{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:32Z","timestamp":1791928772071,"version":"4.3.4"},"reference-count":21,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"8","license":[{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2020,7,8]]},"DOI":"10.1167\/iovs.61.8.9","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T10:31:46Z","timestamp":1594204306000},"page":"9","source":"Crossref","is-referenced-by-count":16,"title":["Combined Transplantation With Human Mesenchymal Stem Cells Improves Retinal Rescue Effect of Human Fetal RPE Cells in Retinal Degeneration Mouse Model"],"prefix":"10.1167","volume":"61","author":[{"given":"Ting","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First People's Hospital of Changzhou, Changzhou, 213000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xincheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghuai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","first-page":"3","article-title":"Foreword: dry age-related macular degeneration","volume":"59","author":"Milam","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"6842","DOI":"10.1167\/iovs.11-7179","article-title":"Rates of nonexudative and exudative AMD among Asian American ethnic groups","volume":"52","author":"Stein","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3928\/23258160-20150101-01","article-title":"Geographic atrophy: clinical impact and emerging treatments","volume":"46","author":"Patel","year":"2015","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/319728","article-title":"Antivascular endothelial growth factor agents for neovascular age-related macular degeneration","volume":"2012","author":"Zampros","year":"2012","journal-title":"J Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3934\/molsci.2016.2.196","article-title":"Oxidative stress, innate immunity, and age-related macular degeneration","volume":"3","author":"Shaw","year":"2016","journal-title":"AIMS Mol Sci"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.preteyeres.2007.02.002","article-title":"Transplantation of the RPE in AMD","volume":"26","author":"Binder","year":"2007","journal-title":"Prog Retin Eye Res"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.scr.2015.02.003","article-title":"Stem cell treatment of degenerative eye disease","volume":"14","author":"Mead","year":"2015","journal-title":"Stem Cell Res"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.004","article-title":"Stem cell-based therapies for age-related macular degeneration: the promises and the challenges","volume":"48","author":"Nazari","year":"2015","journal-title":"Prog Retina Eye Res"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/s13287-015-0207-x","article-title":"Transplantation of rat embryonic stem cell-derived retinal progenitor cells preserves the retinal structure and function in rat retinal degeneration","volume":"6","author":"Qu","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"111","DOI":"10.4252\/wjsc.v6.i2.111","article-title":"Progress of mesenchymal stem cell therapy for neural and retinal diseases","volume":"6","author":"Ng","year":"2014","journal-title":"World J Stem Cells"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s13287-016-0432-y","article-title":"Subretinal adipose tissue-derived mesenchymal stem cell implantation in advanced stage retinitis pigmentosa: a phase I clinical safety study","volume":"7","author":"Oner","year":"2016","journal-title":"Stem Cell Res Ther"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1089\/ten.teb.2011.0488","article-title":"Therapeutic applications of mesenchymal stromal cells: paracrine effects and potential improvements","volume":"18","author":"Doorn","year":"2012","journal-title":"Tissue Eng. Part B Rev."},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1097\/TP.0b013e3181ffba31","article-title":"Combined transplantation of pancreatic islets and adipose tissue-derived stem cells enhances the survival and insulin function of islet grafts in diabetic mice","volume":"90","author":"Ohmura","year":"2010","journal-title":"Transplantation"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1055\/s-0033-1337118","article-title":"Combined transplantation of human neuronal and mesenchymal stem cells following spinal cord injury","volume":"3","author":"Park","year":"2013","journal-title":"Global Spine J"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1590\/S0066-782X2004001600004","article-title":"Combined transplantation of skeletal myoblasts and mesenchymal cells (cocultivation) in ventricular dysfunction after myocardial infarction","volume":"83","author":"Souza","year":"2004","journal-title":"Arq Bras Cardiol."},{"key":"bib16","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.biopha.2018.04.038","article-title":"The rescue effect of mesenchymal stem cell on Sodium iodate-induced retinal pigment epithelial cell death through deactivation of NF-kB-mediated NLRP3 inflammasome","volume":"103","author":"Mao","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1007\/s12035-016-9960-9","article-title":"Friend or foe? Resident microglia vs bone marrow-derived microglia and their roles in the retinal degeneration","volume":"54","author":"Jin","year":"2017","journal-title":"Mol Neurobiol."},{"key":"bib18","doi-asserted-by":"publisher","first-page":"6362","DOI":"10.1074\/jbc.M113.513713","article-title":"Human retinal progenitor cell transplantation preserves vision","volume":"289","author":"Luo","year":"2014","journal-title":"J Biol Chem."},{"key":"bib19","doi-asserted-by":"publisher","first-page":"8139","DOI":"10.1523\/JNEUROSCI.5200-13.2014","article-title":"Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa","volume":"34","author":"Peng","year":"2014","journal-title":"J Neurosci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/978-3-319-17121-0","article-title":"Gliosis can impede integration following photoreceptor transplantation into the diseased retina","volume":"854","author":"Hippert","year":"2016","journal-title":"Adv Exp Med Biol."},{"key":"bib21","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3389\/fphys.2012.00359","article-title":"Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy","volume":"3","author":"Baglio","year":"2012","journal-title":"Front Physiol."}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2770263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:22Z","timestamp":1791927082000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2770263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,8]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.61.8.9","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7,8]]}}}