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metabolism.\n\t\t\t\t\tNature.\n\t\t\t\t\t2001;\n\t\t\t\t\t414:\n\t\t\t\t\t799\u2013806.","DOI":"10.1038\/414799a"},{"key":"i1552-5783-60-12-3786-b26","doi-asserted-by":"crossref","unstructured":"Shulman\n\t\t\t\t\t\t\tGI.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCellular mechanisms of insulin resistance.\n\t\t\t\t\tJ Clin Invest.\n\t\t\t\t\t2000;\n\t\t\t\t\t106:\n\t\t\t\t\t171\u2013176.","DOI":"10.1172\/JCI10583"},{"key":"i1552-5783-60-12-3786-b27","doi-asserted-by":"crossref","unstructured":"White\n\t\t\t\t\t\t\tMF.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tThe IRS-signalling system: a network of docking proteins that mediate insulin action.\n\t\t\t\t\tMol Cell 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gene.\n\t\t\t\t\tNature.\n\t\t\t\t\t1994;\n\t\t\t\t\t372:\n\t\t\t\t\t186\u2013190.","DOI":"10.1038\/372186a0"},{"key":"i1552-5783-60-12-3786-b30","doi-asserted-by":"crossref","unstructured":"Withers\n\t\t\t\t\t\t\tDJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBurks\n\t\t\t\t\t\t\tDJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTowery\n\t\t\t\t\t\t\tHH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAltamuro\n\t\t\t\t\t\t\tSL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFlint\n\t\t\t\t\t\t\tCL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWhite\n\t\t\t\t\t\t\tMF.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tIrs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.\n\t\t\t\t\tNat 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express a unique insulin-sensitive glucose transport protein.\n\t\t\t\t\tNature.\n\t\t\t\t\t1988;\n\t\t\t\t\t333:\n\t\t\t\t\t183\u2013185.","DOI":"10.1038\/333183a0"}],"container-title":["Investigative Opthalmology &amp; Visual 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