{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:19Z","timestamp":1791928759023,"version":"4.3.4"},"reference-count":24,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"10","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,8,23]]},"DOI":"10.1167\/iovs.62.10.25","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T10:39:32Z","timestamp":1629715172000},"page":"25","source":"Crossref","is-referenced-by-count":9,"title":["Exploring the Mechanism of the miRNA-145\/Paxillin Axis in Cell Metabolism During VEGF-A\u2013Induced Corneal Angiogenesis"],"prefix":"10.1167","volume":"62","author":[{"given":"Wanju","family":"Yang","sequence":"first","affiliation":[{"name":"Aier Eye Hospital of Wuhan University, Wuhan, China"},{"name":"Department of Ophthalmology, Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanning","family":"Yang","sequence":"additional","affiliation":[{"name":"Eye Center, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wan","sequence":"additional","affiliation":[{"name":"Eye Center, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanruo","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Aier Eye Hospital of Wuhan University, Wuhan, China"},{"name":"Department of Ophthalmology, Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiao","family":"Xing","sequence":"additional","affiliation":[{"name":"Aier Eye Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"1","key":"bib1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13045-017-0418-y","article-title":"Paxillin: a crossroad in pathological cell migration","volume":"10","author":"L\u00f3pez-Colom\u00e9","year":"2017","journal-title":"J Hematol Oncol"},{"issue":"3","key":"bib2","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1002\/ijc.v131.3","article-title":"The novel indole compound SK228 induces apoptosis and FAK\/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse","volume":"131","author":"Huang","year":"2012","journal-title":"Int J Cancer"},{"issue":"7","key":"bib3","doi-asserted-by":"publisher","first-page":"679","DOI":"10.4161\/cbt.25091","article-title":"Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer","volume":"14","author":"Kawada","year":"2013","journal-title":"Cancer Biol Ther"},{"issue":"30","key":"bib4","doi-asserted-by":"publisher","first-page":"48782","DOI":"10.18632\/oncotarget.v8i30","article-title":"Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis","volume":"8","author":"Zhao","year":"2017","journal-title":"Oncotarget"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fnmol.2011.00051","article-title":"PI3K\/AKT\/mTOR pathway in angiogenesis","volume":"4","author":"Karar","year":"2011","journal-title":"Front Mol Neurosci"},{"issue":"11","key":"bib6","doi-asserted-by":"publisher","first-page":"e81773","DOI":"10.1371\/journal.pone.0081773","article-title":"Inhibition of protein kinase C delta attenuates allergic airway inflammation through suppression of PI3K\/Akt\/mTOR\/HIF-1 alpha\/VEGF pathway","volume":"8","author":"Choi","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"bib7","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1152\/japplphysiol.00728.2003","article-title":"HSP90 and Akt modulate Ang-1-induced angiogenesis via NO in coronary artery endothelium","volume":"96","author":"Chen","year":"2004","journal-title":"J Appl Physiol (1985)"},{"issue":"4","key":"bib9","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1002\/cam4.2017.6.issue-4","article-title":"Effects of miR-145-5p through NRAS on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K\/AKT pathways","volume":"6","author":"Liu","year":"2017","journal-title":"Cancer Med"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"4894","DOI":"10.12659\/MSM.910986","article-title":"miR-145-5p inhibits vascular smooth muscle cells (VSMCs) proliferation and migration by dysregulating the transforming growth factor-b signaling cascade","volume":"24","author":"Li","year":"2018","journal-title":"Med Sci Monit"},{"issue":"11","key":"bib11","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1161\/CIRCRESAHA.116.305178","article-title":"TGF\u00df triggers miR-143\/145 transfer from smooth muscle cells to endothelial cells, thereby modulating vessel stabilization","volume":"116","author":"Climent","year":"2015","journal-title":"Circ Res"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.2147\/OTT","article-title":"Curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K\/Akt\/mTOR pathway","volume":"11","author":"Zhu","year":"2018","journal-title":"Onco Targets Ther"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.lfs.2018.03.011","article-title":"Akt modulation by miR-145 during exercise-induced VSMC phenotypic switching in hypertension","volume":"199","author":"Liao","year":"2018","journal-title":"Life Sci"},{"issue":"2","key":"bib14","first-page":"327","article-title":"VEGF-induced corneal neovascularisation in a rabbit experimental model","volume":"51","author":"Coman","year":"2010","journal-title":"Rom J Morphol Embryol"},{"issue":"2","key":"bib15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1124\/pr.56.4.3","article-title":"Vascular endothelial growth factor and angiogenesis","volume":"56","author":"Hoeben","year":"2004","journal-title":"Pharmacol Rev"},{"issue":"3\u20134","key":"bib16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1089\/lrb.2008.6348","article-title":"Corneal (lymph)angiogenesis\u2013from bedside to bench and back: a tribute to Judah Folkman","volume":"6","author":"Regenfuss","year":"2008","journal-title":"Lymphat Res Biol"},{"issue":"12","key":"bib17","doi-asserted-by":"publisher","first-page":"4228","DOI":"10.2337\/db12-1710","article-title":"Anti-angiogenic and anti-neuroinflammatory effects of kallistatin through interactions with the canonical Wnt pathway","volume":"62","author":"Liu","year":"2013","journal-title":"Diabetes"},{"issue":"4","key":"bib18","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1136\/bjophthalmol-2011-301005","article-title":"A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy","volume":"96","author":"Van Geest","year":"2012","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"bib19","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1158\/0008-5472.CAN-10-1303","article-title":"A novel sialyltransferase inhibitor suppresses FAK\/paxillin signaling and cancer angiogenesis and metastasis pathways","volume":"71","author":"Chen","year":"2011","journal-title":"Cancer Res"},{"issue":"5","key":"bib20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nrm1911","article-title":"VEGF receptor signalling - in control of vascular function","volume":"7","author":"Olsson","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"24","key":"bib21","doi-asserted-by":"publisher","first-page":"15442","DOI":"10.1074\/jbc.272.24.15442","article-title":"Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells","volume":"272","author":"Abedi","year":"1997","journal-title":"J Biol Chem"},{"issue":"4","key":"bib22","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1159\/000338819","article-title":"TNF-a stimulates MMP-2 and MMP-9 activities in human corneal epithelial cells via the activation of FAK\/ERK signaling","volume":"48","author":"Yang","year":"2012","journal-title":"Ophthalmic Res"},{"issue":"19","key":"bib23","doi-asserted-by":"publisher","first-page":"28160","DOI":"10.18632\/oncotarget.v7i19","article-title":"Gap junction-mediated transfer of miR-145-5p from microvascular endothelial cells to colon cancer cells inhibits angiogenesis","volume":"7","author":"Thuringer","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"bib24","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3109\/07357907.2015.1025407","article-title":"Overexpression of miR-145-5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression","volume":"33","author":"Ozen","year":"2015","journal-title":"Cancer Invest"},{"key":"bib8","first-page":"187","article-title":"MicroRNA regulation of angiogenesis","volume-title":"Angiogenesis and Vascularisation: Cellular and Molecular Mechanisms in Health and Diseases","author":"Sen","year":"2014"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2776626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:26Z","timestamp":1791927086000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2776626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,23]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,8,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.10.25","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,23]]}}}