{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:43Z","timestamp":1791928783134,"version":"4.3.4"},"reference-count":61,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,9,16]]},"DOI":"10.1167\/iovs.62.12.14","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T11:32:09Z","timestamp":1631791929000},"page":"14","source":"Crossref","is-referenced-by-count":14,"title":["Retinal Degeneration Caused by Ago2 Disruption"],"prefix":"10.1167","volume":"62","author":[{"given":"Xue-Jiao","family":"Chen","sequence":"first","affiliation":[{"name":"School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Laboratory, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Han","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China"},{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Laboratory, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Bing","family":"Jin","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Laboratory, Beijing, China"},{"name":"School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.molcel.2007.05.001","article-title":"Argonaute proteins: mediators of RNA silencing","volume":"26","author":"Peters","year":"2007","journal-title":"Mol Cell"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nrm2321","article-title":"Argonaute proteins: key players in RNA silencing","volume":"9","author":"Hutvagner","year":"2008","journal-title":"Nat Rev Mol Cell Bio"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/nrg3462","article-title":"Argonaute proteins: functional insights and emerging roles","volume":"14","author":"Meister","year":"2013","journal-title":"Nat Rev Gene"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1126\/science.1102514","article-title":"Crystal structure of argonaute and its implications for RISC slicer activity","volume":"305","author":"Song","year":"2004","journal-title":"Science"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nature07755","article-title":"A three-dimensional view of the molecular machinery of RNA interference","volume":"457","author":"Jinek","year":"2009","journal-title":"Nature"},{"key":"bib6","first-page":"71","article-title":"RISC assembly: coordination between small RNAs and Argonaute proteins","volume":"1859","author":"Kobayashi","year":"2016","journal-title":"Bba-Gene Regul Mech"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat Rev Mol Cell Bio"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nrd3625","article-title":"RNA therapeutics: beyond RNA interference and antisense oligonucleotides","volume":"11","author":"Kole","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nrd2310","article-title":"Interfering with disease: a progress report on siRNA-based therapeutics","volume":"6","author":"de Fougerolles","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1126\/science.1102513","article-title":"Argonaute2 is the catalytic engine of mammalian RNAi","volume":"305","author":"Liu","year":"2004","journal-title":"Science"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.ygeno.2007.01.004","article-title":"One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation","volume":"89","author":"Morita","year":"2007","journal-title":"Genomics"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1756-8935-2-9","article-title":"Essential role for Argonaute2 protein in mouse oogenesis","volume":"2","author":"Kaneda","year":"2009","journal-title":"Epigenet Chromatin"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1101\/gad.1565607","article-title":"A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway","volume":"21","author":"O'Carroll","year":"2007","journal-title":"Gene Dev"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s00439-018-1931-y","article-title":"Non-coding RNAs in retinal development and function","volume":"138","author":"Karali","year":"2019","journal-title":"Hum Genet"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1111\/ceo.v48.8","article-title":"Emerging roles of non-coding RNAs in retinal diseases: a review","volume":"48","author":"Sun","year":"2020","journal-title":"Clin Exp Ophthalmol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"4878","DOI":"10.1523\/JNEUROSCI.0828-08.2008","article-title":"Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina","volume":"28","author":"Damiani","year":"2008","journal-title":"J Neurosci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"4048","DOI":"10.1523\/JNEUROSCI.4982-09.2010","article-title":"Dicer is required for the transition from early to late progenitor state in the developing mouse retina","volume":"30","author":"Georgi","year":"2010","journal-title":"J Neurosci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1073\/pnas.1301837110","article-title":"Conserved microRNA pathway regulates developmental timing of retinal neurogenesis","volume":"110","author":"La Torre","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.1167\/iovs.10-6428","article-title":"Dicer plays essential roles for retinal development by regulation of survival and differentiation","volume":"52","author":"Iida","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"e10021","DOI":"10.1371\/journal.pone.0010021","article-title":"Perturbations of microRNA function in mouse Dicer mutants produce retinal defects and lead to aberrant axon pathfinding at the optic chiasm","volume":"5","author":"Pinter","year":"2010","journal-title":"PLoS One"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.neuron.2014.06.020","article-title":"miRNAs 182 and 183 are necessary to maintain adult cone photoreceptor outer segments and visual function","volume":"83","author":"Busskamp","year":"2014","journal-title":"Neuron"},{"key":"bib22","first-page":"2487","article-title":"MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors","volume":"142","author":"Ohana","year":"2015","journal-title":"Development"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"6376","DOI":"10.1073\/pnas.1618757114","article-title":"miR-183\/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance","volume":"114","author":"Xiang","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1073\/pnas.1212655110","article-title":"Inactivation of the microRNA-183\/96\/182 cluster results in syndromic retinal degeneration","volume":"110","author":"Lumayag","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/iovs.61.3.12","article-title":"Ablation of mature miR-183 leads to retinal dysfunction in mice","volume":"61","author":"Zhang","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1167\/iovs.18-24166","article-title":"Deletion of miR-182 leads to retinal dysfunction in mice","volume":"60","author":"Wu","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"15491","DOI":"10.1073\/pnas.0914785107","article-title":"miR-204 is required for lens and retinal development via Meis2 targeting","volume":"107","author":"Conte","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1167\/iovs.06-0866","article-title":"Identification and characterization of MicroRNAs expressed in the mouse eye","volume":"48","author":"Karali","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1038\/nn.2897","article-title":"miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression","volume":"14","author":"Sanuki","year":"2011","journal-title":"Nat Neurosci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1038\/s41467-017-01624-y","article-title":"Muller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture","volume":"8","author":"Wohl","year":"2017","journal-title":"Nat Commun"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"35423","DOI":"10.1038\/srep35423","article-title":"The microRNA expression profile of mouse Muller glia in vivo and in vitro","volume":"6","author":"Wohl","year":"2016","journal-title":"Sci Rep UK"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.cub.2005.02.027","article-title":"The noncoding RNA Taurine upregulated gene 1 is required for differentiation of the murine retina","volume":"15","author":"Young","year":"2005","journal-title":"Curr Biol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1242\/jcs.009357","article-title":"The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons","volume":"120","author":"Sone","year":"2007","journal-title":"J Cell Sci"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1471-213X-10-49","article-title":"The long noncoding RNA RNCR2 directs mouse retinal cell specification","volume":"10","author":"Rapicavoli","year":"2010","journal-title":"BMC Dev Biol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1093\/hmg\/ddi084","article-title":"Natural antisense transcripts associated with genes involved in eye development","volume":"14","author":"Alfano","year":"2005","journal-title":"Hum Mol Genet"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/j.bbrc.2018.01.177","article-title":"Long non-coding RNA MEG3 silencing protects against light-induced retinal degeneration","volume":"496","author":"Zhu","year":"2018","journal-title":"Biochem Bioph Res Co"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.cell.2007.10.032","article-title":"Dual role for argonautes in MicroRNA processing and posttranscriptional regulation of MicroRNA expression","volume":"131","author":"Diederichs","year":"2007","journal-title":"Cell"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.omtn.2019.11.016","article-title":"The circular RNome of developmental retina in mice","volume":"19","author":"Chen","year":"2020","journal-title":"Mol Ther Nucl Acids"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nature02123","article-title":"Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain","volume":"426","author":"Lingel","year":"2003","journal-title":"Nature"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1038\/nsb1016","article-title":"The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes","volume":"10","author":"Song","year":"2003","journal-title":"Nat Struct Biol"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1126\/science.1073827","article-title":"A microRNA in a multiple-turnover RNAi enzyme complex","volume":"297","author":"Hutvagner","year":"2002","journal-title":"Science"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1093\/nar\/gkw039","article-title":"High-resolution analysis of the human retina miRNome reveals isomiR variations and novel microRNAs","volume":"44","author":"Karali","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"25053","DOI":"10.1074\/jbc.M700501200","article-title":"MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster","volume":"282","author":"Xu","year":"2007","journal-title":"J Biol Chem"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1749-8104-6-32","article-title":"The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity","volume":"6","author":"Rapicavoli","year":"2011","journal-title":"Neural Dev"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1261\/rna.029454.111","article-title":"The long noncoding RNA Vax2os1 controls the cell cycle progression of photoreceptor progenitors in the mouse retina","volume":"18","author":"Meola","year":"2012","journal-title":"RNA"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1089\/hum.2017.020","article-title":"Rod outer segment development influences AAV-mediated photoreceptor transduction after subretinal injection","volume":"28","author":"Petit","year":"2017","journal-title":"Hum Gene Ther"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1159\/000479157","article-title":"Subretinal injection: a review on the novel route of therapeutic delivery for vitreoretinal diseases","volume":"58","author":"Peng","year":"2017","journal-title":"Ophthalmic Res"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0079-6123(09)17510-6","article-title":"Gene therapy and transplantation in the retinofugal pathway","volume":"175","author":"Harvey","year":"2009","journal-title":"Prog Brain Res"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1093\/hmg\/ddu426","article-title":"Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3(-\/-)\/Nrl(-\/-) mice, an all-cone model of CNGA3 achromatopsia(aEuro)","volume":"24","author":"Du","year":"2015","journal-title":"Hum Mol Genet"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1101\/gad.1384005","article-title":"A human, ATP-independent, RISC assembly machine fueled by pre-miRNA","volume":"19","author":"Maniataki","year":"2005","journal-title":"Gene Dev"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1016\/j.cub.2005.10.048","article-title":"Identification of novel argonaute-associated proteins","volume":"15","author":"Meister","year":"2005","journal-title":"Curr Biol"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"17004","DOI":"10.1038\/s41598-017-17331-z","article-title":"MiR-211 is essential for adult cone photoreceptor maintenance and visual function","volume":"7","author":"Barbato","year":"2017","journal-title":"Sci Rep UK"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/ng1253","article-title":"Dicer is essential for mouse development","volume":"35","author":"Bernstein","year":"2003","journal-title":"Nat Genet"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/ng1969","article-title":"DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal","volume":"39","author":"Wang","year":"2007","journal-title":"Nat Genet"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/nature06904","article-title":"Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes","volume":"453","author":"Tam","year":"2008","journal-title":"Nature"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"36957","DOI":"10.1074\/jbc.M005494200","article-title":"Human RNase III is a 160-kDa protein involved in preribosomal RNA processing","volume":"275","author":"Wu","year":"2000","journal-title":"J Biol Chem"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1073\/pnas.0810766105","article-title":"DGCR8-dependent microRNA biogenesis is essential for skin development","volume":"106","author":"Yi","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/nature03868","article-title":"TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing","volume":"436","author":"Chendrimada","year":"2005","journal-title":"Nature"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/sj.emboj.7600942","article-title":"The role of PACT in the RNA silencing pathway","volume":"25","author":"Lee","year":"2006","journal-title":"EMBO J"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1002\/sctm.16-0428","article-title":"Bone marrow-derived mesenchymal stem cells-derived exosomes promote survival of retinal ganglion cells through miRNA-dependent mechanisms","volume":"6","author":"Mead","year":"2017","journal-title":"Stem Cell Transl Med"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1167\/iovs.17-22855","article-title":"Mesenchymal stem cell-derived small extracellular vesicles promote neuroprotection in rodent models of glaucoma","volume":"59","author":"Mead","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2777905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:24Z","timestamp":1791927084000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2777905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,16]]},"references-count":61,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,9,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.12.14","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,16]]}}}