{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:47:31Z","timestamp":1792651651096,"version":"4.5.0"},"reference-count":22,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2019,1,10]]},"DOI":"10.1167\/iovs.18-25930","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T12:31:06Z","timestamp":1547123466000},"page":"113","source":"Crossref","is-referenced-by-count":35,"title":["An In Vitro Human Lens Capsular Bag Model Adopting a Graded Culture Regime to Assess Putative Impact of IOLs on PCO Formation"],"prefix":"10.1167","volume":"60","author":[{"given":"Julie A.","family":"Eldred","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of East Anglia, Norwich, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyun","family":"Zheng","sequence":"additional","affiliation":[{"name":"HOYA Surgical Optics, Disruptive Target Research Group, Global R&D, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulin","family":"Chen","sequence":"additional","affiliation":[{"name":"HOYA Surgical Optics, Disruptive Target Research Group, Global R&D, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Michael","family":"Wormstone","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of East Anglia, Norwich, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-60-1-113-b01","unstructured":"McCarty\n\t\t\t\t\t\t\tCA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTaylor\n\t\t\t\t\t\t\tHR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe genetics of cataract.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2001;\n\t\t\t\t\t42:\n\t\t\t\t\t1677\u20131678."},{"key":"i1552-5783-60-1-113-b02","doi-asserted-by":"crossref","unstructured":"Wormstone\n\t\t\t\t\t\t\tIM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWang\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLiu\n\t\t\t\t\t\t\tCS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPosterior capsule opacification.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2009;\n\t\t\t\t\t88:\n\t\t\t\t\t257\u2013269.","DOI":"10.1016\/j.exer.2008.10.016"},{"key":"i1552-5783-60-1-113-b03","doi-asserted-by":"crossref","unstructured":"Eldred\n\t\t\t\t\t\t\tJA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSpalton\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWormstone\n\t\t\t\t\t\t\tIM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAn in vitro evaluation of the Anew Zephyr(R) open bag IOL in the prevention of posterior capsule opacification using a human capsular bag model.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2014;\n\t\t\t\t\t55:\n\t\t\t\t\t7057\u20137064.","DOI":"10.1167\/iovs.14-15302"},{"key":"i1552-5783-60-1-113-b04","doi-asserted-by":"crossref","unstructured":"Hollick\n\t\t\t\t\t\t\tEJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSpalton\n\t\t\t\t\t\t\tDJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tUrsell\n\t\t\t\t\t\t\tPG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMeacock\n\t\t\t\t\t\t\tWR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBarman\n\t\t\t\t\t\t\tSA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBoyce\n\t\t\t\t\t\t\tJF.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPosterior capsular opacification with hydrogel, polymethylmethacrylate, and silicone intraocular lenses: two-year results of a randomized prospective trial.\n\t\t\t\t\tAm J Ophthalmol.\n\t\t\t\t\t2000;\n\t\t\t\t\t129:\n\t\t\t\t\t577\u2013584.","DOI":"10.1016\/S0002-9394(99)00447-X"},{"key":"i1552-5783-60-1-113-b05","doi-asserted-by":"crossref","unstructured":"Hollick\n\t\t\t\t\t\t\tEJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSpalton\n\t\t\t\t\t\t\tDJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tUrsell\n\t\t\t\t\t\t\tPG,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tThe effect of polymethylmethacrylate, silicone, and polyacrylic intraocular lenses on posterior capsular opacification 3 years after cataract surgery.\n\t\t\t\t\tOphthalmology\n\t\t\t\t\t1999;\n\t\t\t\t\t106:\n\t\t\t\t\t49\u201354;\n\t\t\t\t\tdiscussion 54\u201355.","DOI":"10.1016\/S0161-6420(99)90047-7"},{"key":"i1552-5783-60-1-113-b06","doi-asserted-by":"crossref","unstructured":"Ursell\n\t\t\t\t\t\t\tPG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSpalton\n\t\t\t\t\t\t\tDJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPande\n\t\t\t\t\t\t\tMV,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tRelationship between intraocular lens biomaterials and posterior capsule opacification.\n\t\t\t\t\tJ Cataract Refract Surg.\n\t\t\t\t\t1998;\n\t\t\t\t\t24:\n\t\t\t\t\t352\u2013360.","DOI":"10.1016\/S0886-3350(98)80323-4"},{"key":"i1552-5783-60-1-113-b07","doi-asserted-by":"crossref","unstructured":"Aliancy\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWerner\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLudlow\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tLong-term capsule clarity with a disk-shaped intraocular lens.\n\t\t\t\t\tJ Cataract Refract Surg.\n\t\t\t\t\t2018;\n\t\t\t\t\t44:\n\t\t\t\t\t504\u2013509.","DOI":"10.1016\/j.jcrs.2017.12.029"},{"key":"i1552-5783-60-1-113-b08","doi-asserted-by":"crossref","unstructured":"Wormstone\n\t\t\t\t\t\t\tIM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEldred\n\t\t\t\t\t\t\tJA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tExperimental models for posterior capsule opacification research.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2016;\n\t\t\t\t\t142:\n\t\t\t\t\t2\u201312.","DOI":"10.1016\/j.exer.2015.04.021"},{"key":"i1552-5783-60-1-113-b09","doi-asserted-by":"crossref","unstructured":"Eldred\n\t\t\t\t\t\t\tJA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMcDonald\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWilkes\n\t\t\t\t\t\t\tHS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSpalton\n\t\t\t\t\t\t\tDJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWormstone\n\t\t\t\t\t\t\tIM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tGrowth factor restriction impedes progression of wound healing following cataract surgery: identification of VEGF as a putative therapeutic target.\n\t\t\t\t\tSci Rep.\n\t\t\t\t\t2016;\n\t\t\t\t\t6:\n\t\t\t\t\t24453.","DOI":"10.1038\/srep24453"},{"key":"i1552-5783-60-1-113-b10","unstructured":"Liu\n\t\t\t\t\t\t\tCS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWormstone\n\t\t\t\t\t\t\tIM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDuncan\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarcantonio\n\t\t\t\t\t\t\tJM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWebb\n\t\t\t\t\t\t\tSF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDavies\n\t\t\t\t\t\t\tPD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tA study of human lens cell growth in vitro. A model for posterior capsule opacification.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t1996;\n\t\t\t\t\t37:\n\t\t\t\t\t906\u2013914."},{"key":"i1552-5783-60-1-113-b11","doi-asserted-by":"crossref","unstructured":"Duncan\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWormstone\n\t\t\t\t\t\t\tIM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLiu\n\t\t\t\t\t\t\tCS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarcantonio\n\t\t\t\t\t\t\tJM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDavies\n\t\t\t\t\t\t\tPD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThapsigargin-coated intraocular lenses inhibit human lens cell growth.\n\t\t\t\t\tNat Med.\n\t\t\t\t\t1997;\n\t\t\t\t\t3:\n\t\t\t\t\t1026\u20131028.","DOI":"10.1038\/nm0997-1026"},{"key":"i1552-5783-60-1-113-b12","doi-asserted-by":"crossref","unstructured":"Dawes\n\t\t\t\t\t\t\tLJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIllingworth\n\t\t\t\t\t\t\tCD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWormstone\n\t\t\t\t\t\t\tIM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tA fully human in vitro capsular bag model to permit intraocular lens evaluation.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2012;\n\t\t\t\t\t53:\n\t\t\t\t\t23\u201329.","DOI":"10.1167\/iovs.11-8851"},{"key":"i1552-5783-60-1-113-b13","doi-asserted-by":"crossref","unstructured":"Cleary\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSpalton\n\t\t\t\t\t\t\tDJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhang\n\t\t\t\t\t\t\tJJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarshall\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tIn vitro lens capsule model for investigation of posterior capsule opacification.\n\t\t\t\t\tJ Cataract Refract Surg.\n\t\t\t\t\t2010;\n\t\t\t\t\t36:\n\t\t\t\t\t1249\u20131252.","DOI":"10.1016\/j.jcrs.2010.05.006"},{"key":"i1552-5783-60-1-113-b14","doi-asserted-by":"crossref","unstructured":"Pande\n\t\t\t\t\t\t\tMV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSpalton\n\t\t\t\t\t\t\tDJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKerr-Muir\n\t\t\t\t\t\t\tMG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarshall\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPostoperative inflammatory response to phacoemulsification and extracapsular cataract surgery: aqueous flare and cells.\n\t\t\t\t\tJ Cataract Refract Surg.\n\t\t\t\t\t1996;\n\t\t\t\t\t22\n\t\t\t\t\t(suppl 1):\n\t\t\t\t\t770\u2013774.","DOI":"10.1016\/S0886-3350(96)80160-X"},{"key":"i1552-5783-60-1-113-b15","unstructured":"Wormstone\n\t\t\t\t\t\t\tIM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTamiya\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAnderson\n\t\t\t\t\t\t\tI,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDuncan\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2002;\n\t\t\t\t\t43:\n\t\t\t\t\t2301\u20132308."},{"key":"i1552-5783-60-1-113-b16","doi-asserted-by":"crossref","unstructured":"Eldred\n\t\t\t\t\t\t\tJA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDawes\n\t\t\t\t\t\t\tLJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWormstone\n\t\t\t\t\t\t\tIM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe lens as a model for fibrotic disease.\n\t\t\t\t\tPhilos Trans R Soc Lond B Biol Sci.\n\t\t\t\t\t2011;\n\t\t\t\t\t366:\n\t\t\t\t\t1301\u20131319.","DOI":"10.1098\/rstb.2010.0341"},{"key":"i1552-5783-60-1-113-b17","doi-asserted-by":"crossref","unstructured":"Wormstone\n\t\t\t\t\t\t\tIM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAnderson\n\t\t\t\t\t\t\tIK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEldred\n\t\t\t\t\t\t\tJA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDawes\n\t\t\t\t\t\t\tLJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDuncan\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tShort-term exposure to transforming growth factor beta induces long-term fibrotic responses.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2006;\n\t\t\t\t\t83:\n\t\t\t\t\t1238\u20131245.","DOI":"10.1016\/j.exer.2006.06.013"},{"key":"i1552-5783-60-1-113-b18","doi-asserted-by":"crossref","unstructured":"Fukaya\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHara\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHara\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIwata\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tLight scattering caused by cells on the intraocular lens.\n\t\t\t\t\tJ Cataract Refract Surg.\n\t\t\t\t\t1988;\n\t\t\t\t\t14:\n\t\t\t\t\t396\u2013399.","DOI":"10.1016\/S0886-3350(88)80146-9"},{"key":"i1552-5783-60-1-113-b19","doi-asserted-by":"crossref","unstructured":"Apple\n\t\t\t\t\t\t\tDJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPeng\n\t\t\t\t\t\t\tQ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVisessook\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tEradication of posterior capsule opacification: documentation of a marked decrease in Nd: YAG laser posterior capsulotomy rates noted in an analysis of 5416 pseudophakic human eyes obtained postmortem.\n\t\t\t\t\tOphthalmology.\n\t\t\t\t\t2001;\n\t\t\t\t\t108:\n\t\t\t\t\t505\u2013518.","DOI":"10.1016\/S0161-6420(00)00589-3"},{"key":"i1552-5783-60-1-113-b20","doi-asserted-by":"crossref","unstructured":"Linnola\n\t\t\t\t\t\t\tRJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tSandwich theory: bioactivity-based explanation for posterior capsule opacification.\n\t\t\t\t\tJ Cataract Refract Surg.\n\t\t\t\t\t1997;\n\t\t\t\t\t23:\n\t\t\t\t\t1539\u20131542.","DOI":"10.1016\/S0886-3350(97)80026-0"},{"key":"i1552-5783-60-1-113-b21","doi-asserted-by":"crossref","unstructured":"Matsushima\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIwamoto\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMukai\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tObara\n\t\t\t\t\t\t\tY.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tActive oxygen processing for acrylic intraocular lenses to prevent posterior capsule opacification.\n\t\t\t\t\tCataract Refract Surg.\n\t\t\t\t\t2006;\n\t\t\t\t\t32:\n\t\t\t\t\t1035\u20131040.","DOI":"10.1016\/j.jcrs.2006.02.042"},{"key":"i1552-5783-60-1-113-b22","doi-asserted-by":"crossref","unstructured":"El-Osta\n\t\t\t\t\t\t\tAA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSpalton\n\t\t\t\t\t\t\tDJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarshall\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tIn vitro model for the study of human posterior capsule opacification.\n\t\t\t\t\tJ Cataract Refract Surg.\n\t\t\t\t\t2003;\n\t\t\t\t\t29:\n\t\t\t\t\t1593\u20131600.","DOI":"10.1016\/S0886-3350(03)00221-9"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2720802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:02Z","timestamp":1791927062000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.18-25930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,10]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.18-25930","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1,10]]}}}