{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:20Z","timestamp":1791928700786,"version":"4.3.4"},"reference-count":36,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2019,5,15]]},"DOI":"10.1167\/iovs.19-26585","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T15:01:49Z","timestamp":1557932509000},"page":"2072","source":"Crossref","is-referenced-by-count":24,"title":["Effects of Salidroside on Trabecular Meshwork Cell Extracellular Matrix Expression and Mouse Intraocular Pressure"],"prefix":"10.1167","volume":"60","author":[{"given":"Yuchen","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"},{"name":"Bengbu Medicine College, Bengbu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Luan Affiliated Hospital of Anhui Medicine University, Luan, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Wei","sequence":"additional","affiliation":[{"name":"Bengbu Medicine College, Bengbu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-60-6-2072-b01","doi-asserted-by":"crossref","unstructured":"The AGIS Investigators.\n\t\t\t\t\tThe Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration.\n\t\t\t\t\tAm J Ophthalmol.\n\t\t\t\t\t2000;\n\t\t\t\t\t130:\n\t\t\t\t\t429\u2013440.","DOI":"10.1016\/S0002-9394(00)00538-9"},{"key":"i1552-5783-60-6-2072-b02","doi-asserted-by":"crossref","unstructured":"Quigley\n\t\t\t\t\t\t\tHA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tGlaucoma.\n\t\t\t\t\tLancet.\n\t\t\t\t\t2011;\n\t\t\t\t\t377:\n\t\t\t\t\t1367\u20131377.","DOI":"10.1016\/S0140-6736(10)61423-7"},{"key":"i1552-5783-60-6-2072-b03","doi-asserted-by":"crossref","unstructured":"Min\n\t\t\t\t\t\t\tSH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLee\n\t\t\t\t\t\t\tTI,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChung\n\t\t\t\t\t\t\tYS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKim\n\t\t\t\t\t\t\tHK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTransforming growth factor-beta levels in human aqueous humor of glaucomatous, diabetic and uveitic eyes.\n\t\t\t\t\tKorean J Ophthalmol.\n\t\t\t\t\t2006;\n\t\t\t\t\t20:\n\t\t\t\t\t162\u2013165.","DOI":"10.3341\/kjo.2006.20.3.162"},{"key":"i1552-5783-60-6-2072-b04","doi-asserted-by":"crossref","unstructured":"Ochiai\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOchiai\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tHigher concentration of transforming growth factor-beta in aqueous humor of glaucomatous eyes and diabetic eyes.\n\t\t\t\t\tJpn J Ophthalmol.\n\t\t\t\t\t2002;\n\t\t\t\t\t46:\n\t\t\t\t\t249\u2013253.","DOI":"10.1016\/S0021-5155(01)00523-8"},{"key":"i1552-5783-60-6-2072-b05","doi-asserted-by":"crossref","unstructured":"Picht\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWelge-Luessen\n\t\t\t\t\t\t\tU,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGrehn\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tL\u00fctjen-Drecoll\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTransforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development.\n\t\t\t\t\tGraefes Arch Clin Exp Ophthalmol.\n\t\t\t\t\t2001;\n\t\t\t\t\t239:\n\t\t\t\t\t199\u2013207.","DOI":"10.1007\/s004170000252"},{"key":"i1552-5783-60-6-2072-b06","doi-asserted-by":"crossref","unstructured":"Tripathi\n\t\t\t\t\t\t\tRC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChan\n\t\t\t\t\t\t\tWF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTripathi\n\t\t\t\t\t\t\tBJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t1994;\n\t\t\t\t\t59:\n\t\t\t\t\t723\u2013727.","DOI":"10.1006\/exer.1994.1158"},{"key":"i1552-5783-60-6-2072-b07","doi-asserted-by":"crossref","unstructured":"Yamamoto\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tItonaga\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarunouchi\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMajima\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tConcentration of transforming growth factor beta 2 in aqueous humor.\n\t\t\t\t\tOphthalmic Res.\n\t\t\t\t\t2005;\n\t\t\t\t\t37:\n\t\t\t\t\t29\u201333.","DOI":"10.1159\/000083019"},{"key":"i1552-5783-60-6-2072-b08","doi-asserted-by":"crossref","unstructured":"Koliakos\n\t\t\t\t\t\t\tGG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchlotzer-Schrehardt\n\t\t\t\t\t\t\tU,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKonstas\n\t\t\t\t\t\t\tAG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBufidis\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGeorgiadis\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDimitriadou\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTransforming and insulin-like growth factors in the aqueous humour of patients with exfoliation syndrome.\n\t\t\t\t\tGraefes Arch Clin Exp Ophthalmol.\n\t\t\t\t\t2001;\n\t\t\t\t\t239:\n\t\t\t\t\t482\u2013487.","DOI":"10.1007\/s004170100287"},{"key":"i1552-5783-60-6-2072-b09","doi-asserted-by":"crossref","unstructured":"Ozcan\n\t\t\t\t\t\t\tAA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOzdemir\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCanataroglu\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe aqueous levels of TGF-beta2 in patients with glaucoma.\n\t\t\t\t\tInt Ophthalmol.\n\t\t\t\t\t2004;\n\t\t\t\t\t25:\n\t\t\t\t\t19\u201322.","DOI":"10.1023\/B:INTE.0000018524.48581.79"},{"key":"i1552-5783-60-6-2072-b10","doi-asserted-by":"crossref","unstructured":"Medina-Ortiz\n\t\t\t\t\t\t\tWE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBelmares\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNeubauer\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWordinger\n\t\t\t\t\t\t\tRJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tClark\n\t\t\t\t\t\t\tAF.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCellular fibronectin expression in human trabecular meshwork and induction by transforming growth factor-\u00df2.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2013;\n\t\t\t\t\t54:\n\t\t\t\t\t6779\u20136788.","DOI":"10.1167\/iovs.13-12298"},{"key":"i1552-5783-60-6-2072-b11","doi-asserted-by":"crossref","unstructured":"Vranka\n\t\t\t\t\t\t\tJA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKelley\n\t\t\t\t\t\t\tMJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAcott\n\t\t\t\t\t\t\tTS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKeller\n\t\t\t\t\t\t\tKE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tExtracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2015;\n\t\t\t\t\t133:\n\t\t\t\t\t112\u2013125.","DOI":"10.1016\/j.exer.2014.07.014"},{"key":"i1552-5783-60-6-2072-b12","doi-asserted-by":"crossref","unstructured":"Qu\n\t\t\t\t\t\t\tZQ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhou\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZeng\n\t\t\t\t\t\t\tYS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChung\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPretreatment with Rhodiola rosea extract reduces cognitive impairment induced by intracerebroventricular streptozotocin in rats: implication of anti-oxidative and neuroprotective effects.\n\t\t\t\t\tBiomed Environ Sci.\n\t\t\t\t\t2009;\n\t\t\t\t\t22:\n\t\t\t\t\t318\u2013326.","DOI":"10.1016\/S0895-3988(09)60062-3"},{"key":"i1552-5783-60-6-2072-b13","doi-asserted-by":"crossref","unstructured":"Fleenor\n\t\t\t\t\t\t\tDL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShepard\n\t\t\t\t\t\t\tAR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHellberg\n\t\t\t\t\t\t\tPE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJacobson\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPang\n\t\t\t\t\t\t\tIH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tClark\n\t\t\t\t\t\t\tAF.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTGF-beta2-induced changes in human trabecular meshwork: implications for intraocular pressure.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2006;\n\t\t\t\t\t47:\n\t\t\t\t\t226\u2013234.","DOI":"10.1167\/iovs.05-1060"},{"key":"i1552-5783-60-6-2072-b14","doi-asserted-by":"crossref","unstructured":"Wordinger\n\t\t\t\t\t\t\tRJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFleenor\n\t\t\t\t\t\t\tDL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHellberg\n\t\t\t\t\t\t\tPE,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tEffects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2007;\n\t\t\t\t\t48:\n\t\t\t\t\t1191\u20131200.","DOI":"10.1167\/iovs.06-0296"},{"key":"i1552-5783-60-6-2072-b15","doi-asserted-by":"crossref","unstructured":"Shepard\n\t\t\t\t\t\t\tAR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMillar\n\t\t\t\t\t\t\tJC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPang\n\t\t\t\t\t\t\tIH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJacobson\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWang\n\t\t\t\t\t\t\tWH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tClark\n\t\t\t\t\t\t\tAF.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAdenoviral gene transfer of active human transforming growth factor-beta2 elevates intraocular pressure and reduces outflow facility in rodent eyes.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2010;\n\t\t\t\t\t51:\n\t\t\t\t\t2067\u20132076.","DOI":"10.1167\/iovs.09-4567"},{"key":"i1552-5783-60-6-2072-b16","doi-asserted-by":"crossref","unstructured":"Qu\n\t\t\t\t\t\t\tZQ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhou\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZeng\n\t\t\t\t\t\t\tYS,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tProtective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2012;\n\t\t\t\t\t7:\n\t\t\t\t\te29641.","DOI":"10.1371\/journal.pone.0029641"},{"key":"i1552-5783-60-6-2072-b17","doi-asserted-by":"crossref","unstructured":"Zheng\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSheng\n\t\t\t\t\t\t\tZ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLu\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tSalidroside inhibits oxygen glucose deprivation (OGD)\/re-oxygenation-induced H9c2 cell necrosis through activating of Akt-Nrf2 signaling.\n\t\t\t\t\tBiochem Biophys Res Commun.\n\t\t\t\t\t2014;\n\t\t\t\t\t451:\n\t\t\t\t\t79\u201385.","DOI":"10.1016\/j.bbrc.2014.07.072"},{"key":"i1552-5783-60-6-2072-b18","doi-asserted-by":"crossref","unstructured":"Guan\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tXiong\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSong\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSong\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWang\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChu\n\t\t\t\t\t\t\tX.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tProtective effects of salidroside from Rhodiola rosea on LPS-induced acute lung injury in mice.\n\t\t\t\t\tImmunopharmacol Immunotoxicol.\n\t\t\t\t\t2012;\n\t\t\t\t\t34:\n\t\t\t\t\t667\u2013672.","DOI":"10.3109\/08923973.2011.650175"},{"key":"i1552-5783-60-6-2072-b19","unstructured":"Zhang\n\t\t\t\t\t\t\tZ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDing\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWu\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tXu\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZheng\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHuang\n\t\t\t\t\t\t\tX.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tSalidroside alleviates paraquat-induced rat acute lung injury by repressing TGF-beta1 expression.\n\t\t\t\t\tInt J Clin Exp Pathol.\n\t\t\t\t\t2014;\n\t\t\t\t\t7:\n\t\t\t\t\t8841\u20138847"},{"key":"i1552-5783-60-6-2072-b20","doi-asserted-by":"crossref","unstructured":"Huang\n\t\t\t\t\t\t\tX,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZou\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYu\n\t\t\t\t\t\t\tX,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tSalidroside attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2a receptor related mitochondria-dependent apoptosis pathway.\n\t\t\t\t\tJ Mol Cell Cardiol.\n\t\t\t\t\t2015;\n\t\t\t\t\t82:\n\t\t\t\t\t153\u2013166.","DOI":"10.1016\/j.yjmcc.2015.03.005"},{"key":"i1552-5783-60-6-2072-b21","doi-asserted-by":"crossref","unstructured":"Tang\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGao\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMao\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHe\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLiu\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCai\n\t\t\t\t\t\t\tX.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tSalidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-?B and TGF-\u00df1\/Smad-2\/-3 pathways.\n\t\t\t\t\tCell Stress Chaperones.\n\t\t\t\t\t2015;\n\t\t\t\t\t21:\n\t\t\t\t\t239\u2013249.","DOI":"10.1007\/s12192-015-0654-4"},{"key":"i1552-5783-60-6-2072-b22","doi-asserted-by":"crossref","unstructured":"Feng\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tXia\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tSalidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-?B and TGF-\u00df1\/Smad3 pathways.\n\t\t\t\t\tDrug Des Devel Ther.\n\t\t\t\t\t2018;\n\t\t\t\t\t12:\n\t\t\t\t\t1837\u20131853.","DOI":"10.2147\/DDDT.S162950"},{"key":"i1552-5783-60-6-2072-b23","unstructured":"Ouyang\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGao\n\t\t\t\t\t\t\tZ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRen\n\t\t\t\t\t\t\tZ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHong\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tQiao\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tY.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tSynergistic effects of rMSCs and salidroside on the experimental hepatic fibrosis.\n\t\t\t\t\tPharmazie.\n\t\t\t\t\t2010;\n\t\t\t\t\t65:\n\t\t\t\t\t607\u2013613"},{"key":"i1552-5783-60-6-2072-b24","doi-asserted-by":"crossref","unstructured":"Keller\n\t\t\t\t\t\t\tKE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBhattacharya\n\t\t\t\t\t\t\tSK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBorr\u00e1s\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tConsensus recommendations for trabecular meshwork cell isolation, characterization and culture.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2018;\n\t\t\t\t\t171:\n\t\t\t\t\t164\u2013173","DOI":"10.1016\/j.exer.2018.03.001"},{"key":"i1552-5783-60-6-2072-b25","doi-asserted-by":"crossref","unstructured":"McDowell\n\t\t\t\t\t\t\tCM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHernandez\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMao\n\t\t\t\t\t\t\tW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tClark\n\t\t\t\t\t\t\tAF.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tGremlin induces ocular hypertension in mice through Smad3-dependent signaling.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2015;\n\t\t\t\t\t56:\n\t\t\t\t\t5485\u20135492.","DOI":"10.1167\/iovs.15-16993"},{"key":"i1552-5783-60-6-2072-b26","doi-asserted-by":"crossref","unstructured":"McDowell\n\t\t\t\t\t\t\tCM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTebow\n\t\t\t\t\t\t\tHE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWordinger\n\t\t\t\t\t\t\tRJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tClark\n\t\t\t\t\t\t\tAF.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tSmad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2013;\n\t\t\t\t\t116:\n\t\t\t\t\t419\u2013423.","DOI":"10.1016\/j.exer.2013.10.017"},{"key":"i1552-5783-60-6-2072-b27","doi-asserted-by":"crossref","unstructured":"Chen\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMa\n\t\t\t\t\t\t\tZ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhu\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJiang\n\t\t\t\t\t\t\tW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWei\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhou\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tSuppressing Receptor-Interacting Protein 140: a new sight for salidroside to treat cerebral ischemia.\n\t\t\t\t\tMol Neurobiol.\n\t\t\t\t\t2015;\n\t\t\t\t\t53:\n\t\t\t\t\t1\u201311.","DOI":"10.1007\/s12035-014-8834-2"},{"key":"i1552-5783-60-6-2072-b28","doi-asserted-by":"crossref","unstructured":"Wang\n\t\t\t\t\t\t\tWH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMillar\n\t\t\t\t\t\t\tJC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPang\n\t\t\t\t\t\t\tIH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWax\n\t\t\t\t\t\t\tMB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tClark\n\t\t\t\t\t\t\tAF.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tNoninvasive measurement of rodent intraocular pressure with a rebound tonometer.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2005;\n\t\t\t\t\t46:\n\t\t\t\t\t4617\u20134621.","DOI":"10.1167\/iovs.05-0781"},{"key":"i1552-5783-60-6-2072-b29","doi-asserted-by":"crossref","unstructured":"Rohen\n\t\t\t\t\t\t\tJW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLutjen-Drecoll\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFlugel\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMeyer\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGrierson\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tUltrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma (POAG).\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t1993;\n\t\t\t\t\t56:\n\t\t\t\t\t683\u2013692.","DOI":"10.1006\/exer.1993.1085"},{"key":"i1552-5783-60-6-2072-b30","doi-asserted-by":"crossref","unstructured":"Johnson\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGottanka\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFlugel\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHoffmann\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFuta\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLutjen-Drecoll\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tUltrastructural changes in the trabecular meshwork of human eyes treated with corticosteroids.\n\t\t\t\t\tArch Ophthalmol.\n\t\t\t\t\t1997;\n\t\t\t\t\t115:\n\t\t\t\t\t375\u2013383.","DOI":"10.1001\/archopht.1997.01100150377011"},{"key":"i1552-5783-60-6-2072-b31","unstructured":"Clark\n\t\t\t\t\t\t\tAF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWilson\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Kater\n\t\t\t\t\t\t\tAW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAllingham\n\t\t\t\t\t\t\tRR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMcCartney\n\t\t\t\t\t\t\tMD.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tDexamethasone-induced ocular hypertension in perfusion-cultured human eyes.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t1995;\n\t\t\t\t\t36:\n\t\t\t\t\t478\u2013489."},{"key":"i1552-5783-60-6-2072-b32","unstructured":"Acott\n\t\t\t\t\t\t\tTS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKelley\n\t\t\t\t\t\t\tMJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tExtracellular matrix in the trabecular meshwork.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2008;\n\t\t\t\t\t864:\n\t\t\t\t\t543\u2013561."},{"key":"i1552-5783-60-6-2072-b33","doi-asserted-by":"crossref","unstructured":"Inatani\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTanihara\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKatsuta\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHonjo\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKido\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHonda\n\t\t\t\t\t\t\tY.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTransforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes.\n\t\t\t\t\tGraefes Arch Clin Exp Ophthalmol.\n\t\t\t\t\t2001;\n\t\t\t\t\t239:\n\t\t\t\t\t109\u2013113.","DOI":"10.1007\/s004170000241"},{"key":"i1552-5783-60-6-2072-b34","doi-asserted-by":"crossref","unstructured":"Schlotzer-Schrehardt\n\t\t\t\t\t\t\tU,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZenkel\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKuchle\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSakai\n\t\t\t\t\t\t\tLY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNaumann\n\t\t\t\t\t\t\tGO.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tRole of transforming growth factor-beta1 and its latent form binding protein in pseudoexfoliation syndrome.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2001;\n\t\t\t\t\t73:\n\t\t\t\t\t765\u2013780.","DOI":"10.1006\/exer.2001.1084"},{"key":"i1552-5783-60-6-2072-b35","doi-asserted-by":"crossref","unstructured":"Tripathi\n\t\t\t\t\t\t\tRC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChan\n\t\t\t\t\t\t\tWF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTripathi\n\t\t\t\t\t\t\tBJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t1994;\n\t\t\t\t\t59:\n\t\t\t\t\t723\u2013727.","DOI":"10.1006\/exer.1994.1158"},{"key":"i1552-5783-60-6-2072-b36","unstructured":"Wei\n\t\t\t\t\t\t\tZ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMing\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYang\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tXiao\n\t\t\t\t\t\t\tZ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSong\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLin\n\t\t\t\t\t\t\tZ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tProtective effects of salidroside on mitochondrial functions against exertional heat stroke-induced organ damage in the rat.\n\t\t\t\t\tEvid Based Complement Alt Med.\n\t\t\t\t\t2015;\n\t\t\t\t\t2015:\n\t\t\t\t\t504567."}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2733989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:04Z","timestamp":1791927064000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.19-26585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,15]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.19-26585","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,15]]}}}