{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:31Z","timestamp":1791928711782,"version":"4.3.4"},"reference-count":33,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2019,8,30]]},"DOI":"10.1167\/iovs.19-27079","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T12:32:22Z","timestamp":1567168342000},"page":"3644","source":"Crossref","is-referenced-by-count":18,"title":["Rescue of M-cone Function in Aged\n                    <i>\n                      Opn1mw\n                      <sup>\u2212\/\u2212<\/sup>\n                    <\/i>\n                    Mice, a Model for Late-Stage Blue Cone Monochromacy"],"prefix":"10.1167","volume":"60","author":[{"given":"Wen-Tao","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Florida, Gainesville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida, Gainesville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida, Gainesville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beau","family":"Freedman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida, Gainesville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Clay","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida, Gainesville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Baehr","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, John A. Moran Eye Center, University of Utah Health Science Center, Salt Lake City, Utah, United States"},{"name":"Department of Neurobiology and Anatomy, University of Utah Health Science Center, Salt Lake City, Utah, United States"},{"name":"Department of Biology, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Hauswirth","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida, Gainesville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-60-10-3644-b01","doi-asserted-by":"crossref","unstructured":"Buena-Atienza\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRuther\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBaumann\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tDe novo intrachromosomal gene conversion from OPN1MW to OPN1LW in the male germline results in Blue Cone Monochromacy.\n\t\t\t\t\tSci Rep.\n\t\t\t\t\t2016;\n\t\t\t\t\t6:\n\t\t\t\t\t28253.","DOI":"10.1038\/srep28253"},{"key":"i1552-5783-60-10-3644-b02","unstructured":"Gardner\n\t\t\t\t\t\t\tJC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMichaelides\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHolder\n\t\t\t\t\t\t\tGE,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tBlue cone monochromacy: causative mutations and associated phenotypes.\n\t\t\t\t\tMol Vis.\n\t\t\t\t\t2009;\n\t\t\t\t\t15:\n\t\t\t\t\t876\u2013884."},{"key":"i1552-5783-60-10-3644-b03","unstructured":"Kazmi\n\t\t\t\t\t\t\tMA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSakmar\n\t\t\t\t\t\t\tTP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOstrer\n\t\t\t\t\t\t\tH.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tMutation of a conserved cysteine in the X-linked cone opsins causes color vision deficiencies by disrupting protein folding and stability.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t1997;\n\t\t\t\t\t38:\n\t\t\t\t\t1074\u20131081."},{"key":"i1552-5783-60-10-3644-b04","doi-asserted-by":"crossref","unstructured":"Nathans\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDavenport\n\t\t\t\t\t\t\tCM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMaumenee\n\t\t\t\t\t\t\tIH,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tMolecular genetics of human blue cone monochromacy.\n\t\t\t\t\tScience.\n\t\t\t\t\t1989;\n\t\t\t\t\t245:\n\t\t\t\t\t831\u2013838.","DOI":"10.1126\/science.2788922"},{"key":"i1552-5783-60-10-3644-b05","doi-asserted-by":"crossref","unstructured":"Smallwood\n\t\t\t\t\t\t\tPM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWang\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNathans\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tRole of a locus control region in the mutually exclusive expression of human red and green cone pigment genes.\n\t\t\t\t\tProc Natl Acad Sci U S A.\n\t\t\t\t\t2002;\n\t\t\t\t\t99:\n\t\t\t\t\t1008\u20131011.","DOI":"10.1073\/pnas.022629799"},{"key":"i1552-5783-60-10-3644-b06","doi-asserted-by":"crossref","unstructured":"Michaelides\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJohnson\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSimunovic\n\t\t\t\t\t\t\tMP,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tBlue cone monochromatism: a phenotype and genotype assessment with evidence of progressive loss of cone function in older individuals.\n\t\t\t\t\tEye (Lond).\n\t\t\t\t\t2005;\n\t\t\t\t\t19:\n\t\t\t\t\t2\u201310.","DOI":"10.1038\/sj.eye.6701391"},{"key":"i1552-5783-60-10-3644-b07","doi-asserted-by":"crossref","unstructured":"Michaelides\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHunt\n\t\t\t\t\t\t\tDM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMoore\n\t\t\t\t\t\t\tAT.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe cone dysfunction syndromes.\n\t\t\t\t\tBr J Ophthalmol.\n\t\t\t\t\t2004;\n\t\t\t\t\t88:\n\t\t\t\t\t291\u2013297.","DOI":"10.1136\/bjo.2003.027102"},{"key":"i1552-5783-60-10-3644-b08","doi-asserted-by":"crossref","unstructured":"Wang\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMacke\n\t\t\t\t\t\t\tJP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMerbs\n\t\t\t\t\t\t\tSL,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tA locus control region adjacent to the human red and green visual pigment genes.\n\t\t\t\t\tNeuron.\n\t\t\t\t\t1992;\n\t\t\t\t\t9:\n\t\t\t\t\t429\u2013440.","DOI":"10.1016\/0896-6273(92)90181-C"},{"key":"i1552-5783-60-10-3644-b09","doi-asserted-by":"crossref","unstructured":"Yamaguchi\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMotulsky\n\t\t\t\t\t\t\tAG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDeeb\n\t\t\t\t\t\t\tSS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tVisual pigment gene structure and expression in human retinae.\n\t\t\t\t\tHum Mol Genet.\n\t\t\t\t\t1997;\n\t\t\t\t\t6:\n\t\t\t\t\t981\u2013990.","DOI":"10.1093\/hmg\/6.7.981"},{"key":"i1552-5783-60-10-3644-b10","doi-asserted-by":"crossref","unstructured":"Carroll\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDubra\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGardner\n\t\t\t\t\t\t\tJC,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tThe effect of cone opsin mutations on retinal structure and the integrity of the photoreceptor mosaic.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2012;\n\t\t\t\t\t53:\n\t\t\t\t\t8006\u20138015.","DOI":"10.1167\/iovs.12-11087"},{"key":"i1552-5783-60-10-3644-b11","doi-asserted-by":"crossref","unstructured":"Carroll\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRossi\n\t\t\t\t\t\t\tEA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPorter\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tDeletion of the X-linked opsin gene array locus control region (LCR) results in disruption of the cone mosaic.\n\t\t\t\t\tVision Res.\n\t\t\t\t\t2010;\n\t\t\t\t\t50:\n\t\t\t\t\t1989\u20131999.","DOI":"10.1016\/j.visres.2010.07.009"},{"key":"i1552-5783-60-10-3644-b12","doi-asserted-by":"crossref","unstructured":"Cideciyan\n\t\t\t\t\t\t\tAV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHufnagel\n\t\t\t\t\t\t\tRB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCarroll\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tHuman cone visual pigment deletions spare sufficient photoreceptors to warrant gene therapy.\n\t\t\t\t\tHum Gene Ther.\n\t\t\t\t\t2013;\n\t\t\t\t\t24:\n\t\t\t\t\t993\u20131006.","DOI":"10.1089\/hum.2013.153"},{"key":"i1552-5783-60-10-3644-b13","doi-asserted-by":"crossref","unstructured":"Sumaroka\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGarafalo\n\t\t\t\t\t\t\tAV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCideciyan\n\t\t\t\t\t\t\tAV,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tBlue cone monochromacy caused by the C203R missense mutation or large deletion mutations.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2018;\n\t\t\t\t\t59:\n\t\t\t\t\t5762\u20135772.","DOI":"10.1167\/iovs.18-25280"},{"key":"i1552-5783-60-10-3644-b14","doi-asserted-by":"crossref","unstructured":"Applebury\n\t\t\t\t\t\t\tML,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAntoch\n\t\t\t\t\t\t\tMP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBaxter\n\t\t\t\t\t\t\tLC,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tThe murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.\n\t\t\t\t\tNeuron.\n\t\t\t\t\t2000;\n\t\t\t\t\t27:\n\t\t\t\t\t513\u2013523.","DOI":"10.1016\/S0896-6273(00)00062-3"},{"key":"i1552-5783-60-10-3644-b15","doi-asserted-by":"crossref","unstructured":"Haverkamp\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWassle\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDuebel\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tThe primordial, blue-cone color system of the mouse retina.\n\t\t\t\t\tJ Neurosci.\n\t\t\t\t\t2005;\n\t\t\t\t\t25:\n\t\t\t\t\t5438\u20135445.","DOI":"10.1523\/JNEUROSCI.1117-05.2005"},{"key":"i1552-5783-60-10-3644-b16","doi-asserted-by":"crossref","unstructured":"Daniele\n\t\t\t\t\t\t\tLL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tInsinna\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChance\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tA mouse M-opsin monochromat: retinal cone photoreceptors have increased M-opsin expression when S-opsin is knocked out.\n\t\t\t\t\tVision Res.\n\t\t\t\t\t2011;\n\t\t\t\t\t51:\n\t\t\t\t\t447\u2013458.","DOI":"10.1016\/j.visres.2010.12.017"},{"key":"i1552-5783-60-10-3644-b17","doi-asserted-by":"crossref","unstructured":"Lyubarsky\n\t\t\t\t\t\t\tAL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFalsini\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPennesi\n\t\t\t\t\t\t\tME,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tValentini\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPugh\n\t\t\t\t\t\t\tEN\n\t\t\t\t\t\t\tJr.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tUV- and midwave-sensitive cone-driven retinal responses of the mouse: a possible phenotype for coexpression of cone photopigments.\n\t\t\t\t\tJ Neurosci.\n\t\t\t\t\t1999;\n\t\t\t\t\t19:\n\t\t\t\t\t442\u2013455.","DOI":"10.1523\/JNEUROSCI.19-01-00442.1999"},{"key":"i1552-5783-60-10-3644-b18","doi-asserted-by":"crossref","unstructured":"Nikonov\n\t\t\t\t\t\t\tSS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKholodenko\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLem\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPugh\n\t\t\t\t\t\t\tEN\n\t\t\t\t\t\t\tJr.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPhysiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.\n\t\t\t\t\tJ Gen Physiol.\n\t\t\t\t\t2006;\n\t\t\t\t\t127:\n\t\t\t\t\t359\u2013374.","DOI":"10.1085\/jgp.200609490"},{"key":"i1552-5783-60-10-3644-b19","unstructured":"Deng\n\t\t\t\t\t\t\tWT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhu\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tHuman L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy.\n\t\t\t\t\tMol Vis.\n\t\t\t\t\t2018;\n\t\t\t\t\t24:\n\t\t\t\t\t17\u201328."},{"key":"i1552-5783-60-10-3644-b20","doi-asserted-by":"crossref","unstructured":"Zhang\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDeng\n\t\t\t\t\t\t\tWT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDu\n\t\t\t\t\t\t\tW,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tGene-based therapy in a mouse model of blue cone monochromacy.\n\t\t\t\t\tSci Rep.\n\t\t\t\t\t2017;\n\t\t\t\t\t7:\n\t\t\t\t\t6690.","DOI":"10.1038\/s41598-017-06982-7"},{"key":"i1552-5783-60-10-3644-b21","doi-asserted-by":"crossref","unstructured":"Mancuso\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHauswirth\n\t\t\t\t\t\t\tWW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tQ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tGene therapy for red-green colour blindness in adult primates.\n\t\t\t\t\tNature.\n\t\t\t\t\t2009;\n\t\t\t\t\t461:\n\t\t\t\t\t784\u2013787.","DOI":"10.1038\/nature08401"},{"key":"i1552-5783-60-10-3644-b22","doi-asserted-by":"crossref","unstructured":"Zolotukhin\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPotter\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZolotukhin\n\t\t\t\t\t\t\tI,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tProduction and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors.\n\t\t\t\t\tMethods.\n\t\t\t\t\t2002;\n\t\t\t\t\t28:\n\t\t\t\t\t158\u2013167.","DOI":"10.1016\/S1046-2023(02)00220-7"},{"key":"i1552-5783-60-10-3644-b23","doi-asserted-by":"crossref","unstructured":"Pang\n\t\t\t\t\t\t\tJJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBoye\n\t\t\t\t\t\t\tSL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKumar\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2008;\n\t\t\t\t\t49:\n\t\t\t\t\t4278\u20134283.","DOI":"10.1167\/iovs.07-1622"},{"key":"i1552-5783-60-10-3644-b24","doi-asserted-by":"crossref","unstructured":"Pang\n\t\t\t\t\t\t\tJJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChang\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKumar\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tGene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis.\n\t\t\t\t\tMol Ther.\n\t\t\t\t\t2006;\n\t\t\t\t\t13:\n\t\t\t\t\t565\u2013572.","DOI":"10.1016\/j.ymthe.2005.09.001"},{"key":"i1552-5783-60-10-3644-b25","doi-asserted-by":"crossref","unstructured":"Smith\n\t\t\t\t\t\t\tTS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSpitzbarth\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tLight-dependent phosphorylation of Bardet-Biedl syndrome 5 in photoreceptor cells modulates its interaction with arrestin1.\n\t\t\t\t\tCell Mol Life Sci.\n\t\t\t\t\t2013;\n\t\t\t\t\t70:\n\t\t\t\t\t4603\u20134616.","DOI":"10.1007\/s00018-013-1403-4"},{"key":"i1552-5783-60-10-3644-b26","unstructured":"Zhu\n\t\t\t\t\t\t\tX,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrown\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tMouse cone arrestin expression pattern: light induced translocation in cone photoreceptors.\n\t\t\t\t\tMol Vis.\n\t\t\t\t\t2002;\n\t\t\t\t\t8:\n\t\t\t\t\t462\u2013471."},{"key":"i1552-5783-60-10-3644-b27","doi-asserted-by":"crossref","unstructured":"Jeon\n\t\t\t\t\t\t\tCJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStrettoi\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMasland\n\t\t\t\t\t\t\tRH.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe major cell populations of the mouse retina.\n\t\t\t\t\tJ Neurosci.\n\t\t\t\t\t1998;\n\t\t\t\t\t18:\n\t\t\t\t\t8936\u20138946.","DOI":"10.1523\/JNEUROSCI.18-21-08936.1998"},{"key":"i1552-5783-60-10-3644-b28","doi-asserted-by":"crossref","unstructured":"Williams\n\t\t\t\t\t\t\tGA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJacobs\n\t\t\t\t\t\t\tGH.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCone-based vision in the aging mouse.\n\t\t\t\t\tVision Res.\n\t\t\t\t\t2007;\n\t\t\t\t\t47:\n\t\t\t\t\t2037\u20132046.","DOI":"10.1016\/j.visres.2007.03.023"},{"key":"i1552-5783-60-10-3644-b29","doi-asserted-by":"crossref","unstructured":"Richards\n\t\t\t\t\t\t\tJE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tScott\n\t\t\t\t\t\t\tKM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSieving\n\t\t\t\t\t\t\tPA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tDisruption of conserved rhodopsin disulfide bond by Cys187Tyr mutation causes early and severe autosomal dominant retinitis pigmentosa.\n\t\t\t\t\tOphthalmology.\n\t\t\t\t\t1995;\n\t\t\t\t\t102:\n\t\t\t\t\t669\u2013677.","DOI":"10.1016\/S0161-6420(95)30972-4"},{"key":"i1552-5783-60-10-3644-b30","doi-asserted-by":"crossref","unstructured":"May-Simera\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNagel-Wolfrum\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWolfrum\n\t\t\t\t\t\t\tU.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCilia\u2014the sensory antennae in the eye.\n\t\t\t\t\tProg Retin Eye Res.\n\t\t\t\t\t2017;\n\t\t\t\t\t60:\n\t\t\t\t\t144\u2013180.","DOI":"10.1016\/j.preteyeres.2017.05.001"},{"key":"i1552-5783-60-10-3644-b31","doi-asserted-by":"crossref","unstructured":"Sedmak\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWolfrum\n\t\t\t\t\t\t\tU.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tIntraflagellar transport proteins in ciliogenesis of photoreceptor cells.\n\t\t\t\t\tBiol Cell.\n\t\t\t\t\t2011;\n\t\t\t\t\t103:\n\t\t\t\t\t449\u2013466.","DOI":"10.1042\/BC20110034"},{"key":"i1552-5783-60-10-3644-b32","doi-asserted-by":"crossref","unstructured":"Humphries\n\t\t\t\t\t\t\tMM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRancourt\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFarrar\n\t\t\t\t\t\t\tGJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tRetinopathy induced in mice by targeted disruption of the rhodopsin gene.\n\t\t\t\t\tNat Genet.\n\t\t\t\t\t1997;\n\t\t\t\t\t15:\n\t\t\t\t\t216\u2013219.","DOI":"10.1038\/ng0297-216"},{"key":"i1552-5783-60-10-3644-b33","doi-asserted-by":"crossref","unstructured":"Lem\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKrasnoperova\n\t\t\t\t\t\t\tNV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCalvert\n\t\t\t\t\t\t\tPD,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tMorphological, physiological, and biochemical changes in rhodopsin knockout mice.\n\t\t\t\t\tProc Natl Acad Sci U S A.\n\t\t\t\t\t1999;\n\t\t\t\t\t96:\n\t\t\t\t\t736\u2013741.","DOI":"10.1073\/pnas.96.2.736"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2749544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:08Z","timestamp":1791927068000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2749544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,30]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.19-27079","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8,30]]}}}