{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:33Z","timestamp":1791928773592,"version":"4.3.4"},"reference-count":55,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"1","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,1,13]]},"DOI":"10.1167\/iovs.62.1.15","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T03:09:52Z","timestamp":1610593792000},"page":"15","source":"Crossref","is-referenced-by-count":22,"title":["Differential Tissue Metabolic Signatures in IgG4-Related Ophthalmic Disease and Orbital Mucosa-Associated Lymphoid Tissue Lymphoma"],"prefix":"10.1167","volume":"62","author":[{"given":"Hiroyuki","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Wakita","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Aita","sequence":"additional","affiliation":[{"name":"Research and Development Center for Minimally Invasive Therapies, Institute of Medical Science, Tokyo Medical University, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsumi","family":"Tomita","sequence":"additional","affiliation":[{"name":"Research and Development Center for Minimally Invasive Therapies, Institute of Medical Science, Tokyo Medical University, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinya","family":"Tsubota","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Asakage","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Nezu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Umazume","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Research and Development Center for Minimally Invasive Therapies, Institute of Medical Science, Tokyo Medical University, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s10384-013-0266-4","article-title":"Japanese study group of Ig Grod. A prevalence study of IgG4-related ophthalmic disease in Japan","volume":"57","year":"2013","journal-title":"Jpn J Ophthalmol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1016\/S0140-6736(14)60720-0","article-title":"IgG4-related disease","volume":"385","author":"Kamisawa","year":"2015","journal-title":"Lancet"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1182\/blood-2015-12-624304","article-title":"The spectrum of MALT lymphoma at different sites: biological and therapeutic relevance","volume":"127","author":"Zucca","year":"2016","journal-title":"Blood"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.1002\/art.39205","article-title":"IgG4-related disease: clinical and laboratory features in one hundred twenty-five patients","volume":"67","author":"Wallace","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"36621","DOI":"10.1038\/srep36621","article-title":"Comprehensive polymerase chain reaction assay for detection of pathogenic DNA in lymphoproliferative disorders of the ocular adnexa","volume":"6","author":"Usui","year":"2016","journal-title":"Sci Rep"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"36","DOI":"10.17816\/OV20182","article-title":"IgG4 and IgE co-positive group found in idiopathic orbital inflammatory disease","volume":"11","author":"Zhao","year":"2018","journal-title":"Int J Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1182\/blood-2008-12-195453","article-title":"Extranodal marginal zone lymphoma of the ocular adnexa","volume":"114","author":"Stefanovic","year":"2009","journal-title":"Blood"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.3174\/ajnr.A3986","article-title":"Orbital lymphoproliferative disorders (OLPDs): value of MR imaging for differentiating orbital lymphoma from benign OPLDs","volume":"35","author":"Haradome","year":"2014","journal-title":"AJNR Am J Neuroradiol"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"132","DOI":"10.22608\/21620989","article-title":"Lymphoproliferative tumors of the ocular adnexa","volume":"6","author":"Verdijk","year":"2017","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1136\/jcp.2010.082156","article-title":"Ocular adnexal marginal zone B cell lymphoma infiltrated by IgG4-positive plasma cells","volume":"63","author":"Kubota","year":"2010","journal-title":"J Clin Pathol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1097\/PAS.0b013e31816148ad","article-title":"Ocular adnexal lymphoma associated with IgG4+ chronic sclerosing dacryoadenitis: a previously undescribed complication of IgG4-related sclerosing disease","volume":"32","author":"Cheuk","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/pin.2008.58.issue-8","article-title":"Ocular adnexal IgG4-related disease has uniform clinicopathology","volume":"58","author":"Sato","year":"2008","journal-title":"Pathol Int"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1016\/j.cgh.2017.02.007","article-title":"Increases in IgE, eosinophils, and mast cells can be used in diagnosis and to predict relapse of IgG4-related disease","volume":"15","author":"Culver","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/ajg.2016.40","article-title":"Elevated serum IgG4 levels in diagnosis, treatment response, organ involvement, and relapse in a prospective IgG4-related disease UK cohort","volume":"111","author":"Culver","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1136\/bjophthalmol-2017-311519","article-title":"Clinicoserological factors associated with response to steroid treatment and recurrence in patients with IgG4-related ophthalmic disease","volume":"102","author":"Hong","year":"2018","journal-title":"Br J Ophthalmol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.semarthrit.2013.11.008","article-title":"Ophthalmic manifestations of IgG4-related disease: single-center experience and literature review","volume":"43","author":"Wallace","year":"2014","journal-title":"Semin Arthritis Rheum"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nrrheum.2016.1","article-title":"Metabolomics in rheumatic diseases: desperately seeking biomarkers","volume":"12","author":"Guma","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.bbcan.2018.04.009","article-title":"Applications of metabolomics to study cancer metabolism","volume":"1870","author":"Kaushik","year":"2018","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1111\/apl.v22.8","article-title":"Efficacy and safety of iguratimod plus corticosteroid as bridge therapy in treating mild IgG4-related diseases: a prospective clinical trial","volume":"22","author":"Zhang","year":"2019","journal-title":"Int J Rheum Dis"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1038\/s41366-020-0558-y","article-title":"Relationships between plasma lipidomic profiles and brown adipose tissue density in humans","volume":"44","author":"Fuse","year":"2020","journal-title":"Int J Obes (Lond)"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/odi.v26.1","article-title":"Discrimination of oral squamous cell carcinoma from oral lichen planus by salivary metabolomics","volume":"26","author":"Ishikawa","year":"2020","journal-title":"Oral Dis"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"756","DOI":"10.3390\/ijms19030756","article-title":"Urinary polyamine biomarker panels with machine-learning differentiated colorectal cancers, benign disease, and healthy controls","volume":"19","author":"Nakajima","year":"2018","journal-title":"Int J Mol Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3390\/ijms18040767","article-title":"Serum metabolomic profiles for human pancreatic cancer discrimination","volume":"18","author":"Itoi","year":"2017","journal-title":"Int J Mol Sci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3109\/s10165-011-0571-z","article-title":"Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011","volume":"22","author":"Umehara","year":"2012","journal-title":"Mod Rheumatol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10384-014-0352-2","article-title":"Japanese Study Group for Ig GROD. Diagnostic criteria for IgG4-related ophthalmic disease","volume":"59","author":"Goto","year":"2015","journal-title":"Jpn J Ophthalmol"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"e86","DOI":"10.1002\/cpbi.v68.1","article-title":"Using MetaboAnalyst 4.0 for comprehensive and integrative metabolomics data analysis","volume":"68","author":"Chong","year":"2019","journal-title":"Curr Protoc Bioinformatics"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/s41568-018-0050-3","article-title":"Polyamine metabolism and cancer: treatments, challenges and opportunities","volume":"18","author":"Casero","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/PL00000852","article-title":"Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications","volume":"58","author":"Thomas","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"14904","DOI":"10.1074\/jbc.R116.731661","article-title":"Functions of polyamines in mammals","volume":"291","author":"Pegg","year":"2016","journal-title":"J Biol Chem"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.virusres.2013.07.004","article-title":"Downregulation of the polyamine regulator spermidine\/spermine N(1)-acetyltransferase by Epstein-Barr virus in a Burkitt's lymphoma cell line","volume":"177","author":"Shi","year":"2013","journal-title":"Virus Res"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1006\/excr.2001.5177","article-title":"Involvement of polyamines in B cell receptor-mediated apoptosis: spermine functions as a negative modulator","volume":"265","author":"Nitta","year":"2001","journal-title":"Exp Cell Res"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s13238-017-0451-1","article-title":"The emerging role and targetability of the TCA cycle in cancer metabolism","volume":"9","author":"Anderson","year":"2018","journal-title":"Protein Cell"},{"key":"bib33","first-page":"370","article-title":"Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells","volume":"1826","author":"Chen","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.tips.2012.02.004","article-title":"Prostaglandins and chronic inflammation","volume":"33","author":"Aoki","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1038\/nature05877","article-title":"Resolvin E1 and protectin D1 activate inflammation-resolution programmes","volume":"447","author":"Schwab","year":"2007","journal-title":"Nature"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"353ra111","DOI":"10.1126\/scitranslmed.aaf7483","article-title":"Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses","volume":"8","author":"Chiurchiu","year":"2016","journal-title":"Sci Transl Med"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"5408","DOI":"10.4049\/jimmunol.1100225","article-title":"Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype","volume":"187","author":"Titos","year":"2011","journal-title":"J Immunol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.4049\/jimmunol.1103483","article-title":"Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells","volume":"189","author":"Ramon","year":"2012","journal-title":"J Immunol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.bbrc.2008.01.012","article-title":"Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma","volume":"367","author":"Aoki","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.bbrc.2010.08.025","article-title":"Protective effect of resolvin E1 on the development of asthmatic airway inflammation","volume":"400","author":"Aoki","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1080\/00365520152584842","article-title":"CD4+ Th1-cells predominate in low-grade B-cell lymphoma of gastric mucosa-associated lymphoid tissue (MALT type)","volume":"36","author":"Riedel","year":"2001","journal-title":"Scand J Gastroenterol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.micpath.2018.01.040","article-title":"T cell subsets play an important role in the determination of the clinical outcome of Helicobacter pylori infection","volume":"116","author":"Jafarzadeh","year":"2018","journal-title":"Microb Pathog"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"13716","DOI":"10.18632\/aging.v12i13","article-title":"Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo","volume":"12","author":"Fischer","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1172\/JCI13210","article-title":"Arachidonic acid as a bioactive molecule","volume":"107","author":"Brash","year":"2001","journal-title":"J Clin Invest"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nri3859","article-title":"Eicosanoid storm in infection and inflammation","volume":"15","author":"Dennis","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/978-1-4899-0179-8","article-title":"Arachidonate-phospholipid remodeling and cell proliferation","volume":"416","author":"Chilton","year":"1996","journal-title":"Adv Exp Med Biol"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"e0143741","DOI":"10.1371\/journal.pone.0143741","article-title":"The polyunsaturated fatty acids arachidonic acid and docosahexaenoic acid induce mouse dendritic cells maturation but reduce T-cell responses in vitro","volume":"10","author":"Carlsson","year":"2015","journal-title":"PLoS One"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1194\/jlr.R046094","article-title":"Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells","volume":"55","author":"Hishikawa","year":"2014","journal-title":"J Lipid Res"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1194\/jlr.M037044","article-title":"Fatty acid remodeling in cellular glycerophospholipids following the activation of human T cells","volume":"54","author":"Robichaud","year":"2013","journal-title":"J Lipid Res"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1042\/CS20050012","article-title":"Eicosanoids: mediators and therapeutic targets in fibrotic lung disease","volume":"108","author":"Charbeneau","year":"2005","journal-title":"Clin Sci (Lond)"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"F243","DOI":"10.1152\/ajprenal.00224.2014","article-title":"Chronic kidney disease: targeting prostaglandin E2 receptors","volume":"307","author":"Nasrallah","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"641","DOI":"10.4049\/jimmunol.178.2.641","article-title":"Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation","volume":"178","author":"Levick","year":"2007","journal-title":"J Immunol"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1097\/BOR.0000000000000686","article-title":"Immune mechanisms of fibrosis and inflammation in IgG4-related disease","volume":"32","author":"Pillai","year":"2020","journal-title":"Curr Opin Rheumatol"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:24Z","timestamp":1791927084000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,13]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,4]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.1.15","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1,13]]}}}