{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:05Z","timestamp":1791928745563,"version":"4.3.4"},"reference-count":79,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2020,3,31]]},"DOI":"10.1167\/iovs.61.3.42","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T20:31:06Z","timestamp":1585600266000},"page":"42","source":"Crossref","is-referenced-by-count":60,"title":["IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model"],"prefix":"10.1167","volume":"61","author":[{"given":"Se Hyun","family":"Choi","sequence":"first","affiliation":[{"name":"Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea"},{"name":"Department of Ophthalmology, Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Won","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Institute of Natural Science, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin, Republic of Korea"},{"name":"Department of Biomedical Science and Technology, Kyung Hee Medical Science Research Institute, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Suk","family":"Ryu","sequence":"additional","affiliation":[{"name":"Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Institute of Natural Science, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin-Hyeog","family":"Im","sequence":"additional","affiliation":[{"name":"Division of Integrative Biosciences and Biotechnology, Department of Life Science, Pohang University of Science and Technology, Pohang, Republic of Korea"},{"name":"Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Pyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Institute of Natural Science, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin, Republic of Korea"},{"name":"Department of Biomedical Science and Technology, Kyung Hee Medical Science Research Institute, Kyung Hee University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mee Kum","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea"},{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1126\/science.1124234","article-title":"Metagenomic analysis of the human distal gut microbiome","volume":"312","author":"Gill","year":"2006","journal-title":"Science"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1101\/gr.096651.109","article-title":"The NIH Human Microbiome Project","volume":"19","author":"Group","year":"2009","journal-title":"Genome Res"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/535047a","article-title":"Intestinal microbiota in health and disease","volume":"535","author":"Kahrstrom","year":"2016","journal-title":"Nature"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nature18848","article-title":"The microbiota in adaptive immune homeostasis and disease","volume":"535","author":"Honda","year":"2016","journal-title":"Nature"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nature18847","article-title":"The microbiome and innate immunity","volume":"535","author":"Thaiss","year":"2016","journal-title":"Nature"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"2532314","DOI":"10.1155\/2018\/2532314","article-title":"Innate and adaptive cell populations driving inflammation in dry eye disease","volume":"2018","author":"Reyes","year":"2018","journal-title":"Mediators Inflamm"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/odi.2016.22.issue-8","article-title":"The microbiome-systemic diseases connection","volume":"22","author":"van der Meulen","year":"2016","journal-title":"Oral Dis"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/dna.2016.3432","article-title":"Regulation of autoimmunity by the microbiome","volume":"35","author":"Zarate-Blades","year":"2016","journal-title":"DNA Cell Biol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1080\/1744666X.2017.1288098","article-title":"Commensal microbiota as a potential trigger of autoimmune uveitis","volume":"13","author":"Horai","year":"2017","journal-title":"Expert Rev Clin Immunol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2014.02.004","article-title":"T cell epitope mimicry between Sjogren's syndrome Antigen A (SSA)\/Ro60 and oral, gut, skin and vaginal bacteria","volume":"152","author":"Szymula","year":"2014","journal-title":"Clin Immunol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"23561","DOI":"10.1038\/srep23561","article-title":"Altered mucosal microbiome diversity and disease severity in Sjogren syndrome","volume":"6","author":"de Paiva","year":"2016","journal-title":"Sci Rep"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s12088-018-0746-9","article-title":"Dysbiosis in the gut bacterial microbiome of patients with uveitis, an inflammatory disease of the eye","volume":"58","author":"Kalyana Chakravarthy","year":"2018","journal-title":"Indian J Microbiol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/ICU.0000000000000465","article-title":"The role of the intestinal microbiome in ocular inflammatory disease","volume":"29","author":"Lin","year":"2018","journal-title":"Curr Opin Ophthalmol"},{"issue":"suppl","key":"bib14","doi-asserted-by":"publisher","first-page":"S103","DOI":"10.3177\/jnsv.61.S103","article-title":"Probiotics as an immune modulator","volume":"61","author":"Kang","year":"2015","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4103\/2277-9175.192625","article-title":"Probiotics: a new era of biotherapy","volume":"6","author":"Alok","year":"2017","journal-title":"Adv Biomed Res"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"e9166","DOI":"10.1097\/MD.0000000000009166","article-title":"Effect of probiotics on lipid profiles and blood pressure in patients with type 2 diabetes: a meta-analysis of RCTs","volume":"96","author":"He","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/pr.2017.218","article-title":"Effects of probiotics on experimental necrotizing enterocolitis: a systematic review and meta-analysis","volume":"83","author":"Athalye-Jape","year":"2018","journal-title":"Pediatr Res"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/apt.2017.46.issue-4","article-title":"Systematic review with meta-analysis: the efficacy of probiotics in inflammatory bowel disease","volume":"46","author":"Derwa","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"580","DOI":"10.7205\/MILMED-D-13-00546","article-title":"Comparative probiotic strain efficacy in the prevention of eczema in infants and children: a systematic review and meta-analysis","volume":"179","author":"Mansfield","year":"2014","journal-title":"Mil Med"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s10787-017-0436-y","article-title":"The efficacy of probiotic supplementation in rheumatoid arthritis: a meta-analysis of randomized, controlled trials","volume":"26","author":"Aqaeinezhad Rudbane","year":"2018","journal-title":"Inflammopharmacology"},{"key":"bib21","first-page":"e181","article-title":"The mixture of bifidobacterium associated with fructo-oligosaccharides reduces the damage of the ocular surface","volume":"168","author":"Chisari","year":"2017","journal-title":"Clin Ter"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.clim.2013.01.001","article-title":"Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response","volume":"146","author":"Kwon","year":"2013","journal-title":"Clin Immunol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"e52119","DOI":"10.1371\/journal.pone.0052119","article-title":"Prophylactic effect of probiotics on the development of experimental autoimmune myasthenia gravis","volume":"7","author":"Chae","year":"2012","journal-title":"PLoS One"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.intimp.2015.04.021","article-title":"The probiotic mixture IRT5 ameliorates age-dependent colitis in rats","volume":"26","author":"Jeong","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"E1166","DOI":"10.3390\/nu9111166","article-title":"Clinical effect of IRT-5 probiotics on immune modulation of autoimmunity or alloimmunity in the eye","volume":"9","author":"Kim","year":"2017","journal-title":"Nutrients"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"eaat6975","DOI":"10.1126\/sciimmunol.aat6975","article-title":"Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3(+) regulatory T cells","volume":"3","author":"Verma","year":"2018","journal-title":"Sci Immunol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.carbpol.2019.05.006","article-title":"Bifidobacterium bifidum presents on the cell surface a complex mixture of glucans and galactans with different immunological properties","volume":"218","author":"Speciale","year":"2019","journal-title":"Carbohydr Polym"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"13363","DOI":"10.1038\/s41598-017-13817-y","article-title":"Proteomic analysis of human lacrimal and tear fluid in dry eye disease","volume":"7","author":"Jung","year":"2017","journal-title":"Sci Rep"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1136\/bjophthalmol-2012-302402","article-title":"Influence of single-fraction Gamma-Knife radiosurgery on ocular surface and tear function in choroidal melanoma patients","volume":"97","author":"Horwath-Winter","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wisniewski","year":"2009","journal-title":"Nat Methods"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1471-2105-13-31","article-title":"PANDAseq: paired-end assembler for illumina sequences","volume":"13","author":"Masella","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"e1002195","DOI":"10.1371\/journal.pcbi.1002195","article-title":"Accelerated Profile HMM Searches","volume":"7","author":"Eddy","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"e0181463","DOI":"10.1371\/journal.pone.0181463","article-title":"DUDE-Seq: fast, flexible, and robust denoising for targeted amplicon sequencing","volume":"12","author":"Lee","year":"2017","journal-title":"PLoS One"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"Edgar","year":"2010","journal-title":"Bioinformatics"},{"key":"bib36","first-page":"11","article-title":"Optimal alignments in linear space","volume":"4","author":"Myers","year":"1988","journal-title":"Comput Appl Biosci"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","article-title":"UCHIME improves sensitivity and speed of chimera detection","volume":"27","author":"Edgar","year":"2011","journal-title":"Bioinformatics"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3164\/jcbn.15-148","article-title":"Vitamin A deficiency impacts the structural segregation of gut microbiota in children with persistent diarrhea","volume":"59","author":"Lv","year":"2016","journal-title":"J Clin Biochem Nutr"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1038\/mi.2016.119","article-title":"Lacrimal gland-derived IL-22 regulates IL-17-mediated ocular mucosal inflammation","volume":"10","author":"Ji","year":"2017","journal-title":"Mucosal Immunol"},{"key":"bib40","doi-asserted-by":"crossref","first-page":"7542929","DOI":"10.1155\/2016\/7542929","article-title":"Review: the lacrimal gland and its role in dry eye","volume":"2016","author":"Conrady","year":"2016","journal-title":"J Ophthalmol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s00296-014-3152-6","article-title":"Identification of potential genomic biomarkers for Sjogren's syndrome using data pooling of gene expression microarrays","volume":"35","author":"Khuder","year":"2015","journal-title":"Rheumatol Int"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1002\/art.v66.3","article-title":"Genome-wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjogren's syndrome","volume":"66","author":"Altorok","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"18855","DOI":"10.1038\/srep18855","article-title":"Network-assisted analysis of primary Sjogren's syndrome GWAS data in Han Chinese","volume":"5","author":"Fang","year":"2015","journal-title":"Sci Rep"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.exer.2008.10.006","article-title":"Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjogren's syndrome (SJS)-like disease of the C57BL\/6.NOD-Aec1Aec2 mouse","volume":"88","author":"Nguyen","year":"2009","journal-title":"Exp Eye Res"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1053\/sarh.2002.32557","article-title":"TAP, HLA-DQB1, and HLA-DRB1 polymorphism in Colombian patients with primary Sjogren's syndrome","volume":"31","author":"Anaya","year":"2002","journal-title":"Semin Arthritis Rheum"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/00002281-199909000-00007","article-title":"Current issues in the diagnosis and treatment of Sjogren's syndrome","volume":"11","author":"Fox","year":"1999","journal-title":"Curr Opin Rheumatol"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.coi.2012.11.004","article-title":"The immunoproteasome in antigen processing and other immunological functions","volume":"25","author":"Basler","year":"2013","journal-title":"Curr Opin Immunol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.4049\/jimmunol.165.6.3073","article-title":"Thymic selection generates T cells expressing self-reactive TCRs in the absence of CD45","volume":"165","author":"Trop","year":"2000","journal-title":"J Immunol"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/s00011-017-1047-1","article-title":"Genetic association between TAP1 and TAP2 polymorphisms and ankylosing spondylitis: a systematic review and meta-analysis","volume":"66","author":"Qian","year":"2017","journal-title":"Inflamm Res"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"e0183678","DOI":"10.1371\/journal.pone.0183678","article-title":"Effects of subconjunctival administration of anti-high mobility group box 1 on dry eye in a mouse model of Sjogren's syndrome","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS One"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"e11531","DOI":"10.1097\/MD.0000000000011531","article-title":"Association of serum\/plasma high mobility group box 1 with autoimmune diseases: a systematic review and meta-analysis","volume":"97","author":"Zhu","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/acr.v70.6","article-title":"Association of high mobility group box chromosomal protein 1 and receptor for advanced glycation end products serum concentrations with extraglandular involvement and disease activity in Sjogren's syndrome","volume":"70","author":"Kanne","year":"2018","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1002\/(ISSN)1529-0131","article-title":"Increased extracellular levels of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in minor salivary glands of patients with Sjogren's syndrome","volume":"54","author":"Ek","year":"2006","journal-title":"Arthritis Rheum"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3109\/03009742.2011.633099","article-title":"Increased serum levels of high-mobility group box 1 (HMGB1) in primary Sjogren's syndrome","volume":"41","author":"Dupire","year":"2012","journal-title":"Scand J Rheumatol"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"320906","DOI":"10.1155\/2014\/320906","article-title":"Purinergic receptors in ocular inflammation","volume":"2014","author":"Guzman-Aranguez","year":"2014","journal-title":"Mediators Inflamm"},{"key":"bib57","first-page":"255","article-title":"The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases","volume":"3","author":"Wang","year":"2006","journal-title":"Cell Mol Immunol"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3920\/BM2011.0032","article-title":"A comprehensive post-market review of studies on a probiotic product containing Lactobacillus helveticus R0052 and Lactobacillus rhamnosus R0011","volume":"2","author":"Foster","year":"2011","journal-title":"Benef Microbes"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1111\/jam.2006.101.issue-3","article-title":"In vitro antibacterial activity of Lactobacillus helveticus strain KS300 against diarrhoeagenic, uropathogenic and vaginosis-associated bacteria","volume":"101","author":"Atassi","year":"2006","journal-title":"J Appl Microbiol"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/09540100220137682","article-title":"Immunostimulatory actions of lactobacilli: mitogenic induction of antibody production and spleen cell proliferation by Lactobacillus delbrueckii subsp. bulgaricus and Lactobacillus acidophilus.","volume":"14","author":"Easo","year":"2002","journal-title":"Food Agricult Immunol"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"466","DOI":"10.4315\/0362-028X-66.3.466","article-title":"Interactions of lactic acid bacteria with human intestinal epithelial cells: effects on cytokine production","volume":"66","author":"Wallace","year":"2003","journal-title":"J Food Protection"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s12866-015-0525-2","article-title":"Probiotic and anti-inflammatory attributes of an isolate Lactobacillus helveticus NS8 from Mongolian fermented koumiss","volume":"15","author":"Rong","year":"2015","journal-title":"BMC Microbiol"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1111\/jgh.2019.34.issue-7","article-title":"Single probiotic supplement suppresses colitis-associated colorectal tumorigenesis by modulating inflammatory development and microbial homeostasis","volume":"34","author":"Rong","year":"2019","journal-title":"J Gastroenterol Hepatol"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1046\/j.1365-2222.2000.00948.x","article-title":"Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG","volume":"30","author":"Pessi","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1016\/j.cell.2018.08.047","article-title":"Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT","volume":"174","author":"Suez","year":"2018","journal-title":"Cell"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1101\/gr.107987.110","article-title":"Reshaping the gut microbiome with bacterial transplantation and antibiotic intake","volume":"20","author":"Manichanh","year":"2010","journal-title":"Genome Res"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"5811","DOI":"10.1128\/AAC.00789-12","article-title":"High-throughput sequencing reveals the incomplete, short-term recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin","volume":"56","author":"Fouhy","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"279","DOI":"10.4161\/gmic.1.4.12614","article-title":"Antibiotic administration alters the community structure of the gastrointestinal micobiota","volume":"1","author":"Robinson","year":"2010","journal-title":"Gut Microbes"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"e280","DOI":"10.1371\/journal.pbio.0060280","article-title":"The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing","volume":"6","author":"Dethlefsen","year":"2008","journal-title":"PLoS Biol"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.chom.2015.04.006","article-title":"Antibiotics, pediatric dysbiosis, and disease","volume":"17","author":"Vangay","year":"2015","journal-title":"Cell Host Microbe"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3389\/fimmu.2014.00318","article-title":"Blowing on embers: commensal microbiota and our immune system","volume":"5","author":"Spasova","year":"2014","journal-title":"Front Immunol"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.cell.2018.08.041","article-title":"Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features","volume":"174","author":"Zmora","year":"2018","journal-title":"Cell"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1089\/jir.2013.0046","article-title":"Microbial activation of gut dendritic cells and the control of mucosal immunity","volume":"33","author":"Owen","year":"2013","journal-title":"J Interferon Cytokine Res"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/imm.12933","article-title":"Impacts of microbiome metabolites on immune regulation and autoimmunity","volume":"154","author":"Haase","year":"2018","journal-title":"Immunology"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1099\/00207713-42-1-166","article-title":"How close is close: 16S rRNA sequence identity may not be sufficient to guarantee species identity","volume":"42","author":"Fox","year":"1992","journal-title":"Int J Syst Bacteriol"},{"issue":"4","key":"bib76","doi-asserted-by":"publisher","first-page":"fix029","DOI":"10.1093\/femsec\/fix029","article-title":"Reconciliation between operational taxonomic units and species boundaries","volume":"93","author":"Mysara","year":"2017","journal-title":"FEMS Microbiol Ecol"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.2353\/ajpath.2007.070388","article-title":"Autoimmune dacryoadenitis of NOD\/LtJ mice and its subsequent effects on tear protein composition","volume":"171","author":"Doyle","year":"2007","journal-title":"Am J Pathol"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/s41564-018-0143-5","article-title":"Richness and ecosystem development across faecal snapshots of the gut microbiota","volume":"3","author":"Falony","year":"2018","journal-title":"Nat Microbiol"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"4065","DOI":"10.1038\/s41598-018-21986-7","article-title":"The influence of caging, bedding, and diet on the composition of the microbiota in different regions of the mouse gut","volume":"8","author":"Ericsson","year":"2018","journal-title":"Sci Rep"},{"key":"bib56","article-title":"Peroxisomes","volume-title":"Molecular Biology of the Cell","author":"Alberts","year":"2002"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2763549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:19Z","timestamp":1791927079000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2763549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,31]]},"references-count":79,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3,9]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.61.3.42","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3,31]]}}}