{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:05Z","timestamp":1791928745740,"version":"4.3.4"},"reference-count":41,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2020,3,9]]},"DOI":"10.1167\/iovs.61.3.5","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T10:30:48Z","timestamp":1583749848000},"page":"5","source":"Crossref","is-referenced-by-count":22,"title":["Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa"],"prefix":"10.1167","volume":"61","author":[{"given":"Haiyan","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia,United States"},{"name":"James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, Georgia,United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia,United States"},{"name":"James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, Georgia,United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Saul","sequence":"additional","affiliation":[{"name":"James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, Georgia,United States"},{"name":"Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, Georgia,United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia B.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia,United States"},{"name":"James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, Georgia,United States"},{"name":"Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, Georgia,United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/tvst.7.4.6","article-title":"Inherited retinal degenerations: current landscape and knowledge gaps","volume":"7","author":"Duncan","year":"2018","journal-title":"Transl Vis Sci Technol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/cge.2013.84.issue-2","article-title":"Genes and mutations causing retinitis pigmentosa","volume":"84","author":"Daiger","year":"2013","journal-title":"Clin Genet"},{"issue":"3","key":"bib3","article-title":"Progesterone, lipoic acid, and sulforaphane as promising antioxidants for retinal diseases: a review","volume":"8","author":"Hern\u00e1ndez-Rabaza","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.10.002","article-title":"The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy","volume":"62","author":"Athanasiou","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.preteyeres.2017.08.004","article-title":"The mechanism of cone cell death in retinitis pigmentosa","volume":"62","author":"Campochiaro","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-3-319-50174-1","article-title":"Sigma-1 receptors and neurodegenerative diseases: towards a hypothesis of sigma-1 receptors as amplifiers of neurodegeneration and neuroprotection","volume":"964","author":"Nguyen","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1517\/14728222.12.1.45","article-title":"An update on the development of drugs for neuropsychiatric disorders: focusing on the sigma 1 receptor ligand","volume":"12","author":"Hayashi","year":"2008","journal-title":"Expert Opin Ther Targets"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/S0014-2999(98)00398-7","article-title":"Highly selective sigma receptor ligands elevate inositol 1,4,5-trisphosphate production in rat cardiac myocytes","volume":"353","author":"Novakova","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"4993","DOI":"10.1167\/iovs.08-1867","article-title":"Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction","volume":"49","author":"Tchedre","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"28198","DOI":"10.1074\/jbc.M802099200","article-title":"Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells","volume":"283","author":"Wu","year":"2008","journal-title":"J Biol Chem"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/emm.2005.44","article-title":"Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress","volume":"37","author":"Whang","year":"2005","journal-title":"Exp Mol Med"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"5576","DOI":"10.1167\/iovs.06-0608","article-title":"Expression, subcellular localization, and regulation of sigma receptor in retinal M\u00fcller cells","volume":"47","author":"Jiang","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","article-title":"Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival","volume":"131","author":"Hayashi","year":"2007","journal-title":"Cell"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.expneurol.2009.10.019","article-title":"Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase\/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons","volume":"221","author":"Yang","year":"2010","journal-title":"Exp Neurol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ejphar.2012.01.030","article-title":"The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements","volume":"682","author":"Pal","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.freeradbiomed.2015.04.009","article-title":"Sigma 1 receptor regulates the oxidative stress response in primary retinal M\u00fcller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger","volume":"86","author":"Wang","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.preteyeres.2018.07.003","article-title":"Sigma 1 Receptor as a therapeutic target in retinal disease","volume":"67","author":"Smith","year":"2018","journal-title":"Prog Retinal Eye Res"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"E3764","DOI":"10.1073\/pnas.1521749113","article-title":"Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration","volume":"113","author":"Wang","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","article-title":"The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis","volume":"98","author":"Yamamoto","year":"2018","journal-title":"Physiol Rev"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.redox.2018.05.002","article-title":"Antioxidant response elements: discovery, classes, regulation and potential applications","volume":"17","author":"Raghunath","year":"2018","journal-title":"Redox Biol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.freeradbiomed.2019.02.001","article-title":"The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2","volume":"134","author":"Wang","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1093\/brain\/awq386","article-title":"Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway","volume":"134","author":"Linker","year":"2011","journal-title":"Brain"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"6332","DOI":"10.1523\/JNEUROSCI.0426-16.2016","article-title":"Distinct Nrf2 signaling mechanisms of fumaric acid esters and their role in neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced experimental Parkinson's-like disease","volume":"36","author":"Ahuja","year":"2016","journal-title":"J Neurosci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1186\/s12974-015-0452-z","article-title":"Monomethyl fumarate promotes Nrf2-dependent neuroprotection in retinal ischemia-reperfusion","volume":"12","author":"Cho","year":"2015","journal-title":"J Neuroinflammation"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.bcp.2017.11.005","article-title":"Differential effects of the Nrf2 activators tBHQ and CDDO-Im on the early events of T cell activation","volume":"147","author":"Zagorski","year":"2018","journal-title":"Biochem Pharmacol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1167\/iovs.03-1114","article-title":"Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice","volume":"45","author":"Tan","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"4974","DOI":"10.1167\/iovs.13-12289","article-title":"Survey of common eye diseases in laboratory mouse strains","volume":"54","author":"Chang","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"4397","DOI":"10.1167\/iovs.19-27709","article-title":"Activation of Sigma 1 Receptor extends survival of cones and improves visual acuity in a murine model of retinitis pigmentosa","volume":"60","author":"Wang","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"101199","DOI":"10.1016\/j.redox.2019.101199","article-title":"Hyperhomocysteinemia-induced death of retinal ganglion cells: the role of M\u00fcller glial cells and NRF2","volume":"24","author":"Navneet","year":"2019","journal-title":"Redox Biol"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"4611","DOI":"10.1167\/iovs.04-0541","article-title":"Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system","volume":"45","author":"Prusky","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/vision1010003","article-title":"Multifocal Electroretinography in the presence of temporal and spatial correlations and eye movements","volume":"1","author":"Saul","year":"2016","journal-title":"Vision"},{"key":"bib33","first-page":"9620876","article-title":"Simultaneous fluorescein angiography and spectral domain optical coherence tomography correlate retinal thickness changes to vascular abnormalities in an in vivo mouse model of retinopathy of prematurity","author":"Mezu-Ndubuisi","year":"2017","journal-title":"J Ophthalmol"},{"issue":"2","key":"bib34","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/(ISSN)1096-9861","article-title":"Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study","volume":"500","author":"Gargini","year":"2007","journal-title":"J Comp Neurol"},{"issue":"11","key":"bib35","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.1167\/iovs.17-21947","article-title":"Absence of sigma 1 receptor accelerates photoreceptor cell death in a murine model of retinitis pigmentosa","volume":"58","author":"Wang","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.exer.2016.12.001","article-title":"Nrf2 protects photoreceptor cells from photo-oxidative stress induced by blue light","volume":"154","author":"Chen","year":"2017","journal-title":"Exp Eye Res"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1167\/iovs.18-24398","article-title":"Monomethyl fumarate protects the retina from light-induced retinopathy","volume":"60","author":"Jiang","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1096\/fsb2.v15.7","article-title":"Modeling of risk factors for the degeneration of retinal ganglion cells after ischemia\/reperfusion in rats: effects of age, caloric restriction, diabetes, pigmentation, and glaucoma","volume":"15","author":"Kawai","year":"2001","journal-title":"FASEB J"},{"issue":"1","key":"bib39","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12699","article-title":"Ketone body 3-hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina","volume":"17","author":"Izuta","year":"2018","journal-title":"Aging Cell"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1089\/ars.2016.6638","article-title":"Oral monomethyl fumarate therapy ameliorates retinopathy in a humanized mouse model of sickle cell disease","volume":"25","author":"Promsote","year":"2016","journal-title":"Antioxid Redox Signal"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"10551","DOI":"10.1074\/jbc.M110.209759","article-title":"Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations","volume":"286","author":"Sakami","year":"2011","journal-title":"J Biol Chem"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2762923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:20Z","timestamp":1791927080000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2762923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,9]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3,9]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.61.3.5","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3,9]]}}}