{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:06Z","timestamp":1791928746752,"version":"4.3.4"},"reference-count":29,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2020,3,9]]},"DOI":"10.1167\/iovs.61.3.8","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T10:30:45Z","timestamp":1583749845000},"page":"8","source":"Crossref","is-referenced-by-count":18,"title":["The Potential Inhibitory Effects of miR-19b on Ocular Inflammation are Mediated Upstream of the JAK\/STAT Pathway in a Murine Model of Allergic Conjunctivitis"],"prefix":"10.1167","volume":"61","author":[{"given":"Chen","family":"Guo","sequence":"first","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Hao","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China"},{"name":"Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China"},{"name":"Nankai University Affiliated Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China"},{"name":"Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China"},{"name":"Nankai University Affiliated Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Sui","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghan","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Ying","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China"},{"name":"Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China"},{"name":"Nankai University Affiliated Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Han","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China"},{"name":"Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China"},{"name":"Nankai University Affiliated Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China"},{"name":"Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China"},{"name":"Nankai University Affiliated Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China"},{"name":"Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin, China"},{"name":"Nankai University Affiliated Eye Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jaci.2004.10.042","article-title":"Allergic conjunctivitis: update on pathophysiology and prospects for future treatment","volume":"115","author":"Ono","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.ebiom.2018.01.024","article-title":"Allergic conjunctivitis-induced retinal inflammation promotes myopia progression","volume":"28","author":"Wei","year":"2018","journal-title":"EBioMedicine"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1590\/s1806-37562016000000255","article-title":"Epidemiological trends of allergic diseases in adolescents","volume":"43","author":"Fernandes","year":"2017","journal-title":"J Bras Pneumol"},{"key":"bib4","first-page":"200","article-title":"Allergic eye disease","volume":"2","author":"Patel","year":"2017","journal-title":"BMJ"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1084\/jem.20150402","article-title":"TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand","volume":"214","author":"Pattarini","year":"2017","journal-title":"J Exp Med"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/ni.2541","article-title":"The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses","volume":"14","author":"Bell","year":"2013","journal-title":"Nat Immunol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"19455","DOI":"10.1073\/pnas.1008271107","article-title":"Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7\u2013induced signaling","volume":"107","author":"Rochman","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cytogfr.2016.05.001","article-title":"STAT3 signaling in immunity","volume":"31","author":"Hillmer","year":"2016","journal-title":"Cytokine Growth Factor Rev"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1515\/bc.2010.029","article-title":"Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function","volume":"391","author":"Wohlmann","year":"2010","journal-title":"Biol Chem"},{"key":"bib10","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4049\/jimmunol.162.2.677","article-title":"Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism","volume":"162","author":"Levin","year":"1999","journal-title":"J Immunol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s11010-017-2963-7","article-title":"Inhibition of JAK\/STAT pathway restrains TSLP-activated dendritic cells mediated inflammatory T helper type 2 cell response in allergic rhinitis","volume":"430","author":"Shi","year":"2017","journal-title":"Mol Cell Biochem"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.immuni.2010.12.013","article-title":"The transcription factor STAT3 is required for T helper 2 cell development","volume":"34","author":"Stritesky","year":"2011","journal-title":"Immunity"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jneuroim.2015.08.013","article-title":"Aberrant decrease of microRNA19b regulates TSLP expression and contributes to Th17 cells development in myasthenia gravis related thymomas","volume":"288","author":"Wang","year":"2015","journal-title":"J Neuroimmunol"},{"key":"bib14","doi-asserted-by":"crossref","first-page":"47533","DOI":"10.18632\/oncotarget.17258","article-title":"Effects of microRNA-19b on airway remodeling, airway inflammation and degree of oxidative stress by targeting TSLP through the Stat3 signaling pathway in a mouse model of asthma","volume":"8","author":"Ye","year":"2017","journal-title":"Oncotarget"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/cbf.v34.6","article-title":"Allergen-specific immune response suppresses interleukin 10 expression in B cells via increasing micro-RNA-17-92 cluster","volume":"34","author":"Geng","year":"2016","journal-title":"Cell Biochem Funct"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1038\/ni.3026","article-title":"A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production","volume":"15","author":"Simpson","year":"2014","journal-title":"Nat Immunol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.jaci.2014.12.1926","article-title":"Culture medium from TNF-alpha-stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms","volume":"136","author":"Su","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1006\/clin.1997.4507","article-title":"A novel murine model of allergic conjunctivitis","volume":"87","author":"Magone","year":"1998","journal-title":"Clin Immunol Immunopathol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1046\/j.1398-9995.2003.00326.x","article-title":"Animal models of allergic and inflammatory conjunctivitis","volume":"58","author":"Groneberg","year":"2003","journal-title":"Allergy"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/cei.2008.153.issue-s1","article-title":"Allergy and the eye","volume":"1","author":"Leonardi","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1038\/s41467-019-09530-1","article-title":"Therapeutic role of miR-19a\/19b in cardiac regeneration and protection from myocardial infarction","volume":"10","author":"Gao","year":"2019","journal-title":"Nat Commun"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"4780","DOI":"10.1128\/JVI.02586-15","article-title":"MicroRNA-19b-3p modulates Japanese encephalitis virus-mediated inflammation via targeting RNF11","volume":"90","author":"Ashraf","year":"2016","journal-title":"J Virol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"ra4","DOI":"10.1126\/scisignal.2000567","article-title":"Distinct signal codes generate dendritic cell functional plasticity","volume":"3","author":"Arima","year":"2010","journal-title":"Sci Signal"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"19455","DOI":"10.1073\/pnas.1008271107","article-title":"Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling","volume":"107","author":"Rochman","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1093\/carcin\/bgv017","article-title":"Aberrantly expressed Fra-1 by IL-6\/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial-mesenchymal transition","volume":"36","author":"Liu","year":"2015","journal-title":"Carcinogenesis"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/all.2018.73.issue-3","article-title":"Serine protease allergen favours Th2 responses via PAR-2 and STAT3 activation in murine model","volume":"73","author":"Agrawal","year":"2018","journal-title":"Allergy"},{"key":"bib27","first-page":"15","article-title":"Mast cell-derived exosomes promote Th2 cell differentiation via OX40L-OX40 ligation","volume":"3623898","author":"Li","year":"2016","journal-title":"J Immunol Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"164","DOI":"10.4049\/jimmunol.1003392","article-title":"High-affinity IgE receptors on dendritic cells exacerbate Th2-dependent inflammation","volume":"187","author":"Sallmann","year":"2011","journal-title":"J Immunol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/nri914","article-title":"Regulation of mast-cell and basophil function and survival by IgE","volume":"2","author":"Kawakami","year":"2002","journal-title":"Nat Rev Immunol"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2762926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:22Z","timestamp":1791927082000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2762926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,9]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3,9]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.61.3.8","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3,9]]}}}