{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:16Z","timestamp":1791928756327,"version":"4.3.4"},"reference-count":49,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"6","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,5,11]]},"DOI":"10.1167\/iovs.62.6.12","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T12:26:17Z","timestamp":1620735977000},"page":"12","source":"Crossref","is-referenced-by-count":14,"title":["Bilateral Limbal Stem Cell Alterations in Patients With Unilateral Herpes Simplex Keratitis and Herpes Zoster Ophthalmicus as Shown by In Vivo Confocal Microscopy"],"prefix":"10.1167","volume":"62","author":[{"given":"Xintian","family":"Liu","sequence":"first","affiliation":[{"name":"Eye Hospital, The First Affiliated Hospital of Harbin Medical University, No.143, Yiman Street, Harbin City, Nangang District, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Xu","sequence":"additional","affiliation":[{"name":"Eye Hospital, The First Affiliated Hospital of Harbin Medical University, No.143, Yiman Street, Harbin City, Nangang District, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbin","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye Hospital, The First Affiliated Hospital of Harbin Medical University, No.143, Yiman Street, Harbin City, Nangang District, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[{"name":"Eye Hospital, The First Affiliated Hospital of Harbin Medical University, No.143, Yiman Street, Harbin City, Nangang District, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shi","sequence":"additional","affiliation":[{"name":"Eye Hospital, The First Affiliated Hospital of Harbin Medical University, No.143, Yiman Street, Harbin City, Nangang District, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eye Hospital, The First Affiliated Hospital of Harbin Medical University, No.143, Yiman Street, Harbin City, Nangang District, Heilongjiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"31","key":"bib1","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1556\/650.2017.30821","article-title":"Diagnostics and treatment of infectious keratitis[J]","volume":"158","author":"Szentmary","year":"2017","journal-title":"Orv Hetil"},{"issue":"1","key":"bib2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/0022-510X(93)90082-A","article-title":"Age distribution of latent herpes simplex virus 1 and varicella-zoster virus genome in human nervous tissue[J]","volume":"116","author":"Liedtke","year":"1993","journal-title":"J Neurol Sci"},{"issue":"7","key":"bib3","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1097\/ICO.0000000000000425","article-title":"Do unilateral herpetic stromal keratitis and neurotrophic ulcers cause bilateral dry eye?","volume":"34","author":"Jabbarvand","year":"2015","journal-title":"Cornea"},{"issue":"1","key":"bib4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00003226-200101000-00001","article-title":"Herpes simplex virus epidemiology and ocular importance","volume":"20","author":"Liesegang","year":"2001","journal-title":"Cornea"},{"issue":"2 Suppl","key":"bib5","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.ophtha.2007.10.009","article-title":"Herpes zoster ophthalmicus natural history, risk factors, clinical presentation, and morbidity","volume":"115","author":"Liesegang","year":"2008","journal-title":"Ophthalmology"},{"issue":"1 Suppl 1","key":"bib6","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.jpain.2007.10.002","article-title":"Natural history and treatment of herpes zoster","volume":"9","author":"Schmader","year":"2008","journal-title":"J Pain"},{"issue":"1","key":"bib7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00003226-200101000-00001","article-title":"Herpes simplex virus epidemiology and ocular importance","volume":"20","author":"Liesegang","year":"2001","journal-title":"Cornea"},{"issue":"3","key":"bib8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00018-018-2938-1","article-title":"Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea","volume":"76","author":"Koujah","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2012.07.002","article-title":"Pathogenesis of herpes stromal keratitis\u2013a focus on corneal neovascularization","volume":"33","author":"Gimenez","year":"2013","journal-title":"Prog Retin Eye Res"},{"issue":"6","key":"bib10","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1111\/bjh.2010.148.issue-6","article-title":"Activated protein C action in inflammation","volume":"148","author":"Sarangi","year":"2010","journal-title":"Br J Haematol"},{"issue":"1","key":"bib11","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s00417-019-04519-4","article-title":"Intrastromal bevacizumab in the management of corneal neovascularization: a retrospective review.","volume":"258","author":"Gupta","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib12","first-page":"721","article-title":"The limbal palisades of Vogt.","volume":"89","author":"Townsend W","year":"1991","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"1","key":"bib13","first-page":"96","article-title":"Corneal epithelial wound healing in the absence of limbal epithelium.","volume":"32","author":"Huang","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib14","first-page":"155","article-title":"Limbal palisades of Vogt","volume":"80","author":"Goldberg M","year":"1982","journal-title":"Trans Am Ophthalmol Soc"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"37173","DOI":"10.1038\/srep37173","article-title":"Development of functional human oral mucosal epithelial stem\/progenitor cell sheets using a feeder-free and serum-free culture system for ocular surface reconstruction","volume":"6","author":"Nakamura","year":"2016","journal-title":"Sci Rep"},{"issue":"5","key":"bib16","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s00417-011-1616-x","article-title":"Assessment of limbus and central cornea in patients with keratolimbal allograft transplantation using in vivo laser scanning confocal microscopy: an observational study","volume":"249","author":"Hong","year":"2011","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"1","key":"bib17","doi-asserted-by":"publisher","first-page":"5","DOI":"10.4103\/0974-9233.106381","article-title":"Presentation, diagnosis and management of limbal stem cell deficiency","volume":"20","author":"Sejpal","year":"2013","journal-title":"Middle East Afr J Ophthalmol"},{"issue":"1","key":"bib18","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jtos.2017.11.002","article-title":"The diagnosis of limbal stem cell deficiency","volume":"16","author":"Le","year":"2018","journal-title":"Ocul Surf"},{"key":"bib19","article-title":"Limbal stem cell deficiency associated with herpes keratitis","author":"Carreno-Galeano","journal-title":"Cornea"},{"issue":"2","key":"bib20","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.ajo.2012.08.017","article-title":"In vivo confocal microscopy in diagnosis of limbal stem cell deficiency","volume":"155","author":"Nubile","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ajo.2018.03.010","article-title":"In vivo confocal microscopy cellular features of host and organism in bacterial, fungal, and acanthamoeba keratitis","volume":"190","author":"Chidambaram","year":"2018","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"bib22","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s00417-011-1616-x","article-title":"Assessment of limbus and central cornea in patients with keratolimbal allograft transplantation using in vivo laser scanning confocal microscopy: an observational study","volume":"249","author":"Hong","year":"2011","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"7","key":"bib23","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1167\/iovs.05-1492","article-title":"Laser scanning in vivo confocal microscopy of the normal human corneoscleral limbus","volume":"47","author":"Patel","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib24","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/ceo.2017.45.issue-3","article-title":"Correlation between the existence of the palisades of Vogt and limbal epithelial thickness in limbal stem cell deficiency","volume":"45","author":"Le","year":"2017","journal-title":"Clin Exp Ophthalmol"},{"issue":"1","key":"bib25","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jtos.2017.09.004","article-title":"In vivo confocal microscopy detects bilateral changes of corneal immune cells and nerves in unilateral herpes zoster ophthalmicus","volume":"16","author":"Cavalcanti","year":"2018","journal-title":"Ocul Surf"},{"issue":"11","key":"bib26","doi-asserted-by":"publisher","first-page":"6612","DOI":"10.1167\/iovs.15-16560","article-title":"Contralateral clinically unaffected eyes of patients with unilateral infectious keratitis demonstrate a sympathetic immune response","volume":"56","author":"Cruzat","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"bib27","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1016\/j.ophtha.2012.03.005","article-title":"Cellular changes of the corneal epithelium and stroma in herpes simplex keratitis: an in vivo confocal microscopy study","volume":"119","author":"Hamrah","year":"2012","journal-title":"Ophthalmology"},{"issue":"11","key":"bib28","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/S0161-6420(02)01250-2","article-title":"Idiopathic limbal stem cell deficiency","volume":"109","author":"Espana","year":"2002","journal-title":"Ophthalmology"},{"issue":"1","key":"bib29","first-page":"96","article-title":"Corneal epithelial wound healing in the absence of limbal epithelium","volume":"32","author":"Huang","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib30","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.ajo.2015.06.026","article-title":"Limbal basal cell density decreases in limbal stem cell deficiency","volume":"160","author":"Chan","year":"2015","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"bib31","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jtos.2017.11.002","article-title":"The diagnosis of limbal stem cell deficiency","volume":"16","author":"Le","year":"2018","journal-title":"Ocul Surf"},{"issue":"11","key":"bib32","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/S1474-4422(07)70267-3","article-title":"The neurotropic herpes viruses: herpes simplex and varicella-zoster","volume":"6","author":"Steiner","year":"2007","journal-title":"Lancet Neurol"},{"issue":"8","key":"bib33","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/sj.eye.6700616","article-title":"Neurotrophic keratitis","volume":"17","author":"Bonini","year":"2003","journal-title":"Eye (Lond)"},{"issue":"4","key":"bib34","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1023\/A:1017935624867","article-title":"Limbal stem cells in health and disease","volume":"21","author":"Sangwan V","year":"2001","journal-title":"Biosci Rep"},{"issue":"5","key":"bib35","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1136\/bjo.2004.049742","article-title":"Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche","volume":"89","author":"Dua H","year":"2005","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"bib36","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s00441-014-2032-4","article-title":"Roles of limbal microvascular net and limbal stroma in regulating maintenance of limbal epithelial stem cells","volume":"359","author":"Huang","year":"2015","journal-title":"Cell Tissue Res"},{"issue":"8","key":"bib37","first-page":"2219","article-title":"Abnormal corneal epithelial wound healing in partial-thickness removal of limbal epithelium","volume":"32","author":"Chen","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib38","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ophtha.2012.07.036","article-title":"Unilateral herpes zoster ophthalmicus results in bilateral corneal nerve alteration: an in vivo confocal microscopy study","volume":"120","author":"Hamrah","year":"2013","journal-title":"Ophthalmology"},{"issue":"35","key":"bib39","doi-asserted-by":"publisher","first-page":"e4234","DOI":"10.1097\/MD.0000000000004234","article-title":"Using optical coherence tomography to assess the role of age and region in corneal epithelium and palisades of vogt","volume":"95","author":"Lin","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"bib40","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/j.1365-2990.1994.tb00982.x","article-title":"A molecular and cellular model to explain the differences in reactivation from latency by herpes simplex and varicella-zoster viruses","volume":"20","author":"Kennedy","year":"1994","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"10","key":"bib41","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1016\/j.ophtha.2010.07.010","article-title":"Corneal sensation and subbasal nerve alterations in patients with herpes simplex keratitis: an in vivo confocal microscopy study","volume":"117","author":"Hamrah","year":"2010","journal-title":"Ophthalmology"},{"issue":"11","key":"bib42","first-page":"4584","article-title":"Effects of nerve growth factor on nerve regeneration after corneal nerve damage","volume":"7","author":"Ma","year":"2014","journal-title":"Int J Clin Exp Med"},{"issue":"2","key":"bib43","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3928\/1081597X-20140120-10","article-title":"Nerve growth factor expression and nerve regeneration in monkey corneas after LASIK","volume":"30","author":"Chen","year":"2014","journal-title":"J Refract Surg"},{"issue":"5","key":"bib44","first-page":"1063","article-title":"Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas","volume":"41","author":"Lambiase","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib45","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0014-4835(03)00050-2","article-title":"Corneal nerves: structure, contents and function","volume":"76","author":"Muller","year":"2003","journal-title":"Exp Eye Res"},{"issue":"1","key":"bib46","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/stem.2921","article-title":"The role of nerve growth factor in maintaining proliferative capacity, colony-forming efficiency, and the limbal stem cell phenotype","volume":"37","author":"Kolli","year":"2019","journal-title":"Stem Cells"},{"issue":"6","key":"bib47","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1097\/ICU.0000000000000618","article-title":"Ocular manifestations of herpes simplex virus","volume":"30","author":"Valerio","year":"2019","journal-title":"Curr Opin Ophthalmol"},{"issue":"1","key":"bib48","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jtos.2018.10.002","article-title":"Pathogenesis of herpes simplex keratitis: The host cell response and ocular surface sequelae to infection and inflammation","volume":"17","author":"Lobo","year":"2019","journal-title":"Ocul Surf"},{"issue":"11","key":"bib49","doi-asserted-by":"publisher","first-page":"e187864","DOI":"10.1371\/journal.pone.0187864","article-title":"In vivo imaging of palisades of Vogt in dry eye versus normal subjects using en-face spectral-domain optical coherence tomography","volume":"12","author":"Ghouali","year":"2017","journal-title":"PLoS One"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:23Z","timestamp":1791927083000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,11]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,5,3]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.6.12","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5,11]]}}}