{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:26Z","timestamp":1791928706157,"version":"4.3.4"},"reference-count":56,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2019,8,14]]},"DOI":"10.1167\/iovs.19-27135","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T06:15:49Z","timestamp":1565936149000},"page":"3527","source":"Crossref","is-referenced-by-count":24,"title":["Characterization of Inner Retinal Hyperreflective Alterations in Early Cognitive Impairment on Adaptive Optics Scanning Laser Ophthalmoscopy"],"prefix":"10.1167","volume":"60","author":[{"given":"Yi Stephanie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex C.","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahej","family":"Samra","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"},{"name":"Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani A.","family":"Fawzi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-60-10-3527-b01","doi-asserted-by":"crossref","unstructured":"Koronyo\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBiggs\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBarron\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tRetinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease.\n\t\t\t\t\tJCI Insight.\n\t\t\t\t\t2017;\n\t\t\t\t\t2:\n\t\t\t\t\te93621.","DOI":"10.1172\/jci.insight.93621"},{"key":"i1552-5783-60-10-3527-b02","doi-asserted-by":"crossref","unstructured":"Blanks\n\t\t\t\t\t\t\tJC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTorigoe\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHinton\n\t\t\t\t\t\t\tDR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBlanks\n\t\t\t\t\t\t\tRH.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tRetinal pathology in Alzheimer's disease. I. Ganglion cell loss in foveal\/parafoveal retina.\n\t\t\t\t\tNeurobiol Aging.\n\t\t\t\t\t1996;\n\t\t\t\t\t17:\n\t\t\t\t\t377\u2013384.","DOI":"10.1016\/0197-4580(96)00010-3"},{"key":"i1552-5783-60-10-3527-b03","doi-asserted-by":"crossref","unstructured":"Blanks\n\t\t\t\t\t\t\tJC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchmidt\n\t\t\t\t\t\t\tSY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTorigoe\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPorrello\n\t\t\t\t\t\t\tKV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHinton\n\t\t\t\t\t\t\tDR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBlanks\n\t\t\t\t\t\t\tRH.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tRetinal pathology in Alzheimer's disease. II. Regional neuron loss and glial changes in GCL.\n\t\t\t\t\tNeurobiol Aging.\n\t\t\t\t\t1996;\n\t\t\t\t\t17:\n\t\t\t\t\t385\u2013395.","DOI":"10.1016\/0197-4580(96)00009-7"},{"key":"i1552-5783-60-10-3527-b04","doi-asserted-by":"crossref","unstructured":"Albert\n\t\t\t\t\t\t\tMS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDeKosky\n\t\t\t\t\t\t\tST,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDickson\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tThe diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.\n\t\t\t\t\tAlzheimers Dement.\n\t\t\t\t\t2011;\n\t\t\t\t\t7:\n\t\t\t\t\t270\u2013279.","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"i1552-5783-60-10-3527-b05","doi-asserted-by":"crossref","unstructured":"Fischer\n\t\t\t\t\t\t\tP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJungwirth\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZehetmayer\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tConversion from subtypes of mild cognitive impairment to Alzheimer dementia.\n\t\t\t\t\tNeurology.\n\t\t\t\t\t2007;\n\t\t\t\t\t68:\n\t\t\t\t\t288\u2013291.","DOI":"10.1212\/01.wnl.0000252358.03285.9d"},{"key":"i1552-5783-60-10-3527-b06","doi-asserted-by":"crossref","unstructured":"Coppola\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDi Renzo\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZiccardi\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tOptical coherence tomography in Alzheimer's disease: a meta-analysis.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2015;\n\t\t\t\t\t10:\n\t\t\t\t\te0134750.","DOI":"10.1371\/journal.pone.0134750"},{"key":"i1552-5783-60-10-3527-b07","doi-asserted-by":"crossref","unstructured":"Knoll\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSimonett\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVolpe\n\t\t\t\t\t\t\tNJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tRetinal nerve fiber layer thickness in amnestic mild cognitive impairment: case-control study and meta-analysis.\n\t\t\t\t\tAlzheimers Dement (Amst).\n\t\t\t\t\t2016;\n\t\t\t\t\t4:\n\t\t\t\t\t85\u201393.","DOI":"10.1016\/j.dadm.2016.07.004"},{"key":"i1552-5783-60-10-3527-b08","doi-asserted-by":"crossref","unstructured":"Cheung\n\t\t\t\t\t\t\tCY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOng\n\t\t\t\t\t\t\tYT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHilal\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tRetinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease.\n\t\t\t\t\tJ Alzheimers Dis.\n\t\t\t\t\t2015;\n\t\t\t\t\t45:\n\t\t\t\t\t45\u201356.","DOI":"10.3233\/JAD-141659"},{"key":"i1552-5783-60-10-3527-b09","doi-asserted-by":"crossref","unstructured":"Lad\n\t\t\t\t\t\t\tEM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMukherjee\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStinnett\n\t\t\t\t\t\t\tSS,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tEvaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2018;\n\t\t\t\t\t13:\n\t\t\t\t\te0192646.","DOI":"10.1371\/journal.pone.0192646"},{"key":"i1552-5783-60-10-3527-b10","doi-asserted-by":"crossref","unstructured":"Inman\n\t\t\t\t\t\t\tDM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHorner\n\t\t\t\t\t\t\tPJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tReactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma.\n\t\t\t\t\tGlia.\n\t\t\t\t\t2007;\n\t\t\t\t\t55:\n\t\t\t\t\t942\u2013953.","DOI":"10.1002\/glia.20516"},{"key":"i1552-5783-60-10-3527-b11","unstructured":"Ogden\n\t\t\t\t\t\t\tTE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tNerve fiber layer astrocytes of the primate retina: morphology, distribution, and density.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t1978;\n\t\t\t\t\t17:\n\t\t\t\t\t499\u2013510."},{"key":"i1552-5783-60-10-3527-b12","doi-asserted-by":"crossref","unstructured":"Fernandez-Albarral\n\t\t\t\t\t\t\tJA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSalobrar-Garcia\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMartinez-Paramo\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tRetinal glial changes in Alzheimer's disease - a review.\n\t\t\t\t\tJ Optom.\n\t\t\t\t\t2019;\n\t\t\t\t\t12:\n\t\t\t\t\t198\u2013207.","DOI":"10.1016\/j.optom.2018.07.001"},{"key":"i1552-5783-60-10-3527-b13","doi-asserted-by":"crossref","unstructured":"Ramirez\n\t\t\t\t\t\t\tAI,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Hoz\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSalobrar-Garcia\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tThe role of microglia in retinal neurodegeneration: Alzheimer's disease, Parkinson, and glaucoma.\n\t\t\t\t\tFront Aging Neurosci.\n\t\t\t\t\t2017;\n\t\t\t\t\t9:\n\t\t\t\t\t214.","DOI":"10.3389\/fnagi.2017.00214"},{"key":"i1552-5783-60-10-3527-b14","doi-asserted-by":"crossref","unstructured":"Perez-Nievas\n\t\t\t\t\t\t\tBG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSerrano-Pozo\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tDeciphering the astrocyte reaction in Alzheimer's disease.\n\t\t\t\t\tFront Aging Neurosci.\n\t\t\t\t\t2018;\n\t\t\t\t\t10:\n\t\t\t\t\t114.","DOI":"10.3389\/fnagi.2018.00114"},{"key":"i1552-5783-60-10-3527-b15","doi-asserted-by":"crossref","unstructured":"Grieshaber\n\t\t\t\t\t\t\tMC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMoramarco\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchoetzau\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFlammer\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOrguel\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tDetection of retinal glial cell activation in glaucoma by time domain optical coherence tomography.\n\t\t\t\t\tKlin Monbl Augenheilkd.\n\t\t\t\t\t2012;\n\t\t\t\t\t229:\n\t\t\t\t\t314\u2013318.","DOI":"10.1055\/s-0031-1281857"},{"key":"i1552-5783-60-10-3527-b16","doi-asserted-by":"crossref","unstructured":"Ashimatey\n\t\t\t\t\t\t\tBS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKing\n\t\t\t\t\t\t\tBJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSwanson\n\t\t\t\t\t\t\tWH.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tRetinal putative glial alterations: implication for glaucoma care.\n\t\t\t\t\tOphthalmic Physiol Opt.\n\t\t\t\t\t2018;\n\t\t\t\t\t38:\n\t\t\t\t\t56\u201365.","DOI":"10.1111\/opo.12425"},{"key":"i1552-5783-60-10-3527-b17","doi-asserted-by":"crossref","unstructured":"Takayama\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOoto\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHangai\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tHigh-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2012;\n\t\t\t\t\t7:\n\t\t\t\t\te33158.","DOI":"10.1371\/journal.pone.0033158"},{"key":"i1552-5783-60-10-3527-b18","doi-asserted-by":"crossref","unstructured":"Scoles\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHiggins\n\t\t\t\t\t\t\tBP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCooper\n\t\t\t\t\t\t\tRF,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tMicroscopic inner retinal hyper-reflective phenotypes in retinal and neurologic disease.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2014;\n\t\t\t\t\t55:\n\t\t\t\t\t4015\u20134029.","DOI":"10.1167\/iovs.14-14668"},{"key":"i1552-5783-60-10-3527-b19","doi-asserted-by":"crossref","unstructured":"McKhann\n\t\t\t\t\t\t\tGM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKnopman\n\t\t\t\t\t\t\tDS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChertkow\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tThe diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.\n\t\t\t\t\tAlzheimers Dement.\n\t\t\t\t\t2011;\n\t\t\t\t\t7:\n\t\t\t\t\t263\u2013269.","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"i1552-5783-60-10-3527-b20","doi-asserted-by":"crossref","unstructured":"Oboudiyat\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGefen\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVarelas\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tCerebrospinal fluid markers detect Alzheimer's disease in nonamnestic dementia.\n\t\t\t\t\tAlzheimers Dement.\n\t\t\t\t\t2017;\n\t\t\t\t\t13:\n\t\t\t\t\t598\u2013601.","DOI":"10.1016\/j.jalz.2017.01.006"},{"key":"i1552-5783-60-10-3527-b21","doi-asserted-by":"crossref","unstructured":"Liu\n\t\t\t\t\t\t\tCC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLiu\n\t\t\t\t\t\t\tCC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKanekiyo\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tXu\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBu\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tApolipoprotein\n\t\t\t\t\t\t\tE\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tand Alzheimer disease: risk, mechanisms and therapy.\n\t\t\t\t\tNat Rev Neurol.\n\t\t\t\t\t2013;\n\t\t\t\t\t9:\n\t\t\t\t\t106\u2013118.","DOI":"10.1038\/nrneurol.2012.263"},{"key":"i1552-5783-60-10-3527-b22","doi-asserted-by":"crossref","unstructured":"Monsell\n\t\t\t\t\t\t\tSE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDodge\n\t\t\t\t\t\t\tHH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhou\n\t\t\t\t\t\t\tXH,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tResults from the NACC Uniform Data Set Neuropsychological Battery Crosswalk Study.\n\t\t\t\t\tAlzheimer Dis Assoc Disord.\n\t\t\t\t\t2016;\n\t\t\t\t\t30:\n\t\t\t\t\t134\u2013139.","DOI":"10.1097\/WAD.0000000000000111"},{"key":"i1552-5783-60-10-3527-b23","doi-asserted-by":"crossref","unstructured":"Gold\n\t\t\t\t\t\t\tDA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAn examination of instrumental activities of daily living assessment in older adults and mild cognitive impairment.\n\t\t\t\t\tJ Clin Exp Neuropsychol.\n\t\t\t\t\t2012;\n\t\t\t\t\t34:\n\t\t\t\t\t11\u201334.","DOI":"10.1080\/13803395.2011.614598"},{"key":"i1552-5783-60-10-3527-b24","unstructured":"Johnson\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBarion\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRademaker\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRehkemper\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWeintraub\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe Activities of Daily Living Questionnaire: a validation study in patients with dementia.\n\t\t\t\t\tAlzheimer Dis Assoc Disord.\n\t\t\t\t\t2004;\n\t\t\t\t\t18:\n\t\t\t\t\t223\u2013230."},{"key":"i1552-5783-60-10-3527-b25","doi-asserted-by":"crossref","unstructured":"Weintraub\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBesser\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDodge\n\t\t\t\t\t\t\tHH,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tVersion 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS).\n\t\t\t\t\tAlzheimer Dis Assoc Disord.\n\t\t\t\t\t2018;\n\t\t\t\t\t32:\n\t\t\t\t\t10\u201317.","DOI":"10.1097\/WAD.0000000000000223"},{"key":"i1552-5783-60-10-3527-b26","doi-asserted-by":"crossref","unstructured":"Morris\n\t\t\t\t\t\t\tJC.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe Clinical Dementia Rating (CDR): current version and scoring rules.\n\t\t\t\t\tNeurology.\n\t\t\t\t\t1993;\n\t\t\t\t\t43:\n\t\t\t\t\t2412\u20132414.","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"i1552-5783-60-10-3527-b27","doi-asserted-by":"crossref","unstructured":"Dubra\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSulai\n\t\t\t\t\t\t\tY.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tReflective afocal broadband adaptive optics scanning ophthalmoscope.\n\t\t\t\t\tBiomed Opt Express.\n\t\t\t\t\t2011;\n\t\t\t\t\t2:\n\t\t\t\t\t1757\u20131768.","DOI":"10.1364\/BOE.2.001757"},{"key":"i1552-5783-60-10-3527-b28","doi-asserted-by":"crossref","unstructured":"Onishi\n\t\t\t\t\t\t\tAC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRoberts\n\t\t\t\t\t\t\tPK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJampol\n\t\t\t\t\t\t\tLM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNesper\n\t\t\t\t\t\t\tPL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFawzi\n\t\t\t\t\t\t\tAA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCharacterization and correlation of \u201cJampol dots\u201d on adaptive optics with foveal granularity on conventional fundus imaging.\n\t\t\t\t\tRetina.\n\t\t\t\t\t2019;\n\t\t\t\t\t39:\n\t\t\t\t\t235\u2013246.","DOI":"10.1097\/IAE.0000000000001958"},{"key":"i1552-5783-60-10-3527-b29","doi-asserted-by":"crossref","unstructured":"Schneider\n\t\t\t\t\t\t\tCA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRasband\n\t\t\t\t\t\t\tWS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEliceiri,\n\t\t\t\t\t\t\tKW. NIH\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tImage to ImageJ: 25 years of image analysis.\n\t\t\t\t\tNat Methods.\n\t\t\t\t\t2012;\n\t\t\t\t\t9:\n\t\t\t\t\t671\u2013675.","DOI":"10.1038\/nmeth.2089"},{"key":"i1552-5783-60-10-3527-b30","doi-asserted-by":"crossref","unstructured":"Koronyo-Hamaoui\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKoronyo\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLjubimov\n\t\t\t\t\t\t\tAV,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tIdentification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model.\n\t\t\t\t\tNeuroimage.\n\t\t\t\t\t2011;\n\t\t\t\t\t54\n\t\t\t\t\t(suppl 1):\n\t\t\t\t\tS204\u2013S217.","DOI":"10.1016\/j.neuroimage.2010.06.020"},{"key":"i1552-5783-60-10-3527-b31","unstructured":"Tackenberg\n\t\t\t\t\t\t\tMA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTucker\n\t\t\t\t\t\t\tBA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSwift\n\t\t\t\t\t\t\tJS,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tM\u00fcller cell activation, proliferation and migration following laser injury.\n\t\t\t\t\tMol Vis.\n\t\t\t\t\t2009;\n\t\t\t\t\t15:\n\t\t\t\t\t1886\u20131896."},{"key":"i1552-5783-60-10-3527-b32","doi-asserted-by":"crossref","unstructured":"Edwards\n\t\t\t\t\t\t\tMM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRodriguez\n\t\t\t\t\t\t\tJJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGutierrez-Lanza\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYates\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVerkhratsky\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLutty\n\t\t\t\t\t\t\tGA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tRetinal macroglia changes in a triple transgenic mouse model of Alzheimer's disease.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2014;\n\t\t\t\t\t127:\n\t\t\t\t\t252\u2013260.","DOI":"10.1016\/j.exer.2014.08.006"},{"key":"i1552-5783-60-10-3527-b33","doi-asserted-by":"crossref","unstructured":"Thomson\n\t\t\t\t\t\t\tKL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYeo\n\t\t\t\t\t\t\tJM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWaddell\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCameron\n\t\t\t\t\t\t\tJR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPal\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tA systematic review and meta-analysis of retinal nerve fiber layer change in dementia, using optical coherence tomography.\n\t\t\t\t\tAlzheimers Dement (Amst).\n\t\t\t\t\t2015;\n\t\t\t\t\t1:\n\t\t\t\t\t136\u2013143.","DOI":"10.1016\/j.dadm.2015.03.001"},{"key":"i1552-5783-60-10-3527-b34","doi-asserted-by":"crossref","unstructured":"Kwon\n\t\t\t\t\t\t\tJY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYang\n\t\t\t\t\t\t\tJH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHan\n\t\t\t\t\t\t\tJS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKim\n\t\t\t\t\t\t\tDG.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tAnalysis of the retinal nerve fiber layer thickness in Alzheimer disease and mild cognitive impairment.\n\t\t\t\t\tKorean J Ophthalmol.\n\t\t\t\t\t2017;\n\t\t\t\t\t31:\n\t\t\t\t\t548\u2013556.","DOI":"10.3341\/kjo.2016.0118"},{"key":"i1552-5783-60-10-3527-b35","doi-asserted-by":"crossref","unstructured":"Kashani\n\t\t\t\t\t\t\tAH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tChen\n\t\t\t\t\t\t\tCL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGahm\n\t\t\t\t\t\t\tJK,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tOptical coherence tomography angiography: a comprehensive review of current methods and clinical applications.\n\t\t\t\t\tProg Retin Eye Res.\n\t\t\t\t\t2017;\n\t\t\t\t\t60:\n\t\t\t\t\t66\u2013100.","DOI":"10.1016\/j.preteyeres.2017.07.002"},{"key":"i1552-5783-60-10-3527-b36","doi-asserted-by":"crossref","unstructured":"Jiang\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWei\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShi\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAltered macular microvasculature in mild cognitive impairment and Alzheimer disease.\n\t\t\t\t\tJ Neuroophthalmol.\n\t\t\t\t\t2018;\n\t\t\t\t\t38:\n\t\t\t\t\t292\u2013298.","DOI":"10.1097\/WNO.0000000000000580"},{"key":"i1552-5783-60-10-3527-b37","doi-asserted-by":"crossref","unstructured":"Bulut\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKurtulus\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGozkaya\n\t\t\t\t\t\t\tO,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tEvaluation of optical coherence tomography angiographic findings in Alzheimer's type dementia.\n\t\t\t\t\tBr J Ophthalmol.\n\t\t\t\t\t2018;\n\t\t\t\t\t102:\n\t\t\t\t\t233\u2013237.","DOI":"10.1136\/bjophthalmol-2017-310476"},{"key":"i1552-5783-60-10-3527-b38","doi-asserted-by":"crossref","unstructured":"Bailey\n\t\t\t\t\t\t\tTL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRivara\n\t\t\t\t\t\t\tCB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRocher\n\t\t\t\t\t\t\tAB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHof\n\t\t\t\t\t\t\tPR.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe nature and effects of cortical microvascular pathology in aging and Alzheimer's disease.\n\t\t\t\t\tNeurol Res,\n\t\t\t\t\t2004;\n\t\t\t\t\t26:\n\t\t\t\t\t573\u2013578.","DOI":"10.1179\/016164104225016272"},{"key":"i1552-5783-60-10-3527-b39","doi-asserted-by":"crossref","unstructured":"Kisler\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNelson\n\t\t\t\t\t\t\tAR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMontagne\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZlokovic\n\t\t\t\t\t\t\tBV.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease.\n\t\t\t\t\tNat Rev.\n\t\t\t\t\t2017;\n\t\t\t\t\t18:\n\t\t\t\t\t419\u2013434.","DOI":"10.1038\/nrn.2017.48"},{"key":"i1552-5783-60-10-3527-b40","doi-asserted-by":"crossref","unstructured":"Zhang\n\t\t\t\t\t\t\tYS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhou\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKnoll\n\t\t\t\t\t\t\tBM,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tParafoveal vessel loss and correlation between peripapillary vessel density and cognitive performance in amnestic mild cognitive impairment and early Alzheimer's disease on optical coherence tomography angiography.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2019;\n\t\t\t\t\t14:\n\t\t\t\t\te0214685.","DOI":"10.1371\/journal.pone.0214685"},{"key":"i1552-5783-60-10-3527-b41","doi-asserted-by":"crossref","unstructured":"Lambert\n\t\t\t\t\t\t\tJC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHeath\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEven\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tGenome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.\n\t\t\t\t\tNat Genet.\n\t\t\t\t\t2009;\n\t\t\t\t\t41:\n\t\t\t\t\t1094\u20131099.","DOI":"10.1038\/ng.439"},{"key":"i1552-5783-60-10-3527-b42","doi-asserted-by":"crossref","unstructured":"Farrer\n\t\t\t\t\t\t\tLA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCupples\n\t\t\t\t\t\t\tLA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHaines\n\t\t\t\t\t\t\tJL,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tEffects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.\n\t\t\t\t\tJAMA.\n\t\t\t\t\t1997;\n\t\t\t\t\t278:\n\t\t\t\t\t1349\u20131356.","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"i1552-5783-60-10-3527-b43","doi-asserted-by":"crossref","unstructured":"Mattsson\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZetterberg\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHansson\n\t\t\t\t\t\t\tO,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tCSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.\n\t\t\t\t\tJAMA.\n\t\t\t\t\t2009;\n\t\t\t\t\t302:\n\t\t\t\t\t385\u2013393.","DOI":"10.1001\/jama.2009.1064"},{"key":"i1552-5783-60-10-3527-b44","doi-asserted-by":"crossref","unstructured":"Hertze\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMinthon\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZetterberg\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVanmechelen\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBlennow\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHansson\n\t\t\t\t\t\t\tO.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tEvaluation of CSF biomarkers as predictors of Alzheimer's disease: a clinical follow-up study of 4.7 years.\n\t\t\t\t\tJ Alzheimers Dis.\n\t\t\t\t\t2010;\n\t\t\t\t\t21:\n\t\t\t\t\t1119\u20131128.","DOI":"10.3233\/JAD-2010-100207"},{"key":"i1552-5783-60-10-3527-b45","doi-asserted-by":"crossref","unstructured":"Graf\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFlammer\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPr\u00fcnte\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHendrickson\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tGliosis-like retinal alterations in glaucoma patients.\n\t\t\t\t\tJ Glaucoma.\n\t\t\t\t\t1993;\n\t\t\t\t\t2:\n\t\t\t\t\t257\u2013259.","DOI":"10.1097\/00061198-199300240-00006"},{"key":"i1552-5783-60-10-3527-b46","doi-asserted-by":"crossref","unstructured":"Al Rashaed\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKhan\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNowilaty\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEdward\n\t\t\t\t\t\t\tDP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKozak\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tSpectral-domain optical coherence tomography reveals prelaminar membranes in optic nerve head pallor in eyes with retinitis pigmentosa.\n\t\t\t\t\tGraefes Arch Clin Exp Ophthalmol.\n\t\t\t\t\t2016;\n\t\t\t\t\t254:\n\t\t\t\t\t77\u201381.","DOI":"10.1007\/s00417-015-3015-1"},{"key":"i1552-5783-60-10-3527-b47","doi-asserted-by":"crossref","unstructured":"Haritoglou\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchumann\n\t\t\t\t\t\t\tRG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWolf\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tEpiretinal gliosis.\n\t\t\t\t\tOphthalmologe.\n\t\t\t\t\t2014;\n\t\t\t\t\t111:\n\t\t\t\t\t485\u2013497.","DOI":"10.1007\/s00347-014-3040-1"},{"key":"i1552-5783-60-10-3527-b48","doi-asserted-by":"crossref","unstructured":"Lombardo\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tScarinci\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRipandelli\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAdaptive optics imaging of idiopathic epiretinal membranes.\n\t\t\t\t\tOphthalmology.\n\t\t\t\t\t2013;\n\t\t\t\t\t120:\n\t\t\t\t\t1508\u20131509.e1.","DOI":"10.1016\/j.ophtha.2013.02.004"},{"key":"i1552-5783-60-10-3527-b49","doi-asserted-by":"crossref","unstructured":"Bosco\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSteele\n\t\t\t\t\t\t\tMR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVetter\n\t\t\t\t\t\t\tML.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tEarly microglia activation in a mouse model of chronic glaucoma.\n\t\t\t\t\tJ Comp Neurol.\n\t\t\t\t\t2011;\n\t\t\t\t\t519:\n\t\t\t\t\t599\u2013620.","DOI":"10.1002\/cne.22516"},{"key":"i1552-5783-60-10-3527-b50","doi-asserted-by":"crossref","unstructured":"Williams\n\t\t\t\t\t\t\tPA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarsh-Armstrong\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHowell\n\t\t\t\t\t\t\tGR;\n\t\t\t\t\t\t\n\t\t\t\t\t\tLasker\/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants.\n\t\t\t\t\t\n\t\t\t\t\tNeuroinflammation in glaucoma: a new opportunity.\n\t\t\t\t\tExp Eye Res.\n\t\t\t\t\t2017;\n\t\t\t\t\t157:\n\t\t\t\t\t20\u201327.","DOI":"10.1016\/j.exer.2017.02.014"},{"key":"i1552-5783-60-10-3527-b51","doi-asserted-by":"crossref","unstructured":"Grieshaber\n\t\t\t\t\t\t\tMC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOrgul\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchoetzau\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFlammer\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tRelationship between retinal glial cell activation in glaucoma and vascular dysregulation.\n\t\t\t\t\tJ Glaucoma.\n\t\t\t\t\t2007;\n\t\t\t\t\t16:\n\t\t\t\t\t215\u2013219.","DOI":"10.1097\/IJG.0b013e31802d045a"},{"key":"i1552-5783-60-10-3527-b52","doi-asserted-by":"crossref","unstructured":"Alzheimer's Association.\n\t\t\t\t\t2019 Alzheimer's disease facts and figures.\n\t\t\t\t\tAlzheimers Dement.\n\t\t\t\t\t2019;\n\t\t\t\t\t15:\n\t\t\t\t\t321\u2013387.","DOI":"10.1016\/j.jalz.2019.01.010"},{"key":"i1552-5783-60-10-3527-b53","doi-asserted-by":"crossref","unstructured":"Sharma\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSingh\n\t\t\t\t\t\t\tAN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tExploring biomarkers for Alzheimer's disease.\n\t\t\t\t\tJ Clin Diagn Res.\n\t\t\t\t\t2016;\n\t\t\t\t\t10:\n\t\t\t\t\tKE01\u2013KE06.","DOI":"10.7860\/JCDR\/2016\/18828.8166"},{"key":"i1552-5783-60-10-3527-b54","doi-asserted-by":"crossref","unstructured":"Handels\n\t\t\t\t\t\t\tRLH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWimo\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDodel\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tCost-utility of using Alzheimer's disease biomarkers in cerebrospinal fluid to predict progression from mild cognitive impairment to dementia.\n\t\t\t\t\tJ Alzheimers Dis.\n\t\t\t\t\t2017;\n\t\t\t\t\t60:\n\t\t\t\t\t1477\u20131487.","DOI":"10.3233\/JAD-170324"},{"key":"i1552-5783-60-10-3527-b55","doi-asserted-by":"crossref","unstructured":"Counts\n\t\t\t\t\t\t\tSE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tIkonomovic\n\t\t\t\t\t\t\tMD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMercado\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVega\n\t\t\t\t\t\t\tIE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMufson\n\t\t\t\t\t\t\tEJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tBiomarkers for the early detection and progression of Alzheimer's disease.\n\t\t\t\t\tNeurotherapeutics.\n\t\t\t\t\t2017;\n\t\t\t\t\t14:\n\t\t\t\t\t35\u201353.","DOI":"10.1007\/s13311-016-0481-z"},{"key":"i1552-5783-60-10-3527-b56","doi-asserted-by":"crossref","unstructured":"Hinton\n\t\t\t\t\t\t\tDR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSadun\n\t\t\t\t\t\t\tAA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBlanks\n\t\t\t\t\t\t\tJC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMiller\n\t\t\t\t\t\t\tCA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tOptic-nerve degeneration in Alzheimer's disease.\n\t\t\t\t\tN Engl J Med.\n\t\t\t\t\t1986;\n\t\t\t\t\t315:\n\t\t\t\t\t485\u2013487.","DOI":"10.1056\/NEJM198608213150804"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2748641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:08Z","timestamp":1791927068000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2748641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,14]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,8,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.19-27135","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8,14]]}}}