{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:45Z","timestamp":1791928785285,"version":"4.3.4"},"reference-count":90,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,3,22]]},"DOI":"10.1167\/iovs.62.3.31","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T11:31:24Z","timestamp":1616412684000},"page":"31","source":"Crossref","is-referenced-by-count":2,"title":["Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells"],"prefix":"10.1167","volume":"62","author":[{"given":"Lorena Teixeira","family":"Frasson","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Development, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Dalmaso","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Development, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla Sayami","family":"Akamine","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Development, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edna Teruko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Development, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e2nia Emi","family":"Hamassaki","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Development, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Beltrame","family":"Del Debbio","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Development, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1126\/science.287.5460.2032","article-title":"Retinal stem cells in the adult mammalian eye","volume":"287","author":"Tropepe","year":"2000","journal-title":"Science"},{"key":"bib2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1006\/bbrc.2000.2473","article-title":"Identification of neural progenitors in the adult mammalian eye","volume":"270","author":"Ahmad","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"bib3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s40135-019-00195-z","article-title":"Adult stem cells, tools for repairing the retina","volume":"7","author":"Aladdad","year":"2019","journal-title":"Curr Ophthalmol Rep"},{"key":"bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2004.01.172","article-title":"Adult human retinal pigment epithelial cells capable of differentiating into neurons","volume":"316","author":"Amemiya","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"bib5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1471-2202-14-130","article-title":"Adult ciliary epithelial stem cells generate functional neurons and differentiate into both early and late born retinal neurons under non-cell autonomous influences","volume":"14","author":"Del Debbio","year":"2013","journal-title":"BMC Neurosci"},{"key":"bib6","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/cne.21860","article-title":"Gradual morphogenesis of retinal neurons in the peripheral retinal margin of adult monkeys and humans","volume":"511","author":"Mart\u00ednez-Navarrete","year":"2008","journal-title":"J Comp Neurol"},{"key":"bib7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.stem.2011.11.018","article-title":"Adult human RPE can be activated into a multipotent stem cell that produces mesenchymal derivatives","volume":"10","author":"Salero","year":"2012","journal-title":"Cell Stem Cell"},{"key":"bib8","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1167\/iovs.06-1034","article-title":"Characteristics of progenitor cells derived from adult ciliary body in mouse, rat, and human eyes","volume":"48","author":"Xu","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.semcdb.2003.09.003","article-title":"Neural stem cells in the mammalian eye: types and regulation","volume":"15","author":"Ahmad","year":"2004","journal-title":"Semin Cell Dev Biol"},{"key":"bib10","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.visres.2004.12.017","article-title":"Retinal properties and potential of the adult mammalian ciliary epithelium stem cells","volume":"45","author":"Das","year":"2005","journal-title":"Vision Res"},{"key":"bib11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1569-2590(05)10005-6","article-title":"Ciliary body and ciliary epithelium","volume":"10","author":"Delamere","year":"2005","journal-title":"Adv Organ Biol"},{"key":"bib12","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.preteyeres.2005.04.003","article-title":"Membrane properties of retinal stem cells\/progenitors","volume":"24","author":"Das","year":"2005","journal-title":"Prog Retin Eye Res"},{"key":"bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.preteyeres.2018.11.003","article-title":"Stemming retinal regeneration with pluripotent stem cells","volume":"69","author":"Jin","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"bib14","doi-asserted-by":"crossref","first-page":"5722","DOI":"10.3390\/ijms20225722","article-title":"Gene therapy in retinal dystrophies","volume":"20","author":"Ziccardi","year":"2019","journal-title":"Int J Mol Sci"},{"key":"bib15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1146\/annurev-genom-083118-015043","article-title":"Gene and induced pluripotent stem cell therapy for retinal diseases","volume":"20","author":"Maeda","year":"2019","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.exer.2018.09.003","article-title":"Optogenetic approaches to vision restoration","volume":"178","author":"Simunovic","year":"2019","journal-title":"Exp Eye Res"},{"key":"bib17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ajo.2019.05.010","article-title":"Optic disc pit maculopathy: new perspectives on the natural history","volume":"207","author":"Bloch","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"bib18","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41565-020-0696-3","article-title":"Subretinally injected semiconducting polymer nanoparticles rescue vision in a rat model of retinal dystrophy","volume":"15","author":"Maya-Vetencourt","year":"2020","journal-title":"Nat Nanotechnol"},{"key":"bib19","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1167\/iovs.13-13162","article-title":"Rho GTPases control ciliary epithelium cells proliferation and progenitor profile induction in vivo","volume":"55","author":"Del Debbio","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s40139-017-0127-9","article-title":"Retinal degeneration and regeneration\u2014lessons from fishes and amphibians","volume":"5","author":"Ail","year":"2017","journal-title":"Curr Pathobiol Rep"},{"key":"bib21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"bib22","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1167\/iovs.09-4657","article-title":"MicroRNA profile of the developing mouse retina","volume":"51","author":"Hackler","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib23","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1186\/1471-2164-11-715","article-title":"miRNeye: a microRNA expression atlas of the mouse eye","volume":"11","author":"Karali","year":"2010","journal-title":"BMC Genomics"},{"key":"bib24","doi-asserted-by":"crossref","first-page":"E2362","DOI":"10.1073\/pnas.1301837110","article-title":"Conserved microRNA pathway regulates developmental timing of retinal neurogenesis","volume":"110","author":"La Torre","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ydbio.2015.12.010","article-title":"Let-7 microRNA regulates neurogliogenesis in the mammalian retina through Hmga2","volume":"410","author":"Xia","year":"2016","journal-title":"Dev Biol"},{"key":"bib26","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1523\/JNEUROSCI.4853-07.2008","article-title":"The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration","volume":"28","author":"Fausett","year":"2008","journal-title":"J Neurosci"},{"key":"bib27","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.exer.2010.02.001","article-title":"Pax6a and Pax6b are required at different points in neuronal progenitor cell proliferation during zebrafish photoreceptor regeneration","volume":"90","author":"Thummel","year":"2010","journal-title":"Exp Eye Res"},{"key":"bib28","doi-asserted-by":"crossref","first-page":"9310","DOI":"10.1073\/pnas.0811186106","article-title":"Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish","volume":"106","author":"Qin","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib29","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.cell.2013.09.059","article-title":"Lin28 enhances tissue repair by reprogramming cellular metabolism","volume":"155","author":"Shyh-Chang","year":"2013","journal-title":"Cell"},{"key":"bib30","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","article-title":"Induced pluripotent stem cell lines derived from human somatic cells","volume":"318","author":"Yu","year":"2007","journal-title":"Science"},{"key":"bib31","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.cell.2011.10.020","article-title":"Molecular basis for interaction of Let-7 microRNAs with Lin28","volume":"147","author":"Nam","year":"2011","journal-title":"Cell"},{"key":"bib32","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.cell.2009.08.002","article-title":"TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation","volume":"138","author":"Heo","year":"2009","journal-title":"Cell"},{"key":"bib33","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.1093\/nar\/gks355","article-title":"The Lin28 cold-shock domain remodels pre-Let-7 microRNA","volume":"40","author":"Mayr","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"bib34","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1242\/dev.042895","article-title":"LIN28 alters cell fate succession and acts independently of the Let-7 microRNA during neurogliogenesis in vitro","volume":"137","author":"Balzer","year":"2010","journal-title":"Development"},{"key":"bib35","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1158\/0008-5472.CAN-17-3045","article-title":"Lessons from the crypt: HMGA1-amping up Wnt for stem cells and tumor progression","volume":"78","author":"Resar","year":"2018","journal-title":"Cancer Res"},{"key":"bib36","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1101\/gad.1540407","article-title":"The tumor suppressor microRNA Let-7 represses the HMGA2 oncogene","volume":"21","author":"Lee","year":"2007","journal-title":"Genes Dev"},{"key":"bib37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.stem.2008.10.008","article-title":"Ink4a\/Arf regulation by Let-7b and Hmga2: a genetic pathway governing stem cell aging","volume":"3","author":"Tzatsos","year":"2008","journal-title":"Cell Stem Cell"},{"key":"bib38","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1186\/1471-2407-14-694","article-title":"HMGA1 and HMGA2 expression and comparative analyses of HMGA2, Lin28 and Let-7 miRNAs in oral squamous cell carcinoma","volume":"14","author":"Sterenczak","year":"2014","journal-title":"BMC Cancer"},{"key":"bib39","doi-asserted-by":"crossref","first-page":"376326","DOI":"10.1155\/2014\/376326","article-title":"Role of miRNA Let-7 and its major targets in prostate cancer","volume":"2014","author":"Wagner","year":"2014","journal-title":"Biomed Res Int"},{"key":"bib40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.canlet.2016.04.020","article-title":"The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma","volume":"377","author":"Kaur","year":"2016","journal-title":"Cancer Lett"},{"key":"bib41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12885-016-2104-9","article-title":"The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma\u2013differences in histological subtypes","volume":"16","author":"Eide","year":"2016","journal-title":"BMC Cancer"},{"key":"bib42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fendo.2014.00037","article-title":"Mechanisms of therapeutic resistance in cancer (stem) cells with emphasis on thyroid cancer cells","volume":"5","author":"Hombach-Klonisch","year":"2014","journal-title":"Front Endocrinol (Lausanne)"},{"key":"bib43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ydbio.2004.05.023","article-title":"Identification of c-Kit receptor as a regulator of adult neural stem cells in the mammalian eye: interactions with Notch signaling","volume":"273","author":"Das","year":"2004","journal-title":"Dev Biol"},{"key":"bib44","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1167\/iovs.02-0899","article-title":"Direct identification and enrichment of retinal stem cells\/progenitors by Hoechst dye efflux assay","volume":"44","author":"Bhattacharya","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib45","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1093\/hmg\/ddy239","article-title":"Identifying core biological processes distinguishing human eye tissues with precise systems-level gene expression analyses and weighted correlation networks","volume":"27","author":"Bryan","year":"2018","journal-title":"Hum Mol Genet"},{"key":"bib46","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1167\/iovs.19-27106","article-title":"Eye in a disk: eyeIntegration Human Pan-Eye and Body Transcriptome Database Version 1.0","volume":"60","author":"Swamy","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib47","first-page":"4376","article-title":"Transcriptome analysis reveals rod\/cone photoreceptor specific signatures across mammalian retinas","volume":"25","author":"Mustafi","year":"2016","journal-title":"Hum Mol Genet"},{"key":"bib48","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.exer.2014.11.001","article-title":"Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE\/choroid by RNA-Seq","volume":"129","author":"Whitmore","year":"2014","journal-title":"Exp Eye Res"},{"key":"bib49","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1093\/hmg\/ddu114","article-title":"Comprehensive analysis of gene expression in human retina and supporting tissues","volume":"23","author":"Li","year":"2014","journal-title":"Hum Mol Genet"},{"key":"bib50","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1186\/1471-2164-14-486","article-title":"Transcriptome analyses of the human retina identify unprecedented transcript diversity and 3.5 Mb of novel transcribed sequence via significant alternative splicing and novel genes","volume":"14","author":"Farkas","year":"2013","journal-title":"BMC Genomics"},{"key":"bib51","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12864-018-4660-7","article-title":"Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular","volume":"19","author":"Izuogu","year":"2018","journal-title":"BMC Genomics"},{"key":"bib52","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.neuron.2017.04.022","article-title":"The dynamic epigenetic landscape of the retina during development, reprogramming, and tumorigenesis","volume":"94","author":"Aldiri","year":"2017","journal-title":"Neuron"},{"key":"bib53","first-page":"663","article-title":"Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal","volume":"25","author":"Kaya","year":"2019","journal-title":"Mol Vis"},{"key":"bib54","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/ncb3201","article-title":"An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes","volume":"17","author":"Wheway","year":"2015","journal-title":"Nat Cell Biol"},{"key":"bib55","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1167\/iovs.16-20018","article-title":"Restoration of mesenchymal RPE by transcription factor-mediated reprogramming","volume":"58","author":"Shih","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib56","doi-asserted-by":"crossref","first-page":"E4504","DOI":"10.1073\/pnas.1609643113","article-title":"Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture","volume":"113","author":"Darrow","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib57","first-page":"60","article-title":"Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells","volume":"23","author":"Samuel","year":"2017","journal-title":"Mol Vis"},{"key":"bib58","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.stem.2016.12.015","article-title":"Nicotinamide ameliorates disease phenotypes in a human iPSC model of age-related macular degeneration","volume":"20","author":"Saini","year":"2017","journal-title":"Cell Stem Cell"},{"key":"bib59","doi-asserted-by":"crossref","first-page":"e0183939","DOI":"10.1371\/journal.pone.0183939","article-title":"Characterization of lincRNA expression in the human retinal pigment epithelium and differentiated induced pluripotent stem cells","volume":"12","author":"Au","year":"2017","journal-title":"PLoS One"},{"key":"bib60","doi-asserted-by":"crossref","first-page":"534","DOI":"10.5966\/sctm.2012-0134","article-title":"Engineering a blood-retinal barrier with human embryonic stem cell-derived retinal pigment epithelium: transcriptome and functional analysis","volume":"2","author":"Peng","year":"2013","journal-title":"Stem Cells Transl Med"},{"key":"bib61","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0012-1606(03)00126-X","article-title":"Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites","volume":"258","author":"Moss","year":"2003","journal-title":"Dev Biol"},{"key":"bib62","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/j.fertnstert.2008.12.116","article-title":"Cellular senescence in usual type uterine leiomyoma","volume":"93","author":"Laser","year":"2010","journal-title":"Fertil Steril"},{"key":"bib63","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/ncb2115","article-title":"Ascl1a regulates M\u00fcller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, Let-7 microRNA signalling pathway","volume":"12","author":"Ramachandran","year":"2010","journal-title":"Nat Cell Biol"},{"key":"bib64","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cell.2008.09.017","article-title":"Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression","volume":"135","author":"Nishino","year":"2008","journal-title":"Cell"},{"key":"bib65","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.1158\/0008-5472.CAN-07-1083","article-title":"The Let-7 microRNA represses cell proliferation pathways in human cells","volume":"67","author":"Johnson","year":"2007","journal-title":"Cancer Res"},{"key":"bib66","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature08725","article-title":"Opposing microRNA families regulate self-renewal in mouse embryonic stem cells","volume":"463","author":"Melton","year":"2010","journal-title":"Nature"},{"key":"bib67","doi-asserted-by":"crossref","first-page":"107883","DOI":"10.1016\/j.exer.2019.107883","article-title":"MicroRNA profiling reveals important functions of miR-125b and Let-7a during human retinal pigment epithelial cell differentiation","volume":"190","author":"Shahriari","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib68","first-page":"1000","article-title":"Retinal regeneration in the Xenopus laevis tadpole: a new model system","volume":"15","author":"Vergara","year":"2009","journal-title":"Mol Vis"},{"key":"bib69","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1038\/srep06043","article-title":"The newt reprograms mature RPE cells into a unique multipotent state for retinal regeneration","volume":"4","author":"Islam","year":"2014","journal-title":"Sci Rep"},{"key":"bib70","doi-asserted-by":"crossref","first-page":"15772","DOI":"10.1073\/pnas.0401596101","article-title":"Facile isolation and the characterization of human retinal stem cells","volume":"101","author":"Coles","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib71","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exer.2008.09.020","article-title":"A comparison of epithelial and neural properties in progenitor cells derived from the adult human ciliary body and brain","volume":"88","author":"Moe","year":"2009","journal-title":"Exp Eye Res"},{"key":"bib72","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3390\/cells8080840","article-title":"Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies","volume":"8","author":"Khan","year":"2019","journal-title":"Cells"},{"key":"bib73","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1158\/0008-5472.CAN-04-0637","article-title":"Reduced expression of the Let-7 microRNAs in human lung cancers in association with shortened postoperative survival","volume":"64","author":"Takamizawa","year":"2004","journal-title":"Cancer Res"},{"key":"bib74","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1093\/nar\/gki863","article-title":"Real-time expression profiling of microRNA precursors in human cancer cell lines","volume":"33","author":"Jiang","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"bib75","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12943-015-0402-5","article-title":"Aberrant regulation of the LIN28A\/LIN28B and Let-7 loop in human malignant tumors and its effects on the hallmarks of cancer","volume":"14","author":"Wang","year":"2015","journal-title":"Mol Cancer"},{"key":"bib76","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00441-014-1872-2","article-title":"Lin28 and Let-7: ancient milestones on the road from pluripotency to neurogenesis","volume":"359","author":"Rehfeld","year":"2015","journal-title":"Cell Tissue Res"},{"key":"bib77","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/ncb3144","article-title":"Ascl1a regulates M\u00fcller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, Let-7 microRNA signalling pathway","volume":"17","author":"Ramachandran","year":"2015","journal-title":"Nat Cell Biol"},{"key":"bib78","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.molcel.2008.09.014","article-title":"Lin28 mediates the terminal uridylation of Let-7 precursor MicroRNA","volume":"32","author":"Heo","year":"2008","journal-title":"Mol Cell"},{"key":"bib79","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1261\/rna.1155108","article-title":"Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing","volume":"14","author":"Newman","year":"2008","journal-title":"RNA"},{"key":"bib80","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1096\/fj.201801118R","article-title":"The RNA-binding protein LIN28 controls progenitor and neuronal cell fate during postnatal neurogenesis","volume":"33","author":"Romer-Seibert","year":"2019","journal-title":"FASEB J"},{"key":"bib81","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ydbio.2018.05.007","article-title":"Lin28a regulates neurogliogenesis in mammalian retina through the Igf signaling","volume":"440","author":"Xia","year":"2018","journal-title":"Dev Biol"},{"key":"bib82","doi-asserted-by":"crossref","first-page":"9463","DOI":"10.1158\/0008-5472.CAN-10-2388","article-title":"Double-negative feedback loop between reprogramming factor LIN28 and microRNA Let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells","volume":"70","author":"Yang","year":"2010","journal-title":"Cancer Res"},{"key":"bib83","doi-asserted-by":"crossref","first-page":"e0172787","DOI":"10.1371\/journal.pone.0172787","article-title":"Disturbance of the Let-7\/LIN28 double-negative feedback loop is associated with radio- and chemo-resistance in non-small cell lung cancer","volume":"12","author":"Yin","year":"2017","journal-title":"PLoS One"},{"key":"bib84","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/cell.2017.0015","article-title":"Concise review: LIN28\/Let-7 signaling, a critical double-negative feedback loop during pluripotency, reprogramming, and tumorigenicity","volume":"19","author":"Farzaneh","year":"2017","journal-title":"Cell Reprogram"},{"key":"bib85","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/mrd.23226","article-title":"LIN28B regulates androgen receptor in human trophoblast cells through Let-7c","volume":"86","author":"McWhorter","year":"2019","journal-title":"Mol Reprod Dev"},{"key":"bib86","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.celrep.2015.08.086","article-title":"A single Let-7 microRNA bypasses LIN28-mediated repression","volume":"13","author":"Triboulet","year":"2015","journal-title":"Cell Rep"},{"key":"bib87","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.devcel.2012.10.019","article-title":"An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis","volume":"23","author":"Li","year":"2012","journal-title":"Dev Cell"},{"key":"bib88","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/nn.3165","article-title":"HMGA regulates the global chromatin state and neurogenic potential in neocortical precursor cells","volume":"15","author":"Kishi","year":"2012","journal-title":"Nat Neurosci"},{"key":"bib89","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1242\/dev.107326","article-title":"Hmga2 regulates self-renewal of retinal progenitors","volume":"141","author":"Parameswaran","year":"2014","journal-title":"Development"},{"key":"bib90","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.mad.2010.01.001","article-title":"Genetic instability and diminished differentiation capacity in long-term cultured mouse neurosphere cells","volume":"131","author":"Vukicevic","year":"2010","journal-title":"Mech Ageing Dev"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:28Z","timestamp":1791927088000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,22]]},"references-count":90,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.3.31","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,22]]}}}