and in world regions 1990 - 2010: a meta-analysis. PLoS One. 2016; 11: e0162229.","DOI":"10.1371\/journal.pone.0162229"},{"key":"i1552-5783-60-4-1105-b03","doi-asserted-by":"crossref","unstructured":"Quigley HA. Glaucoma. Lancet. 2011; 377: 1367\u20131377.","DOI":"10.1016\/S0140-6736(10)61423-7"},{"key":"i1552-5783-60-4-1105-b04","doi-asserted-by":"crossref","unstructured":"Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006; 90: 262\u2013267.","DOI":"10.1136\/bjo.2005.081224"},{"key":"i1552-5783-60-4-1105-b05","doi-asserted-by":"crossref","unstructured":"Kwon YH, Fingert JH, Kuehn MH, et al. Primary open-angle glaucoma. N Engl J Med. 2009; 360: 1113\u20131124.","DOI":"10.1056\/NEJMra0804630"},{"key":"i1552-5783-60-4-1105-b06","doi-asserted-by":"crossref","unstructured":"Worley A, Grimmer-Somers K. Risk factors for glaucoma: what do they really mean? Aust J Prim Health. 2011; 17: 233\u2013239.","DOI":"10.1071\/PY10042"},{"key":"i1552-5783-60-4-1105-b07","doi-asserted-by":"crossref","unstructured":"Liu Y, Allingham RR. Major review: molecular genetics of primary open-angle glaucoma. Exp Eye Res. 2017; 160: 62\u201384.","DOI":"10.1016\/j.exer.2017.05.002"},{"key":"i1552-5783-60-4-1105-b08","doi-asserted-by":"crossref","unstructured":"Takamoto M, Araie M. Genetics of primary open angle glaucoma. Jpn J Ophthalmol. 2014; 58: 1\u201315.","DOI":"10.1007\/s10384-013-0286-0"},{"key":"i1552-5783-60-4-1105-b09","doi-asserted-by":"crossref","unstructured":"Gu X, Reagan AM, McClellan ME, et al. Caveolins and caveolae in ocular physiology and pathophysiology. Prog Retin Eye Res. 2017; 56: 84\u2013106.","DOI":"10.1016\/j.preteyeres.2016.09.005"},{"key":"i1552-5783-60-4-1105-b10","doi-asserted-by":"crossref","unstructured":"Burdon KP, Macgregor S, Hewitt AW, et al. Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. Nat Genet. 2011; 43: 574\u2013578.","DOI":"10.1038\/ng.824"},{"key":"i1552-5783-60-4-1105-b11","doi-asserted-by":"crossref","unstructured":"Nakano M, Ikeda Y, Tokuda Y, et al. Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese. PloS One. 2012; 7: e33389.","DOI":"10.1371\/journal.pone.0033389"},{"key":"i1552-5783-60-4-1105-b12","doi-asserted-by":"crossref","unstructured":"Osman W, Low SK, Takahashi A, et al. A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma. Hum Mol Genet. 2012; 21: 2836\u20132842.","DOI":"10.1093\/hmg\/dds103"},{"key":"i1552-5783-60-4-1105-b13","doi-asserted-by":"crossref","unstructured":"Ulmer M, Li J, Yaspan BL, et al. Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia. Invest Ophthalmol Vis Sci. 2012; 53: 4468\u20134474.","DOI":"10.1167\/iovs.12-9784"},{"key":"i1552-5783-60-4-1105-b14","doi-asserted-by":"crossref","unstructured":"Suh W, Won HH, Kee C. The association of single-nucleotide polymorphisms in the MMP-9 gene with normal tension glaucoma and primary open-angle glaucoma. Curr Eye Res. 2018; 43: 534\u2013538.","DOI":"10.1080\/02713683.2017.1410177"},{"key":"i1552-5783-60-4-1105-b15","doi-asserted-by":"crossref","unstructured":"Li J, Feng Y, Sung MS, et al. Association of interleukin-1 gene clusters polymorphisms with primary open-angle glaucoma: a meta-analysis. BMC Ophthalmol. 2017; 17: 218.","DOI":"10.1186\/s12886-017-0616-y"},{"key":"i1552-5783-60-4-1105-b16","doi-asserted-by":"crossref","unstructured":"Panic N, Leoncini E, de Belvis G, et al. Evaluation of the endorsement of the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement on the quality of published systematic review and meta-analyses. PLoS One. 2013; 8: e83138.","DOI":"10.1371\/journal.pone.0083138"},{"key":"i1552-5783-60-4-1105-b17","doi-asserted-by":"crossref","unstructured":"Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010; 25: 603\u2013605.","DOI":"10.1007\/s10654-010-9491-z"},{"key":"i1552-5783-60-4-1105-b18","doi-asserted-by":"crossref","unstructured":"Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003; 327: 557\u2013560.","DOI":"10.1136\/bmj.327.7414.557"},{"key":"i1552-5783-60-4-1105-b19","doi-asserted-by":"crossref","unstructured":"DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986; 7: 177\u2013188.","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"i1552-5783-60-4-1105-b20","doi-asserted-by":"crossref","unstructured":"Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315: 629\u2013634.","DOI":"10.1136\/bmj.315.7109.629"},{"key":"i1552-5783-60-4-1105-b21","doi-asserted-by":"crossref","unstructured":"Fang Kho P, Lea RA, Benton MC, et al . Expression QTL analysis of glaucoma endophenotypes in the Norfolk Island isolate provides evidence that immune-related genes are associated with optic disc size. J Hum Genet. 2018; 63: 83\u201387.","DOI":"10.1038\/s10038-017-0374-y"},{"key":"i1552-5783-60-4-1105-b22","doi-asserted-by":"crossref","unstructured":"Narooie-Nejad M, Rasouli A, Mousavi M, et al. Study of MYOC gene mutation in POAG patients in Zahedan, Iran. Clin Lab. 2017; 63: 1283\u20131291.","DOI":"10.7754\/Clin.Lab.2017.161109"},{"key":"i1552-5783-60-4-1105-b23","doi-asserted-by":"crossref","unstructured":"Kosior-Jarecka E, Lukasik U, Wrobel-Dudzinska D, et al. Risk factors for normal and high-tension glaucoma in Poland in connection with polymorphisms of the endothelial nitric oxide synthase gene. PloS One. 2016; 11: e0147540.","DOI":"10.1371\/journal.pone.0147540"},{"key":"i1552-5783-60-4-1105-b24","doi-asserted-by":"crossref","unstructured":"Trikha S, Saffari E, Nongpiur M, et al. A genetic variant in TGFBR3-CDC7 is associated with visual field progression in primary open-angle glaucoma patients from Singapore. Ophthalmology. 2015; 122: 2416\u20132422.","DOI":"10.1016\/j.ophtha.2015.08.016"},{"key":"i1552-5783-60-4-1105-b25","doi-asserted-by":"crossref","unstructured":"Pasquale LR, Loomis SJ, Kang JH, et al. CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States. Am J Ophthalmol. 2013; 155: 342\u2013353 e345.","DOI":"10.1016\/j.ajo.2012.07.023"},{"key":"i1552-5783-60-4-1105-b26","doi-asserted-by":"crossref","unstructured":"Kumar V, Singh S, Ahmed RS, et al. Frequency of common CYP1B1 polymorphic variations in Delhi population of Northern India. Environ Toxicol Pharmacol. 2009; 28: 392\u2013396.","DOI":"10.1016\/j.etap.2009.06.006"},{"key":"i1552-5783-60-4-1105-b27","unstructured":"Tanito M, Minami M, Akahori M, et al. LOXL1 variants in elderly Japanese patients with exfoliation syndrome\/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract. Mol Vis. 2008; 14: 1898\u20131905."},{"key":"i1552-5783-60-4-1105-b28","doi-asserted-by":"crossref","unstructured":"Liu Y, Bailey JC, Helwa I, et al. A common variant in MIR182 is associated with primary open-angle glaucoma in the NEIGHBORHOOD consortium. Invest Ophthalmol Vis Sci. 2016; 57: 3974\u20133981.","DOI":"10.1167\/iovs.16-19688"},{"key":"i1552-5783-60-4-1105-b29","unstructured":"Collins DW, Gudiseva HV, Trachtman B, et al. Association of primary open-angle glaucoma with mitochondrial variants and haplogroups common in African Americans. Mol Vis. 2016; 22: 454\u2013471."},{"key":"i1552-5783-60-4-1105-b30","doi-asserted-by":"crossref","unstructured":"Vishal M, Sharma A, Kaurani L, et al. Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma. BMC Med Genomics. 2016; 9: 15.","DOI":"10.1186\/s12920-016-0177-6"},{"key":"i1552-5783-60-4-1105-b31","doi-asserted-by":"crossref","unstructured":"Liu XL, Jia QJ, Wang LN, et al. Roles of CYP2C19 gene polymorphisms in susceptibility to POAG and individual differences in drug treatment response. Med Sci Monit. 2016; 22: 310\u2013315.","DOI":"10.12659\/MSM.894868"},{"key":"i1552-5783-60-4-1105-b32","doi-asserted-by":"crossref","unstructured":"Dewundara SS, Wiggs JL, Sullivan DA, et al. Is estrogen a therapeutic target for glaucoma? Semin Ophthalmol. 2016; 31: 140\u2013146.","DOI":"10.3109\/08820538.2015.1114845"},{"key":"i1552-5783-60-4-1105-b33","doi-asserted-by":"crossref","unstructured":"Gharahkhani P, Burdon KP, Hewitt AW, et al. Accurate imputation-based screening of Gln368Ter myocilin variant in primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2015; 56: 5087\u20135093.","DOI":"10.1167\/iovs.15-17305"},{"key":"i1552-5783-60-4-1105-b34","doi-asserted-by":"crossref","unstructured":"Philomenadin FS, Asokan R, N V, et al. Genetic association of SNPs near ATOH7, CARD10, CDKN2B, CDC7 and SIX1\/SIX6 with the endophenotypes of primary open angle glaucoma in Indian population. PLoS One. 2015; 10: e0119703.","DOI":"10.1371\/journal.pone.0119703"},{"key":"i1552-5783-60-4-1105-b35","doi-asserted-by":"crossref","unstructured":"Gong B, Qu C, Li X, et al. Mutation spectrum of CYP1B1 in Chinese patients with primary open-angle glaucoma. Br J Ophthalmol. 2015; 99: 425\u2013430.","DOI":"10.1136\/bjophthalmol-2014-306054"},{"key":"i1552-5783-60-4-1105-b36","doi-asserted-by":"crossref","unstructured":"Jakobsson C, Kheir V, Munier FL, et al. Molecular analysis of NOTCH2 in patients with primary open-angle glaucoma. Klin Monbl Augenheilkd. 2015; 232: 427\u2013431.","DOI":"10.1055\/s-0035-1545781"},{"key":"i1552-5783-60-4-1105-b37","doi-asserted-by":"crossref","unstructured":"Barbosa AM, Frare AB, Costa NB, et al. GSTM1 polymorphism in patients with primary open-angle glaucoma. Genet Mol Res. 2012; 11: 3256\u20133262.","DOI":"10.4238\/2012.September.12.8"},{"key":"i1552-5783-60-4-1105-b38","doi-asserted-by":"crossref","unstructured":"Wolf C, Gramer E, Muller-Myhsok B, et al. Mitochondrial haplogroup U is associated with a reduced risk to develop exfoliation glaucoma in the German population. BMC Genet. 2010; 11: 8.","DOI":"10.1186\/1471-2156-11-8"},{"key":"i1552-5783-60-4-1105-b39","unstructured":"Rakhmanov VV, Nikitina N, Zakharova FM, et al. Mutations and polymorphisms in the genes for myocilin and optineur in as the risk factors of primary open-angle glaucoma [in Russian]. Genetika. 2005; 41: 1567\u20131574."},{"key":"i1552-5783-60-4-1105-b40","doi-asserted-by":"crossref","unstructured":"de Voogd S, Wolfs RC, Jansonius NM, et al. Estrogen receptors alpha and beta and the risk of open-angle glaucoma: the Rotterdam Study. Arch Ophthalmol. 2008; 126: 110\u2013114.","DOI":"10.1001\/archopht.126.1.110"},{"key":"i1552-5783-60-4-1105-b41","doi-asserted-by":"crossref","unstructured":"Fingert JH, Alward WL, Kwon YH, et al. No association between variations in the WDR36 gene and primary open-angle glaucoma. Arch Ophthalmol. 2007; 125: 434\u2013436.","DOI":"10.1001\/archopht.125.3.434-b"},{"key":"i1552-5783-60-4-1105-b42","doi-asserted-by":"crossref","unstructured":"Unal M, Guven M, Devranoglu K, et al. Glutathione S transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population. Br J Ophthalmol. 2007; 91: 527\u2013530.","DOI":"10.1136\/bjo.2006.102418"},{"key":"i1552-5783-60-4-1105-b43","doi-asserted-by":"crossref","unstructured":"Guven M, Unal M, Sarici A, et al. Glutathione-S-transferase M1 and T1 genetic polymorphisms and the risk of cataract development: a study in the Turkish population. Curr Eye Res. 2007; 32: 447\u2013454.","DOI":"10.1080\/02713680701338108"},{"key":"i1552-5783-60-4-1105-b44","unstructured":"Ressiniotis T, Griffiths PG, Birch M, et al. Apolipoprotein E promoter polymorphisms do not have a major influence on the risk of developing primary open angle glaucoma. Mol Vis. 2004; 10: 805\u2013807."},{"key":"i1552-5783-60-4-1105-b45","unstructured":"Fan BJ, Leung YF, Wang N, et al. Genetic and environmental risk factors for primary open-angle glaucoma. Chin Med J (Engl). 2004; 117: 706\u2013710."},{"key":"i1552-5783-60-4-1105-b46","doi-asserted-by":"crossref","unstructured":"Toda Y, Tang S, Kashiwagi K, et al. Mutations in the optineurin gene in Japanese patients with primary open-angle glaucoma and normal tension glaucoma. Am J Med Genet A. 2004; 125A: 1\u20134.","DOI":"10.1002\/ajmg.a.20439"},{"key":"i1552-5783-60-4-1105-b47","doi-asserted-by":"crossref","unstructured":"Alward WL, Kwon YH, Kawase K, et al. Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma. Am J Ophthalmol. 2003; 136: 904\u2013910.","DOI":"10.1016\/S0002-9394(03)00577-4"},{"key":"i1552-5783-60-4-1105-b48","unstructured":"Fan BJ, Leung YF, Pang CP, et al. Single nucleotide polymorphisms of the myocilin gene in primary open-angle glaucoma patients [in Chinese]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004; 21: 70\u201373."},{"key":"i1552-5783-60-4-1105-b49","doi-asserted-by":"crossref","unstructured":"Tang S, Toda Y, Kashiwagi K, et al. The association between Japanese primary open-angle glaucoma and normal tension glaucoma patients and the optineurin gene. Hum Genet. 2003; 113: 276\u2013279.","DOI":"10.1007\/s00439-003-0964-y"},{"key":"i1552-5783-60-4-1105-b50","doi-asserted-by":"crossref","unstructured":"Jansson M, Rada A, Tomic L, et al. Analysis of the glutathione S-transferase M1 gene using pyrosequencing and multiplex PCR\u2013no evidence of association to glaucoma. Exp Eye Res. 2003; 77: 239\u2013243.","DOI":"10.1016\/S0014-4835(03)00109-X"},{"key":"i1552-5783-60-4-1105-b51","doi-asserted-by":"crossref","unstructured":"Sjostrand A, Tomic L, Larsson LI, et al. No evidence of association between GT\/CA-repeat polymorphism in the GLC1A gene promoter and primary open-angle or exfoliation glaucoma. Acta Ophthalmol Scand. 2002; 80: 384\u2013386.","DOI":"10.1034\/j.1600-0420.2002.800407.x"},{"key":"i1552-5783-60-4-1105-b52","unstructured":"Wang N, Peng Z, Fan B, et al. Case control study on the risk factors of primary open angle glaucoma in China [in Chinese]. Zhonghua Liu Xing Bing Xue Za Zhi. 2002; 23: 293\u2013296."},{"key":"i1552-5783-60-4-1105-b53","doi-asserted-by":"crossref","unstructured":"Aung T, Ocaka L, Ebenezer ND, et al. Investigating the association between OPA1 polymorphisms and glaucoma: comparison between normal tension and high tension primary open angle glaucoma. Hum Genet. 2002; 110: 513\u2013514.","DOI":"10.1007\/s00439-002-0711-9"},{"key":"i1552-5783-60-4-1105-b54","doi-asserted-by":"crossref","unstructured":"Juronen E, Tasa G, Veromann S, et al. Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. Exp Eye Res. 2000; 71: 447\u2013452.","DOI":"10.1006\/exer.2000.0899"},{"key":"i1552-5783-60-4-1105-b55","doi-asserted-by":"crossref","unstructured":"Wiggs JL, Hauser MA, Abdrabou W, et al. The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables. J Glaucoma. 2013; 22: 517\u2013525.","DOI":"10.1097\/IJG.0b013e31824d4fd8"},{"key":"i1552-5783-60-4-1105-b56","doi-asserted-by":"crossref","unstructured":"Banerjee D, Banerjee A, Mookherjee S, et al. Mitochondrial genome analysis of primary open angle glaucoma patients. PloS One. 2013; 8: e70760.","DOI":"10.1371\/journal.pone.0070760"},{"key":"i1552-5783-60-4-1105-b57","doi-asserted-by":"crossref","unstructured":"Chen Y, Lin Y, Vithana EN, et al. Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma. Nat Genet. 2014; 46: 1115\u20131119.","DOI":"10.1038\/ng.3078"},{"key":"i1552-5783-60-4-1105-b58","doi-asserted-by":"crossref","unstructured":"Hysi PG, Cheng CY, Springelkamp H, et al. Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. Nat Genet. 2014; 46: 1126\u20131130.","DOI":"10.1038\/ng.3087"},{"key":"i1552-5783-60-4-1105-b59","unstructured":"Park S, Jamshidi Y, Vaideanu D, et al. Common TGFbeta2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma. Mol Vis. 2012; 18: 1526\u20131539."},{"key":"i1552-5783-60-4-1105-b60","unstructured":"Motushchuk AE, Komarova T, Grudinina NA, et al. Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg [in Russian]. Genetika. 2009; 45: 1659\u20131667."},{"key":"i1552-5783-60-4-1105-b61","doi-asserted-by":"crossref","unstructured":"Gong B, Shi Y, Qu C, et al. Association of catalase polymorphisms with primary open-angle glaucoma in a Chinese population. Ophthalmic Genet. 2018; 39: 35\u201340.","DOI":"10.1080\/13816810.2017.1342132"},{"key":"i1552-5783-60-4-1105-b62","doi-asserted-by":"crossref","unstructured":"Kondkar AA, Azad TA, Almobarak FA, et al. Polymorphism rs10483727 in the SIX1\/SIX6 gene locus is a risk factor for primary open angle glaucoma in a Saudi cohort. Genet Test Mol Biomarkers. 2018; 22: 74\u201378.","DOI":"10.1089\/gtmb.2017.0159"},{"key":"i1552-5783-60-4-1105-b63","doi-asserted-by":"crossref","unstructured":"Kondkar AA, Azad TA, Almobarak FA, et al. Polymorphism rs11656696 in GAS7 is not associated with primary open angle glaucoma in a Saudi Cohort. Genet Test Mol Biomarkers. 2017; 21: 754\u2013758.","DOI":"10.1089\/gtmb.2017.0147"},{"key":"i1552-5783-60-4-1105-b64","doi-asserted-by":"crossref","unstructured":"Mabuchi F, Mabuchi N, Takamoto M, et al. Genetic variant near PLXDC2 influences the risk of primary open-angle glaucoma by increasing intraocular pressure in the Japanese population. J Glaucoma. 2017; 26: 963\u2013966.","DOI":"10.1097\/IJG.0000000000000790"},{"key":"i1552-5783-60-4-1105-b65","doi-asserted-by":"crossref","unstructured":"Nunes HF, Ananina G, Costa VP, et al. Investigation of CAV1\/CAV2 rs4236601 and CDKN2B-AS1 rs2157719 in primary open-angle glaucoma patients from Brazil. Ophthalmic Genet. 2018; 39: 194\u2013199.","DOI":"10.1080\/13816810.2017.1393830"},{"key":"i1552-5783-60-4-1105-b66","doi-asserted-by":"crossref","unstructured":"Navarro-Partida J, Alvarado Castillo B, Martinez-Rizo AB, et al. Association of single-nucleotide polymorphisms in non-coding regions of the TLR4 gene with primary open angle glaucoma in a Mexican population. Ophthalmic Genet. 2017; 38: 325\u2013329.","DOI":"10.1080\/13816810.2016.1227454"},{"key":"i1552-5783-60-4-1105-b67","doi-asserted-by":"crossref","unstructured":"Yoshikawa M, Nakanishi H, Yamashiro K, et al. Association of glaucoma-susceptible genes to regional circumpapillary retinal nerve fiber layer thickness and visual field defects. Invest Ophthalmol Vis Sci. 2017; 58: 2510\u20132519.","DOI":"10.1167\/iovs.16-20797"},{"key":"i1552-5783-60-4-1105-b68","doi-asserted-by":"crossref","unstructured":"Abu-Amero KK, Kondkar AA, Mousa A, et al. Analysis of toll-like receptor rs4986790 polymorphism in Saudi patients with primary open angle glaucoma. Ophthalmic Genet. 2017; 38: 133\u2013137.","DOI":"10.3109\/13816810.2016.1151900"},{"key":"i1552-5783-60-4-1105-b69","doi-asserted-by":"crossref","unstructured":"Kimura Y, Akagi T, Miyake M, et al. Association between the CDKN2B-AS1 gene and primary open angle glaucoma with high myopia in Japanese patients. Ophthalmic Genet. 2016; 37: 242\u2013244.","DOI":"10.3109\/13816810.2015.1020559"},{"key":"i1552-5783-60-4-1105-b70","doi-asserted-by":"crossref","unstructured":"Mousa A, Kondkar AA, Al-Obeidan SA, et al. Lack of association between polymorphism rs4986791 in TLR4 and primary open-angle glaucoma in a Saudi cohort. Genet Test Mol Biomarkers. 2016; 20: 556\u2013559.","DOI":"10.1089\/gtmb.2016.0095"},{"key":"i1552-5783-60-4-1105-b71","doi-asserted-by":"crossref","unstructured":"Ng SK, Burdon KP, Fitzgerald JT, et al. Genetic association at the 9p21 glaucoma locus contributes to sex bias in normal-tension glaucoma. Invest Ophthalmol Vis Sci. 2016; 57: 3416\u20133421.","DOI":"10.1167\/iovs.16-19401"},{"key":"i1552-5783-60-4-1105-b72","doi-asserted-by":"crossref","unstructured":"Rong SS, Chen LJ, Leung CK, et al. Ethnic specific association of the CAV1\/CAV2 locus with primary open-angle glaucoma. Sci Rep. 2016; 6: 27837.","DOI":"10.1038\/srep27837"},{"key":"i1552-5783-60-4-1105-b73","doi-asserted-by":"crossref","unstructured":"Sang J, Jia L, Zhao B, et al. Association of three single nucleotide polymorphisms at the SIX1-SIX6 locus with primary open angle glaucoma in the Chinese population. Sci China Life Sci. 2016; 59: 694\u2013699.","DOI":"10.1007\/s11427-016-5073-y"},{"key":"i1552-5783-60-4-1105-b74","doi-asserted-by":"crossref","unstructured":"Cuchra M, Markiewicz L, Mucha B, et al. The role of base excision repair in the development of primary open angle glaucoma in the Polish population. Mutat Res. 2015; 778: 26\u201340.","DOI":"10.1016\/j.mrfmmm.2015.05.003"},{"key":"i1552-5783-60-4-1105-b75","doi-asserted-by":"crossref","unstructured":"Chen Y, Hughes G, Chen X, et al. Genetic variants associated with different risks for high tension glaucoma and normal tension glaucoma in a Chinese population. Invest Ophthalmol Vis Sci. 2015; 56: 2595\u20132600.","DOI":"10.1167\/iovs.14-16269"},{"key":"i1552-5783-60-4-1105-b76","unstructured":"Gong B, Li X, Li N, et al. Association between LOXL1 gene polymorphisms and primary open angle glaucoma in Sichuan population [in Chinese]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015; 32: 89\u201393."},{"key":"i1552-5783-60-4-1105-b77","unstructured":"Kim S, Kim K, Heo DW, et al. Expression-associated polymorphisms of CAV1-CAV2 affect intraocular pressure and high-tension glaucoma risk. Mol Vis. 2015; 21: 548\u2013554."},{"key":"i1552-5783-60-4-1105-b78","doi-asserted-by":"crossref","unstructured":"Nowak A, Majsterek I, Przybylowska-Sygut K, et al. Analysis of the expression and polymorphism of APOE, HSP, BDNF, and GRIN2B genes associated with the neurodegeneration process in the pathogenesis of primary open angle glaucoma. Biomed Res Int. 2015; 2015: 258281.","DOI":"10.1155\/2015\/258281"},{"key":"i1552-5783-60-4-1105-b79","doi-asserted-by":"crossref","unstructured":"Nowak A, Przybylowska-Sygut K, Gacek M, et al. Neurodegenerative genes polymorphisms of the -491A\/T APOE, the -877T\/C APP and the risk of primary open-angle glaucoma in the Polish population. Ophthalmic Genet. 2015; 36: 105\u2013112.","DOI":"10.3109\/13816810.2013.838277"},{"key":"i1552-5783-60-4-1105-b80","doi-asserted-by":"crossref","unstructured":"Zanon-Moreno V, Zanon-Moreno L, Ortega-Azorin C, et al. Genetic polymorphism related to exfoliative glaucoma is also associated with primary open-angle glaucoma risk. Clin Exp Ophthalmol. 2015; 43: 26\u201330.","DOI":"10.1111\/ceo.12367"},{"key":"i1552-5783-60-4-1105-b81","doi-asserted-by":"crossref","unstructured":"Anastasopoulos E, Coleman AL, Wilson MR, et al. Association of LOXL1 polymorphisms with pseudoexfoliation, glaucoma, intraocular pressure, and systemic diseases in a Greek population. The Thessaloniki eye study. Invest Ophthalmol Vis Sci. 2014; 55: 4238\u20134243.","DOI":"10.1167\/iovs.14-13991"},{"key":"i1552-5783-60-4-1105-b82","doi-asserted-by":"crossref","unstructured":"Burdon KP, Mitchell P, Lee A, et al. Association of open-angle glaucoma loci with incident glaucoma in the Blue Mountains Eye Study. Am J Ophthalmol. 2015; 159: 31\u201336 e31.","DOI":"10.1016\/j.ajo.2014.09.020"},{"key":"i1552-5783-60-4-1105-b83","unstructured":"Emam WA, Zidan HE, Abdulhalim BE, et al. Endothelial nitric oxide synthase polymorphisms and susceptibility to high-tension primary open-angle glaucoma in an Egyptian cohort. Mol Vis. 2014; 20: 804\u2013811."},{"key":"i1552-5783-60-4-1105-b84","doi-asserted-by":"crossref","unstructured":"Loomis SJ, Kang JH, Weinreb RN, et al. Association of CAV1\/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss. Ophthalmology. 2014; 121: 508\u2013516.","DOI":"10.1016\/j.ophtha.2013.09.012"},{"key":"i1552-5783-60-4-1105-b85","unstructured":"Micheal S, Ayub H, Khan MI, et al. Association of known common genetic variants with primary open angle, primary angle closure, and pseudoexfoliation glaucoma in Pakistani cohorts. Mol Vis. 2014; 20: 1471\u20131479."},{"key":"i1552-5783-60-4-1105-b86","doi-asserted-by":"crossref","unstructured":"Nowak A, Przybylowska-Sygut K, Szymanek K, et al. The relationship of TP53 and GRIN2B gene polymorphisms with risk of occurrence and progression of primary open-angle glaucoma in a Polish population. Pol J Pathol. 2014; 65: 313\u2013321.","DOI":"10.5114\/pjp.2014.48193"},{"key":"i1552-5783-60-4-1105-b87","doi-asserted-by":"crossref","unstructured":"Abu-Amero KK, Kondkar AA, Mousa A, et al. Association of Mn-SOD mutation (c.47T > C) with various POAG clinical indices. Ophthalmic Genet. 2014; 35: 85\u201390.","DOI":"10.3109\/13816810.2013.796390"},{"key":"i1552-5783-60-4-1105-b88","doi-asserted-by":"crossref","unstructured":"Bachernegg A, El-Shabrawi Y, Weger M, et al. Role of rs1533428 and rs12994401 in patients with primary open angle glaucoma in an European population. Ophthalmic Genet. 2013; 34: 48\u201351.","DOI":"10.3109\/13816810.2012.736592"},{"key":"i1552-5783-60-4-1105-b89","doi-asserted-by":"crossref","unstructured":"Buentello-Volante B, Elizondo-Olascoaga C, Miranda-Duarte A, et al. Association study of multiple gene polymorphisms with the risk of adult-onset primary open-angle glaucoma in a Mexican population. Exp Eye Res. 2013; 107: 59\u201364.","DOI":"10.1016\/j.exer.2012.11.013"},{"key":"i1552-5783-60-4-1105-b90","doi-asserted-by":"crossref","unstructured":"Cuchra M, Szaflik JP, Przybylowska-Sygut K, et al. The role of the 148 Asp\/Glu polymorphism of the APE1 gene in the development and progression of primary open angle glaucoma development in the Polish population. Pol J Pathol. 2013; 64: 296\u2013302.","DOI":"10.5114\/pjp.2013.39339"},{"key":"i1552-5783-60-4-1105-b91","unstructured":"Chiras D, Tzika K, Kokotas H, et al. Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome\/glaucoma in a Greek population. Mol Vis. 2013; 19: 1006\u20131016."},{"key":"i1552-5783-60-4-1105-b92","doi-asserted-by":"crossref","unstructured":"Kato T, Meguro A, Nomura E, et al. Association study of genetic variants on chromosome 7q31 with susceptibility to normal tension glaucoma in a Japanese population. Eye. 2013; 27: 979\u2013983.","DOI":"10.1038\/eye.2013.123"},{"key":"i1552-5783-60-4-1105-b93","unstructured":"Kasim B, Irkec M, Alikasifoglu M, et al. Association of LOXL1 gene polymorphisms with exfoliation syndrome\/glaucoma and primary open angle glaucoma in a Turkish population. Mol Vis. 2013; 19: 114\u2013120."},{"key":"i1552-5783-60-4-1105-b94","doi-asserted-by":"crossref","unstructured":"Markiewicz L, Majsterek I, Przybylowska K, et al. Gene polymorphisms of the MMP1, MMP9, MMP12, IL-1beta and TIMP1 and the risk of primary open-angle glaucoma. Acta Ophthalmol. 2013; 91: e516\u2013e523.","DOI":"10.1111\/aos.12149"},{"key":"i1552-5783-60-4-1105-b95","unstructured":"Micheal S, Yousaf S, Khan MI, et al. Polymorphisms in matrix metalloproteinases MMP1 and MMP9 are associated with primary open-angle and angle closure glaucoma in a Pakistani population. Mol Vis. 2013; 19: 441\u2013447."},{"key":"i1552-5783-60-4-1105-b96","doi-asserted-by":"crossref","unstructured":"Szaflik JP, Cuchra M, Przybylowska-Sygut K, et al. Association of the 399Arg\/Gln XRCC1, the 194 Arg\/Trp XRCC1, the 326Ser\/Cys OGG1, and the 324Gln\/His MUTYH gene polymorphisms with clinical parameters and the risk for development of primary open-angle glaucoma. Mutat Res. 2013; 753: 12\u201322.","DOI":"10.1016\/j.mrgentox.2012.12.019"},{"key":"i1552-5783-60-4-1105-b97","unstructured":"Zanon-Moreno V, Asensio-Marquez EM, Ciancotti-Oliver L, et al. Effects of polymorphisms in vitamin E-, vitamin C-, and glutathione peroxidase-related genes on serum biomarkers and associations with glaucoma. Mol Vis. 2013; 19: 231\u2013242."},{"key":"i1552-5783-60-4-1105-b98","doi-asserted-by":"crossref","unstructured":"Abu-Amero KK, Osman EA, Azad MT, et al. Lack of association between LOXL1 gene polymorphisms and primary open angle glaucoma in the Saudi Arabian population. Ophthalmic Genet. 2012; 33: 130\u2013133.","DOI":"10.3109\/13816810.2011.575430"},{"key":"i1552-5783-60-4-1105-b99","doi-asserted-by":"crossref","unstructured":"Balasubbu S, Krishnadas SR, Jiao X, et al. Evaluation of SNPs on chromosome 2p with primary open angle glaucoma in the South Indian cohort. Invest Ophthalmol Vis Sci. 2012; 53: 1861\u20131864.","DOI":"10.1167\/iovs.11-8602"},{"key":"i1552-5783-60-4-1105-b100","doi-asserted-by":"crossref","unstructured":"Bozkurt B, Mesci L, Irkec M, et al. Association of tumour necrosis factor-alpha -308 G\/A polymorphism with primary open-angle glaucoma. Clin Exp Ophthalmol. 2012; 40: e156\u2013e162.","DOI":"10.1111\/j.1442-9071.2011.02595.x"},{"key":"i1552-5783-60-4-1105-b101","unstructured":"Chen LJ, Tam PO, Leung DY, et al. SNP rs1533428 at 2p16.3 as a marker for late-onset primary open-angle glaucoma. Mol Vis. 2012; 18: 1629\u20131639."},{"key":"i1552-5783-60-4-1105-b102","doi-asserted-by":"crossref","unstructured":"Cao D, Jiao X, Liu X, et al. CDKN2B polymorphism is associated with primary open-angle glaucoma (POAG) in the Afro-Caribbean population of Barbados, West Indies. PLoS One. 2012; 7: e39278.","DOI":"10.1371\/journal.pone.0039278"},{"key":"i1552-5783-60-4-1105-b103","doi-asserted-by":"crossref","unstructured":"Dimasi DP, Burdon KP, Hewitt AW, et al. Genetic investigation into the endophenotypic status of central corneal thickness and optic disc parameters in relation to open-angle glaucoma. Am J Ophthalmol. 2012; 154: 833\u2013842.","DOI":"10.1016\/j.ajo.2012.04.023"},{"key":"i1552-5783-60-4-1105-b104","doi-asserted-by":"crossref","unstructured":"Majsterek I, Markiewicz L, Przybylowska K, et al. Association of MMP1-1607 1G\/2G and TIMP1 372 T\/C gene polymorphisms with risk of primary open angle glaucoma in a Polish population. Med Sci Monit. 2011; 17: CR417\u2013CR421.","DOI":"10.12659\/MSM.881854"},{"key":"i1552-5783-60-4-1105-b105","unstructured":"Nilforoushan N, Aghapour S, Raoofian R, et al. Lack of association between the C677T single nucleotide polymorphism of the MTHFR gene and glaucoma in Iranian patients. Acta Med Iran. 2012; 50: 208\u2013212."},{"key":"i1552-5783-60-4-1105-b106","doi-asserted-by":"crossref","unstructured":"Magalhaes da Silva T, Rocha AV, Lacchini R, et al . Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. Gene. 2012; 502: 142\u2013146.","DOI":"10.1016\/j.gene.2012.04.047"},{"key":"i1552-5783-60-4-1105-b107","doi-asserted-by":"crossref","unstructured":"Takano Y, Shi D, Shimizu A, et al. Association of toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma. Am J Ophthalmol. 2012; 154: 825\u2013832.","DOI":"10.1016\/j.ajo.2012.03.050"},{"key":"i1552-5783-60-4-1105-b108","unstructured":"Wang CY, Shen YC, Wei LC, et al. Polymorphism in the TNF-alpha(-863) locus associated with reduced risk of primary open angle glaucoma. Mol Vis. 2012; 18: 779\u2013785."},{"key":"i1552-5783-60-4-1105-b109","doi-asserted-by":"crossref","unstructured":"Chen JH, Wang D, Huang C, et al. Interactive effects of ATOH7 and RFTN1 in association with adult-onset primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2012; 53: 779\u2013785.","DOI":"10.1167\/iovs.11-8277"},{"key":"i1552-5783-60-4-1105-b110","doi-asserted-by":"crossref","unstructured":"Fan BJ, Wang DY, Pasquale LR, et al. Genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma in a US Caucasian population. Invest Ophthalmol Vis Sci. 2011; 52: 1788\u20131792.","DOI":"10.1167\/iovs.10-6339"},{"key":"i1552-5783-60-4-1105-b111","unstructured":"Kang JH, Wiggs JL, Haines J, et al. Reproductive factors and NOS3 variant interactions in primary open-angle glaucoma. Mol Vis. 2011; 17: 2544\u20132551."},{"key":"i1552-5783-60-4-1105-b112","doi-asserted-by":"crossref","unstructured":"Kang JH, Wiggs JL, Rosner BA, et al. Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smoking. Arch Ophthalmol. 2011; 129: 773\u2013780.","DOI":"10.1001\/archophthalmol.2011.118"},{"key":"i1552-5783-60-4-1105-b113","unstructured":"Mossb\u00f6ck G, Weger M, Faschinger C, et al. Role of cholesterol 24S-hydroxylase gene polymorphism (rs754203) in primary open angle glaucoma. Mol Vis. 2011; 17: 616\u2013620."},{"key":"i1552-5783-60-4-1105-b114","unstructured":"Suh W, Kim S, Ki CS, et al. Toll-like receptor 4 gene polymorphisms do not associate with normal tension glaucoma in a Korean population. Mol Vis. 2011; 17: 2343\u20132348."},{"key":"i1552-5783-60-4-1105-b115","doi-asserted-by":"crossref","unstructured":"Wiggs JL, Kang JH, Yaspan BL, et al. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA. Hum Mol Genet. 2011; 20: 4707\u20134713.","DOI":"10.1093\/hmg\/ddr382"},{"key":"i1552-5783-60-4-1105-b116","unstructured":"Yousaf S, Khan MI, Micheal S, et al. XRCC1 and XPD DNA repair gene polymorphisms: a potential risk factor for glaucoma in the Pakistani population. Mol Vis. 2011; 17: 1153\u20131163."},{"key":"i1552-5783-60-4-1105-b117","unstructured":"Zanon-Moreno V, Ciancotti-Olivares L, Asencio J, et al. Association between a SLC23A2 gene variation, plasma vitamin C levels, and risk of glaucoma in a Mediterranean population. Mol Vis. 2011; 17: 2997\u20133004."},{"key":"i1552-5783-60-4-1105-b118","doi-asserted-by":"crossref","unstructured":"Fan BJ, Liu K, Wang DY, et al. Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2010; 51: 4110\u20134116.","DOI":"10.1167\/iovs.09-4974"},{"key":"i1552-5783-60-4-1105-b119","doi-asserted-by":"crossref","unstructured":"Liu Y, Qin X, Schmidt S, et al. Association between chromosome 2p16.3 variants and glaucoma in populations of African descent. Proc Natl Acad Sci U S A. 2010; 107: E61; author reply E62.","DOI":"10.1073\/pnas.0913838107"},{"key":"i1552-5783-60-4-1105-b120","doi-asserted-by":"crossref","unstructured":"Mabuchi F, Sakurada Y, Kashiwagi K, et al. Lack of association of common variants on chromosome 2p with primary open-angle glaucoma in the Japanese population. Proc Natl Acad Sci U S A. 2010; 107: E90\u2013E91.","DOI":"10.1073\/pnas.0914903107"},{"key":"i1552-5783-60-4-1105-b121","unstructured":"Mossbock G, Weger M, Faschinger C, et al. Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas. Mol Vis. 2010; 16: 1764\u20131770."},{"key":"i1552-5783-60-4-1105-b122","doi-asserted-by":"crossref","unstructured":"Yu-Wai-Man P, Stewart JD, Hudson G, et al. OPA1 increases the risk of normal but not high tension glaucoma. J Med Genet. 2010; 47: 120\u2013125.","DOI":"10.1136\/jmg.2009.067512"},{"key":"i1552-5783-60-4-1105-b123","doi-asserted-by":"crossref","unstructured":"Caixeta-Umbelino C, de Vasconcellos JP, Costa VP, et al. Lack of association between optineurin gene variants T34T, E50K, M98K, 691_692insAG and R545Q and primary open angle glaucoma in Brazilian patients. Ophthalmic Genet. 2009; 30: 13\u201318.","DOI":"10.1080\/13816810802502970"},{"key":"i1552-5783-60-4-1105-b124","doi-asserted-by":"crossref","unstructured":"Fourgeux C, Martine L, Bjorkhem I, et al. Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. Invest Ophthalmol Vis Sci. 2009; 50: 5712\u20135717.","DOI":"10.1167\/iovs.09-3655"},{"key":"i1552-5783-60-4-1105-b125","doi-asserted-by":"crossref","unstructured":"Jiao X, Yang Z, Yang X, et al. Common variants on chromosome 2 and risk of primary open-angle glaucoma in the Afro-Caribbean population of Barbados. Proc Natl Acad Sci U S A. 2009; 106: 17105\u201317110.","DOI":"10.1073\/pnas.0907564106"},{"key":"i1552-5783-60-4-1105-b126","doi-asserted-by":"crossref","unstructured":"Lemmela S, Forsman E, Onkamo P, et al. Association of LOXL1 gene with Finnish exfoliation syndrome patients. J Hum Genet. 2009; 54: 289\u2013297.","DOI":"10.1038\/jhg.2009.28"},{"key":"i1552-5783-60-4-1105-b127","unstructured":"Micheal S, Qamar R, Akhtar F, et al. MTHFR gene C677T and A1298C polymorphisms and homocysteine levels in primary open angle and primary closed angle glaucoma. Mol Vis. 2009; 15: 2268\u20132278."},{"key":"i1552-5783-60-4-1105-b128","doi-asserted-by":"crossref","unstructured":"Nakano M, Ikeda Y, Taniguchi T, et al. Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population. Proc Natl Acad Sci U S A. 2009; 106: 12838\u201312842.","DOI":"10.1073\/pnas.0906397106"},{"key":"i1552-5783-60-4-1105-b129","doi-asserted-by":"crossref","unstructured":"Zetterberg M, Tasa G, Palmer MS, et al. Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma. Ophthalmic Genet. 2007; 28: 47\u201350.","DOI":"10.1080\/13816810701329046"},{"key":"i1552-5783-60-4-1105-b130","doi-asserted-by":"crossref","unstructured":"Chakrabarti S, Rao KN, Kaur I, et al. The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas. Invest Ophthalmol Vis Sci. 2008; 49: 2343\u20132347.","DOI":"10.1167\/iovs.07-1557"},{"key":"i1552-5783-60-4-1105-b131","unstructured":"Gong WF, Chiang SW, Chen LJ, et al. Evaluation of LOXL1 polymorphisms in primary open-angle glaucoma in southern and northern Chinese. Mol Vis. 2008; 14: 2381\u20132389."},{"key":"i1552-5783-60-4-1105-b132","unstructured":"Mabuchi F, Sakurada Y, Kashiwagi K, et al. Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome. Mol Vis. 2008; 14: 1303\u20131308."},{"key":"i1552-5783-60-4-1105-b133","unstructured":"Michael S, Qamar R, Akhtar F, et al. C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with primary closed angle glaucoma. Mol Vis. 2008; 14: 661\u2013665."},{"key":"i1552-5783-60-4-1105-b134","doi-asserted-by":"crossref","unstructured":"Shibuya E, Meguro A, Ota M, et al. Association of toll-like receptor 4 gene polymorphisms with normal tension glaucoma. Invest Ophthalmol Vis Sci. 2008; 49: 4453\u20134457.","DOI":"10.1167\/iovs.07-1575"},{"key":"i1552-5783-60-4-1105-b135","doi-asserted-by":"crossref","unstructured":"How AC, Aung T, Chew X, et al. Lack of association between interleukin-1 gene cluster polymorphisms and glaucoma in Chinese subjects. Invest Ophthalmol Vis Sci. 2007; 48: 2123\u20132126.","DOI":"10.1167\/iovs.06-1213"},{"key":"i1552-5783-60-4-1105-b136","unstructured":"Wang CY, Shen YC, Su CH, et al. Investigation of the association between interleukin-1beta polymorphism and normal tension glaucoma. Mol Vis. 2007; 13: 719\u2013723."},{"key":"i1552-5783-60-4-1105-b137","doi-asserted-by":"crossref","unstructured":"Funayama T, Mashima Y, Ohtake Y, et al. SNPs and interaction analyses of noelin 2, myocilin, and optineurin genes in Japanese patients with open-angle glaucoma. Invest Ophthalmol Vis Sci. 2006; 47: 5368\u20135375.","DOI":"10.1167\/iovs.06-0196"},{"key":"i1552-5783-60-4-1105-b138","doi-asserted-by":"crossref","unstructured":"Lam CY, Fan BJ, Wang DY, et al. Association of apolipoprotein E polymorphisms with normal tension glaucoma in a Chinese population. J Glaucoma. 2006; 15: 218\u2013222.","DOI":"10.1097\/01.ijg.0000212217.19804.a7"},{"key":"i1552-5783-60-4-1105-b139","unstructured":"Mabuchi F, Tang S, Kashiwagi K, et al. Methylenetetrahydrofolate reductase gene polymorphisms c.677C\/T and c.1298A\/C are not associated with open angle glaucoma. Mol Vis. 2006; 12: 735\u2013739."},{"key":"i1552-5783-60-4-1105-b140","doi-asserted-by":"crossref","unstructured":"Mossb\u00f6ck G, Weger M, Moray M, et al. TNF-alpha promoter polymorphisms and primary open-angle glaucoma. Eye. 2006; 20: 1040\u20131043.","DOI":"10.1038\/sj.eye.6702078"},{"key":"i1552-5783-60-4-1105-b141","unstructured":"Mossb\u00f6ck G, Weger M, Faschinger C, et al. Methylenetetrahydrofolatereductase (MTHFR) 677C>T polymorphism and open angle glaucoma. Mol Vis. 2006; 12: 356\u2013359."},{"key":"i1552-5783-60-4-1105-b142","doi-asserted-by":"crossref","unstructured":"Mabuchi F, Tang S, Kashiwagi K, et al. The OPA1 gene polymorphism is associated with normal tension and high tension glaucoma. Am J Ophthalmol. 2007; 143: 125\u2013130.","DOI":"10.1016\/j.ajo.2006.09.028"},{"key":"i1552-5783-60-4-1105-b143","unstructured":"Yao W, Jiao X, Hejtmancik JF, et al. Evaluation of the association between OPA1 polymorphisms and primary open-angle glaucoma in Barbados families. Mol Vis. 2006; 12: 649\u2013654."},{"key":"i1552-5783-60-4-1105-b144","unstructured":"Fan BJ, Wang DY, Fan DS, et al. SNPs and interaction analyses of myocilin, optineurin, and apolipoprotein E in primary open angle glaucoma patients. Mol Vis. 2005; 11: 625\u2013631."},{"key":"i1552-5783-60-4-1105-b145","doi-asserted-by":"crossref","unstructured":"Funayama T, Ishikawa K, Ohtake Y, et al. Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma. Invest Ophthalmol Vis Sci. 2004; 45: 4359\u20134367.","DOI":"10.1167\/iovs.03-1403"},{"key":"i1552-5783-60-4-1105-b146","doi-asserted-by":"crossref","unstructured":"Woo SJ, Kim DM, Kim JY, et al. Investigation of the association between OPA1 polymorphisms and normal-tension glaucoma in Korea. J Glaucoma. 2004; 13: 492\u2013495.","DOI":"10.1097\/01.ijg.0000137870.25779.40"},{"key":"i1552-5783-60-4-1105-b147","unstructured":"Powell BL, Toomes C, Scott S, et al. Polymorphisms in OPA1 are associated with normal tension glaucoma. Mol Vis. 2003; 9: 460\u2013464."},{"key":"i1552-5783-60-4-1105-b148","doi-asserted-by":"crossref","unstructured":"Copin B, Brezin AP, Valtot F, et al. Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene. Am J Hum Genet. 2002; 70: 1575\u20131581.","DOI":"10.1086\/340733"},{"key":"i1552-5783-60-4-1105-b149","doi-asserted-by":"crossref","unstructured":"Al-Shahrani H, Al-Dabbagh N, Al-Dohayan N, et al. Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population. BMC Ophthalmol. 2016; 16: 156.","DOI":"10.1186\/s12886-016-0337-7"},{"key":"i1552-5783-60-4-1105-b150","doi-asserted-by":"crossref","unstructured":"J\u00fcnemann AG, von Ahsen N, Reulbach U, et al. C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma. Am J Ophthalmol. 2005; 139: 721\u2013723.","DOI":"10.1016\/j.ajo.2004.09.081"},{"key":"i1552-5783-60-4-1105-b151","unstructured":"Kim K, Yun YJ, Kim S, et al. Analysis of an extended chromosome locus 2p14-21 for replication of the 2p16.3 association with glaucoma susceptibility. Mol Vis. 2011; 17: 1136\u20131143."},{"key":"i1552-5783-60-4-1105-b152","doi-asserted-by":"crossref","unstructured":"Fuse N, Takahashi K, Akiyama H, et al. Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population. J Glaucoma. 2004; 13: 299\u2013303.","DOI":"10.1097\/00061198-200408000-00007"},{"key":"i1552-5783-60-4-1105-b153","doi-asserted-by":"crossref","unstructured":"Navarro-Partida J, Martinez-Rizo AB, Ramirez-Barrera P, et al. Association of toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile with the risk of primary open angle glaucoma. Graefes Arch Clin Exp Ophthalmol. 2017; 255: 995\u20131001.","DOI":"10.1007\/s00417-017-3610-4"},{"key":"i1552-5783-60-4-1105-b154","doi-asserted-by":"crossref","unstructured":"Kondkar AA, Edward NB, Kalantan H, et al. Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients. J Negat Results Biomed. 2017; 16: 3.","DOI":"10.1186\/s12952-017-0068-1"},{"key":"i1552-5783-60-4-1105-b155","doi-asserted-by":"crossref","unstructured":"Azad TA, Edward NB, Kondkar AA, et al. Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort. J Negat Results Biomed. 2017; 16: 12.","DOI":"10.1186\/s12952-017-0077-0"},{"key":"i1552-5783-60-4-1105-b156","doi-asserted-by":"crossref","unstructured":"Abu-Amero KK, Kondkar AA, Mousa A, et al. Analysis of catalase SNP rs1001179 in Saudi patients with primary open angle glaucoma. Ophthalmic Genet. 2013; 34: 223\u2013228.","DOI":"10.3109\/13816810.2013.789534"},{"key":"i1552-5783-60-4-1105-b157","doi-asserted-by":"crossref","unstructured":"Abu-Amero KK, Kondkar AA, Mousa A, et al. Analysis of cyclin-dependent kinase inhibitor-2B rs1063192 polymorphism in Saudi patients with primary open-angle glaucoma. Genet Test Mol Biomarkers. 2016; 20: 637\u2013641.","DOI":"10.1089\/gtmb.2016.0140"},{"key":"i1552-5783-60-4-1105-b158","unstructured":"Burdon KP, Hewitt AW, Mackey DA, et al. Tag SNPs detect association of the CYP1B1 gene with primary open angle glaucoma. Mol Vis. 2010; 16: 2286\u20132293."},{"key":"i1552-5783-60-4-1105-b159","unstructured":"Liu Y, Schmidt S, Qin X, et al. No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populations. Mol Vis. 2007; 13: 2137\u20132141."},{"key":"i1552-5783-60-4-1105-b160","unstructured":"Neamatzadeh H, Soleimanizad R, Atefi A, et al. Association between p53 codon 72 (Arg72Pro) polymorphism and primary open-angle glaucoma in Iranian patients. Iran Biomed J. 2015; 19: 51\u201356."},{"key":"i1552-5783-60-4-1105-b161","unstructured":"Daugherty CL, Curtis H, Realini T, et al. Primary open angle glaucoma in a Caucasian population is associated with the p53 codon 72 polymorphism. Mol Vis. 2009; 15: 1939\u20131944."},{"key":"i1552-5783-60-4-1105-b162","unstructured":"Mabuchi F, Sakurada Y, Kashiwagi K, et al. Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population. Mol Vis. 2009; 15: 1045\u20131049."},{"key":"i1552-5783-60-4-1105-b163","doi-asserted-by":"crossref","unstructured":"Lin HJ, Chen WC, Tsai FJ, et al. Distributions of p53 codon 72 polymorphism in primary open angle glaucoma. Br J Ophthalmol. 2002; 86: 767\u2013770.","DOI":"10.1136\/bjo.86.7.767"},{"key":"i1552-5783-60-4-1105-b164","unstructured":"Tikunova E, Ovtcharova V, Reshetnikov E, et al. Genes of tumor necrosis factors and their receptors and the primary open angle glaucoma in the population of Central Russia. Int J Ophthalmol. 2017; 10: 1490\u20131494."},{"key":"i1552-5783-60-4-1105-b165","doi-asserted-by":"crossref","unstructured":"Hamid MA, Moemen L, Labib H, et al. Risk of open angle glaucoma due to tumor necrosis factor alpha gene polymorphisms. Electron Physician. 2016; 8: 1978\u20131983.","DOI":"10.19082\/1978"},{"key":"i1552-5783-60-4-1105-b166","doi-asserted-by":"crossref","unstructured":"Lin HJ, Tsai FJ, Chen WC, et al. Association of tumour necrosis factor alpha -308 gene polymorphism with primary open-angle glaucoma in Chinese. Eye. 2003; 17: 31\u201334.","DOI":"10.1038\/sj.eye.6700227"},{"key":"i1552-5783-60-4-1105-b167","doi-asserted-by":"crossref","unstructured":"Razeghinejad MR, Rahat F, Kamali-Sarvestani E. Association of TNFA -308 G\/A and TNFRI +36 A\/G gene polymorphisms with glaucoma. Ophthalmic Res. 2009; 42: 118\u2013124.","DOI":"10.1159\/000226108"},{"key":"i1552-5783-60-4-1105-b168","doi-asserted-by":"crossref","unstructured":"Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001; 17: 463\u2013516.","DOI":"10.1146\/annurev.cellbio.17.1.463"},{"key":"i1552-5783-60-4-1105-b169","doi-asserted-by":"crossref","unstructured":"Schlotzer-Schrehardt U, Lommatzsch J, Kuchle M, et al. Matrix metalloproteinases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome\/glaucoma and primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2003; 44: 1117\u20131125.","DOI":"10.1167\/iovs.02-0365"},{"key":"i1552-5783-60-4-1105-b170","doi-asserted-by":"crossref","unstructured":"Cheng G, Zhong M, Kawaguchi R, et al. Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF. Elife. 2014; 3: e05401.","DOI":"10.7554\/eLife.05401"},{"key":"i1552-5783-60-4-1105-b171","doi-asserted-by":"crossref","unstructured":"Izzotti A, Bagnis A, Sacca SC. The role of oxidative stress in glaucoma. Mutat Res. 2006; 612: 105\u2013114.","DOI":"10.1016\/j.mrrev.2005.11.001"},{"key":"i1552-5783-60-4-1105-b172","doi-asserted-by":"crossref","unstructured":"Weissman L, de Souza-Pinto NC, Stevnsner T, et al. DNA repair, mitochondria, and neurodegeneration. Neuroscience. 2007; 145: 1318\u20131329.","DOI":"10.1016\/j.neuroscience.2006.08.061"},{"key":"i1552-5783-60-4-1105-b173","doi-asserted-by":"crossref","unstructured":"Gu D, Wang M, Wang S, et al. The DNA repair gene APE1 T1349G polymorphism and risk of gastric cancer in a Chinese population. PLoS One. 2011; 6: e28971.","DOI":"10.1371\/journal.pone.0028971"},{"key":"i1552-5783-60-4-1105-b174","doi-asserted-by":"crossref","unstructured":"McDonald KK, Abramson K, Beltran MA, et al. Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG. J Hum Genet. 2010; 55: 697\u2013700.","DOI":"10.1038\/jhg.2010.91"},{"key":"i1552-5783-60-4-1105-b175","doi-asserted-by":"crossref","unstructured":"De Marco N, Buono M, Troise F, et al. Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus. J Biol Chem. 2006; 281: 16147\u201316156.","DOI":"10.1074\/jbc.M601467200"},{"key":"i1552-5783-60-4-1105-b176","doi-asserted-by":"crossref","unstructured":"Yuki K, Murat D, Kimura I, et al. Reduced-serum vitamin C and increased uric acid levels in normal-tension glaucoma. Graefes Arch Clin Exp Ophthalmol. 2010; 248: 243\u2013248.","DOI":"10.1007\/s00417-009-1183-6"},{"key":"i1552-5783-60-4-1105-b177","doi-asserted-by":"crossref","unstructured":"Hu Z, Ma H, Chen F, et al. XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies. Cancer Epidemiol Biomarkers Prev. 2005; 14: 1810\u20131818.","DOI":"10.1158\/1055-9965.EPI-04-0793"},{"key":"i1552-5783-60-4-1105-b178","doi-asserted-by":"crossref","unstructured":"Drory VE, Birnbaum M, Korczyn AD, et al. Association of APOE epsilon4 allele with survival in amyotrophic lateral sclerosis. J Neurol Sci. 2001; 190: 17\u201320.","DOI":"10.1016\/S0022-510X(01)00569-X"},{"key":"i1552-5783-60-4-1105-b179","doi-asserted-by":"crossref","unstructured":"Mineo C, Shaul PW. Regulation of eNOS in caveolae. Adv Exp Med Biol. 2012; 729: 51\u201362.","DOI":"10.1007\/978-1-4614-1222-9_4"},{"key":"i1552-5783-60-4-1105-b180","doi-asserted-by":"crossref","unstructured":"Ellis DZ, Dismuke WM, Chokshi BM. Characterization of soluble guanylate cyclase in NO-induced increases in aqueous humor outflow facility and in the trabecular meshwork. Invest Ophthalmol Vis Sci. 2009; 50: 1808\u20131813.","DOI":"10.1167\/iovs.08-2750"},{"key":"i1552-5783-60-4-1105-b181","doi-asserted-by":"crossref","unstructured":"Rallabhandi P, Bell J, Boukhvalova MS, et al. Analysis of TLR4 polymorphic variants: new insights into TLR4\/MD-2\/CD14 stoichiometry, structure, and signaling. J Immunol. 2006; 177: 322\u2013332.","DOI":"10.4049\/jimmunol.177.1.322"},{"key":"i1552-5783-60-4-1105-b182","doi-asserted-by":"crossref","unstructured":"Astafurov K, Elhawy E, Ren L, et al. Oral microbiome link to neurodegeneration in glaucoma. PLoS One. 2014; 9: e104416.","DOI":"10.1371\/journal.pone.0104416"},{"key":"i1552-5783-60-4-1105-b183","doi-asserted-by":"crossref","unstructured":"Meczekalski B, Nawrot R, Nowak W, et al. Study on the zona pellucida 4 (ZP4) gene sequence and its expression in the ovaries of patients with polycystic ovary syndrome. J Endocrinol Invest. 2015; 38: 791\u2013797.","DOI":"10.1007\/s40618-015-0260-4"},{"key":"i1552-5783-60-4-1105-b184","doi-asserted-by":"crossref","unstructured":"Rao KN, Kaur I, Chakrabarti S. Lack of association of three primary open-angle glaucoma-susceptible loci with primary glaucomas in an Indian population. Proc Natl Acad Sci U S A. 2009; 106: E125\u2013E126; author reply E127.","DOI":"10.1073\/pnas.0910416106"},{"key":"i1552-5783-60-4-1105-b185","doi-asserted-by":"crossref","unstructured":"Takamoto M, Kaburaki T, Mabuchi A, et al. Common variants on chromosome 9p21 are associated with normal tension glaucoma. PLoS One. 2012; 7: e40107.","DOI":"10.1371\/journal.pone.0040107"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2729028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:02Z","timestamp":1791927062000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-25922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,22]]},"references-count":185,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-25922","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3,22]]}}}