{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:27Z","timestamp":1791928767687,"version":"4.3.4"},"reference-count":56,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,3,17]]},"DOI":"10.1167\/iovs.62.3.26","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T11:31:29Z","timestamp":1615980689000},"page":"26","source":"Crossref","is-referenced-by-count":33,"title":["Modulating Ocular Surface Pain Through Neurokinin-1 Receptor Blockade"],"prefix":"10.1167","volume":"62","author":[{"given":"Romina Mayra","family":"Lasagni Vitar","sequence":"first","affiliation":[{"name":"Cornea and Ocular Surface Disease Unit, Eye Repair Lab, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Barbariga","sequence":"additional","affiliation":[{"name":"Cornea and Ocular Surface Disease Unit, Eye Repair Lab, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Fonteyne","sequence":"additional","affiliation":[{"name":"Cornea and Ocular Surface Disease Unit, Eye Repair Lab, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Bignami","sequence":"additional","affiliation":[{"name":"Cornea and Ocular Surface Disease Unit, Eye Repair Lab, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Rama","sequence":"additional","affiliation":[{"name":"Cornea and Ocular Surface Disease Unit, Eye Repair Lab, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Cornea and Ocular Surface Disease Unit, Eye Repair Lab, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"3","key":"bib1","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.jtos.2017.05.002","article-title":"TFOS DEWS II pain and sensation report","volume":"15","author":"Belmonte","year":"2017","journal-title":"Ocul Surf"},{"issue":"10","key":"bib2","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1016\/j.pain.2011.06.006","article-title":"Chronic (neuropathic) corneal pain and blepharospasm: five case reports","volume":"152","author":"Borsook","year":"2011","journal-title":"Pain"},{"issue":"3","key":"bib3","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1097\/WNO.0000000000000601","article-title":"The most common causes of eye pain at 2 tertiary ophthalmology and neurology clinics","volume":"38","author":"Bowen","year":"2018","journal-title":"J Neuro-Ophthalmology"},{"issue":"3","key":"bib4","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1167\/iovs.15-18447","article-title":"Relationship of corneal pain sensitivity with dry eye symptoms in dry eye with short tear break-up time","volume":"57","author":"Kaido","year":"2016","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"6","key":"bib5","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1055\/s-00000031","article-title":"Hornhautdystrophie-(HD-)bedingte Schmerzen und Visusbeeintr\u00e4chtigung im Kindesalter","volume":"230","author":"Lisch","year":"2013","journal-title":"Klin Monbl Augenheilkd"},{"issue":"5","key":"bib6","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1097\/AJP.0000000000000271","article-title":"Mechanisms of corneal pain and implications for postoperative pain after laser correction of refractive errors","volume":"32","author":"Garcia","year":"2016","journal-title":"Clin J Pain"},{"issue":"1","key":"bib7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/ICO.0b013e31824d6fe3","article-title":"Postoperative pain after corneal collagen cross-linking","volume":"32","author":"Ghanem","year":"2013","journal-title":"Cornea"},{"issue":"10","key":"bib8","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1016\/j.jcrs.2015.11.005","article-title":"Sustained-release dexamethasone for the treatment of ocular inflammation and pain after cataract surgery","volume":"41","author":"Walters","year":"2015","journal-title":"J Cataract Refract Surg"},{"issue":"3","key":"bib9","first-page":"155","article-title":"Comparison of postoperative pain following laser-assisted subepithelial keratectomy and transepithelial photorefractive keratectomy: a prospective, random paired bilateral eye study","volume":"29","author":"Wang","year":"2014","journal-title":"Eye Sci"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"j3614","DOI":"10.1136\/bmj.j3614","article-title":"Painful red eyes in a contact lens wearer","volume":"358","author":"McVeigh","year":"2017","journal-title":"BMJ"},{"issue":"6","key":"bib11","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.mayocp.2013.03.014","article-title":"Herpes zoster eye complications: rates and trends","volume":"88","author":"Yawn","year":"2013","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"bib12","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1136\/bjophthalmol-2014-306280","article-title":"Ocular neuropathic pain","volume":"100","author":"Rosenthal","year":"2016","journal-title":"Br J Ophthalmol"},{"issue":"1\u20132","key":"bib13","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3109\/08820538.2015.1114853","article-title":"Understanding neuropathic corneal pain - Gaps and current therapeutic approaches","volume":"31","author":"Goyal","year":"2016","journal-title":"Semin Ophthalmol"},{"issue":"12","key":"bib14","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1517\/13543784.16.12.1977","article-title":"MK-0517): A neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting","volume":"16","author":"Fosaprepitant","year":"2007","journal-title":"Expert Opin Investig Drugs"},{"issue":"4","key":"bib15","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1634\/theoncologist.2014-0229","article-title":"Aprepitant and fosaprepitant: a 10-year review of efficacy and safety","volume":"20","author":"Aapro","year":"2015","journal-title":"Oncologist"},{"issue":"4","key":"bib16","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1093\/annonc\/mds541","article-title":"Efficacy and safety of single-dose fosaprepitant in the prevention of chemotherapy-induced nausea and vomiting in patients receiving high-dose cisplatin: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial","volume":"24","author":"Saito","year":"2013","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"issue":"10","key":"bib17","doi-asserted-by":"publisher","first-page":"6783","DOI":"10.1167\/iovs.14-14553","article-title":"NK1 receptor antagonists as a new treatment for corneal neovascularization","volume":"55","author":"Bignami","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib18","doi-asserted-by":"publisher","first-page":"e641","DOI":"10.1111\/aos.13304","article-title":"Growth inhibition of formed corneal neovascularization following fosaprepitant treatment","volume":"95","author":"Bignami","year":"2017","journal-title":"Acta Ophthalmol"},{"issue":"13","key":"bib19","doi-asserted-by":"publisher","first-page":"5329","DOI":"10.1167\/iovs.18-24707","article-title":"The effect of aging on nerve morphology and substance P expression in mouse and human corneas","volume":"59","author":"Barbariga","year":"2018","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"1\u20133","key":"bib20","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.brainresprot.2005.10.003","article-title":"Eye-wiping test: a sensitive animal model for acute trigeminal pain studies","volume":"16","author":"Farazifard","year":"2005","journal-title":"Brain Res Protoc"},{"issue":"3","key":"bib21","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1167\/iovs.12-10782","article-title":"Safety and efficacy of topical infliximab in a mouse model of ocular surface scarring","volume":"54","author":"Ferrari","year":"2013","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"5","key":"bib22","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1097\/01.ico.0000114127.63670.06","article-title":"Toxic keratopathy associated with abuse of low-dose anesthetic: a case report","volume":"23","author":"Chen","year":"2004","journal-title":"Cornea"},{"issue":"8","key":"bib23","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1016\/j.jcrs.2007.04.020","article-title":"Topical anesthesia-induced keratopathy after laser-assisted subepithelial keratectomy","volume":"33","author":"Rao","year":"2007","journal-title":"J Cataract Refract Surg"},{"issue":"11","key":"bib24","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1016\/S0886-3350(98)80180-6","article-title":"Topical anesthetic abuse after radial keratotomy","volume":"24","author":"Sugar","year":"1998","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"bib25","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3892\/etm.2016.3296","article-title":"Keratopathy due to ophthalmic drug abuse with corneal melting and perforation presenting as Mooren-like ulcer: a case report","volume":"12","author":"Wu","year":"2016","journal-title":"Exp Ther Med"},{"issue":"5","key":"bib27","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.jemermed.2015.02.051","article-title":"Safety and effectiveness of topical anesthetics in corneal abrasions: systematic review and meta-analysis","volume":"49","author":"Puls","year":"2015","journal-title":"J Emerg Med"},{"issue":"5","key":"bib28","first-page":"CD009781","article-title":"Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions","volume":"2017","author":"Wakai","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"bib29","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/01.ico.0000177835.93130.d4","article-title":"Three cases of corneal melting after instillation of a new nonsteroidal anti-inflammatory drug","volume":"25","author":"Asai","year":"2006","journal-title":"Cornea"},{"issue":"10","key":"bib30","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1016\/j.jcrs.2014.08.001","article-title":"Efficacy and safety of pain relief medications after photorefractive keratectomy: review of prospective randomized trials","volume":"40","author":"Faktorovich","year":"2014","journal-title":"J Cataract Refract Surg"},{"key":"bib31","first-page":"205","article-title":"Corneal melts associated with topically applied nonsteroidal anti-inflammmatory drugs","volume":"99","author":"Flach","year":"2001","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"5","key":"bib32","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/S0161-6420(00)00538-8","article-title":"Keratitis, ulceration, and perforation associated with topical nonsteroidal anti-inflammatory drugs","volume":"108","author":"Guidera","year":"2001","journal-title":"Ophthalmology"},{"issue":"1","key":"bib33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0953-4431(96)00152-X","article-title":"Using systemic analgesics for managing ocular pain","volume":"8","author":"Gurwood","year":"1996","journal-title":"Clin Eye Vis Care"},{"issue":"4 C","key":"bib34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/0166-2236(80)90036-3","article-title":"Substance P and pain: an updating","volume":"3","author":"Henry","year":"1980","journal-title":"Trends Neurosci"},{"issue":"9341","key":"bib35","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/S0140-6736(02)11280-3","article-title":"Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study","volume":"360","author":"Hoek","year":"2002","journal-title":"Lancet"},{"issue":"1","key":"bib36","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00441-018-2922-y","article-title":"Substance P and pain chronicity","volume":"375","author":"Zieglg\u00e4nsberger","year":"2019","journal-title":"Cell Tissue Res"},{"issue":"3","key":"bib37","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/sc.2015.206","article-title":"Role of neurokinin type 1 receptor in nociception at the periphery and the spinal level in the rat","volume":"54","author":"Gautam","year":"2016","journal-title":"Spinal Cord"},{"issue":"3","key":"bib38","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S0306-4522(98)00318-2","article-title":"Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of neuropathic pain in the guinea-pig","volume":"87","author":"Campbell","year":"1998","journal-title":"Neuroscience"},{"issue":"7","key":"bib39","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.3390\/ijms20071596","article-title":"Ion channels involved in substance P-mediated nociception and antinociception","volume":"20","author":"Chang","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"5","key":"bib40","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/S0009-9236(98)90140-0","article-title":"The substance P receptor antagonist CP-99,994 reduces acute postoperative pain","volume":"64","author":"Dionne","year":"1998","journal-title":"Clin Pharmacol Ther"},{"issue":"7","key":"bib41","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/S0165-6147(00)01502-9","article-title":"NK1 (substance P) receptor antagonists\u2013why are they not analgesic in humans?","volume":"21","author":"Hill","year":"2000","journal-title":"Trends Pharmacol Sci"},{"issue":"6","key":"bib42","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.ejpain.2005.08.001","article-title":"The NK1-receptor antagonist TKA731 in painful diabetic neuropathy: a randomised, controlled trial","volume":"10","author":"Sindrup","year":"2006","journal-title":"Eur J Pain"},{"issue":"3","key":"bib43","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/sj.bjp.0702620","article-title":"Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat","volume":"127","author":"Cellier","year":"1999","journal-title":"Br J Pharmacol"},{"issue":"4","key":"bib44","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.exer.2009.12.010","article-title":"Anatomy of the human corneal innervation","volume":"90","author":"Marfurt","year":"2010","journal-title":"Exp Eye Res"},{"issue":"3","key":"bib45","first-page":"387","article-title":"Qualitative analysis of substance P, NK1-receptor and nerve ingrowth in substance P-treated ruptured rat Achilles tendon","volume":"76","author":"Steyaert","year":"2010","journal-title":"Acta Orthop Belg"},{"issue":"4","key":"bib46","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jdsr.2017.01.003","article-title":"Neuropeptides and ATP signaling in the trigeminal ganglion","volume":"53","author":"Goto","year":"2017","journal-title":"Jpn Dent Sci Rev"},{"issue":"8","key":"bib47","doi-asserted-by":"publisher","first-page":"3969","DOI":"10.1167\/iovs.09-4744","article-title":"Cold-sensitive corneal afferents respond to a variety of ocular stimuli central to tear production: implications for dry eye disease","volume":"51","author":"Hirata","year":"2010","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"10","key":"bib48","doi-asserted-by":"publisher","first-page":"6289","DOI":"10.1167\/iovs.14-13984","article-title":"Ocular surface injury induces inflammation in the brain: In vivo and ex vivo evidence of a corneal\u2013trigeminal axis","volume":"55","author":"Ferrari","year":"2014","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"1","key":"bib49","doi-asserted-by":"publisher","first-page":"4582","DOI":"10.1038\/s41598-020-61390-8","article-title":"Novel RvD6 stereoisomer induces corneal nerve regeneration and wound healing post-injury by modulating trigeminal transcriptomic signature","volume":"10","author":"Pham","year":"2020","journal-title":"Sci Rep"},{"issue":"22","key":"bib50","doi-asserted-by":"publisher","first-page":"4249","DOI":"10.1007\/s00018-016-2293-z","article-title":"Neuropeptide substance P and the immune response","volume":"73","author":"Mashaghi","year":"2016","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"bib51","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.4049\/jimmunol.1601751","article-title":"Role of substance P neuropeptide in inflammation, wound healing, and tissue homeostasis","volume":"199","author":"Suvas","year":"2017","journal-title":"J Immunol"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3389\/fncel.2016.00296","article-title":"The therapeutic potential of targeting substance P\/NK-1R interactions in inflammatory CNS disorders","volume":"10","author":"Johnson","year":"2017","journal-title":"Front Cell Neurosci"},{"issue":"6312","key":"bib53","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1126\/science.aaf8924","article-title":"Pain regulation by non-neuronal cells and inflammation","volume":"354","author":"Ji","year":"2016","journal-title":"Science (80-)"},{"issue":"2","key":"bib54","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/AIA.0b013e318034194e","article-title":"Cytokines, inflammation, and pain","volume":"45","author":"Zhang","year":"2007","journal-title":"Int Anesthesiol Clin"},{"issue":"1\u20133","key":"bib55","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0014-2999(01)01311-5","article-title":"Involvement of chemokines in pain","volume":"429","author":"Boddeke","year":"2001","journal-title":"Eur J Pharmacol"},{"issue":"11","key":"bib56","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1038\/nm.2234","article-title":"Interactions between the immune and nervous systems in pain","volume":"16","author":"Ren","year":"2010","journal-title":"Nat Med"},{"key":"bib26","first-page":"e1121","article-title":"Efficacy of topical analgesics in pain control for corneal abrasions: a systematic review","volume-title":"Cureus","author":"Thiel","year":"2017"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:26Z","timestamp":1791927086000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,17]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.3.26","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,17]]}}}