{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:47Z","timestamp":1791928727915,"version":"4.3.4"},"reference-count":36,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2020,3,18]]},"DOI":"10.1167\/iovs.61.3.27","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T11:01:04Z","timestamp":1584529264000},"page":"27","source":"Crossref","is-referenced-by-count":31,"title":["In Vivo Measurements of Prelamina and Lamina Cribrosa Biomechanical Properties in Humans"],"prefix":"10.1167","volume":"61","author":[{"given":"Liang","family":"Zhang","sequence":"first","affiliation":[{"name":"Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna R.","family":"Beotra","sequence":"additional","affiliation":[{"name":"Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani","family":"Baskaran","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore"},{"name":"Duke-National University of Singapore Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin A.","family":"Tun","sequence":"additional","affiliation":[{"name":"Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore"},{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamira A.","family":"Perera","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore"},{"name":"Duke-National University of Singapore Medical School, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Strouthidis","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore"},{"name":"National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital, National Health Service Foundation Trust and University College London, Institute of Ophthalmology, London, United Kingdom"},{"name":"Discipline of Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin","family":"Aung","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore"},{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Boote","sequence":"additional","affiliation":[{"name":"Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore"},{"name":"Structural Biophysics Research Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J. A.","family":"Girard","sequence":"additional","affiliation":[{"name":"Ophthalmic Engineering and Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore"},{"name":"Singapore Eye Research Institute, Singapore National Eye Centre, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"4597","DOI":"10.1167\/iovs.07-0349","article-title":"3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: lamina cribrosa and peripapillary scleral position and thickness","volume":"48","author":"Yang","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1167\/iovs.09-5122","article-title":"Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions","volume":"52","author":"Yang","year":"2011","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib3","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.1167\/iovs.16-21321","article-title":"Biomechanical responses of lamina cribrosa to intraocular pressure change assessed by optical coherence tomography in glaucoma EyesOCT change with IOP","volume":"58","author":"Quigley","year":"2017","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1167\/iovs.15-18986","article-title":"Finite element analysis predicts large optic nerve head strains during horizontal eye movements","volume":"57","author":"Wang","year":"2016","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ophtha.2007.03.017","article-title":"Risk factors for incident open-angle glaucoma: the Barbados Eye Studies","volume":"115","author":"Leske","year":"2008","journal-title":"Ophthalmology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.exer.2010.09.005","article-title":"A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma","volume":"93","author":"Burgoyne","year":"2011","journal-title":"Exp Eye Res"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1001\/archopht.1994.01090170088028","article-title":"Risk factors for the development of glaucomatous visual field loss in ocular hypertension","volume":"112","author":"Quigley","year":"1994","journal-title":"Arch Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"Burgoyne","year":"2005","journal-title":"Prog Retin Eye Res"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1136\/bjo.2004.056614","article-title":"A comparison of four methods of tonometry: method agreement and interobserver variability","volume":"89","author":"Tonnu","year":"2005","journal-title":"Br J Ophthalmol."},{"key":"bib10","doi-asserted-by":"publisher","first-page":"ii34","DOI":"10.1136\/bjophthalmol-2013-304751","article-title":"Recent advances in OCT imaging of the lamina cribrosa","volume":"98","author":"Sigal","year":"2014","journal-title":"Br J Ophthalmol."},{"key":"bib11","doi-asserted-by":"publisher","first-page":"051012","DOI":"10.1115\/1.3113683","article-title":"Peripapillary and posterior scleral mechanics\u2013part II: experimental and inverse finite element characterization","volume":"131","author":"Girard","year":"2009","journal-title":"J Biomech Eng"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"5656","DOI":"10.1167\/iovs.10-6927","article-title":"Biomechanical changes in the sclera of monkey eyes exposed to chronic IOP elevations","volume":"52","author":"Girard","year":"2011","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib13","doi-asserted-by":"publisher","first-page":"8163","DOI":"10.1167\/iovs.14-14029","article-title":"Age-and race-related differences in human scleral material properties scleral material property changes with age and race","volume":"55","author":"Grytz","year":"2014","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib14","doi-asserted-by":"publisher","first-page":"041006","DOI":"10.1115\/1.4029430","article-title":"Collagen structure and mechanical properties of the human sclera: analysis for the effects of age","volume":"137","author":"Coudrillier","year":"2015","journal-title":"J Biomech Eng."},{"key":"bib15","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/0014-4835(88)90053-X","article-title":"A comparison of the elastic properties of human choroid and sclera","volume":"47","author":"Friberg","year":"1988","journal-title":"Exp Eye Res"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1115\/1.3426291","article-title":"The elasticity of sclera and choroid of the human eye, and its implications on scleral rigidity and accommodation","volume":"99","author":"Graebel","year":"1977","journal-title":"J Biomech Eng."},{"key":"bib17","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.jcrs.2003.11.032","article-title":"Collagen crosslinking of human and porcine sclera","volume":"30","author":"Wollensak","year":"2004","journal-title":"J Cataract Refract Surg"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1167\/iovs.11-8009","article-title":"Biomechanics of the human posterior sclera: age- and glaucoma-related changes measured using inflation testing","volume":"53","author":"Coudrillier","year":"2012","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib19","doi-asserted-by":"publisher","first-page":"051011","DOI":"10.1115\/1.3113682","article-title":"Peripapillary and posterior scleral mechanics\u2013part I: development of an anisotropic hyperelastic constitutive model","volume":"131","author":"Girard","year":"2009","journal-title":"J Biomech Eng."},{"key":"bib20","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.jmbbm.2013.03.027","article-title":"Material properties of the posterior human sclera","volume":"29","author":"Grytz","year":"2014","journal-title":"J Mech Behav Biomed Mater"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s10237-016-0858-2","article-title":"Verification of a virtual fields method to extract the mechanical properties of human optic nerve head tissues in vivo","volume":"16","author":"Zhang","year":"2017","journal-title":"Biomech Model Mechanobiol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/str.2006.42.issue-4","article-title":"The virtual fields method for extracting constitutive parameters from full-field measurements: a review","volume":"42","author":"Gr\u00e9diac","year":"2006","journal-title":"Strain"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"4869","DOI":"10.1167\/iovs.16-19753","article-title":"Shape changes of the anterior lamina cribrosa in normal, ocular hypertensive, and glaucomatous eyes following acute intraocular pressure elevation","volume":"57","author":"Tun","year":"2016","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/j.ophtha.2016.02.008","article-title":"In vivo 3-dimensional strain mapping of the optic nerve head following intraocular pressure lowering by trabeculectomy","volume":"123","author":"Girard","year":"2016","journal-title":"Ophthalmology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"20130459","DOI":"10.1098\/rsif.2013.0459","article-title":"In vivo optic nerve head biomechanics: performance testing of a three-dimensional tracking algorithm","volume":"10","author":"Girard","year":"2013","journal-title":"J R Soc Interface"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1002\/jbm.a.34858","article-title":"Elastic properties of human posterior eye","volume":"102","author":"Chen","year":"2014","journal-title":"J Biomed Mater Res A"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1097\/00006982-200412000-00021","article-title":"Biomechanical characteristics of retina","volume":"24","author":"Wollensak","year":"2004","journal-title":"Retina"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.exer.2014.02.020","article-title":"Mechanical properties of murine and porcine ocular tissues in compression","volume":"121","author":"Worthington","year":"2014","journal-title":"Exp Eye Res"},{"key":"bib31","first-page":"287","article-title":"A method to determine the mechanical properties of the retina based on an experiment in vivo","volume":"26","author":"Qian","year":"2015","journal-title":"Biomed Mater Eng"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"4378","DOI":"10.1167\/iovs.04-0133","article-title":"Finite element modeling of optic nerve head biomechanics","volume":"45","author":"Sigal","year":"2004","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib33","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1076\/ceyr.23.3.215.5460","article-title":"Use of a mathematical model to estimate stress and strain during elevated pressure induced lamina cribrosa deformation","volume":"23","author":"Edwards","year":"2001","journal-title":"Curr Eye Res"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3109\/09286589609080113","article-title":"Open-angle glaucoma and ocular hypertension: the Long Island Glaucoma Case-Control Study","volume":"3","author":"Leske","year":"1996","journal-title":"Ophthalmic Epidemiol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1161\/HYPERTENSIONAHA.114.03617","article-title":"Aging, arterial stiffness, and hypertension","volume":"65","author":"Sun","year":"2015","journal-title":"Hypertension."},{"key":"bib36","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1167\/iovs.04-0114","article-title":"Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes","volume":"46","author":"Downs","year":"2005","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"bib23","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4614-1824-5","volume-title":"The Virtual Fields Method: Extracting Constitutive Mechanical Parameters from Full-Field Deformation Measurements","author":"Pierron","year":"2012"},{"key":"bib27","volume-title":"Differential Evolution: A Practical Approach to Global Optimization","author":"Price","year":"2006"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2763330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:16Z","timestamp":1791927076000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2763330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,18]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3,9]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.61.3.27","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3,18]]}}}