{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:19Z","timestamp":1791928759660,"version":"4.3.4"},"reference-count":30,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,2,23]]},"DOI":"10.1167\/iovs.62.2.36","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T11:48:12Z","timestamp":1614080892000},"page":"36","source":"Crossref","is-referenced-by-count":4,"title":["Retinal Phenotyping of Ferrochelatase Mutant Mice Reveals Protoporphyrin Accumulation and Reduced Neovascular Response"],"prefix":"10.1167","volume":"62","author":[{"given":"S. P. B.","family":"Sardar Pasha","sequence":"first","affiliation":[{"name":"Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trupti","family":"Shetty","sequence":"additional","affiliation":[{"name":"Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States"},{"name":"Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A.","family":"Lambert-Cheatham","sequence":"additional","affiliation":[{"name":"Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamakshi","family":"Sishtla","sequence":"additional","affiliation":[{"name":"Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Mathew","sequence":"additional","affiliation":[{"name":"Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anbukkarasi","family":"Muniyandi","sequence":"additional","affiliation":[{"name":"Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta","family":"Patwari","sequence":"additional","affiliation":[{"name":"Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashay D.","family":"Bhatwadekar","sequence":"additional","affiliation":[{"name":"Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States"},{"name":"Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy W.","family":"Corson","sequence":"additional","affiliation":[{"name":"Eugene and Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States"},{"name":"Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States"},{"name":"Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"a011676","DOI":"10.1101\/cshperspect.a011676","article-title":"Erythroid heme biosynthesis and its disorders","volume":"3","author":"Dailey","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.3389\/fphar.2020.01015","article-title":"Mitochondrial heme synthesis enzymes as therapeutic targets in vascular diseases","volume":"11","author":"Shetty","year":"2020","journal-title":"Front Pharmacol"},{"key":"bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/cphy.c120006","article-title":"Porphyrin and heme metabolism and the porphyrias","volume":"3","author":"Bonkovsky","year":"2013","journal-title":"Compr Physiol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1086\/301870","article-title":"Systematic analysis of molecular defects in the ferrochelatase gene from patients with erythropoietic protoporphyria","volume":"62","author":"Rufenacht","year":"1998","journal-title":"Am J Hum Genet"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1006\/geno.1993.1242","article-title":"Ferrochelatase structural mutant (Fechm1Pas) in the house mouse","volume":"16","author":"Boulechfar","year":"1993","journal-title":"Genomics"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1172\/JCI115491","article-title":"Erythropoietic protoporphyria in the house mouse: a recessive inherited ferrochelatase deficiency with anemia, photosensitivity, and liver disease","volume":"88","author":"Tutois","year":"1991","journal-title":"J Clin Invest"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"G1208","DOI":"10.1152\/ajpgi.00505.2004","article-title":"A mouse model provides evidence that genetic background modulates anemia and liver injury in erythropoietic protoporphyria","volume":"288","author":"Abitbol","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1182\/blood-2001-12-0283","article-title":"An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria","volume":"100","author":"Magness","year":"2002","journal-title":"Blood"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"786","DOI":"10.15252\/emmm.201606561","article-title":"Ferrochelatase is a therapeutic target for ocular neovascularization","volume":"9","author":"Basavarajappa","year":"2017","journal-title":"EMBO Mol Med"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"12419","DOI":"10.1096\/fsb2.v34.9","article-title":"Ferrochelatase regulates retinal neovascularization","volume":"34","author":"Pran Babu","year":"2020","journal-title":"FASEB J"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"101391","DOI":"10.1016\/j.isci.2020.101391","article-title":"Heme synthesis inhibition blocks angiogenesis via mitochondrial dysfunction","volume":"23","author":"Shetty","year":"2020","journal-title":"iScience"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1042\/BJ20060753","article-title":"Modulation of inhibition of ferrochelatase by N-methylprotoporphyrin","volume":"399","author":"Shi","year":"2006","journal-title":"Biochem J"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/(ISSN)1096-9896","article-title":"Liver pathology and hepatocarcinogenesis in a long-term mouse model of erythropoietic protoporphyria","volume":"199","author":"Libbrecht","year":"2003","journal-title":"J Pathol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"42545","DOI":"10.1038\/srep42545","article-title":"GARP2 accelerates retinal degeneration in rod cGMP-gated cation channel beta-subunit knockout mice","volume":"7","author":"DeRamus","year":"2017","journal-title":"Sci Rep"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"3332","DOI":"10.1167\/iovs.18-26257","article-title":"Interspecies variation of outer retina and choriocapillaris imaged with optical coherence tomography","volume":"60","author":"Soukup","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"25509","DOI":"10.1038\/srep25509","article-title":"A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapy","volume":"6","author":"Sulaiman","year":"2016","journal-title":"Sci Rep"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1097\/OPX.0000000000000941","article-title":"In vivo angiography quantifies oxygen-induced retinopathy vascular recovery","volume":"93","author":"Mezu-Ndubuisi","year":"2016","journal-title":"Optom Vis Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.exer.2013.04.014","article-title":"A novel ex vivo murine retina angiogenesis (EMRA) assay","volume":"112","author":"Rezzola","year":"2013","journal-title":"Exp Eye Res"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"e69552","DOI":"10.1371\/journal.pone.0069552","article-title":"Choroid sprouting assay: an ex vivo model of microvascular angiogenesis","volume":"8","author":"Shao","year":"2013","journal-title":"PLoS One"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"4611","DOI":"10.1167\/iovs.04-0541","article-title":"Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system","volume":"45","author":"Prusky","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nm.4059","article-title":"Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1","volume":"22","author":"Joyal","year":"2016","journal-title":"Nat Med"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"8428","DOI":"10.1167\/iovs.15-17901","article-title":"Quantification of oxygen consumption in retina ex vivo demonstrates limited reserve capacity of photoreceptor mitochondria","volume":"56","author":"Kooragayala","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1167\/iovs.10-5176","article-title":"The mouse retina as an angiogenesis model","volume":"51","author":"Stahl","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1350-9462(02)00043-5","article-title":"Vascular endothelial growth factors and angiogenesis in eye disease","volume":"22","author":"Witmer","year":"2003","journal-title":"Prog Retin Eye Res"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1126\/science.276.5319.1706","article-title":"Essential role of growth hormone in ischemia-induced retinal neovascularization","volume":"276","author":"Smith","year":"1997","journal-title":"Science"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/BF01974011","article-title":"Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals","volume":"66","author":"Brady","year":"1992","journal-title":"Arch Toxicol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1111\/jde.2007.34.issue-11","article-title":"Erythropoietic protoporphyria with eye complications","volume":"34","author":"Tsuboi","year":"2007","journal-title":"J Dermatol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1167\/iovs.18-25156","article-title":"Viability of mouse retinal explant cultures assessed by preservation of functionality and morphology","volume":"60","author":"Alarautalahti","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/exd.2005.14.issue-1","article-title":"Increased mitochondrial respiratory chain enzyme activities correlate with minor extent of liver damage in mice suffering from erythropoietic protoporphyria","volume":"14","author":"Navarro","year":"2005","journal-title":"Exp Dermatol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1242\/dmm.003467","article-title":"Mouse models of the metabolic syndrome","volume":"3","author":"Kennedy","year":"2010","journal-title":"Dis Model Mech"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:28Z","timestamp":1791927088000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.2.36","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,23]]}}}