{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:58:58Z","timestamp":1791928738477,"version":"4.3.4"},"reference-count":48,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"5","license":[{"start":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T00:00:00Z","timestamp":1590192000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2020,5,23]]},"DOI":"10.1167\/iovs.61.5.42","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T17:01:49Z","timestamp":1590253309000},"page":"42","source":"Crossref","is-referenced-by-count":32,"title":["Inflammatory and Angiogenic Mediators in Amniotic Fluid Are Associated With the Development of Retinopathy of Prematurity in Preterm Infants"],"prefix":"10.1167","volume":"61","author":[{"given":"Se Joon","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subeen","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Mi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Hyon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyo Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S0140-6736(11)61577-8","article-title":"Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review","volume":"379","author":"Mwaniki","year":"2012","journal-title":"Lancet"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","article-title":"Retinopathy of prematurity","volume":"382","author":"Hellstrom","year":"2013","journal-title":"Lancet"},{"issue":"Suppl. 1","key":"bib3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/pr.2013.205","article-title":"Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010","volume":"74","author":"Blencowe","year":"2013","journal-title":"Pediatr Res"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1056\/NEJMra1208129","article-title":"Mechanisms and management of retinopathy of prematurity","volume":"367","author":"Hartnett","year":"2012","journal-title":"N Engl J Med"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"e607","DOI":"10.1542\/peds.2010-2240","article-title":"A clinical prediction model to stratify retinopathy of prematurity risk using postnatal weight gain","volume":"127","author":"Binenbaum","year":"2011","journal-title":"Pediatrics"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12974-017-0943-1","article-title":"Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies","volume":"14","author":"Rivera","year":"2017","journal-title":"J Neuroinflamm"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1203\/PDR.0b013e3181d01a36","article-title":"Perinatal systemic inflammatory response syndrome and retinopathy of prematurity","volume":"67","author":"Sood","year":"2010","journal-title":"Pediatr Res"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"6419","DOI":"10.1167\/iovs.17-21931","article-title":"Systemic inflammation-associated proteins and retinopathy of prematurity in infants born before the 28th week of gestation","volume":"58","author":"Holm","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"5076","DOI":"10.1167\/iovs.16-19653","article-title":"The relationship of novel plasma proteins in the early neonatal period with retinopathy of prematurity","volume":"57","author":"Lynch","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"7052","DOI":"10.1167\/iovs.11-7380","article-title":"Placenta microbiology and histology and the risk for severe retinopathy of prematurity","volume":"52","author":"Chen","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1167\/iovs.10-6279","article-title":"Assessment of the contribution of cytokine plasma levels to detect retinopathy of prematurity in very low birth weight infants","volume":"52","author":"Silveira","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ghir.2017.11.006","article-title":"Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity","volume":"39","author":"Hellgren","year":"2018","journal-title":"Growth Horm IGF Res"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"3813","DOI":"10.1167\/iovs.19-27258","article-title":"Immune and inflammatory proteins in cord blood as predictive biomarkers of retinopathy of prematurity in preterm infants","volume":"60","author":"Park","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/aji.2012.69.issue-2","article-title":"Endoglin in amniotic fluid as a risk factor for the subsequent development of bronchopulmonary dysplasia","volume":"69","author":"Kim","year":"2013","journal-title":"Am J Reprod Immunol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"4209359","DOI":"10.1155\/2018\/4209359","article-title":"Inflammatory and immune proteins in umbilical cord blood: association with hearing screening test failure in preterm neonates","volume":"2018","author":"Shim","year":"2018","journal-title":"Mediators Inflamm"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1055\/s-2006-956773","article-title":"The role of inflammation and infection in preterm birth","volume":"25","author":"Romero","year":"2007","journal-title":"Semin Reprod Med"},{"issue":"Suppl. 20","key":"bib17","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1046\/j.1471-0528.2003.00063.x","article-title":"Intrauterine infection and the development of cerebral palsy","volume":"110","author":"Yoon","year":"2003","journal-title":"BJOG"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1542\/peds.2012-2996","article-title":"Screening examination of premature infants for retinopathy of prematurity","volume":"131","author":"Fierson","year":"2013","journal-title":"Pediatrics"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1542\/peds.2005-2749","article-title":"Screening examination of premature infants for retinopathy of prematurity","volume":"117","author":"Section on Ophthalmology American Academy of Pediatrics, American Academy of Ophthalmology, American Association for Pediatric Ophthalmology, Strabismus","year":"2006","journal-title":"Pediatrics"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1001\/archopht.121.12.1684","article-title":"Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial","volume":"121","author":"Early Treatment for Retinopathy of Prematurity Cooperative Group","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1001\/archophthalmol.2010.72","article-title":"Final visual acuity results in the early treatment for retinopathy of prematurity study","volume":"128","author":"Early Treatment for Retinopathy of Prematurity Cooperative Group","year":"2010","journal-title":"Arch Ophthalmol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"3434","DOI":"10.1167\/iovs.13-11837","article-title":"The relationship between cord blood cytokine levels and perinatal factors and retinopathy of prematurity: a gestational age-matched case-control study","volume":"54","author":"Woo","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/pr.2016.219","article-title":"Relation between amniotic fluid infection or cytokine levels and hearing screen failure in infants at 32 wk gestation or less","volume":"81","author":"Jung","year":"2017","journal-title":"Pediatr Res"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/infdis\/145.1.1","article-title":"Quantitative bacteriology of amniotic fluid from women with clinical intraamniotic infection at term","volume":"145","author":"Gibbs","year":"1982","journal-title":"J Infect Dis"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1177\/1933719111432869","article-title":"Noninvasive prediction of intra-amniotic infection and\/or inflammation in preterm premature rupture of membranes","volume":"19","author":"Park","year":"2012","journal-title":"Reprod Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.3346\/jkms.2013.28.8.1226","article-title":"Intra-amniotic infection\/inflammation as a risk factor for subsequent ruptured membranes after clinically indicated amniocentesis in preterm labor","volume":"28","author":"Lee","year":"2013","journal-title":"J Korean Med Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/aogs.2013.92.issue-5","article-title":"Predictive value of combined cervicovaginal cytokines and gestational age at sampling for intra-amniotic infection in preterm premature rupture of membranes","volume":"92","author":"Ryu","year":"2013","journal-title":"Acta Obstet Gynecol Scand"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1159\/000088424","article-title":"Effect of preeclampsia, magnesium sulfate prophylaxis, and maternal weight on labor induction: a retrospective analysis","volume":"61","author":"Park","year":"2006","journal-title":"Gynecol Obstet Invest"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.ophtha.2014.07.050","article-title":"Pathophysiology and mechanisms of severe retinopathy of prematurity","volume":"122","author":"Hartnett","year":"2015","journal-title":"Ophthalmology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/aogs.13293","article-title":"An overview of confounding. Part 2: how to identify it and special situations","volume":"97","author":"Howards","year":"2018","journal-title":"Acta Obstet Gynecol Scand"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"5312","DOI":"10.1167\/iovs.18-24914","article-title":"An iTRAQ-based quantitative proteomic analysis of plasma proteins in preterm newborns with retinopathy of prematurity","volume":"59","author":"Zasada","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"e351","DOI":"10.1016\/j.ajog.2017.05.029","article-title":"The relationship of the subtypes of preterm birth with retinopathy of prematurity","volume":"217","author":"Lynch","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.siny.2011.08.007","article-title":"Perinatal infection, inflammation, and retinopathy of prematurity","volume":"17","author":"Lee","year":"2012","journal-title":"Semin Fetal Neonatal Med"},{"key":"bib35","first-page":"2283","article-title":"Endoglin (CD105): a review of its role in angiogenesis and tumor diagnosis, progression and therapy","volume":"31","author":"Nassiri","year":"2011","journal-title":"Anticancer Res"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10456-016-9535-4","article-title":"The role of endoglin in post-ischemic revascularization","volume":"20","author":"Nunez-Gomez","year":"2017","journal-title":"Angiogenesis"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"dmm034397","DOI":"10.1242\/dmm.034397","article-title":"Soluble endoglin regulates expression of angiogenesis-related proteins and induction of arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia","volume":"11","author":"Gallardo-Vara","year":"2018","journal-title":"Dis Model Mech"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia","volume":"12","author":"Venkatesha","year":"2006","journal-title":"Nat Med"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3109\/02713683.2014.921312","article-title":"The angiogenic biomarker endocan is upregulated in proliferative diabetic retinopathy and correlates with vascular endothelial growth factor","volume":"40","author":"Abu El-Asrar","year":"2015","journal-title":"Curr Eye Res"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.yexcr.2005.11.015","article-title":"Antiangiogenesis in cancer therapy\u2014endostatin and its mechanisms of action","volume":"312","author":"Folkman","year":"2006","journal-title":"Exp Cell Res"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1097\/IAE.0b013e318285cd9e","article-title":"Intraocular growth factors and cytokines in patients with dry and neovascular age-related macular degeneration","volume":"33","author":"Muether","year":"2013","journal-title":"Retina"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1001\/archopht.120.8.1075","article-title":"Regulation of angiogenesis in diabetic retinopathy: possible balance between vascular endothelial growth factor and endostatin","volume":"120","author":"Noma","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1007\/s004670000362","article-title":"Effects of IGFBP-2 overexpression in vitro and in vivo","volume":"14","author":"Wolf","year":"2000","journal-title":"Pediatr Nephrol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1097\/00001703-200006000-00001","article-title":"Insulin-like growth factors in obstetrics","volume":"12","author":"Rutanen","year":"2000","journal-title":"Curr Opin Obstet Gynecol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/apa.2010.99.issue-4","article-title":"Serum levels of IGF1 are a useful predictor of retinopathy of prematurity","volume":"99","author":"Perez-Munuzuri","year":"2010","journal-title":"Acta Paediatr"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1203\/01.PDR.0000155950.67503.BC","article-title":"The role of maternal factors, postnatal nutrition, weight gain, and gender in regulation of serum IGF-I among preterm infants","volume":"57","author":"Engstrom","year":"2005","journal-title":"Pediatr Res"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.ophtha.2015.11.003","article-title":"Clinical models and algorithms for the prediction of retinopathy of prematurity: a report by the American Academy of Ophthalmology","volume":"123","author":"Hutchinson","year":"2016","journal-title":"Ophthalmology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.survophthal.2018.04.002","article-title":"Retinopathy of prematurity: a review of risk factors and their clinical significance","volume":"63","author":"Kim","year":"2018","journal-title":"Surv Ophthalmol"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2766241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:19Z","timestamp":1791927079000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2766241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,23]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5,11]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.61.5.42","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5,23]]}}}