{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:03Z","timestamp":1791928743349,"version":"4.3.4"},"reference-count":59,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2020,6,23]]},"DOI":"10.1167\/iovs.61.6.49","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T16:31:48Z","timestamp":1592929908000},"page":"49","source":"Crossref","is-referenced-by-count":41,"title":["Retinal Vascular Reactivity in Type 1 Diabetes Patients Without Retinopathy Using Optical Coherence Tomography Angiography"],"prefix":"10.1167","volume":"61","author":[{"given":"David Cordeiro","family":"Sousa","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte,Lisboa, Portugal"},{"name":"Vision Sciences Study Center, CECV, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Leal","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte,Lisboa, Portugal"},{"name":"Vision Sciences Study Center, CECV, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Moreira","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Department, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f3nia","family":"do Vale","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte, Lisboa, Portugal"},{"name":"Endocrinology Department, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana S.","family":"Silva-Herdade","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcio","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Medicine I Department, Centro Hospitalar Universit\u00e1rio Lisboa Norte,Lisboa, Portugal"},{"name":"Cl\u00ednica Universit\u00e1ria de Medicina I, Faculty of Medicine, University of Lisbon, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Dion\u00edsio","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Department, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Abeg\u00e3o Pinto","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte,Lisboa, Portugal"},{"name":"Vision Sciences Study Center, CECV, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A. R. B.","family":"Castanho","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Marques-Neves","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Hospital de Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte,Lisboa, Portugal"},{"name":"Vision Sciences Study Center, CECV, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.4239\/wjd.v6.i3.489","article-title":"Diabetic retinopathy\u2014ocular complications of diabetes mellitus","volume":"6","author":"Nentwich","year":"2015","journal-title":"World J Diabetes"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.2337\/dc15-2171","article-title":"Global estimates on the number of people blind or visually impaired by diabetic retinopathy: a meta-analysis from 1990 to 2010","volume":"39","author":"Leasher","year":"2016","journal-title":"Diabetes Care"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ajo.2016.12.023","article-title":"Retina and Choroid of Diabetic Patients Without Observed Retinal Vascular Changes: A Longitudinal Study","volume":"176","author":"Tavares Ferreira","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.survophthal.2018.04.003","article-title":"Early detection of diabetic retinopathy","volume":"63","author":"Safi","year":"2018","journal-title":"Surv Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1167\/iovs.12-10873","article-title":"Neurovascular dysfunction precedes neural dysfunction in the retina of patients with type 1 diabetes","volume":"54","author":"Lasta","year":"2013","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1167\/iovs.05-0833","article-title":"Early supernormal retinal oxygenation response in patients with diabetes","volume":"47","author":"Trick","year":"2006","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1167\/iovs.15-18356","article-title":"Defective myogenic response of retinal vessels is associated with accelerated onset of retinopathy in type 1 diabetic individuals","volume":"57","author":"Tecilazich","year":"2016","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1167\/iovs.16-21008","article-title":"Dynamic responses in retinal vessel caliber with flicker light stimulation and risk of diabetic retinopathy and its progression","volume":"58","author":"Lim","year":"2017","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib9","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/bjophthalmol-2018-313582","article-title":"Early retinal neurovascular impairment in patients with diabetes without clinically detectable retinopathy","volume":"103","author":"Zeng","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1136\/bjophthalmol-2016-309389","article-title":"Optical coherence tomography angiography: An overview of the technology and an assessment of applications for clinical research","volume":"101","author":"Koustenis","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","article-title":"Optical coherence tomography angiography","volume":"64","author":"Spaide","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.survophthal.2018.03.003","article-title":"Assessment of flow dynamics in retinal and choroidal microcirculation","volume":"63","author":"Wei","year":"2018","journal-title":"Surv Ophthalmol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"5548","DOI":"10.1167\/iovs.17-22036","article-title":"Quantitative analysis of three distinct retinal capillary plexuses in healthy eyes using optical coherence tomography angiography","volume":"58","author":"Garrity","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.oret.2017.05.001","article-title":"Defining the role of OCT angiography in clinical practice","volume":"1","author":"Sadda","year":"2017","journal-title":"Ophthalmol Retin"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s41433-019-0513-0","article-title":"Optical coherence tomography angiography study of the retinal vascular plexuses in type 1 diabetes without retinopathy","volume":"34","author":"Sousa","year":"2020","journal-title":"Eye"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s00592-017-0996-8","article-title":"Optical coherence tomography angiography analysis of retinal vascular plexuses and choriocapillaris in patients with type 1 diabetes without diabetic retinopathy","volume":"54","author":"Carnevali","year":"2017","journal-title":"Acta Diabetol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.3390\/jcm8091409","article-title":"Multimodal imaging assessment of vascular and neurodegenerative retinal alterations in type 1 diabetic patients without fundoscopic signs of diabetic retinopathy","volume":"8","author":"Sacconi","year":"2019","journal-title":"J Clin Med"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1097\/IAE.0000000000000882","article-title":"Detection of microvascular changes in eyes of patients with diabetes but not clinical diabetic retinopathy using optical coherence tomography angiography","volume":"35","author":"De Carlo","year":"2015","journal-title":"Retina"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1167\/iovs.16-20531","article-title":"Quantitative retinal optical coherence tomography angiography in patients with diabetes without diabetic retinopathy","volume":"58","author":"Dimitrova","year":"2017","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1001\/jamaophthalmol.2017.0080","article-title":"Quantification of retinal microvascular density in optical coherence tomographic angiography images in diabetic retinopathy","volume":"135","author":"Durbin","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3389\/fnins.2019.00566","article-title":"A protocol to evaluate retinal vascular response using opticalcoherence tomography angiography","volume":"13","author":"Sousa","year":"2019","journal-title":"Front Neurosci"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/bcp.2004.57.issue-6","article-title":"The revision of the Declaration of Helsinki: Past, present and future","volume":"57","author":"Carlson R","year":"2004","journal-title":"Br J Clin Pharmacol"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1164\/ajrccm\/148.5.1215","article-title":"Detection and correction of hypoxemia associated with air travel","volume":"148","author":"Vohra","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"bib24","first-page":"491","article-title":"The value of cardiovascular autonomic function tests: 10 years experience in diabetes","volume":"8","author":"Ewing","year":"1985","journal-title":"Ewing D, Martyn C al"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1089\/jcr.2012.0018","article-title":"Effects of alcohol, coffee, and tobacco, alone or in combination, on physiological parameters and anxiety in a young population","volume":"2","author":"Vinader-Caerols","year":"2012","journal-title":"J Caffeine Res"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1210\/er.2007-0006","article-title":"Cardiovascular actions of insulin","volume":"28","author":"Muniyappa","year":"2007","journal-title":"Endocr Rev"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.preteyeres.2008.02.002","article-title":"Regulation of retinal blood flow in health and disease","volume":"27","author":"Pournaras","year":"2008","journal-title":"Prog Retin Eye Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1113\/JP271182","article-title":"Relationship between retinal blood flow and arterial oxygen","volume":"594","author":"Cheng","year":"2016","journal-title":"J Physiol"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/aos.13622","article-title":"Hypoxia challenge test and retinal circulation changes\u2014a study using ocular coherence tomography angiography","volume":"96","author":"Sousa","year":"2018","journal-title":"Acta Ophthalmol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1006\/mvre.2001.2321","article-title":"Measurement of blood flow through the retinal circulation of the cat during normoxia and hypoxemia using fluorescent microspheres","volume":"62","author":"Ahmed","year":"2001","journal-title":"Microvasc Res"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2019.04.001","article-title":"Retinal oximetry: Metabolic imaging for diseases of the retina and brain","volume":"70","author":"Stef\u00e1nsson","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"bib32","first-page":"722","article-title":"Retinal blood flow autoregulation in response to an acute increase in blood pressure","volume":"27","author":"Robinson","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1007\/s004170050236","article-title":"Noninvasive measurement of the Bayliss effect in retinal autoregulation","volume":"237","author":"Blum","year":"1999","journal-title":"Graefe's Arch Clin Exp Ophthalmol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"4299","DOI":"10.1167\/iovs.11-9384","article-title":"Blood flow MRI of the human retina\/choroid during rest and isometric exercise","volume":"53","author":"Zhang","year":"2012","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib35","first-page":"e751","article-title":"The greenhouse-geisser correction","volume":"95","author":"Abdi","year":"2010","journal-title":"Encycl Res Des Sage Publ"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1167\/iovs.18-25499","article-title":"Retinal Microvascular Abnormalities in Children with Type 1 Diabetes Mellitus Without Visual Impairment or Diabetic Retinopathy","volume":"60","author":"Li","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"e751","DOI":"10.1111\/aos.13404","article-title":"Early microvascular retinal changes in optical coherence tomography angiography in patients with type 1 diabetes mellitus","volume":"95","author":"Simonett","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"e000044","DOI":"10.1136\/bmjdrc-2014-000044","article-title":"Complication characteristics between young-onset type 2 versus type 1 diabetes in a UK population","volume":"3","author":"Song","year":"2015","journal-title":"BMJ Open Diabetes Res Care"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00592-018-1115-1","article-title":"Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy","volume":"55","author":"Cao","year":"2018","journal-title":"Acta Diabetol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.survophthal.2018.04.003","article-title":"Early detection of diabetic retinopathy","volume":"63","author":"Safi","year":"2018","journal-title":"Surv Ophthalmol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-45194-z","article-title":"Flow density in optical coherence tomography angiography is useful for retinopathy diagnosis in diabetic patients","volume":"9","author":"Kaizu","year":"2019","journal-title":"Sci Rep"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/j.ophtha.2019.06.016","article-title":"OCT angiography metrics predict progression of diabetic retinopathy and development of diabetic macular edema: a prospective study","volume":"126","author":"Sun","year":"2019","journal-title":"Ophthalmology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/aos.2010.88.issue-4","article-title":"Retinal arterioles have impaired reactivity to hyperoxia in type 1 diabetes","volume":"88","author":"Justesen","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1167\/iovs.18-26417","article-title":"Impaired retinal vascular reactivity in diabetic retinopathy as assessed by optical coherence tomography angiography","volume":"60","author":"Ashimatey","year":"2019","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"4115","DOI":"10.1167\/iovs.17-23230","article-title":"Retinal microvascular impairment in the early stages of Parkinson's disease","volume":"59","author":"Kwapong","year":"2018","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1167\/iovs.18-24389","article-title":"Optical coherence tomography angiography quantitative assessment of exercise-induced variations in retinal vascular plexa of healthy subjects","volume":"60","author":"Kim","year":"2019","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1001\/jamaophthalmol.2018.3556","article-title":"Association of preclinical Alzheimer disease with optical coherence tomographic angiography findings","volume":"136","author":"O'Bryhim","year":"2018","journal-title":"JAMA Ophthalmol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1177\/1352458517750009","article-title":"Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis","volume":"25","author":"Feucht","year":"2019","journal-title":"Mult Scler J"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"H201","DOI":"10.1152\/ajpheart.00201.2016","article-title":"Retinal microvascular network alterations: potential biomarkers of cerebrovascular and neural diseases","volume":"312","author":"DeBuc","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"036024","DOI":"10.1088\/1741-2552\/ab1405","article-title":"Toward optical coherence tomography angiography-based biomarkers to assess the safety of peripheral nerve electrostimulation","volume":"16","author":"Vasudevan","year":"2019","journal-title":"J Neural Eng"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"e0214685","DOI":"10.1371\/journal.pone.0214685","article-title":"Parafoveal vessel loss and correlation between peripapillary vessel density and cognitive performance in amnestic mild cognitive impairment and early Alzheimer's Disease on optical coherence tomography angiography","volume":"14","author":"Zhang","year":"2019","journal-title":"PLoS One"},{"key":"bib52","doi-asserted-by":"crossref","DOI":"10.1002\/ar.24340","article-title":"Combining optical coherence tomography with magnetic resonance angiography and Doppler ultrasonography for clinical detection of scleroderma","author":"Zhang","year":"2019","journal-title":"Anat Rec"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1136\/bjophthalmol-2013-304017","article-title":"Prevalence of diabetic retinopathy within a national diabetic retinopathy screening service","volume":"99","author":"Thomas","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/hr.2011.62","article-title":"Involvement of endothelium-dependent and-independent mechanisms in midazolam-induced vasodilation","volume":"34","author":"Colussi","year":"2011","journal-title":"Hypertens Res"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0008-6363(00)00247-9","article-title":"Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: New concepts for cardiovascular disease","volume":"49","author":"Lefer","year":"2001","journal-title":"Cardiovasc Res"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/clpt.2009.121","article-title":"Effects of selective serotonin reuptake inhibitor therapy on endothelial function and inflammatory markers in patients with coronary heart disease","volume":"86","author":"Pizzi","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1093\/cvr\/cvp304","article-title":"Thyroid hormone stimulates NO production via activation of the PI3K\/Akt pathway in vascular myocytes","volume":"85","author":"Carrillo-Sep\u00falveda","year":"2010","journal-title":"Cardiovasc Res"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.diabres.2019.05.024","article-title":"Effect of hyperglycemia on cerebral blood flow in patients with diabetes","volume":"153","author":"Nowaczewska","year":"2019","journal-title":"Diabetes Res Clin Pract"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1111\/aos.2009.87.issue-8","article-title":"Twelve-hour reproducibility of retinal and optic nerve blood flow parameters in healthy individuals","volume":"87","author":"Luksch","year":"2009","journal-title":"Acta Ophthalmol"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2770173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:20Z","timestamp":1791927080000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2770173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,23]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.61.6.49","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6,23]]}}}