{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:24Z","timestamp":1791928764974,"version":"4.3.4"},"reference-count":34,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:00:00Z","timestamp":1615420800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,3,11]]},"DOI":"10.1167\/iovs.62.3.17","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T11:32:11Z","timestamp":1615462331000},"page":"17","source":"Crossref","is-referenced-by-count":15,"title":["NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGF\u03b22-Induced Outflow in HTM\/HSC Constructs"],"prefix":"10.1167","volume":"62","author":[{"given":"Elena","family":"Bastia","sequence":"first","affiliation":[{"name":"Nicox Research Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol B.","family":"Toris","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, Omaha, Nebraska, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Nicox Research Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Galli","sequence":"additional","affiliation":[{"name":"Nicox Research Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Almirante","sequence":"additional","affiliation":[{"name":"Nicox Research Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V. W.","family":"Bergamini","sequence":"additional","affiliation":[{"name":"North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Masini","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Section of Pharmacology, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Sgambellone","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Section of Pharmacology, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Unser","sequence":"additional","affiliation":[{"name":"Glauconicx Biosciences Inc., Albany, New York, Unites States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feryan","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Glauconicx Biosciences Inc., Albany, New York, Unites States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Y.","family":"Torrejon","sequence":"additional","affiliation":[{"name":"Glauconicx Biosciences Inc., Albany, New York, Unites States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Navratil","sequence":"additional","affiliation":[{"name":"Nicox Ophthalmics, Inc., Durham, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Impagnatiello","sequence":"additional","affiliation":[{"name":"Nicox Research Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.preteyeres.2012.07.001","article-title":"Critical pathogenic events underlying progression of neurodegeneration in glaucoma","volume":"31","author":"Calkins","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial","volume":"120","author":"Heijl","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1097\/00055735-200304000-00006","article-title":"Normal Tension Glaucoma Study. Collaborative normal tension glaucoma study","volume":"14","author":"Anderson","year":"2003","journal-title":"Curr Opin Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/ICU.0b013e32834ff23e","article-title":"Current understanding of conventional outflow dysfunction in glaucoma","volume":"23","author":"Stamer","year":"2012","journal-title":"Curr Opin Ophthalmol"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"4673","DOI":"10.2174\/1381612821666150909095553","article-title":"Controversies in glaucoma: current medical treatment and drug development","volume":"21","author":"Bucolo","year":"2015","journal-title":"Curr Pharm Des"},{"issue":"4","key":"bib6","doi-asserted-by":"publisher","first-page":"180","DOI":"10.5694\/mja2.v210.4","article-title":"Current management of glaucoma","volume":"210","author":"Lusthaus","year":"2019","journal-title":"Med J Aust"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"5005","DOI":"10.1167\/iovs.14-14515","article-title":"Nitric oxide (NO): an emerging target for the treatment of glaucoma","volume":"55","author":"Cavet","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1089\/108076801750295263","article-title":"Intraocular pressure and vascular effects of sodium azide in bovine perfused eye","volume":"17","author":"Millar","year":"2001","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"C492","DOI":"10.1152\/ajpcell.00057.2013","article-title":"DIDS inhibits Na-KATPase activity in porcine nonpigmented ciliary epithelial cells by a Src family kinase-dependent mechanism","volume":"305","author":"Shahidullah","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3109\/08820539909061464","article-title":"Prostaglandin analogs in the treatment of glaucoma","volume":"14","author":"Hejkal","year":"1999","journal-title":"Semin Ophthalmol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1167\/iovs.18-23772","article-title":"A novel selective soluble guanylate cyclase activator, MGV354, lowers intraocular pressure in preclinical models, following topical ocular dosing","volume":"59","author":"Prasanna","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ajo.2018.05.015","article-title":"A randomized, controlled phase I\/II study to evaluate the safety and efficacy of MGV354 for ocular hypertension or glaucoma","volume":"192","author":"Stacy","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"8729","DOI":"10.1021\/jm402001w","article-title":"New drug\" designations for new therapeutic entities: new active substance, new chemical entity, new biological entity, new molecular entity","volume":"57","author":"Branch","year":"2014","journal-title":"J Med Chem"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1208\/s12248-010-9183-3","article-title":"Ocular drug delivery","volume":"12","author":"Gaudana","year":"2010","journal-title":"The AAPS J"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1002\/bit.v110.12","article-title":"Recreating a human trabecular meshwork outflow system on microfabricated porous structures","volume":"110","author":"Torrejon","year":"2013","journal-title":"Biotechnol Bioeng"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"38319","DOI":"10.1038\/srep38319","article-title":"TGF\u00df2-induced outflow alterations in a bioengineered trabecular meshwork are offset by a rho-associated kinase inhibitor","volume":"6","author":"Torrejon","year":"2016","journal-title":"Sci Rep"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1167\/iovs.05-1060","article-title":"TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure","volume":"47","author":"Fleenor","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"6558","DOI":"10.1167\/iovs.15-17190","article-title":"Intraocular pressure-lowering activity of NCX 470, a novel nitric oxide-donating bimatoprost in preclinical models","volume":"56","author":"Impagnatiello","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1248\/bpb.28.65","article-title":"Potent reduction of intraocular pressure by nipradilol plus latanoprost in ocular hypertensive rabbits","volume":"28","author":"Orihashi","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1097\/01.ijg.0000146361.15163.ea","article-title":"Effects of travoprost on aqueous humor dynamics in monkeys","volume":"14","author":"Toris","year":"2005","journal-title":"J Glaucoma"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1089\/jop.2008.0091","article-title":"Correlation of in vitro and in vivo kinetics of nitric oxide donors in ocular tissues","volume":"25","author":"Carreiro","year":"2009","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1089\/jop.2016.0168","article-title":"Consequences of puberty on efficacy of intraocular pressure-lowering drugs in male Dutch-belted rabbits","volume":"34","author":"Hays","year":"2018","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib23","first-page":"956","article-title":"Nitrovasodilators as a new class of ocular hypotensive agents","volume":"260","author":"Nathanson","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/IJG.0000000000000831","article-title":"Latanoprostene bunod 0.024% in subjects with open-angle glaucoma or ocular hypertension: pooled phase 3 study findings","volume":"27","author":"Weinreb","year":"2018","journal-title":"J Glaucoma"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.exer.2013.12.012","article-title":"Concentration-related effects of nitric oxide and endothelin-1 on human trabecular meshwork cell contractility","volume":"120","author":"Dismuke","year":"2014","journal-title":"Exp Eye Res"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1136\/bjo.2003.028357","article-title":"Nitric oxide proxies and ocular perfusion pressure in primary open angle glaucoma","volume":"88","author":"Galassi","year":"2004","journal-title":"Br J Ophthalmol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.exer.2011.03.001","article-title":"Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin F2a agonist, in preclinical models","volume":"93","author":"Krauss","year":"2011","journal-title":"Exp Eye Res"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1111\/cxo.v102.6","article-title":"Latanoprostene bunod ophthalmic solution 0.024%: a new treatment option for open-angle glaucoma and ocular hypertension","volume":"102","author":"Fingeret","year":"2019","journal-title":"Clin Exp Optom"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/nrn2214","article-title":"Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity","volume":"8","author":"Calabrese","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"5103","DOI":"10.1167\/iovs.12-11491","article-title":"Effect of nitric oxide on anterior segment physiology in monkeys","volume":"54","author":"Heyne","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.niox.2018.04.010","article-title":"The nitric oxide-guanylate cyclase pathway and glaucoma","volume":"77","author":"Wareham","year":"2018","journal-title":"Nitric Oxide"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.preteyeres.2016.12.004","article-title":"Aqueous outflow\u2014A continuum from trabecular meshwork to episcleral veins","volume":"57","author":"Carreon","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3109\/02713689609017615","article-title":"Short-term hemodynamic changes in episcleral arteriovenous anastomoses correlate with venous pressure and IOP changes in the albino rabbit","volume":"15","author":"Funk","year":"1996","journal-title":"Curr Eye Res"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1167\/iovs.09-4530","article-title":"Episcleral venous pressure responses to topical nitroprusside and N-nitro-L-arginine methyl ester","volume":"51","author":"Zamora","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:24Z","timestamp":1791927084000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,11]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.3.17","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,11]]}}}