{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:36Z","timestamp":1791928716904,"version":"4.3.4"},"reference-count":48,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"4","license":[{"start":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"DOI":"10.1167\/iovs.61.4.1","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T14:14:30Z","timestamp":1586441670000},"page":"1","source":"Crossref","is-referenced-by-count":7,"title":["Endothelial Yes-Associated Protein 1 Promotes Astrocyte Proliferation and Maturation via Cytoplasmic Leukemia Inhibitory Factor Secretion in Oxygen-Induced Retinopathy"],"prefix":"10.1167","volume":"61","author":[{"given":"Li-Qian-Yu","family":"Ai","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Lin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Mei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","published-online":{"date-parts":[[2020,4,9]]},"reference":[{"key":"bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2147\/EB.S94447","article-title":"Revisiting the mouse model of oxygen-induced retinopathy","volume":"8","author":"Kim","year":"2016","journal-title":"Eye Brain"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.preteyeres.2010.05.003","article-title":"Animal models of choroidal and retinal neovascularization","volume":"29","author":"Grossniklaus","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.ophtha.2014.07.050","article-title":"Pathophysiology and mechanisms of severe retinopathy of prematurity","volume":"122","author":"Hartnett","year":"2015","journal-title":"Ophthalmology"},{"key":"bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2147\/EB.S94449","article-title":"Anti-VEGF therapy in the management of retinopathy of prematurity: what we learn from representative animal models of oxygen-induced retinopathy","volume":"8","author":"Wang","year":"2016","journal-title":"Eye Brain"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s10633-009-9201-x","article-title":"Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy","volume":"120","author":"Kermorvant-Duchemin","year":"2010","journal-title":"Doc Ophthalmol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1038\/nprot.2009.187","article-title":"Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis","volume":"4","author":"Connor","year":"2009","journal-title":"Nat Protocol"},{"key":"bib7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/aos.12049","article-title":"The pathophysiology of retinopathy of prematurity: an update of previous and recent knowledge","volume":"92","author":"Giacomo","year":"2014","journal-title":"Acta Ophthalmol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1002\/glia.20680","article-title":"AT1 receptor inhibition prevents astrocyte degeneration and restores vascular growth in oxygen-induced retinopathy","volume":"56","author":"Downie","year":"2008","journal-title":"Glia"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.mcn.2013.06.001","article-title":"Hyperoxia causes reduced density of retinal astrocytes in the central avascular zone in the mouse model of oxygen-induced retinopathy","volume":"56","author":"Bucher","year":"2013","journal-title":"Mol Cell Neurosci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/glia.20900","article-title":"Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy","volume":"58","author":"Dorrell","year":"2010","journal-title":"Glia"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/jcp.26870","article-title":"YAP and TAZ, the conductors that orchestrate eye development, homeostasis, and disease","volume":"234","author":"Zhu","year":"2019","journal-title":"J Cell Physiol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"dev167106","DOI":"10.1242\/dev.167106","article-title":"Hippo signalling during development","volume":"146","author":"Davis","year":"2019","journal-title":"Development"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1152\/physrev.00005.2014","article-title":"The Biology of YAP\/TAZ: Hippo signaling and beyond","volume":"94","author":"Piccolo","year":"2014","journal-title":"Physiol Rev"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1172\/JCI93825","article-title":"YAP\/TAZ regulates sprouting angiogenesis and vascular barrier maturation","volume":"127","author":"Kim","year":"2017","journal-title":"J Clin Invest"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"10918","DOI":"10.1073\/pnas.1704030114","article-title":"YAP\/TAZ-CDC42 signaling regulates vascular tip cell migration","volume":"114","author":"Sakabe","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1073\/pnas.95.6.3178","article-title":"Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor","volume":"95","author":"Koblar","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1523\/JNEUROSCI.21-05-01538.2001","article-title":"Induction of astrocyte differentiation by endothelial cells","volume":"21","author":"Mi","year":"2001","journal-title":"J Neurosci"},{"key":"bib18","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1242\/dev.072330","article-title":"A role for endothelial cells in promoting the maturation of astrocytes through the apelin\/APJ system in mice","volume":"139","author":"Susumu","year":"2012","journal-title":"Development"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1046\/j.1469-7580.2002.00047_13.x","article-title":"Astrocyte\u2013endothelial interactions and blood\u2013brain barrier permeability","volume":"200","author":"Abbott","year":"2002","journal-title":"J Anat"},{"key":"bib21","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse","volume":"35","author":"Smith","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nature14483","article-title":"Cardiac lymphatics are heterogeneous in origin and respond to injury","volume":"522","author":"Klotz","year":"2015","journal-title":"Nature"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"e24419","DOI":"10.7554\/eLife.24419","article-title":"O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals","volume":"6","author":"Sawaguchi","year":"2017","journal-title":"Elife"},{"key":"bib24","first-page":"51","article-title":"Animal experiments in retrolental fibroplasia","volume":"58","author":"Ashton","year":"1954","journal-title":"Trans Am Acad Ophthal Otolaryngol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1002\/cne.22335","article-title":"Comparative study of Pax2 expression in glial cells in the retina and optic nerve of birds and mammals","volume":"518","author":"Stanke","year":"2010","journal-title":"J Comp Neurol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1002\/glia.20320","article-title":"Astrocyte heterogeneity revealed by expression of a GFAP-LacZ transgene","volume":"53","author":"Lee","year":"2006","journal-title":"Glia"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1242\/dev.118.2.539","article-title":"PDGF and its receptors in the developing rodent retina and optic nerve","volume":"118","author":"Mudhar","year":"1993","journal-title":"Development"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.neuron.2011.08.009","article-title":"Role of astrocytes in neurovascular coupling","volume":"71","author":"Petzold Gabor","year":"2011","journal-title":"Neuron"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"e48001","DOI":"10.1371\/journal.pone.0048001","article-title":"A functional requirement for astroglia in promoting blood vessel development in the early postnatal brain","volume":"7","author":"Ma","year":"2012","journal-title":"PLoS One"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2015.11.024","article-title":"The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP","volume":"90","author":"Kimura","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"983","DOI":"10.4103\/1673-5374.175063","article-title":"ROCK inhibition enhances neurite outgrowth in neural stem cells by upregulating YAP expression in vitro","volume":"11","author":"Jia","year":"2016","journal-title":"Neural Regen Res"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/332834a0","article-title":"Retinal astrocytes are immigrants from the optic nerve","volume":"332","author":"Watanabe","year":"1988","journal-title":"Nature"},{"key":"bib34","first-page":"3500","article-title":"Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion","volume":"43","author":"Dorrell","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/cne.902550104","article-title":"Relationship between astrocytes, ganglion cells and vasculature of the retina","volume":"255","author":"Stone","year":"1987","journal-title":"J Comp Neurol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s10456-007-9065-1","article-title":"Development of the retinal vasculature","volume":"10","author":"Fruttiger","year":"2007","journal-title":"Angiogenesis"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0165-3806(88)90119-8","article-title":"The development of astrocytes in the cat retina: evidence of migration from the optic nerve","volume":"44","author":"Ling","year":"1988","journal-title":"Brain Res Dev Brain Res"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s13041-016-0243-1","article-title":"Microvascular endothelial cells-derived microvesicles imply in ischemic stroke by modulating astrocyte and blood brain barrier function and cerebral blood flow","volume":"9","author":"Pan","year":"2016","journal-title":"Mol Brain"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1242\/dev.01732","article-title":"Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes","volume":"132","author":"West","year":"2005","journal-title":"Development"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"17608","DOI":"10.1038\/s41598-017-17962-2","article-title":"Retinal angiogenesis regulates astrocytic differentiation in neonatal mouse retinas by oxygen dependent mechanisms","volume":"7","author":"Duan","year":"2017","journal-title":"Sci Rep"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"6943","DOI":"10.1038\/ncomms7943","article-title":"Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2","volume":"6","author":"Choi","year":"2015","journal-title":"Nat Commun"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/jnr.10090","article-title":"Leukemia inhibitory factor mRNA expression is upregulated in macrophages and olfactory receptor neurons after target ablation","volume":"67","author":"Getchell","year":"2002","journal-title":"J Neurosci Res"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.pharmthera.2017.08.008","article-title":"The role of the leukemia inhibitory factor receptor in neuroprotective signaling","volume":"183","author":"Davis","year":"2018","journal-title":"Pharmacol Ther"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jneuroim.2008.07.015","article-title":"Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages","volume":"204","author":"Hendriks","year":"2008","journal-title":"J Neuroimmunol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1242\/jcs.075796","article-title":"Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF","volume":"124","author":"Tamm","year":"2011","journal-title":"J Cell Sci"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.1038\/s41467-019-11044-9","article-title":"Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer","volume":"10","author":"Wang","year":"2019","journal-title":"Nat Commun"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1167\/iovs.10-5176","article-title":"The mouse retina as an angiogenesis model","volume":"51","author":"Stahl","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1167\/iovs.02-1122","article-title":"Role of hypoxia during normal retinal vessel development and in experimental retinopathy of prematurity","volume":"44","author":"Zhang","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","first-page":"485","article-title":"Leukemia inhibitory factor inhibits the proliferation of primary rat astrocytes induced by oxygen-glucose deprivation","volume-title":"Acta Neurobiol Exp (Wars).","author":"Fan","year":"2013"}],"container-title":["Investigative Ophthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2764411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:13Z","timestamp":1791927073000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2764411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,9]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4,9]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.61.4.1","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4,9]]}}}