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Sci.\n\t\t\t\t\t2016;\n\t\t\t\t\t57:\n\t\t\t\t\t1017\u20131030.","DOI":"10.1167\/iovs.15-18429"},{"key":"i1552-5783-60-8-3034-b02","doi-asserted-by":"crossref","unstructured":"Allikmets\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSingh\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSun\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tA photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy.\n\t\t\t\t\tNat Genet.\n\t\t\t\t\t1997;\n\t\t\t\t\t15:\n\t\t\t\t\t236\u2013246.","DOI":"10.1038\/ng0397-236"},{"key":"i1552-5783-60-8-3034-b03","doi-asserted-by":"crossref","unstructured":"Maeda\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMaeda\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGolczak\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tInvolvement of all-trans-retinal in acute light-induced retinopathy of mice.\n\t\t\t\t\tJ Biol Chem.\n\t\t\t\t\t2009;\n\t\t\t\t\t284:\n\t\t\t\t\t15173\u201315183.","DOI":"10.1074\/jbc.M900322200"},{"key":"i1552-5783-60-8-3034-b04","doi-asserted-by":"crossref","unstructured":"Li\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCai\n\t\t\t\t\t\t\tX,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tXia\n\t\t\t\t\t\t\tQ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tInvolvement of endoplasmic reticulum stress in all-trans-retinal-induced retinal pigment epithelium degeneration.\n\t\t\t\t\tToxicol Sci.\n\t\t\t\t\t2015;\n\t\t\t\t\t143:\n\t\t\t\t\t196\u2013208.","DOI":"10.1093\/toxsci\/kfu223"},{"key":"i1552-5783-60-8-3034-b05","doi-asserted-by":"crossref","unstructured":"Maeda\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMaeda\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGolczak\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPalczewski\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tRetinopathy in mice induced by disrupted all-trans-retinal clearance.\n\t\t\t\t\tJ Biol Chem.\n\t\t\t\t\t2008;\n\t\t\t\t\t283:\n\t\t\t\t\t26684\u201326693.","DOI":"10.1074\/jbc.M804505200"},{"key":"i1552-5783-60-8-3034-b06","doi-asserted-by":"crossref","unstructured":"Chen\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOkano\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMaeda\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tMechanism of all-trans-retinal toxicity with implications for Stargardt disease and age-related macular degeneration.\n\t\t\t\t\tJ Biol Chem.\n\t\t\t\t\t2012;\n\t\t\t\t\t287:\n\t\t\t\t\t5059\u20135069.","DOI":"10.1074\/jbc.M111.315432"},{"key":"i1552-5783-60-8-3034-b07","doi-asserted-by":"crossref","unstructured":"Tarallo\n\t\t\t\t\t\t\tV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHirano\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGelfand\n\t\t\t\t\t\t\tBD,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tDICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.\n\t\t\t\t\tCell.\n\t\t\t\t\t2012;\n\t\t\t\t\t149:\n\t\t\t\t\t847\u2013859.","DOI":"10.1016\/j.cell.2012.03.036"},{"key":"i1552-5783-60-8-3034-b08","doi-asserted-by":"crossref","unstructured":"Doyle\n\t\t\t\t\t\t\tSL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCampbell\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOzaki\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tNLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components.\n\t\t\t\t\tNat Med.\n\t\t\t\t\t2012;\n\t\t\t\t\t18:\n\t\t\t\t\t791\u2013798.","DOI":"10.1038\/nm.2717"},{"key":"i1552-5783-60-8-3034-b09","doi-asserted-by":"crossref","unstructured":"Celkova\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDoyle\n\t\t\t\t\t\t\tSL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCampbell\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tNLRP3 inflammasome and pathobiology in AMD.\n\t\t\t\t\tJ Clin Med.\n\t\t\t\t\t2015;\n\t\t\t\t\t4:\n\t\t\t\t\t172\u2013192.","DOI":"10.3390\/jcm4010172"},{"key":"i1552-5783-60-8-3034-b10","doi-asserted-by":"crossref","unstructured":"Gao\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLiu\n\t\t\t\t\t\t\tRT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCao\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tNLRP3 inflammasome: activation and regulation in age-related macular degeneration.\n\t\t\t\t\tMediators Inflamm.\n\t\t\t\t\t2015;\n\t\t\t\t\t690243.","DOI":"10.1155\/2015\/690243"},{"key":"i1552-5783-60-8-3034-b11","doi-asserted-by":"crossref","unstructured":"Kovacs\n\t\t\t\t\t\t\tSB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMiao\n\t\t\t\t\t\t\tEA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tGasdermins: effectors of pyroptosis.\n\t\t\t\t\tTrends Cell Biol.\n\t\t\t\t\t2017;\n\t\t\t\t\t27:\n\t\t\t\t\t673\u2013684.","DOI":"10.1016\/j.tcb.2017.05.005"},{"key":"i1552-5783-60-8-3034-b12","doi-asserted-by":"crossref","unstructured":"Malik\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKanneganti\n\t\t\t\t\t\t\tTD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tInflammasome activation and assembly at a glance.\n\t\t\t\t\tJ Cell 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gasdermin.\n\t\t\t\t\tNature.\n\t\t\t\t\t2017;\n\t\t\t\t\t547:\n\t\t\t\t\t99\u2013103.","DOI":"10.1038\/nature22393"},{"key":"i1552-5783-60-8-3034-b17","doi-asserted-by":"crossref","unstructured":"Coll\n\t\t\t\t\t\t\tRC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRobertson\n\t\t\t\t\t\t\tAA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChae\n\t\t\t\t\t\t\tJJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tA small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.\n\t\t\t\t\tNat Med.\n\t\t\t\t\t2015;\n\t\t\t\t\t21:\n\t\t\t\t\t248\u2013255.","DOI":"10.1038\/nm.3806"},{"key":"i1552-5783-60-8-3034-b18","doi-asserted-by":"crossref","unstructured":"Jiang\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHe\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tIdentification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders.\n\t\t\t\t\tJ Exp Med.\n\t\t\t\t\t2017;\n\t\t\t\t\t214:\n\t\t\t\t\t3219\u20133238.","DOI":"10.1084\/jem.20171419"},{"key":"i1552-5783-60-8-3034-b19","doi-asserted-by":"crossref","unstructured":"Abais\n\t\t\t\t\t\t\tJM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tXia\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhang\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBoini\n\t\t\t\t\t\t\tKM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tPL.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tRedox regulation of NLRP3 inflammasomes: ROS as trigger or effector?\n\t\t\t\t\tAntioxid Redox 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