{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:11:52Z","timestamp":1793121112455,"version":"4.5.0"},"reference-count":58,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"14","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2020,12,16]]},"DOI":"10.1167\/iovs.61.14.22","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T05:17:21Z","timestamp":1608268641000},"page":"22","source":"Crossref","is-referenced-by-count":30,"title":["Subconjunctival Injection of Regulatory T Cells Potentiates Corneal Healing Via Orchestrating Inflammation and Tissue Repair After Acute Alkali Burn"],"prefix":"10.1167","volume":"61","author":[{"given":"Dan","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangbo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinke","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianxuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0039-6257(96)00007-0","article-title":"Chemical injuries of the eye: current concepts in pathophysiology and therapy","volume":"41","author":"Wagoner","year":"1997","journal-title":"Surv Ophthalmol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jtos.2016.09.002","article-title":"Current and upcoming therapies for ocular surface chemical injuries","volume":"15","author":"Baradaran-Rafii","year":"2017","journal-title":"Ocul Surf"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.survophthal.2017.09.005","article-title":"Treatment of acute ocular chemical burns","volume":"63","author":"Sharma","year":"2018","journal-title":"Surv Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S0161-6420(83)34509-7","article-title":"The effects of chemical injury on the ocular surface","volume":"90","author":"Pfister","year":"1983","journal-title":"Ophthalmology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.advms.2015.10.003","article-title":"Assessment of therapeutic options for reducing alkali burn-induced corneal neovascularization and inflammation","volume":"61","author":"Bakunowicz-Lazarczyk","year":"2016","journal-title":"Adv Med Sci"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1136\/bjophthalmol-2014-306115","article-title":"Long-term outcomes and complications of Moscow Eye Microsurgery Complex in Russia (MICOF) keratoprosthesis following ocular surface burns: clinical experience in China","volume":"99","author":"Wang","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.preteyeres.2015.07.002","article-title":"Progress in corneal wound healing","volume":"49","author":"Ljubimov","year":"2015","journal-title":"Prog Retin Eye Res"},{"issue":"7","key":"bib8","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s41590-018-0120-4","article-title":"Regulatory T cells in autoimmune disease","volume":"19","author":"Dominguez-Villar","year":"2018;","journal-title":"Nat Immunol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1016\/j.jaci.2018.10.015","article-title":"Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: the next frontier","volume":"142","author":"Esensten","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.cell.2013.10.054","article-title":"A special population of regulatory T cells potentiates muscle repair","volume":"155","author":"Burzyn","year":"2013","journal-title":"Cell"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.immuni.2019.02.013","article-title":"Treg-cell control of a CXCL5-IL-17 inflammatory axis promotes hair-follicle-stem-cell differentiation during skin-barrier repair","volume":"50","author":"Mathur","year":"2019","journal-title":"Immunity"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1097\/TP.0000000000002442","article-title":"Local delivery of regulatory T cells promotes corneal allograft survival","volume":"103","author":"Shao","year":"2019","journal-title":"Transplantation"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.maturitas.2017.06.026","article-title":"The role of estrogen in cutaneous ageing and repair","volume":"103","author":"Wilkinson","year":"2017","journal-title":"Maturitas"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"e503","DOI":"10.1111\/aos.2017.95.issue-6","article-title":"Epidemiology and clinical characteristics of patients hospitalized for ocular trauma in South-Central China","volume":"95","author":"Wang","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"9596","DOI":"10.1038\/s41598-019-46116-9","article-title":"Pro-inflammatory role of NLRP3 inflammasome in experimental sterile corneal inflammation","volume":"9","author":"Shimizu","year":"2019","journal-title":"Sci Rep"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1038\/s41385-018-0058-8","article-title":"Role of IL-18 induced amphiregulin expression on virus induced ocular lesions","volume":"11","author":"Varanasi","year":"2018","journal-title":"Mucosal Immunol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1001\/archopht.1969.00990020093022","article-title":"Alkali burns of the cornea","volume":"82","author":"Brown","year":"1969","journal-title":"Arch Ophthalmol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s10384-010-0804-2","article-title":"Innate immunity of the ocular surface.","volume":"54","author":"Kinoshita","year":"2010","journal-title":"Jpn J Ophthalmol."},{"issue":"6204","key":"bib19","doi-asserted-by":"publisher","first-page":"1251086","DOI":"10.1126\/science.1251086","article-title":"Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity","volume":"345","author":"Saeed","year":"2014","journal-title":"Science"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s10456-018-9594-9","article-title":"Selective IKK2 inhibitor IMD0354 disrupts NF-?B signaling to suppress corneal inflammation and angiogenesis","volume":"21","author":"Lennikov","year":"2018","journal-title":"Angiogenesis"},{"issue":"3","key":"bib21","doi-asserted-by":"publisher","first-page":"562","DOI":"10.3390\/ijms18030562","article-title":"Inhibition of NLRP3 inflammasome pathway by butyrate improves corneal wound healing in corneal alkali burn","volume":"18","author":"Bian","year":"2017","journal-title":"Int J Mol Sci"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.jcyt.2016.01.003","article-title":"One for all: a standardized protocol for ex vivo culture of limbal, conjunctival and oral mucosal epithelial cells into corneal lineage","volume":"18","author":"Dhamodaran","year":"2016","journal-title":"Cytotherapy"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"971","DOI":"10.3109\/02713683.2012.700756","article-title":"Structural and functional alteration of corneal epithelial barrier under inflammatory conditions","volume":"37","author":"Contreras-Ruiz","year":"2012","journal-title":"Curr Eye Res"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"4158","DOI":"10.1167\/iovs.10-6726","article-title":"Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation","volume":"52","author":"Davis","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","first-page":"758","article-title":"NGF promotes cell cycle progression by regulating D-type cyclins via PI3K\/Akt and MAPK\/Erk activation in human corneal epithelial cells","volume":"18","author":"Hong","year":"2012","journal-title":"Mol Vis"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.exer.2007.06.009","article-title":"Apoptosis in the initiation, modulation and termination of the corneal wound healing response","volume":"85","author":"Wilson","year":"2007","journal-title":"Exp Eye Res"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1165\/rcmb.2017-0019OC","article-title":"Foxp3(+) regulatory T cell expression of keratinocyte growth factor enhances lung epithelial proliferation","volume":"57","author":"Dial","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"3806","DOI":"10.1016\/j.celrep.2020.02.062","article-title":"Mesenchymal stem and stromal cells harness macrophage-derived amphiregulin to maintain tissue homeostasis","volume":"30","author":"Ko","year":"2020","journal-title":"Cell Rep"},{"key":"bib29","first-page":"1003","article-title":"The molecular mechanisms of action of PPAR-? agonists in the treatment of corneal alkali burns (Review)","volume":"38","author":"Zhou","year":"2016","journal-title":"Int J Mol Med"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1097\/00003226-199703000-00010","article-title":"Inhibition of corneal fibrosis by topical application of blocking antibodies to TGF beta in the rabbit","volume":"16","author":"Jester","year":"1997","journal-title":"Cornea"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/0002-9394(66)90293-5","article-title":"Management of alkali burns of cornea and conjunctiva","volume":"61","author":"Horwitz","year":"1996","journal-title":"Am J Ophthalmol"},{"issue":"52","key":"bib32","doi-asserted-by":"publisher","first-page":"26727","DOI":"10.1073\/pnas.1914848116","article-title":"T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle","volume":"116","author":"Cho","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/febs.13827","article-title":"Regulatory T cells and skeletal muscle regeneration","volume":"284","author":"Schiaffino","year":"2017","journal-title":"FEBS J"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nn.4528","article-title":"Regulatory T cells promote myelin regeneration in the central nervous system","volume":"20","author":"Dombrowski","year":"2017","journal-title":"Nat Neurosci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nrd.2018.148","article-title":"Regulatory T cells in the treatment of disease","volume":"17","author":"Sharabi","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.jtos.2017.05.013","article-title":"Review: The function of regulatory T cells at the ocular surface","volume":"15","author":"Foulsham","year":"2017","journal-title":"Ocul Surf"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1084\/jem.190.7.995","article-title":"An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation","volume":"190","author":"Asseman","year":"1999","journal-title":"J Exp Med"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/imr.2007.220.issue-1","article-title":"'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation","volume":"220","author":"Wan","year":"2007","journal-title":"Immunol Rev"},{"issue":"12","key":"bib39","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1038\/ni1536","article-title":"CD4(+) CD25(+) Foxp3(+) regulatory T cells induce cytokine deprivation -mediated apoptosis of effector CD4(+) T cells","volume":"8","author":"Pandiyan","year":"2007","journal-title":"Nat Immunol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.4049\/jimmunol.1500801","article-title":"Control of regulatory T cell migration, function, and homeostasis","volume":"195","author":"Campbell","year":"2015","journal-title":"J Immunol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1084\/jem.20072594","article-title":"Foxp3(+) regulatory T cells maintain immune homeostasis in the skin","volume":"205","author":"Dudda","year":"2008","journal-title":"J Exp Med"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1002\/sct3.2018.7.issue-12","article-title":"Anti-inflammatory and anti-fibrotic effects of human amniotic membrane mesenchymal stem cells and their potential in corneal repair","volume":"7","author":"Navas","year":"2018","journal-title":"Stem Cells Transl Med"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.3389\/fimmu.2017.01578","article-title":"Tregs: Where we are and what comes next?","volume":"8","author":"Zhao","year":"2017","journal-title":"Front Immunol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"7424","DOI":"10.4049\/jimmunol.179.11.7424","article-title":"Keratinocyte growth factor induces expansion of murine peripheral CD4+Foxp3+ regulatory T cells and increases their thymic output","volume":"179","author":"Bruinsma","year":"2007","journal-title":"J Immunol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.immuni.2015.01.020","article-title":"Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair","volume":"42","author":"Zaiss","year":"2015","journal-title":"Immunity"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.cell.2015.08.021","article-title":"A distinct function of regulatory T cells in tissue protection","volume":"162","author":"Arpaia","year":"2015","journal-title":"Cell"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/s41586-018-0824-5","article-title":"Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery","volume":"565","author":"Ito","year":"2019","journal-title":"Nature"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1093\/intimm\/dxz031","article-title":"Tissue regulatory T cells and neural repair","volume":"31","author":"Ito","year":"2019","journal-title":"Int Immunol"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1155\/2018\/4310419","article-title":"Amphiregulin regulates phagocytosis-induced cell death in monocytes via EGFR and matrix metalloproteinases","volume":"2018","author":"Platen","year":"2018","journal-title":"Mediators Inflamm"},{"issue":"1","key":"bib50","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/molecules24010114","article-title":"PPARa agonist suppresses inflammation after corneal alkali burn by suppressing proinflammatory cytokines, MCP-1, and nuclear translocation of NF-?B","volume":"24","author":"Nakano","year":"2018","journal-title":"Molecules"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1080\/02713683.2019.1597893","article-title":"Absence of therapeutic benefit of the anti-inflammatory protein TSG-6 for corneal alkali injury in a rat model","volume":"44","author":"Choi","year":"2019","journal-title":"Curr Eye Res"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"107665","DOI":"10.1016\/j.exer.2019.05.005","article-title":"Inflammation, vascularization and goblet cell differences in LSCD: validating animal models of corneal alkali burns","volume":"185","author":"Kethiri","year":"2019","journal-title":"Exp Eye Res"},{"issue":"39","key":"bib53","doi-asserted-by":"publisher","first-page":"eaay1160","DOI":"10.1126\/sciimmunol.aay1160","article-title":"Tregs in fibrosis: to know your enemy, you must become your enemy","volume":"4","author":"Bal","year":"2019","journal-title":"Sci Immunol"},{"issue":"39","key":"bib54","doi-asserted-by":"publisher","first-page":"eaaw2910","DOI":"10.1126\/sciimmunol.aaw2910","article-title":"Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses","volume":"4","author":"Kalekar","year":"2019","journal-title":"Sci Immunol"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.numecd.2019.08.004","article-title":"High fat diet downregulates regulatory T cells in the myocardium of spontaneous hypertensive rats","volume":"29","author":"Hong","year":"2019","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/cbdd.2017.90.issue-5","article-title":"Recent drug therapies for corneal neovascularization","volume":"90","author":"Liu","year":"2017","journal-title":"Chem Biol Drug Des"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.2147\/DDDT","article-title":"The long-term effect of tacrolimus on alkali burn-induced corneal neovascularization and inflammation surpasses that of anti-vascular endothelial growth factor","volume":"12","author":"Chen","year":"2018","journal-title":"Drug Des Devel Ther"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/s41467-017-00751-w","article-title":"Foxp3(+) Tregs are recruited to the retina to repair pathological angiogenesis","volume":"8","author":"Deliyanti","year":"2017","journal-title":"Nat Commun"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:16Z","timestamp":1791927076000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,16]]},"references-count":58,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.61.14.22","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,16]]}}}