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Sci.\n\t\t\t\t\t2015;\n\t\t\t\t\t56:\n\t\t\t\t\t5020\u20135028.","DOI":"10.1167\/iovs.15-16702"},{"key":"i1552-5783-60-7-2509-b03","doi-asserted-by":"crossref","unstructured":"Osborne\n\t\t\t\t\t\t\tNN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tN\u00fa\u00f1ez-\u00c1lvarez\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJoglar\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tGlaucoma: focus on mitochondria in relation to pathogenesis and neuroprotection.\n\t\t\t\t\tEur J Pharmacol.\n\t\t\t\t\t2016;\n\t\t\t\t\t787:\n\t\t\t\t\t127\u2013133.","DOI":"10.1016\/j.ejphar.2016.04.032"},{"key":"i1552-5783-60-7-2509-b04","doi-asserted-by":"crossref","unstructured":"Lee\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSheck\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCrowston\n\t\t\t\t\t\t\tJG,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tImpaired complex-I-linked respiration and ATP synthesis in primary open-angle glaucoma patient lymphoblasts.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2012;\n\t\t\t\t\t53:\n\t\t\t\t\t2431\u20132437.","DOI":"10.1167\/iovs.12-9596"},{"key":"i1552-5783-60-7-2509-b05","doi-asserted-by":"crossref","unstructured":"Van Bergen\n\t\t\t\t\t\t\tNJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCrowston\n\t\t\t\t\t\t\tJG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCraig\n\t\t\t\t\t\t\tJE,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tMeasurement of systemic mitochondrial function in advanced primary open-angle glaucoma and Leber hereditary optic neuropathy.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2015;\n\t\t\t\t\t10:\n\t\t\t\t\te0140919.","DOI":"10.1371\/journal.pone.0140919"},{"key":"i1552-5783-60-7-2509-b06","doi-asserted-by":"crossref","unstructured":"Williams\n\t\t\t\t\t\t\tPA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHarder\n\t\t\t\t\t\t\tJM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFoxworth\n\t\t\t\t\t\t\tNE,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet 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preconditioning.\n\t\t\t\t\tAnal Chem.\n\t\t\t\t\t2017;\n\t\t\t\t\t89:\n\t\t\t\t\t2138\u20132146.","DOI":"10.1021\/acs.analchem.6b04912"},{"key":"i1552-5783-60-7-2509-b11","doi-asserted-by":"crossref","unstructured":"Weinreb\n\t\t\t\t\t\t\tRN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKhaw\n\t\t\t\t\t\t\tPT.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPrimary open-angle glaucoma.\n\t\t\t\t\tLancet.\n\t\t\t\t\t2004;\n\t\t\t\t\t363:\n\t\t\t\t\t1711\u20131720.","DOI":"10.1016\/S0140-6736(04)16257-0"},{"key":"i1552-5783-60-7-2509-b12","doi-asserted-by":"crossref","unstructured":"Xia\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWishart\n\t\t\t\t\t\t\tDS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tUsing MetaboAnalyst 3.0 for comprehensive metabolomics data analysis.\n\t\t\t\t\tCurr Protoc 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Neurosci.\n\t\t\t\t\t2017;\n\t\t\t\t\t9:\n\t\t\t\t\t366.","DOI":"10.3389\/fnagi.2017.00366"},{"key":"i1552-5783-60-7-2509-b24","doi-asserted-by":"crossref","unstructured":"Mimura\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKaji\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNoma\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFunatsu\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOkamoto\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe role of SIRT1 in ocular aging.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2013;\n\t\t\t\t\t116:\n\t\t\t\t\t17\u201326.","DOI":"10.1016\/j.exer.2013.07.017"},{"key":"i1552-5783-60-7-2509-b25","doi-asserted-by":"crossref","unstructured":"Ji\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLi\n\t\t\t\t\t\t\tG-Y,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOsborne\n\t\t\t\t\t\t\tNN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tNicotinamide attenuates retinal ischemia and light insults to neurones.\n\t\t\t\t\tNeurochem Int.\n\t\t\t\t\t2008;\n\t\t\t\t\t52:\n\t\t\t\t\t786\u2013798.","DOI":"10.1016\/j.neuint.2007.09.012"},{"key":"i1552-5783-60-7-2509-b26","doi-asserted-by":"crossref","unstructured":"Bruckert\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLabreuche\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAmarenco\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tMeta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis.\n\t\t\t\t\tAtherosclerosis.\n\t\t\t\t\t2010;\n\t\t\t\t\t210:\n\t\t\t\t\t353\u2013361.","DOI":"10.1016\/j.atherosclerosis.2009.12.023"}],"container-title":["Investigative Opthalmology & Visual 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