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Lett.\n\t\t\t\t\t2001;\n\t\t\t\t\t497:\n\t\t\t\t\t1\u20135.","DOI":"10.1016\/S0014-5793(01)02437-1"},{"key":"i1552-5783-60-8-3064-b43","doi-asserted-by":"crossref","unstructured":"Thaler\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFiedorowicz\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRejdak\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tNeuroprotective effects of tempol on retinal ganglion cells in a partial optic nerve crush rat model with and without iron load.\n\t\t\t\t\tExp Eye 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