{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:22Z","timestamp":1791928702943,"version":"4.3.4"},"reference-count":62,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"7","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2019,6,26]]},"DOI":"10.1167\/iovs.19-26631","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T16:30:32Z","timestamp":1561566632000},"page":"2705","source":"Crossref","is-referenced-by-count":58,"title":["The Effects of Aging on Corneal and Ocular Surface Homeostasis in Mice"],"prefix":"10.1167","volume":"60","author":[{"given":"Manikkuwadura Eranda Harshan","family":"De Silva","sequence":"first","affiliation":[{"name":"Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Hill","sequence":"additional","affiliation":[{"name":"Neuroscience and Ophthalmology Research Group, Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Downie","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly R.","family":"Chinnery","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-60-7-2705-b01","doi-asserted-by":"crossref","unstructured":"Shaheen\n\t\t\t\t\t\t\tBS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBakir\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJain\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCorneal nerves in health and disease.\n\t\t\t\t\tSurv Ophthalmol.\n\t\t\t\t\t2014;\n\t\t\t\t\t59:\n\t\t\t\t\t263\u2013285.","DOI":"10.1016\/j.survophthal.2013.09.002"},{"key":"i1552-5783-60-7-2705-b02","doi-asserted-by":"crossref","unstructured":"Vehof\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKozareva\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHysi\n\t\t\t\t\t\t\tPG,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tRelationship between dry eye symptoms and pain sensitivity.\n\t\t\t\t\tJAMA Ophthalmology.\n\t\t\t\t\t2013;\n\t\t\t\t\t131:\n\t\t\t\t\t1304\u20131308.","DOI":"10.1001\/jamaophthalmol.2013.4399"},{"key":"i1552-5783-60-7-2705-b03","doi-asserted-by":"crossref","unstructured":"Pritchard\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEdwards\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVagenas\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRussell\n\t\t\t\t\t\t\tAW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMalik\n\t\t\t\t\t\t\tRA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEfron\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCorneal sensitivity is related to established measures of diabetic peripheral neuropathy.\n\t\t\t\t\tClin Exp Optom.\n\t\t\t\t\t2012;\n\t\t\t\t\t95:\n\t\t\t\t\t355\u2013361.","DOI":"10.1111\/j.1444-0938.2012.00729.x"},{"key":"i1552-5783-60-7-2705-b04","doi-asserted-by":"crossref","unstructured":"Gipson\n\t\t\t\t\t\t\tIK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAge-related changes and diseases of the ocular surface and cornea.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2013;\n\t\t\t\t\t54:\n\t\t\t\t\tORSF48\u2013ORSF53.","DOI":"10.1167\/iovs.13-12840"},{"key":"i1552-5783-60-7-2705-b05","doi-asserted-by":"crossref","unstructured":"Gambato\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLonghin\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCatania\n\t\t\t\t\t\t\tAG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLazzarini\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tParrozzani\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMidena\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAging and corneal layers: an in vivo corneal confocal microscopy study.\n\t\t\t\t\tGraefes Arch Clin Exp Ophthalmol.\n\t\t\t\t\t2015;\n\t\t\t\t\t253:\n\t\t\t\t\t267\u2013275.","DOI":"10.1007\/s00417-014-2812-2"},{"key":"i1552-5783-60-7-2705-b06","doi-asserted-by":"crossref","unstructured":"Tavakoli\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFerdousi\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPetropoulos\n\t\t\t\t\t\t\tIN,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tNormative values for corneal nerve morphology assessed using corneal confocal microscopy: a multinational normative data set.\n\t\t\t\t\tDiabetes Care.\n\t\t\t\t\t2015;\n\t\t\t\t\t38:\n\t\t\t\t\t838\u2013843.","DOI":"10.2337\/dc14-2311"},{"key":"i1552-5783-60-7-2705-b07","doi-asserted-by":"crossref","unstructured":"De Silva\n\t\t\t\t\t\t\tMEH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhang\n\t\t\t\t\t\t\tAC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKarahalios\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChinnery\n\t\t\t\t\t\t\tHR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDownie\n\t\t\t\t\t\t\tLE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tLaser scanning in vivo confocal microscopy (IVCM) for evaluating human corneal sub-basal nerve plexus parameters: protocol for a systematic review.\n\t\t\t\t\tBMJ Open.\n\t\t\t\t\t2017;\n\t\t\t\t\t7:\n\t\t\t\t\te018646.","DOI":"10.1136\/bmjopen-2017-018646"},{"key":"i1552-5783-60-7-2705-b08","doi-asserted-by":"crossref","unstructured":"Erie\n\t\t\t\t\t\t\tJC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMcLaren\n\t\t\t\t\t\t\tJW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHodge\n\t\t\t\t\t\t\tDO,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBourne\n\t\t\t\t\t\t\tWM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe effect of age on the corneal subbasal nerve plexus.\n\t\t\t\t\tCornea.\n\t\t\t\t\t2005;\n\t\t\t\t\t24:\n\t\t\t\t\t705\u2013709.","DOI":"10.1097\/01.ico.0000154387.51355.39"},{"key":"i1552-5783-60-7-2705-b09","doi-asserted-by":"crossref","unstructured":"Niederer\n\t\t\t\t\t\t\tRL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPerumal\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSherwin\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMcGhee\n\t\t\t\t\t\t\tCN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAge-related differences in the normal human cornea: a laser scanning in vivo confocal microscopy study.\n\t\t\t\t\tBr J Ophthalmol.\n\t\t\t\t\t2007;\n\t\t\t\t\t91:\n\t\t\t\t\t1165\u20131169.","DOI":"10.1136\/bjo.2006.112656"},{"key":"i1552-5783-60-7-2705-b10","doi-asserted-by":"crossref","unstructured":"Fitch\n\t\t\t\t\t\t\tKL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNadakavukaren\n\t\t\t\t\t\t\tMJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAge-related changes in the corneal endothelium of the mouse.\n\t\t\t\t\tExp Gerontol.\n\t\t\t\t\t1986;\n\t\t\t\t\t21:\n\t\t\t\t\t31\u201335.","DOI":"10.1016\/0531-5565(86)90015-X"},{"key":"i1552-5783-60-7-2705-b11","doi-asserted-by":"crossref","unstructured":"Jun\n\t\t\t\t\t\t\tAS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChakravarti\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEdelhauser\n\t\t\t\t\t\t\tHF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKimos\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAging changes of mouse corneal endothelium and Descemet's membrane.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2006;\n\t\t\t\t\t83:\n\t\t\t\t\t890\u2013896.","DOI":"10.1016\/j.exer.2006.03.025"},{"key":"i1552-5783-60-7-2705-b12","doi-asserted-by":"crossref","unstructured":"Marco\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAlessandro\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPhilippe\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFabio\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPaolo\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGiulio\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe effect of aging on nerve morphology and substance P expression in mouse and human corneas.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2018;\n\t\t\t\t\t59:\n\t\t\t\t\t5329\u20135335.","DOI":"10.1167\/iovs.18-24707"},{"key":"i1552-5783-60-7-2705-b13","doi-asserted-by":"crossref","unstructured":"Stepp\n\t\t\t\t\t\t\tMA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPal-Ghosh\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTadvalkar\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWilliams\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPflugfelder\n\t\t\t\t\t\t\tSC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Paiva\n\t\t\t\t\t\t\tCS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tReduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL\/6 mice.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2018;\n\t\t\t\t\t169:\n\t\t\t\t\t91\u201398.","DOI":"10.1016\/j.exer.2018.01.024"},{"key":"i1552-5783-60-7-2705-b14","doi-asserted-by":"crossref","unstructured":"Wang\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFu\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tXia\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tZ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tChanges in mouse corneal epithelial innervation with age.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2012;\n\t\t\t\t\t53:\n\t\t\t\t\t5077\u20135084.","DOI":"10.1167\/iovs.12-9704"},{"key":"i1552-5783-60-7-2705-b15","doi-asserted-by":"crossref","unstructured":"Alcalde\n\t\t\t\t\t\t\tI,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tInigo-Portugues\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGonzalez-Gonzalez\n\t\t\t\t\t\t\tO,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tMorphological and functional changes in TRPM8-expressing corneal cold thermoreceptor neurons during aging and their impact on tearing in mice.\n\t\t\t\t\tJ Comp Neurol.\n\t\t\t\t\t2018;\n\t\t\t\t\t526:\n\t\t\t\t\t1859\u20131874.","DOI":"10.1002\/cne.24454"},{"key":"i1552-5783-60-7-2705-b16","doi-asserted-by":"crossref","unstructured":"McClellan\n\t\t\t\t\t\t\tAJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVolpe\n\t\t\t\t\t\t\tEA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhang\n\t\t\t\t\t\t\tX,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tOcular surface disease and dacryoadenitis in aging C57BL\/6 mice.\n\t\t\t\t\tAm J Pathol.\n\t\t\t\t\t2014;\n\t\t\t\t\t184:\n\t\t\t\t\t631\u2013643.","DOI":"10.1016\/j.ajpath.2013.11.019"},{"key":"i1552-5783-60-7-2705-b17","doi-asserted-by":"crossref","unstructured":"Lively\n\t\t\t\t\t\t\tGD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJiang\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHedberg-Buenz\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tGenetic dependence of central corneal thickness among inbred strains of mice.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2010;\n\t\t\t\t\t51:\n\t\t\t\t\t160\u2013171.","DOI":"10.1167\/iovs.09-3429"},{"key":"i1552-5783-60-7-2705-b18","doi-asserted-by":"crossref","unstructured":"Hanlon\n\t\t\t\t\t\t\tSD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPatel\n\t\t\t\t\t\t\tNB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBurns\n\t\t\t\t\t\t\tAR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAssessment of postnatal corneal development in the C57BL\/6 mouse using spectral domain optical coherence tomography and microwave-assisted histology.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2011;\n\t\t\t\t\t93:\n\t\t\t\t\t363\u2013370.","DOI":"10.1016\/j.exer.2011.04.013"},{"key":"i1552-5783-60-7-2705-b19","doi-asserted-by":"crossref","unstructured":"Inomata\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMashaghi\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHong\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNakao\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDana\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tScaling and maintenance of corneal thickness during aging.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2017;\n\t\t\t\t\t12:\n\t\t\t\t\te0185694.","DOI":"10.1371\/journal.pone.0185694"},{"key":"i1552-5783-60-7-2705-b20","doi-asserted-by":"crossref","unstructured":"Yamagami\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYokoo\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tUsui\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYamagami\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAmano\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEbihara\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tDistinct populations of dendritic cells in the normal human donor corneal epithelium.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2005;\n\t\t\t\t\t46:\n\t\t\t\t\t4489\u20134494.","DOI":"10.1167\/iovs.05-0054"},{"key":"i1552-5783-60-7-2705-b21","doi-asserted-by":"crossref","unstructured":"Gao\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYin\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYoon\n\t\t\t\t\t\t\tGS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMi\n\t\t\t\t\t\t\tQS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYu\n\t\t\t\t\t\t\tFS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tDendritic cell-epithelium interplay is a determinant factor for corneal epithelial wound repair.\n\t\t\t\t\tAm J Pathol.\n\t\t\t\t\t2011;\n\t\t\t\t\t179:\n\t\t\t\t\t2243\u20132253.","DOI":"10.1016\/j.ajpath.2011.07.050"},{"key":"i1552-5783-60-7-2705-b22","doi-asserted-by":"crossref","unstructured":"Kheirkhah\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRahimi Darabad\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCruzat\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tCorneal epithelial immune dendritic cell alterations in subtypes of dry eye disease: a pilot in vivo confocal microscopic study.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2015;\n\t\t\t\t\t56:\n\t\t\t\t\t7179\u20137185.","DOI":"10.1167\/iovs.15-17433"},{"key":"i1552-5783-60-7-2705-b23","doi-asserted-by":"crossref","unstructured":"Hamrah\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHuq\n\t\t\t\t\t\t\tSO,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLiu\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhang\n\t\t\t\t\t\t\tQ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDana\n\t\t\t\t\t\t\tMR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCorneal immunity is mediated by heterogeneous population of antigen-presenting cells.\n\t\t\t\t\tJ Leukoc Biol.\n\t\t\t\t\t2003;\n\t\t\t\t\t74:\n\t\t\t\t\t172\u2013178.","DOI":"10.1189\/jlb.1102544"},{"key":"i1552-5783-60-7-2705-b24","doi-asserted-by":"crossref","unstructured":"Knickelbein\n\t\t\t\t\t\t\tJE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWatkins\n\t\t\t\t\t\t\tSC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMcMenamin\n\t\t\t\t\t\t\tPG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHendricks\n\t\t\t\t\t\t\tRL.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tStratification of antigen-presenting cells within the normal cornea.\n\t\t\t\t\tOphthalmol Eye Dis.\n\t\t\t\t\t2009;\n\t\t\t\t\t1:\n\t\t\t\t\t45\u201354.","DOI":"10.4137\/OED.S2813"},{"key":"i1552-5783-60-7-2705-b25","unstructured":"Steinman\n\t\t\t\t\t\t\tRM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHemmi\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tDendritic cells: translating innate to adaptive immunity.\n\t\t\t\t\tCurr Top Microbiol Immunol.\n\t\t\t\t\t2006;\n\t\t\t\t\t311:\n\t\t\t\t\t17\u201358."},{"key":"i1552-5783-60-7-2705-b26","doi-asserted-by":"crossref","unstructured":"Hamrah\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLiu\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhang\n\t\t\t\t\t\t\tQ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDana\n\t\t\t\t\t\t\tMR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe corneal stroma is endowed with a significant number of resident dendritic cells.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2003;\n\t\t\t\t\t44:\n\t\t\t\t\t581\u2013589.","DOI":"10.1167\/iovs.02-0838"},{"key":"i1552-5783-60-7-2705-b27","doi-asserted-by":"crossref","unstructured":"Gao\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLee\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYu\n\t\t\t\t\t\t\tFS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tIntraepithelial dendritic cells and sensory nerves are structurally associated and functional interdependent in the cornea.\n\t\t\t\t\tSci Rep.\n\t\t\t\t\t2016;\n\t\t\t\t\t6:\n\t\t\t\t\t36414.","DOI":"10.1038\/srep36414"},{"key":"i1552-5783-60-7-2705-b28","doi-asserted-by":"crossref","unstructured":"Maruoka\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tInaba\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOgata\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tActivation of dendritic cells in dry eye mouse model.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2018;\n\t\t\t\t\t59:\n\t\t\t\t\t3269\u20133277.","DOI":"10.1167\/iovs.17-22550"},{"key":"i1552-5783-60-7-2705-b29","doi-asserted-by":"crossref","unstructured":"Mastropasqua\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAgnifili\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFasanella\n\t\t\t\t\t\t\tV,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tIn vivo distribution of corneal epithelial dendritic cells in patients with glaucoma.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2016;\n\t\t\t\t\t57:\n\t\t\t\t\t5996\u20136002.","DOI":"10.1167\/iovs.16-20333"},{"key":"i1552-5783-60-7-2705-b30","doi-asserted-by":"crossref","unstructured":"Cavalcanti\n\t\t\t\t\t\t\tBM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCruzat\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSahin\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tet al. In vivo confocal microscopy detects bilateral changes of corneal immune cells and nerves in unilateral herpes zoster ophthalmicus.\n\t\t\t\t\tOcul Surf.\n\t\t\t\t\t2018;\n\t\t\t\t\t16:\n\t\t\t\t\t101\u2013111.","DOI":"10.1016\/j.jtos.2017.09.004"},{"key":"i1552-5783-60-7-2705-b31","doi-asserted-by":"crossref","unstructured":"Cruzat\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWitkin\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBaniasadi\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tInflammation and the nervous system: the connection in the cornea in patients with infectious keratitis.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2011;\n\t\t\t\t\t52:\n\t\t\t\t\t5136\u20135143.","DOI":"10.1167\/iovs.10-7048"},{"key":"i1552-5783-60-7-2705-b32","doi-asserted-by":"crossref","unstructured":"Stapleton\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAlves\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBunya\n\t\t\t\t\t\t\tVY,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tTFOS DEWS II epidemiology report.\n\t\t\t\t\tOcul Surf.\n\t\t\t\t\t2017;\n\t\t\t\t\t15:\n\t\t\t\t\t334\u2013365.","DOI":"10.1016\/j.jtos.2017.05.003"},{"key":"i1552-5783-60-7-2705-b33","unstructured":"Downie\n\t\t\t\t\t\t\tLE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVingrys\n\t\t\t\t\t\t\tAJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAccuracy of laboratory assays in ophthalmic practice.\n\t\t\t\t\tJAMA Ophthalmol.\n\t\t\t\t\t2015;\n\t\t\t\t\t133:\n\t\t\t\t\t1480."},{"key":"i1552-5783-60-7-2705-b34","doi-asserted-by":"crossref","unstructured":"Downie\n\t\t\t\t\t\t\tLE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNaranjo Golborne\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tRecovery of the sub-basal nerve plexus and superficial nerve terminals after corneal epithelial injury in mice.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2018;\n\t\t\t\t\t171:\n\t\t\t\t\t92\u2013100.","DOI":"10.1016\/j.exer.2018.03.012"},{"key":"i1552-5783-60-7-2705-b35","doi-asserted-by":"crossref","unstructured":"Cai\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhu\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPetroll\n\t\t\t\t\t\t\tWM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKoppaka\n\t\t\t\t\t\t\tV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRobertson\n\t\t\t\t\t\t\tDM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe impact of type 1 diabetes mellitus on corneal epithelial nerve morphology and the corneal epithelium.\n\t\t\t\t\tAm J Pathol.\n\t\t\t\t\t2014;\n\t\t\t\t\t184:\n\t\t\t\t\t2662\u20132670.","DOI":"10.1016\/j.ajpath.2014.06.016"},{"key":"i1552-5783-60-7-2705-b36","doi-asserted-by":"crossref","unstructured":"Marsovszky\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tResch\n\t\t\t\t\t\t\tMD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNemeth\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tIn vivo confocal microscopic evaluation of corneal Langerhans cell density, and distribution and evaluation of dry eye in rheumatoid arthritis.\n\t\t\t\t\tInnate Immun.\n\t\t\t\t\t2013;\n\t\t\t\t\t19:\n\t\t\t\t\t348\u2013354.","DOI":"10.1177\/1753425912461677"},{"key":"i1552-5783-60-7-2705-b37","unstructured":"Flurkey\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCurrer\n\t\t\t\t\t\t\tJM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHarrison\n\t\t\t\t\t\t\tDE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe mouse in biomedical research.\n\t\t\t\t\tIn: Fox JG, Davisson MT, Quimby FW, Barthold SW, Newcomer CE, Smith AL, eds.\n\t\t\t\t\tMouse Models in Aging Research.\n\t\t\t\t\t2nd ed. London, UK: Academic Press;\n\t\t\t\t\t2007:\n\t\t\t\t\t637\u2013673."},{"key":"i1552-5783-60-7-2705-b38","doi-asserted-by":"crossref","unstructured":"Dvorscak\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarfurt\n\t\t\t\t\t\t\tCF.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAge-related changes in rat corneal epithelial nerve density.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2008;\n\t\t\t\t\t49:\n\t\t\t\t\t910\u2013916.","DOI":"10.1167\/iovs.07-1324"},{"key":"i1552-5783-60-7-2705-b39","doi-asserted-by":"crossref","unstructured":"Simsek\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKojima\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDogru\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTsubota\n\t\t\t\t\t\t\tK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAlterations of murine subbasal corneal nerves after environmental dry eye stress.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2018;\n\t\t\t\t\t59:\n\t\t\t\t\t1986\u20131995.","DOI":"10.1167\/iovs.17-23743"},{"key":"i1552-5783-60-7-2705-b40","doi-asserted-by":"crossref","unstructured":"Grupcheva\n\t\t\t\t\t\t\tCN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWong\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRiley\n\t\t\t\t\t\t\tAF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMcGhee\n\t\t\t\t\t\t\tCN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAssessing the sub-basal nerve plexus of the living healthy human cornea by in vivo confocal microscopy.\n\t\t\t\t\tClin Exp Ophthalmol.\n\t\t\t\t\t2002;\n\t\t\t\t\t30:\n\t\t\t\t\t187\u2013190.","DOI":"10.1046\/j.1442-9071.2002.00507.x"},{"key":"i1552-5783-60-7-2705-b41","doi-asserted-by":"crossref","unstructured":"Shetty\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSethu\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDeshmukh\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tCorneal dendritic cell density is associated with subbasal nerve plexus features, ocular surface disease index, and serum vitamin D in evaporative dry eye disease.\n\t\t\t\t\tBiomed Res Int.\n\t\t\t\t\t2016;\n\t\t\t\t\t2016:\n\t\t\t\t\t4369750.","DOI":"10.1155\/2016\/4369750"},{"key":"i1552-5783-60-7-2705-b42","doi-asserted-by":"crossref","unstructured":"Zhivov\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStave\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVollmar\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGuthoff\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tIn vivo confocal microscopic evaluation of Langerhans cell density and distribution in the normal human corneal epithelium.\n\t\t\t\t\tGraefes Arch Clin Exp Ophthalmol.\n\t\t\t\t\t2005;\n\t\t\t\t\t243:\n\t\t\t\t\t1056\u20131061.","DOI":"10.1007\/s00417-004-1075-8"},{"key":"i1552-5783-60-7-2705-b43","doi-asserted-by":"crossref","unstructured":"Leppin\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBehrendt\n\t\t\t\t\t\t\tAK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tReichard\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tDiabetes mellitus leads to accumulation of dendritic cells and nerve fiber damage of the subbasal nerve plexus in the cornea.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2014;\n\t\t\t\t\t55:\n\t\t\t\t\t3603\u20133615.","DOI":"10.1167\/iovs.14-14307"},{"key":"i1552-5783-60-7-2705-b44","doi-asserted-by":"crossref","unstructured":"Zacca\n\t\t\t\t\t\t\tER,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCrespo\n\t\t\t\t\t\t\tMI,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAcland\n\t\t\t\t\t\t\tRP,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAging impairs the ability of conventional dendritic cells to cross-prime CD8+ T cells upon stimulation with a TLR7 ligand.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2015;\n\t\t\t\t\t10:\n\t\t\t\t\te0140672.","DOI":"10.1371\/journal.pone.0140672"},{"key":"i1552-5783-60-7-2705-b45","doi-asserted-by":"crossref","unstructured":"Tesar\n\t\t\t\t\t\t\tBM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWalker\n\t\t\t\t\t\t\tWE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tUnternaehrer\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tMurine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging.\n\t\t\t\t\tAging Cell.\n\t\t\t\t\t2006;\n\t\t\t\t\t5:\n\t\t\t\t\t473\u2013486.","DOI":"10.1111\/j.1474-9726.2006.00245.x"},{"key":"i1552-5783-60-7-2705-b46","doi-asserted-by":"crossref","unstructured":"Lee\n\t\t\t\t\t\t\tHS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAmouzegar\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDana\n\t\t\t\t\t\t\tR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tKinetics of corneal antigen presenting cells in experimental dry eye disease.\n\t\t\t\t\tBMJ Open Ophthalmol.\n\t\t\t\t\t2017;\n\t\t\t\t\t1:\n\t\t\t\t\te000078.","DOI":"10.1136\/bmjophth-2017-000078"},{"key":"i1552-5783-60-7-2705-b47","doi-asserted-by":"crossref","unstructured":"Rios\n\t\t\t\t\t\t\tJD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHorikawa\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tLL,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAge-dependent alterations in mouse exorbital lacrimal gland structure, innervation and secretory response.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2005;\n\t\t\t\t\t80:\n\t\t\t\t\t477\u2013491.","DOI":"10.1016\/j.exer.2004.10.012"},{"key":"i1552-5783-60-7-2705-b48","doi-asserted-by":"crossref","unstructured":"Nien\n\t\t\t\t\t\t\tCJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPaugh\n\t\t\t\t\t\t\tJR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMassei\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWahlert\n\t\t\t\t\t\t\tAJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKao\n\t\t\t\t\t\t\tWW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJester\n\t\t\t\t\t\t\tJV.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAge-related changes in the meibomian gland.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2009;\n\t\t\t\t\t89:\n\t\t\t\t\t1021\u20131027.","DOI":"10.1016\/j.exer.2009.08.013"},{"key":"i1552-5783-60-7-2705-b49","doi-asserted-by":"crossref","unstructured":"Kojima\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWakamatsu\n\t\t\t\t\t\t\tTH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDogru\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAge-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice.\n\t\t\t\t\tAm J Pathol.\n\t\t\t\t\t2012;\n\t\t\t\t\t180:\n\t\t\t\t\t1879\u20131896.","DOI":"10.1016\/j.ajpath.2012.01.019"},{"key":"i1552-5783-60-7-2705-b50","doi-asserted-by":"crossref","unstructured":"King-Smith\n\t\t\t\t\t\t\tPE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNichols\n\t\t\t\t\t\t\tJJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBraun\n\t\t\t\t\t\t\tRJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNichols\n\t\t\t\t\t\t\tKK.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tHigh resolution microscopy of the lipid layer of the tear film.\n\t\t\t\t\tOcul Surf.\n\t\t\t\t\t2011;\n\t\t\t\t\t9:\n\t\t\t\t\t197\u2013211.","DOI":"10.1016\/S1542-0124(11)70033-7"},{"key":"i1552-5783-60-7-2705-b51","doi-asserted-by":"crossref","unstructured":"You\n\t\t\t\t\t\t\tI-C,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBian\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVolpe\n\t\t\t\t\t\t\tEA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Paiva\n\t\t\t\t\t\t\tCS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPflugfelder\n\t\t\t\t\t\t\tSC.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAge-related conjunctival disease in the C57BL\/6.NOD-Aec1Aec2 mouse model of sj\u00f6gren syndrome develops independent of lacrimal dysfunction.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2015;\n\t\t\t\t\t56:\n\t\t\t\t\t2224\u20132233.","DOI":"10.1167\/iovs.14-15668"},{"key":"i1552-5783-60-7-2705-b52","doi-asserted-by":"crossref","unstructured":"Yoon\n\t\t\t\t\t\t\tKC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAhn\n\t\t\t\t\t\t\tKY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChoi\n\t\t\t\t\t\t\tW,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tTear production and ocular surface changes in experimental dry eye after elimination of desiccating stress.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2011;\n\t\t\t\t\t52:\n\t\t\t\t\t7267\u20137273.","DOI":"10.1167\/iovs.11-7231"},{"key":"i1552-5783-60-7-2705-b53","doi-asserted-by":"crossref","unstructured":"Sahlin\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tEvaluation of the lacrimal drainage function by the drop test.\n\t\t\t\t\tAm J Ophthalmol.\n\t\t\t\t\t1996;\n\t\t\t\t\t122:\n\t\t\t\t\t701\u2013708.","DOI":"10.1016\/S0002-9394(14)70490-8"},{"key":"i1552-5783-60-7-2705-b54","doi-asserted-by":"crossref","unstructured":"Meng\n\t\t\t\t\t\t\tID,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKurose\n\t\t\t\t\t\t\tM.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe role of corneal afferent neurons in regulating tears under normal and dry eye conditions.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2013;\n\t\t\t\t\t117:\n\t\t\t\t\t79\u201387.","DOI":"10.1016\/j.exer.2013.08.011"},{"key":"i1552-5783-60-7-2705-b55","doi-asserted-by":"crossref","unstructured":"Alamri\n\t\t\t\t\t\t\tAS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWood\n\t\t\t\t\t\t\tRJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIvanusic\n\t\t\t\t\t\t\tJJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrock\n\t\t\t\t\t\t\tJA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe neurochemistry and morphology of functionally identified corneal polymodal nociceptors and cold thermoreceptors.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2018;\n\t\t\t\t\t13:\n\t\t\t\t\te0195108.","DOI":"10.1371\/journal.pone.0195108"},{"key":"i1552-5783-60-7-2705-b56","doi-asserted-by":"crossref","unstructured":"Parra\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMadrid\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEchevarria\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tOcular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea.\n\t\t\t\t\tNat Med.\n\t\t\t\t\t2010;\n\t\t\t\t\t16:\n\t\t\t\t\t1396\u20131399.","DOI":"10.1038\/nm.2264"},{"key":"i1552-5783-60-7-2705-b57","doi-asserted-by":"crossref","unstructured":"Stewart\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tZ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFarley\n\t\t\t\t\t\t\tW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOlmos\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPflugfelder\n\t\t\t\t\t\t\tSC.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tEffect of experimental dry eye on tear sodium concentration in the mouse.\n\t\t\t\t\tEye Contact Lens.\n\t\t\t\t\t2005;\n\t\t\t\t\t31:\n\t\t\t\t\t175\u2013178.","DOI":"10.1097\/01.ICL.0000161705.19602.C9"},{"key":"i1552-5783-60-7-2705-b58","doi-asserted-by":"crossref","unstructured":"Martinez-Carrasco\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSanchez-Abarca\n\t\t\t\t\t\t\tLI,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNieto-Gomez\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAssessment of dry eye in a GVHD murine model: approximation through tear osmolarity measurement.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2017;\n\t\t\t\t\t154:\n\t\t\t\t\t64\u201369.","DOI":"10.1016\/j.exer.2016.11.004"},{"key":"i1552-5783-60-7-2705-b59","doi-asserted-by":"crossref","unstructured":"Martinez-Carrasco\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSanchez-Abarca\n\t\t\t\t\t\t\tLI,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNieto-Gomez\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tSubconjunctival injection of mesenchymal stromal cells protects the cornea in an experimental model of GVHD.\n\t\t\t\t\tOcul Surf.\n\t\t\t\t\t2019;\n\t\t\t\t\t17:\n\t\t\t\t\t285\u2013294.","DOI":"10.1016\/j.jtos.2019.01.001"},{"key":"i1552-5783-60-7-2705-b60","doi-asserted-by":"crossref","unstructured":"Sullivan\n\t\t\t\t\t\t\tBD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWhitmer\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNichols\n\t\t\t\t\t\t\tKK,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAn objective approach to dry eye disease severity.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2010;\n\t\t\t\t\t51:\n\t\t\t\t\t6125\u20136130.","DOI":"10.1167\/iovs.10-5390"},{"key":"i1552-5783-60-7-2705-b61","doi-asserted-by":"crossref","unstructured":"Roh\n\t\t\t\t\t\t\tDS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDu\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGabriele\n\t\t\t\t\t\t\tML,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRobinson\n\t\t\t\t\t\t\tAR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNiedernhofer\n\t\t\t\t\t\t\tLJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFunderburgh\n\t\t\t\t\t\t\tJL.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAge-related dystrophic changes in corneal endothelium from DNA repair-deficient mice.\n\t\t\t\t\tAging Cell.\n\t\t\t\t\t2013;\n\t\t\t\t\t12:\n\t\t\t\t\t1122\u20131131.","DOI":"10.1111\/acel.12143"},{"key":"i1552-5783-60-7-2705-b62","doi-asserted-by":"crossref","unstructured":"Fitch\n\t\t\t\t\t\t\tKL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNadakavukaren\n\t\t\t\t\t\t\tMJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRichardson\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAge-related changes in the corneal endothelium of the rat.\n\t\t\t\t\tExp Gerontol.\n\t\t\t\t\t1982;\n\t\t\t\t\t17:\n\t\t\t\t\t179\u2013183.","DOI":"10.1016\/0531-5565(82)90023-7"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2737202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:06Z","timestamp":1791927066000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.19-26631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,26]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,6,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.19-26631","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6,26]]}}}