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diabetes mellitus: an update on diagnosis and management.\n\t\t\t\t\tClin Perinatol.\n\t\t\t\t\t2018;\n\t\t\t\t\t45:\n\t\t\t\t\t41\u201359.","DOI":"10.1016\/j.clp.2017.10.006"},{"key":"i1552-5783-60-5-1604-b47","doi-asserted-by":"crossref","unstructured":"Au\n\t\t\t\t\t\t\tSC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTang\n\t\t\t\t\t\t\tSM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRong\n\t\t\t\t\t\t\tSS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tLJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYam\n\t\t\t\t\t\t\tJC.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAssociation between hyperglycemia and retinopathy of prematurity: a systemic review and meta-analysis.\n\t\t\t\t\tSci 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Physiol.\n\t\t\t\t\t2007;\n\t\t\t\t\t148:\n\t\t\t\t\t780\u2013784.","DOI":"10.1016\/j.cbpa.2007.05.004"},{"key":"i1552-5783-60-5-1604-b50","doi-asserted-by":"crossref","unstructured":"Sharma\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDavis\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShekhawat\n\t\t\t\t\t\t\tPS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tHypoglycemia in the preterm neonate: etiopathogenesis, diagnosis, management and long-term outcomes.\n\t\t\t\t\tTransl Pediatr.\n\t\t\t\t\t2017;\n\t\t\t\t\t6:\n\t\t\t\t\t335\u2013348.","DOI":"10.21037\/tp.2017.10.06"},{"key":"i1552-5783-60-5-1604-b51","doi-asserted-by":"crossref","unstructured":"Bauer\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWerner\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGerss\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tMetabolic rate analysis of healthy preterm and full-term infants during the first weeks of life.\n\t\t\t\t\tAm J Clin 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