{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:01Z","timestamp":1791928741521,"version":"4.3.4"},"reference-count":41,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"13","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2020,11,24]]},"DOI":"10.1167\/iovs.61.13.34","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T23:10:17Z","timestamp":1606259417000},"page":"34","source":"Crossref","is-referenced-by-count":11,"title":["RasV12 Expression in Microglia Initiates Retinal Inflammation and Induces Photoreceptor Degeneration"],"prefix":"10.1167","volume":"61","author":[{"given":"Yuta","family":"Moriuchi","sequence":"first","affiliation":[{"name":"Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Iwagawa","sequence":"additional","affiliation":[{"name":"Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asano","family":"Tsuhako","sequence":"additional","affiliation":[{"name":"Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Koso","sequence":"additional","affiliation":[{"name":"Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumiko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"9","key":"bib1","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.1172\/JCI90602","article-title":"Microglia in steady state","volume":"127","author":"Kierdorf","year":"2017","journal-title":"J Clin Invest"},{"issue":"9","key":"bib2","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1038\/nm.4397","article-title":"Microglia emerge as central players in brain disease","volume":"23","author":"Salter","year":"2017","journal-title":"Nat Med"},{"issue":"1","key":"bib3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev-vision-091517-034425","article-title":"Microglia in the retina: roles in development, maturity, and disease","volume":"4","author":"Silverman","year":"2018","journal-title":"Annu Rev Vis Sci"},{"issue":"4","key":"bib4","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1002\/cne.v518:4","article-title":"Microglial response to light-induced photoreceptor degeneration in the mouse retina","volume":"518","author":"Santos","year":"2010","journal-title":"J Comp Neurol"},{"issue":"13","key":"bib5","first-page":"3301","article-title":"Light-induced migration of retinal microglia into the subretinal space","volume":"42","author":"Ng","year":"2001","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"9","key":"bib6","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.15252\/emmm.201505298","article-title":"Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration","volume":"7","author":"Zhao","year":"2015","journal-title":"EMBO Mol Med"},{"issue":"24","key":"bib7","doi-asserted-by":"publisher","first-page":"8139","DOI":"10.1523\/JNEUROSCI.5200-13.2014","article-title":"Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa","volume":"34","author":"Tipoe","year":"2014","journal-title":"J Neurosci"},{"issue":"18","key":"bib8","doi-asserted-by":"publisher","first-page":"4540","DOI":"10.1523\/JNEUROSCI.0492-05.2005","article-title":"The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia","volume":"25","author":"Rattner","year":"2005","journal-title":"J Neurosci"},{"issue":"51","key":"bib9","doi-asserted-by":"publisher","first-page":"13765","DOI":"10.1523\/JNEUROSCI.5114-08.2008","article-title":"Leukemia inhibitory factor extends the lifespan of injured photoreceptors in vivo","volume":"28","author":"Joly","year":"2008","journal-title":"J Neurosci"},{"issue":"3","key":"bib10","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/j.1471-4159.2007.05180.x","article-title":"STAT3 activation in photoreceptors by leukemia inhibitory factor is associated with protection from light damage","volume":"105","author":"Ueki","year":"2008","journal-title":"J Neurochem"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S1350-9462(00)00017-3","article-title":"Retinal pigment epithelium-immune system interactions: cytokine production and cytokine-induced changes","volume":"20","author":"Holtkamp","year":"2001","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.cell.2017.06.009","article-title":"McCormick F. RAS proteins and their regulators in human disease","volume":"170","author":"Simanshu","year":"2017","journal-title":"Cell"},{"issue":"11","key":"bib13","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.tcb.2004.09.016","article-title":"CSF-1 regulation of the wandering macrophage: complexity in action","volume":"14","author":"Pixley","year":"2004","journal-title":"Trends Cell Biol"},{"issue":"6","key":"bib14","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1189\/jlb.0403128","article-title":"Fc? receptor signaling in primary human microglia: differential roles of PI-3K and Ras\/ERK MAPK pathways in phagocytosis and chemokine induction","volume":"75","author":"Song","year":"2004","journal-title":"J Leukoc Biol"},{"issue":"4","key":"bib15","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nrn.2016.7","article-title":"TREM2 variants: new keys to decipher Alzheimer disease pathogenesis","volume":"17","author":"Colonna","year":"2016","journal-title":"Nat Rev Neurosci"},{"issue":"14","key":"bib16","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.1158\/0008-5472.CAN-19-3682","article-title":"The frequency of Ras mutations in cancer","volume":"80","author":"Prior","year":"2020","journal-title":"Cancer Res"},{"issue":"9","key":"bib17","doi-asserted-by":"publisher","first-page":"5917","DOI":"10.4049\/jimmunol.0803336","article-title":"Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses","volume":"183","author":"Brahmachari","year":"2009","journal-title":"J Immunol"},{"issue":"7672","key":"bib18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature23672","article-title":"A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease","volume":"549","author":"Mass","year":"2017","journal-title":"Nature"},{"issue":"1","key":"bib19","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"issue":"5","key":"bib20","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/ncb3509","article-title":"Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes","volume":"19","author":"Kon","year":"2017","journal-title":"Nat Cell Biol"},{"issue":"3","key":"bib21","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0014-5793(00)01338-7","article-title":"A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination","volume":"470","author":"Kawamoto","year":"2000","journal-title":"FEBS Lett"},{"issue":"11","key":"bib22","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1002\/glia.23038","article-title":"Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina","volume":"64","author":"Koso","year":"2016","journal-title":"Glia"},{"issue":"March","key":"bib23","first-page":"1","article-title":"Microglia, seen from the CX3CR1 angle","volume":"7","author":"Wolf","year":"2013","journal-title":"Front Cell Neurosci"},{"issue":"4","key":"bib24","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1182\/blood-2008-07-170787","article-title":"CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival","volume":"113","author":"Landsman","year":"2009","journal-title":"Blood"},{"issue":"AUG","key":"bib25","first-page":"1","article-title":"Microglia in retinal degeneration","volume":"10","author":"Rashid","year":"2019","journal-title":"Front Immunol"},{"issue":"12","key":"bib26","doi-asserted-by":"publisher","first-page":"E1738","DOI":"10.1073\/pnas.1525528113","article-title":"New tools for studying microglia in the mouse and human CNS","volume":"113","author":"Bennett","year":"2016","journal-title":"Proc Natl Acad Sci"},{"issue":"March","key":"bib27","first-page":"1","article-title":"Retinal microglia \u2013 A key player in healthy and diseased retina","author":"Rathnasamy","year":"2018","journal-title":"Prog Neurobiol"},{"issue":"4","key":"bib28","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cell.2017.07.023","article-title":"TREM2 maintains microglial metabolic fitness in Alzheimer's disease","volume":"170","author":"Ulland","year":"2017","journal-title":"Cell"},{"issue":"12","key":"bib29","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.3390\/ph7121028","article-title":"Role of microglial M1\/M2 polarization in relapse and remission of psychiatric disorders and diseases","volume":"7","author":"Nakagawa","year":"2014","journal-title":"Pharmaceuticals"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.pneurobio.2015.05.003","article-title":"Alternatively activated microglia and macrophages in the central nervous system","volume":"131","author":"Franco","year":"2015","journal-title":"Prog Neurobiol"},{"issue":"1","key":"bib31","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0022-1759(95)00072-I","article-title":"A novel assay for apoptosisfFlow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V","volume":"184","author":"Vermes","year":"1995","journal-title":"J Immunol Methods"},{"issue":"9","key":"bib32","first-page":"1363","article-title":"Accumulation of glial fibrillary acidic protein in Muller radial glia during retinal degeneration","volume":"29","author":"Ekstrom","year":"1988","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"975849","DOI":"10.1155\/2014\/975849","article-title":"P2Y(12) receptor on the verge of a neuroinflammatory breakdown","volume":"2014","author":"Amadio","year":"2014","journal-title":"Mediators Inflamm"},{"issue":"12","key":"bib34","doi-asserted-by":"publisher","first-page":"9124","DOI":"10.1167\/iovs.11-7736","article-title":"Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa","volume":"52","author":"Arroba","year":"2011","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"July","key":"bib35","first-page":"1","article-title":"Microglia Inhibition Delays Retinal Degeneration Due to MerTK Phagocytosis Receptor Deficiency","volume":"11","author":"Lew","year":"2020","journal-title":"Front Immunol"},{"key":"bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.42049","article-title":"Absence of TGF\u00df signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization","volume":"8","author":"Ma","year":"2019","journal-title":"Elife"},{"issue":"4","key":"bib37","doi-asserted-by":"publisher","first-page":"e35551","DOI":"10.1371\/journal.pone.0035551","article-title":"Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling","volume":"7","author":"Luhmann","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"bib38","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1002\/glia.v64.9","article-title":"Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa","volume":"64","author":"Zabel","year":"2016","journal-title":"Glia"},{"issue":"13","key":"bib39","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1182\/blood-2012-05-430140","article-title":"High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses","volume":"120","author":"Haroche","year":"2012","journal-title":"Blood"},{"issue":"4","key":"bib40","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1084\/jem.20130977","article-title":"BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups","volume":"211","author":"Berres","year":"2014","journal-title":"J Exp Med"},{"issue":"20","key":"bib41","doi-asserted-by":"publisher","first-page":"4619","DOI":"10.1242\/jcs.01481","article-title":"MAP kinases and cell migration","volume":"117","author":"Huang","year":"2004","journal-title":"J Cell Sci"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2771994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:18Z","timestamp":1791927078000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2771994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,24]]},"references-count":41,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,11,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.61.13.34","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,24]]}}}