{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:34Z","timestamp":1791928714657,"version":"4.3.4"},"reference-count":43,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"14","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2019,11,15]]},"DOI":"10.1167\/iovs.19-28309","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T23:01:18Z","timestamp":1573858878000},"page":"4740","source":"Crossref","is-referenced-by-count":38,"title":["Aqueous Humor Biomarkers Identify Three Prognostic Groups in Uveal Melanoma"],"prefix":"10.1167","volume":"60","author":[{"given":"Annemijn P. A.","family":"Wierenga","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"Mouthaan","sequence":"additional","affiliation":[{"name":"Olink Proteomics, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan","family":"van Weeghel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Verdijk","sequence":"additional","affiliation":[{"name":"Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Pathology, Section Ophthalmic Pathology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd G.","family":"van Duinen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma G. M.","family":"Kroes","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Dogrus\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Marinkovic","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd S. H.","family":"van der Burg","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorius P. M.","family":"Luyten","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine J.","family":"Jager","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"i1552-5783-60-14-4740-b01","unstructured":"Berus\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHalon\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarkiewicz\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOrlowska-Heitzman\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRomanowska-Dixon\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDonizy\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tClinical, histopathological and cytogenetic prognosticators in uveal melanoma - a comprehensive review.\n\t\t\t\t\tAnticancer Res.\n\t\t\t\t\t2017;\n\t\t\t\t\t37:\n\t\t\t\t\t6541\u20136549."},{"key":"i1552-5783-60-14-4740-b02","doi-asserted-by":"crossref","unstructured":"Amaro\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGangemi,\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPiaggio\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tThe biology of uveal melanoma.\n\t\t\t\t\tCancer Metastasis Rev.\n\t\t\t\t\t2017;\n\t\t\t\t\t36:\n\t\t\t\t\t109\u2013140.","DOI":"10.1007\/s10555-017-9663-3"},{"key":"i1552-5783-60-14-4740-b03","unstructured":"Dogrusoz\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJager\n\t\t\t\t\t\t\tMJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDamato\n\t\t\t\t\t\t\tB.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tUveal melanoma treatment and prognostication.\n\t\t\t\t\tAsia Pac J Ophthalmol (Phila).\n\t\t\t\t\t2017;\n\t\t\t\t\t6:\n\t\t\t\t\t186\u2013196."},{"key":"i1552-5783-60-14-4740-b04","doi-asserted-by":"crossref","unstructured":"Dogrusoz\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJager\n\t\t\t\t\t\t\tMJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tGenetic prognostication in uveal melanoma.\n\t\t\t\t\tActa Ophthalmol.\n\t\t\t\t\t2018;\n\t\t\t\t\t96:\n\t\t\t\t\t331\u2013347.","DOI":"10.1111\/aos.13580"},{"key":"i1552-5783-60-14-4740-b05","doi-asserted-by":"crossref","unstructured":"Onken\n\t\t\t\t\t\t\tMD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWorley\n\t\t\t\t\t\t\tLA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEhlers\n\t\t\t\t\t\t\tJP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHarbour\n\t\t\t\t\t\t\tJW.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tGene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death.\n\t\t\t\t\tCancer Res.\n\t\t\t\t\t2004;\n\t\t\t\t\t64:\n\t\t\t\t\t7205\u20137209.","DOI":"10.1158\/0008-5472.CAN-04-1750"},{"key":"i1552-5783-60-14-4740-b06","doi-asserted-by":"crossref","unstructured":"Harbour\n\t\t\t\t\t\t\tJW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tOnken\n\t\t\t\t\t\t\tMD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRoberson\n\t\t\t\t\t\t\tED,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tFrequent mutation of BAP1 in metastasizing uveal melanomas.\n\t\t\t\t\tScience.\n\t\t\t\t\t2010;\n\t\t\t\t\t330:\n\t\t\t\t\t1410\u20131413.","DOI":"10.1126\/science.1194472"},{"key":"i1552-5783-60-14-4740-b07","doi-asserted-by":"crossref","unstructured":"van Essen\n\t\t\t\t\t\t\tTH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan Pelt\n\t\t\t\t\t\t\tSI,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVersluis\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tPrognostic parameters in uveal melanoma and their association with BAP1 expression.\n\t\t\t\t\tBr J Ophthalmol.\n\t\t\t\t\t2014;\n\t\t\t\t\t98:\n\t\t\t\t\t1738\u20131743.","DOI":"10.1136\/bjophthalmol-2014-305047"},{"key":"i1552-5783-60-14-4740-b08","doi-asserted-by":"crossref","unstructured":"Kalirai\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDodson\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFaqir\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDamato\n\t\t\t\t\t\t\tBE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCoupland\n\t\t\t\t\t\t\tSE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tLack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing.\n\t\t\t\t\tBr J Cancer.\n\t\t\t\t\t2014;\n\t\t\t\t\t111:\n\t\t\t\t\t1373\u20131380.","DOI":"10.1038\/bjc.2014.417"},{"key":"i1552-5783-60-14-4740-b09","doi-asserted-by":"crossref","unstructured":"Koopmans\n\t\t\t\t\t\t\tAE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVerdijk\n\t\t\t\t\t\t\tRM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBrouwer\n\t\t\t\t\t\t\tRW,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tClinical significance of immunohistochemistry for detection of BAP1 mutations in uveal melanoma.\n\t\t\t\t\tMod Pathol.\n\t\t\t\t\t2014;\n\t\t\t\t\t27:\n\t\t\t\t\t1321\u20131330.","DOI":"10.1038\/modpathol.2014.43"},{"key":"i1552-5783-60-14-4740-b10","doi-asserted-by":"crossref","unstructured":"Robertson\n\t\t\t\t\t\t\tAG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShih\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tYau\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tIntegrative analysis identifies four molecular and clinical subsets in uveal melanoma.\n\t\t\t\t\tCancer Cell.\n\t\t\t\t\t2018;\n\t\t\t\t\t33:\n\t\t\t\t\t151.","DOI":"10.1016\/j.ccell.2017.12.013"},{"key":"i1552-5783-60-14-4740-b11","doi-asserted-by":"crossref","unstructured":"Grossniklaus\n\t\t\t\t\t\t\tHE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tUnderstanding uveal melanoma metastasis to the liver: the Zimmerman effect and the Zimmerman hypothesis.\n\t\t\t\t\tOphthalmology.\n\t\t\t\t\t2019;\n\t\t\t\t\t126:\n\t\t\t\t\t483\u2013487.","DOI":"10.1016\/j.ophtha.2018.09.031"},{"key":"i1552-5783-60-14-4740-b12","doi-asserted-by":"crossref","unstructured":"Gezgin\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDogrusoz\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan Essen\n\t\t\t\t\t\t\tTH,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tGenetic evolution of uveal melanoma guides the development of an inflammatory microenvironment.\n\t\t\t\t\tCancer Immun Immunother.\n\t\t\t\t\t2017;\n\t\t\t\t\t66:\n\t\t\t\t\t903\u2013912.","DOI":"10.1007\/s00262-017-1991-1"},{"key":"i1552-5783-60-14-4740-b13","doi-asserted-by":"crossref","unstructured":"Maat\n\t\t\t\t\t\t\tW,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLy\n\t\t\t\t\t\t\tLV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJordanova\n\t\t\t\t\t\t\tES,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tMonosomy of chromosome 3 and an inflammatory phenotype occur together in uveal melanoma.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2008;\n\t\t\t\t\t49:\n\t\t\t\t\t505\u2013510.","DOI":"10.1167\/iovs.07-0786"},{"key":"i1552-5783-60-14-4740-b14","doi-asserted-by":"crossref","unstructured":"Usui\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTsubota\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAgawa\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAqueous immune mediators in malignant uveal melanomas in comparison to benign pigmented intraocular tumors.\n\t\t\t\t\tGraefes Arch Clin Exp Ophthalmol.\n\t\t\t\t\t2017;\n\t\t\t\t\t255:\n\t\t\t\t\t393\u2013399.","DOI":"10.1007\/s00417-016-3541-5"},{"key":"i1552-5783-60-14-4740-b15","doi-asserted-by":"crossref","unstructured":"Cheng\n\t\t\t\t\t\t\tY,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFeng\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tZhu\n\t\t\t\t\t\t\tX,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLiang\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCytokines concentrations in aqueous humor of eyes with uveal melanoma.\n\t\t\t\t\tMedicine.\n\t\t\t\t\t2019;\n\t\t\t\t\t98:\n\t\t\t\t\te14030.","DOI":"10.1097\/MD.0000000000014030"},{"key":"i1552-5783-60-14-4740-b16","doi-asserted-by":"crossref","unstructured":"Dunavoelgyi\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFunk\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSacu\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tIntraocular activation of angiogenic and inflammatory pathways in uveal melanoma.\n\t\t\t\t\tRetina.\n\t\t\t\t\t2012;\n\t\t\t\t\t32:\n\t\t\t\t\t1373\u20131384.","DOI":"10.1097\/IAE.0b013e318239e299"},{"key":"i1552-5783-60-14-4740-b17","doi-asserted-by":"crossref","unstructured":"Boyd\n\t\t\t\t\t\t\tSR,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTan\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBunce\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tVascular endothelial growth factor is elevated in ocular fluids of eyes harbouring uveal melanoma: identification of a potential therapeutic window.\n\t\t\t\t\tBr J Ophthalmol.\n\t\t\t\t\t2002;\n\t\t\t\t\t86:\n\t\t\t\t\t448\u2013452.","DOI":"10.1136\/bjo.86.4.448"},{"key":"i1552-5783-60-14-4740-b18","doi-asserted-by":"crossref","unstructured":"Nagarkatti-Gude\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBronkhorst\n\t\t\t\t\t\t\tIH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan Duinen\n\t\t\t\t\t\t\tSG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLuyten\n\t\t\t\t\t\t\tGP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJager\n\t\t\t\t\t\t\tMJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tCytokines and chemokines in the vitreous fluid of eyes with uveal melanoma.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2012;\n\t\t\t\t\t53:\n\t\t\t\t\t6748\u20136755.","DOI":"10.1167\/iovs.12-10123"},{"key":"i1552-5783-60-14-4740-b19","doi-asserted-by":"crossref","unstructured":"Ly\n\t\t\t\t\t\t\tLV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBronkhorst\n\t\t\t\t\t\t\tIHG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan Beelen\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tInflammatory cytokines in eyes with uveal melanoma and relation with macrophage infiltration.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2010;\n\t\t\t\t\t51:\n\t\t\t\t\t5445\u20135451.","DOI":"10.1167\/iovs.10-5526"},{"key":"i1552-5783-60-14-4740-b20","doi-asserted-by":"crossref","unstructured":"Angi\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKalirai\n\t\t\t\t\t\t\tH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTaktak\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tPrognostic biopsy of choroidal melanoma: an optimised surgical and laboratory approach.\n\t\t\t\t\tBr J Ophthalmol.\n\t\t\t\t\t2017;\n\t\t\t\t\t101:\n\t\t\t\t\t1143\u20131146.","DOI":"10.1136\/bjophthalmol-2017-310361"},{"key":"i1552-5783-60-14-4740-b21","doi-asserted-by":"crossref","unstructured":"Sellam\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDesjardins\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBarnhill\n\t\t\t\t\t\t\tR,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tFine needle aspiration biopsy in uveal melanoma: technique, complications, and outcomes.\n\t\t\t\t\tAm J Ophthalmol.\n\t\t\t\t\t2016;\n\t\t\t\t\t162:\n\t\t\t\t\t28\u201334.","DOI":"10.1016\/j.ajo.2015.11.005"},{"key":"i1552-5783-60-14-4740-b22","doi-asserted-by":"crossref","unstructured":"Singh\n\t\t\t\t\t\t\tAD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMedina\n\t\t\t\t\t\t\tCA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSingh\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tAronow\n\t\t\t\t\t\t\tME,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBiscotti\n\t\t\t\t\t\t\tCV,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTriozzi\n\t\t\t\t\t\t\tPL.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tFine-needle aspiration biopsy of uveal melanoma: outcomes and complications.\n\t\t\t\t\tBr J Ophthalmol.\n\t\t\t\t\t2016;\n\t\t\t\t\t100:\n\t\t\t\t\t456\u2013462.","DOI":"10.1136\/bjophthalmol-2015-306921"},{"key":"i1552-5783-60-14-4740-b23","doi-asserted-by":"crossref","unstructured":"Wierenga\n\t\t\t\t\t\t\tAPA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCao\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLuyten\n\t\t\t\t\t\t\tGPM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJager\n\t\t\t\t\t\t\tMJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tImmune checkpoint inhibitors in uveal and conjunctival melanoma.\n\t\t\t\t\tInt Ophthalmol Clin.\n\t\t\t\t\t2019;\n\t\t\t\t\t59:\n\t\t\t\t\t53\u201363.","DOI":"10.1097\/IIO.0000000000000263"},{"key":"i1552-5783-60-14-4740-b24","unstructured":"Font\n\t\t\t\t\t\t\tRL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCroxatto\n\t\t\t\t\t\t\tJO,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRao\n\t\t\t\t\t\t\tNA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tTumors of the Eye and Ocular Adnexa. AFIP Atlas of Tumor Pathology: Series 4.\n\t\t\t\t\tSilver Spring, MD:\n\t\t\t\t\tThe American Registry of Pathology; Armed Forces Institute of Pathology;\n\t\t\t\t\t2006:\n\t\t\t\t\t56\u201360."},{"key":"i1552-5783-60-14-4740-b25","unstructured":"Amin\n\t\t\t\t\t\t\tMB,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGress\n\t\t\t\t\t\t\tDM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMeyer Vega\n\t\t\t\t\t\t\tLR,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tAJCC Cancer Staging Manual. 8th ed.\n\t\t\t\t\tChicago, IL:\n\t\t\t\t\tAmerican College of Surgeons;\n\t\t\t\t\t2018."},{"key":"i1552-5783-60-14-4740-b26","unstructured":"Kivel\u00e4\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tEskelin\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tM\u00e4kitie\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSummanen\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tExudative retinal detachment from malignant uveal melanoma: predictors and prognostic significance.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2001;\n\t\t\t\t\t42:\n\t\t\t\t\t2085\u20132093."},{"key":"i1552-5783-60-14-4740-b27","doi-asserted-by":"crossref","unstructured":"Muller\n\t\t\t\t\t\t\tK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNowak\n\t\t\t\t\t\t\tPJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tde Pan\n\t\t\t\t\t\t\tC,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tEffectiveness of fractionated stereotactic radiotherapy for uveal melanoma.\n\t\t\t\t\tInt J Radiat Oncol Biol Phys.\n\t\t\t\t\t2005;\n\t\t\t\t\t63:\n\t\t\t\t\t116\u2013122.","DOI":"10.1016\/j.ijrobp.2005.01.058"},{"key":"i1552-5783-60-14-4740-b28","doi-asserted-by":"crossref","unstructured":"Dogrusoz\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBagger\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan Duinen\n\t\t\t\t\t\t\tSG,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tThe prognostic value of AJCC staging in uveal melanoma is enhanced by adding chromosome 3 and 8q status.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2017;\n\t\t\t\t\t58:\n\t\t\t\t\t833\u2013842.","DOI":"10.1167\/iovs.16-20212"},{"key":"i1552-5783-60-14-4740-b29","doi-asserted-by":"crossref","unstructured":"Assarsson\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLundberg\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHolmquist\n\t\t\t\t\t\t\tG,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tHomogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2014;\n\t\t\t\t\t9:\n\t\t\t\t\te95192.","DOI":"10.1371\/journal.pone.0095192"},{"key":"i1552-5783-60-14-4740-b30","doi-asserted-by":"crossref","unstructured":"de Lange\n\t\t\t\t\t\t\tMJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tvan Pelt\n\t\t\t\t\t\t\tSI,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVersluis\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tHeterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma.\n\t\t\t\t\tOncotarget.\n\t\t\t\t\t2015;\n\t\t\t\t\t6:\n\t\t\t\t\t37824\u201337835.","DOI":"10.18632\/oncotarget.5637"},{"key":"i1552-5783-60-14-4740-b31","doi-asserted-by":"crossref","unstructured":"Singh\n\t\t\t\t\t\t\tAD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShields\n\t\t\t\t\t\t\tCL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tShields\n\t\t\t\t\t\t\tJA.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPrognostic factors in uveal melanoma.\n\t\t\t\t\tMelanoma Res.\n\t\t\t\t\t2001;\n\t\t\t\t\t11:\n\t\t\t\t\t255\u2013263.","DOI":"10.1097\/00008390-200106000-00007"},{"key":"i1552-5783-60-14-4740-b32","doi-asserted-by":"crossref","unstructured":"Zhu\n\t\t\t\t\t\t\tJ,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPowis de Tenbossche\n\t\t\t\t\t\t\tCG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCan\u00e9\n\t\t\t\t\t\t\tS,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tResistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes.\n\t\t\t\t\tNat Commun.\n\t\t\t\t\t2017;\n\t\t\t\t\t8:\n\t\t\t\t\t1404.","DOI":"10.1038\/s41467-017-00784-1"},{"key":"i1552-5783-60-14-4740-b33","doi-asserted-by":"crossref","unstructured":"Basile\n\t\t\t\t\t\t\tMS,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMazzon\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tRusso\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tDifferential modulation and prognostic values of immune-escape genes in uveal melanoma.\n\t\t\t\t\tPLoS One.\n\t\t\t\t\t2019;\n\t\t\t\t\t14:\n\t\t\t\t\te0210276.","DOI":"10.1371\/journal.pone.0210276"},{"key":"i1552-5783-60-14-4740-b34","doi-asserted-by":"crossref","unstructured":"Enninga\n\t\t\t\t\t\t\tEAL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNevala\n\t\t\t\t\t\t\tWK,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHoltan\n\t\t\t\t\t\t\tSG,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLeontovich\n\t\t\t\t\t\t\tAA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMarkovic\n\t\t\t\t\t\t\tSN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tGalectin-9 modulates immunity by promoting Th2\/M2 differentiation and impacts survival in patients with metastatic melanoma.\n\t\t\t\t\tMelanoma Res.\n\t\t\t\t\t2016;\n\t\t\t\t\t26:\n\t\t\t\t\t429\u2013441.","DOI":"10.1097\/CMR.0000000000000281"},{"key":"i1552-5783-60-14-4740-b35","doi-asserted-by":"crossref","unstructured":"Zhou\n\t\t\t\t\t\t\tX,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSun\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJing\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tGalectin-9 expression predicts favorable clinical outcome in solid tumors: a systematic review and meta-analysis.\n\t\t\t\t\tFront Physiol.\n\t\t\t\t\t2018;\n\t\t\t\t\t9:\n\t\t\t\t\t452.","DOI":"10.3389\/fphys.2018.00452"},{"key":"i1552-5783-60-14-4740-b36","doi-asserted-by":"crossref","unstructured":"Gieseke\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKruchen\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTzaribachev\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBentzien\n\t\t\t\t\t\t\tF,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDominici\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tM\u00fcller\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tProinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation.\n\t\t\t\t\tEur J Immunol.\n\t\t\t\t\t2013;\n\t\t\t\t\t43:\n\t\t\t\t\t2741\u20132749.","DOI":"10.1002\/eji.201343335"},{"key":"i1552-5783-60-14-4740-b37","doi-asserted-by":"crossref","unstructured":"Bronkhorst\n\t\t\t\t\t\t\tIH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVu\n\t\t\t\t\t\t\tTH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJordanova\n\t\t\t\t\t\t\tES,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLuyten\n\t\t\t\t\t\t\tGP,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBurg\n\t\t\t\t\t\t\tSH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJager\n\t\t\t\t\t\t\tMJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tDifferent subsets of tumor-infiltrating lymphocytes correlate with macrophage influx and monosomy 3 in uveal melanoma.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2012;\n\t\t\t\t\t53:\n\t\t\t\t\t5370\u20135378.","DOI":"10.1167\/iovs.11-9280"},{"key":"i1552-5783-60-14-4740-b38","doi-asserted-by":"crossref","unstructured":"Mougiakakos\n\t\t\t\t\t\t\tD,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tJohansson\n\t\t\t\t\t\t\tCC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tTrocme\n\t\t\t\t\t\t\tE,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tIntratumoral forkhead box P3-positive regulatory T cells predict poor survival in cyclooxygenase-2-positive uveal melanoma.\n\t\t\t\t\tCancer.\n\t\t\t\t\t2010;\n\t\t\t\t\t116:\n\t\t\t\t\t2224\u20132233.","DOI":"10.1002\/cncr.24999"},{"key":"i1552-5783-60-14-4740-b39","doi-asserted-by":"crossref","unstructured":"Golden-Mason\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMcMahan\n\t\t\t\t\t\t\tRH,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tStrong\n\t\t\t\t\t\t\tM,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tGalectin-9 functionally impairs natural killer cells in humans and mice.\n\t\t\t\t\tJ Virol.\n\t\t\t\t\t2013;\n\t\t\t\t\t87:\n\t\t\t\t\t4835\u20134845.","DOI":"10.1128\/JVI.01085-12"},{"key":"i1552-5783-60-14-4740-b40","doi-asserted-by":"crossref","unstructured":"Uner\n\t\t\t\t\t\t\tOE,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tUlrich\n\t\t\t\t\t\t\tBC,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHubbard\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPotential of aqueous humor as a surrogate tumor biopsy for retinoblastoma.\n\t\t\t\t\tJAMA Ophthalmol.\n\t\t\t\t\t2018;\n\t\t\t\t\t136:\n\t\t\t\t\t597\u2013598.","DOI":"10.1001\/jamaophthalmol.2018.0392"},{"key":"i1552-5783-60-14-4740-b41","doi-asserted-by":"crossref","unstructured":"Berry\n\t\t\t\t\t\t\tJL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tXu\n\t\t\t\t\t\t\tL,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMurphree\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tPotential of aqueous humor as a surrogate tumor biopsy for retinoblastoma.\n\t\t\t\t\tJAMA Ophthalmol.\n\t\t\t\t\t2017;\n\t\t\t\t\t135:\n\t\t\t\t\t1221\u20131230.","DOI":"10.1001\/jamaophthalmol.2017.4097"},{"key":"i1552-5783-60-14-4740-b42","doi-asserted-by":"crossref","unstructured":"Cassoux\n\t\t\t\t\t\t\tN,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGiron\n\t\t\t\t\t\t\tA,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBodaghi\n\t\t\t\t\t\t\tB,\n\t\t\t\t\t\t\n\t\t\t\t\t\tet al.\n\t\t\t\t\t\n\t\t\t\t\tIL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma.\n\t\t\t\t\tInvest Ophthalmol Vis Sci.\n\t\t\t\t\t2007;\n\t\t\t\t\t48:\n\t\t\t\t\t3253\u20133259.","DOI":"10.1167\/iovs.06-0031"},{"key":"i1552-5783-60-14-4740-b43","doi-asserted-by":"crossref","unstructured":"Kivel\u00e4\n\t\t\t\t\t\t\tT,\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKujala\n\t\t\t\t\t\t\tE.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\tPrognostication in eye cancer: the latest tumor, node, metastasis classification and beyond.\n\t\t\t\t\tEye (Lond).\n\t\t\t\t\t2013;\n\t\t\t\t\t27:\n\t\t\t\t\t243\u2013252.","DOI":"10.1038\/eye.2012.256"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2755740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:11Z","timestamp":1791927071000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2755740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":43,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2019,11,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.19-28309","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11,15]]}}}