{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:29Z","timestamp":1791928709631,"version":"4.3.4"},"reference-count":34,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2019,5,29]]},"DOI":"10.1167\/iovs.19-26683","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T12:34:44Z","timestamp":1559133284000},"page":"2380","source":"Crossref","is-referenced-by-count":24,"title":["Tau Is Involved in Death of Retinal Ganglion Cells of Rats From Optic Nerve Crush"],"prefix":"10.1167","volume":"60","author":[{"given":"Hidehiro","family":"Oku","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Osaka Medical College, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyo","family":"Kida","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Osaka Medical College, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeko","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Osaka Medical College, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Taki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Osaka Medical College, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Mimura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Osaka Medical College, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Osaka Medical College, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunehiko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Osaka Medical College, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-60-6-2380-b01","doi-asserted-by":"crossref","unstructured":"Mercken M, Fischer I, Kosik KS, Nixon RA. Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo. J Neurosci. 1995; 15: 8259\u20138267.","DOI":"10.1523\/JNEUROSCI.15-12-08259.1995"},{"key":"i1552-5783-60-6-2380-b02","doi-asserted-by":"crossref","unstructured":"Bull ND, Guidi A, Goedert M, Martin KR, Spillantini MG. Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau. PLoS One. 2012; 7: e34724.","DOI":"10.1371\/journal.pone.0034724"},{"key":"i1552-5783-60-6-2380-b03","doi-asserted-by":"crossref","unstructured":"Chiasseu M, Cueva Vargas JL, Destroismaisons L, Vande Velde C, Leclerc N, Di Polo A. Tau accumulation, altered phosphorylation, and missorting promote neurodegeneration in glaucoma. J Neurosci. 2016; 36: 5785\u20135798.","DOI":"10.1523\/JNEUROSCI.3986-15.2016"},{"key":"i1552-5783-60-6-2380-b04","doi-asserted-by":"crossref","unstructured":"Friedlander R, Jarosch E, Urban J, Volkwein C, Sommer T. A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol. 2000; 2: 379\u2013384.","DOI":"10.1038\/35017001"},{"key":"i1552-5783-60-6-2380-b05","doi-asserted-by":"crossref","unstructured":"Russell RC, Yuan HX, Guan KL. Autophagy regulation by nutrient signaling. Cell Res. 2014; 24: 42\u201357.","DOI":"10.1038\/cr.2013.166"},{"key":"i1552-5783-60-6-2380-b06","doi-asserted-by":"crossref","unstructured":"Dunn WA Jr. Autophagy and related mechanisms of lysosome-mediated protein degradation. Trends Cell Biol. 1994; 4: 139\u2013143.","DOI":"10.1016\/0962-8924(94)90069-8"},{"key":"i1552-5783-60-6-2380-b07","doi-asserted-by":"crossref","unstructured":"Son JH, Shim JH, Kim KH, Ha JY, Han JY. Neuronal autophagy and neurodegenerative diseases. Exp Mol Med. 2012; 44: 89\u201398.","DOI":"10.3858\/emm.2012.44.2.031"},{"key":"i1552-5783-60-6-2380-b08","doi-asserted-by":"crossref","unstructured":"Komatsu M, Ichimura Y. Physiological significance of selective degradation of p62 by autophagy. FEBS Lett. 2010; 584: 1374\u20131378.","DOI":"10.1016\/j.febslet.2010.02.017"},{"key":"i1552-5783-60-6-2380-b09","doi-asserted-by":"crossref","unstructured":"Ramesh Babu J, Lamar Seibenhener M, Peng J, et al . Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration. J Neurochem. 2008; 106: 107\u2013120.","DOI":"10.1111\/j.1471-4159.2008.05340.x"},{"key":"i1552-5783-60-6-2380-b10","doi-asserted-by":"crossref","unstructured":"Tonari M, Kurimoto T, Horie T, Sugiyama T, Ikeda T, Oku H. Blocking endothelin-B receptors rescues retinal ganglion cells from optic nerve injury through suppression of neuroinflammation. Invest Ophthalmol Vis Sci. 2012; 53: 3490\u20133500.","DOI":"10.1167\/iovs.11-9415"},{"key":"i1552-5783-60-6-2380-b11","doi-asserted-by":"crossref","unstructured":"Berkelaar M, Clarke DB, Wang YC, Bray GM, Aguayo AJ. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J Neurosci. 1994; 14: 4368\u20134374.","DOI":"10.1523\/JNEUROSCI.14-07-04368.1994"},{"key":"i1552-5783-60-6-2380-b12","doi-asserted-by":"crossref","unstructured":"Winkler BS. The electroretinogram of the isolated rat retina. Vision Res. 1972; 12: 1183\u20131198.","DOI":"10.1016\/0042-6989(72)90106-X"},{"key":"i1552-5783-60-6-2380-b13","unstructured":"Jiang SM, Zeng LP, Zeng JH, Tang L, Chen XM, Wei X. beta-III-Tubulin: a reliable marker for retinal ganglion cell labeling in experimental models of glaucoma. Int J Ophthalmol. 2015; 8: 643\u2013652."},{"key":"i1552-5783-60-6-2380-b14","doi-asserted-by":"crossref","unstructured":"Abraha A, Ghoshal N, Gamblin TC, et al. C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease. J Cell Sci. 2000; 113 (pt 21): 3737\u20133745.","DOI":"10.1242\/jcs.113.21.3737"},{"key":"i1552-5783-60-6-2380-b15","doi-asserted-by":"crossref","unstructured":"Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell. 2010; 140: 313\u2013326.","DOI":"10.1016\/j.cell.2010.01.028"},{"key":"i1552-5783-60-6-2380-b16","doi-asserted-by":"crossref","unstructured":"Sharma RK, Netland PA. Early born lineage of retinal neurons express class III beta-tubulin isotype. Brain Res. 2007; 1176: 11\u201317.","DOI":"10.1016\/j.brainres.2007.07.090"},{"key":"i1552-5783-60-6-2380-b17","doi-asserted-by":"crossref","unstructured":"Iqbal K, Liu F, Gong CX. Tau and neurodegenerative disease: the story so far. Nat Rev Neurol. 2016; 12: 15\u201327.","DOI":"10.1038\/nrneurol.2015.225"},{"key":"i1552-5783-60-6-2380-b18","doi-asserted-by":"crossref","unstructured":"Clavaguera F, Bolmont T, Crowther RA, et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009; 11: 909\u2013913.","DOI":"10.1038\/ncb1901"},{"key":"i1552-5783-60-6-2380-b19","doi-asserted-by":"crossref","unstructured":"Pankiv S, Clausen TH, Lamark T, et al. p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem. 2007; 282: 24131\u201324145.","DOI":"10.1074\/jbc.M702824200"},{"key":"i1552-5783-60-6-2380-b20","doi-asserted-by":"crossref","unstructured":"Saatman KE, Abai B, Grosvenor A, Vorwerk CK, Smith DH, Meaney DF. Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice. J Cereb Blood Flow Metab. 2003; 23: 34\u201342.","DOI":"10.1097\/01.WCB.0000035040.10031.B0"},{"key":"i1552-5783-60-6-2380-b21","doi-asserted-by":"crossref","unstructured":"Knoferle J, Koch JC, Ostendorf T, et al. Mechanisms of acute axonal degeneration in the optic nerve in vivo. Proc Natl Acad Sci U S A. 2010; 107: 6064\u20136069.","DOI":"10.1073\/pnas.0909794107"},{"key":"i1552-5783-60-6-2380-b22","doi-asserted-by":"crossref","unstructured":"Park HY, Kim JH, Park CK. Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model. Cell Death Dis. 2012; 3: e290.","DOI":"10.1038\/cddis.2012.26"},{"key":"i1552-5783-60-6-2380-b23","doi-asserted-by":"crossref","unstructured":"Rodriguez-Muela N, Germain F, Marino G, Fitze PS, Boya P. Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice. Cell Death Differ. 2012; 19: 162\u2013169.","DOI":"10.1038\/cdd.2011.88"},{"key":"i1552-5783-60-6-2380-b24","doi-asserted-by":"crossref","unstructured":"Otomo C, Metlagel Z, Takaesu G, Otomo T. Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. Nat Struct Mol Biol. 2013; 20: 59\u201366.","DOI":"10.1038\/nsmb.2431"},{"key":"i1552-5783-60-6-2380-b25","doi-asserted-by":"crossref","unstructured":"Jiang P, Mizushima N. LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells. Methods. 2015; 75: 13\u201318.","DOI":"10.1016\/j.ymeth.2014.11.021"},{"key":"i1552-5783-60-6-2380-b26","unstructured":"Koch JC, Lingor P. The role of autophagy in axonal degeneration of the optic nerve. Exp Eye Res. 2015; 144: 81\u201389."},{"key":"i1552-5783-60-6-2380-b27","doi-asserted-by":"crossref","unstructured":"Sahani MH, Itakura E, Mizushima N. Expression of the autophagy substrate SQSTM1\/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids. Autophagy. 2014; 10: 431\u2013441.","DOI":"10.4161\/auto.27344"},{"key":"i1552-5783-60-6-2380-b28","doi-asserted-by":"crossref","unstructured":"Lipinski MM, Wu J, Faden AI, Sarkar C. Function and mechanisms of autophagy in brain and spinal cord trauma. Antioxid Redox Signal. 2015; 23: 565\u2013577.","DOI":"10.1089\/ars.2015.6306"},{"key":"i1552-5783-60-6-2380-b29","doi-asserted-by":"crossref","unstructured":"Schaeffer V, Lavenir I, Ozcelik S, Tolnay M, Winkler DT, Goedert M. Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy. Brain. 2012; 135: 2169\u20132177.","DOI":"10.1093\/brain\/aws143"},{"key":"i1552-5783-60-6-2380-b30","doi-asserted-by":"crossref","unstructured":"Simic G, Babic Leko M, Wray S, et al. Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies. Biomolecules. 2016; 6: 6.","DOI":"10.3390\/biom6010006"},{"key":"i1552-5783-60-6-2380-b31","doi-asserted-by":"crossref","unstructured":"Lopes de Faria JM, Duarte DA, Montemurro C, Papadimitriou A, Consonni SR, Lopes de Faria JB. Defective autophagy in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2016; 57: 4356\u20134366.","DOI":"10.1167\/iovs.16-19197"},{"key":"i1552-5783-60-6-2380-b32","doi-asserted-by":"crossref","unstructured":"Oku H, Morishita S, Horie T, et al. P7C3 suppresses neuroinflammation and protects retinal ganglion cells of rats from optic nerve crush. Invest Ophthalmol Vis Sci. 2017; 58: 4877\u20134888.","DOI":"10.1167\/iovs.17-22179"},{"key":"i1552-5783-60-6-2380-b33","doi-asserted-by":"crossref","unstructured":"Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006; 124: 471\u2013484.","DOI":"10.1016\/j.cell.2006.01.016"},{"key":"i1552-5783-60-6-2380-b34","doi-asserted-by":"crossref","unstructured":"Caccamo A, Magri A, Medina DX, et al. mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies. Aging Cell. 2013; 12: 370\u2013380.","DOI":"10.1111\/acel.12057"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2735097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:05Z","timestamp":1791927065000},"score":1,"resource":{"primary":{"URL":"http:\/\/iovs.arvojournals.org\/article.aspx?doi=10.1167\/iovs.19-26683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,29]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,5,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.19-26683","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,29]]}}}