{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:45Z","timestamp":1791928785361,"version":"4.3.4"},"reference-count":69,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"7","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,6,22]]},"DOI":"10.1167\/iovs.62.7.24","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T12:16:54Z","timestamp":1624364214000},"page":"24","source":"Crossref","is-referenced-by-count":32,"title":["Small RNA Sequencing of Aqueous Humor and Plasma in Patients With Primary Open-Angle Glaucoma"],"prefix":"10.1167","volume":"62","author":[{"given":"Wouter H. G.","family":"Hubens","sequence":"first","affiliation":[{"name":"University Eye Clinic Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands"},{"name":"School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Krauskopf","sequence":"additional","affiliation":[{"name":"Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henny J. M.","family":"Beckers","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos C. S.","family":"Kleinjans","sequence":"additional","affiliation":[{"name":"Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carroll A. B.","family":"Webers","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo G. M. F.","family":"Gorgels","sequence":"additional","affiliation":[{"name":"University Eye Clinic Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"issue":"2","key":"bib3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/00055735-199704000-00007","article-title":"New definitions of glaucoma","volume":"8","author":"Gupta","year":"1997","journal-title":"Curr Opin Ophthalmol"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.preteyeres.2013.09.001","article-title":"The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology","volume":"37","author":"Janssen","year":"2013","journal-title":"Prog Retin Eye Res"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0002-9394(00)00538-9","article-title":"The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. The AGIS Investigators","volume":"130","author":"AGIS","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1001\/archopht.120.6.714","article-title":"The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma","volume":"120","author":"Gordon","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"bib7","first-page":"89","article-title":"Incidence of open-angle glaucoma: the Barbados Eye Studies. The Barbados Eye Studies Group","volume":"119","author":"Leske","year":"2001","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"bib8","doi-asserted-by":"publisher","first-page":"180","DOI":"10.5694\/mja2.v210.4","article-title":"Current management of glaucoma","volume":"210","author":"Lusthaus","year":"2019","journal-title":"Med J Aust"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1097\/IJG.0000000000000389","article-title":"A systematic review of end-of-life visual impairment in open-angle glaucoma: an epidemiological autopsy","volume":"25","author":"Mokhles","year":"2016","journal-title":"J Glaucoma"},{"issue":"4","key":"bib10","first-page":"69616","article-title":"MicroRNAs in gene regulation: when the smallest governs it all","volume":"2006","author":"Ouellet","year":"2006","journal-title":"J Biomed Biotechnol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/S1097-2765(02)00541-5","article-title":"Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells","volume":"9","author":"Zeng","year":"2002","journal-title":"Mol Cell"},{"issue":"2","key":"bib12","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nrg2290","article-title":"Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?","volume":"9","author":"Filipowicz","year":"2008","journal-title":"Nat Rev Genet"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1167\/iovs.17-23599","article-title":"MicroRNA profiling in glaucoma eyes with varying degrees of optic neuropathy by using next-generation sequencing","volume":"59","author":"Liu","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"5089","DOI":"10.1038\/srep05089","article-title":"Profiles of extracellular miRNAs in the aqueous humor of glaucoma patients assessed with a microarray system","volume":"4","author":"Tanaka","year":"2014","journal-title":"Sci Rep"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1167\/iovs.17-21844","article-title":"Comparison of microRNA expression in aqueous humor of normal and primary open-angle glaucoma patients using PCR arrays: a pilot study","volume":"58","author":"Jayaram","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1093\/hmg\/ddy040","article-title":"Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma","volume":"27","author":"Drewry","year":"2018","journal-title":"Hum Mol Genet"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1167\/iovs.18-24878","article-title":"Identification of candidate miRNA biomarkers for glaucoma","volume":"60","author":"Hindle","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1167\/iovs.19-26663","article-title":"Discovery and validation of circulating Hsa-miR-210-3p as a potential biomarker for primary open-angle glaucoma","volume":"60","author":"Liu","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib20","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s12859-018-2287-y","article-title":"MiRge 2.0 for comprehensive analysis of microRNA sequencing data","volume":"19","author":"Lu","year":"2018","journal-title":"BMC Bioinformatics"},{"key":"bib21","first-page":"129","article-title":"MiRBase: the microRNA sequence database","volume":"342","author":"Griffiths-Jones","year":"2006","journal-title":"Methods Mol Biol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.envint.2019.04.063","article-title":"Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks","volume":"128","author":"Krauskopf","year":"2019","journal-title":"Environ Int"},{"issue":"10","key":"bib24","doi-asserted-by":"publisher","first-page":"e0206239","DOI":"10.1371\/journal.pone.0206239","article-title":"miRWalk: An online resource for prediction of microRNA binding sites","volume":"13","author":"Sticht","year":"2018","journal-title":"PLoS One"},{"issue":"Pt B","key":"bib25","doi-asserted-by":"publisher","first-page":"114392","DOI":"10.1016\/j.envpol.2020.114392","article-title":"MicroRNA expression profiles and personal monitoring of exposure to particulate matter","volume":"263","author":"Mancini","year":"2020","journal-title":"Environ Pollut"},{"issue":"Database issue","key":"bib26","doi-asserted-by":"publisher","first-page":"D163","DOI":"10.1093\/nar\/gkq1107","article-title":"MiRTarBase: a database curates experimentally validated microRNA-target interactions","volume":"39","author":"Hsu","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"issue":"W1","key":"bib28","doi-asserted-by":"publisher","first-page":"W460","DOI":"10.1093\/nar\/gkv403","article-title":"DIANA-miRPath v3.0: deciphering microRNA function with experimental support","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ajo.2005.07.044","article-title":"Categorizing the stage of glaucoma from pre-diagnosis to end-stage disease","volume":"141","author":"Mills","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1261\/rna.1947110","article-title":"Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression","volume":"16","author":"Git","year":"2010","journal-title":"RNA"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/jlb.2000.67.issue-4","article-title":"Does innate immune privilege exist?","volume":"67","author":"Streilein","year":"2000","journal-title":"J Leukoc Biol"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0002-9394(14)73519-6","article-title":"Photoreceptor outer segments in the aqueous humor of patients with atopic dermatitis and retinal detachment","volume":"115","author":"Matsuo","year":"1993","journal-title":"Am J Ophthalmol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.exer.2015.01.019","article-title":"Human aqueous humor exosomes","volume":"132","author":"Dismuke","year":"2015","journal-title":"Exp Eye Res"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1016\/j.bbrc.2018.08.082","article-title":"Intraocular miR-211 exacerbates pressure-induced cell death in retinal ganglion cells via direct repression of FRS2 signaling","volume":"503","author":"Yang","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"108197","DOI":"10.1016\/j.exer.2020.108197","article-title":"MiR-21-5p: a viable therapeutic strategy for regulating intraocular pressure","volume":"200","author":"Tan","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/s41598-017-01003-z","article-title":"Regulation of intraocular pressure by microRNA cluster miR-143\/145","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ebiom.2016.03.048","article-title":"Prolactin protects retinal pigment epithelium by inhibiting sirtuin 2-dependent cell death","volume":"7","author":"Melendez Garcia","year":"2016","journal-title":"EBioMedicine"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.neurobiolaging.2019.10.002","article-title":"Prolactin mitigates deficiencies of retinal function associated with aging","volume":"85","author":"Arnold","year":"2020","journal-title":"Neurobiol Aging"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.exer.2007.11.003","article-title":"Expression and cellular localization of prolactin and the prolactin receptor in mammalian retina","volume":"86","author":"Rivera","year":"2008","journal-title":"Exp Eye Res"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1097\/IJG.0000000000001513","article-title":"Serum apelin and asymmetric dimethylarginine levels in patients with exfoliation syndrome or exfoliative glaucoma","volume":"29","author":"Bezci Aygun","year":"2020","journal-title":"J Glaucoma"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ejphar.2016.08.036","article-title":"Apelin-36 is protective against N-methyl-D-aspartic-acid-induced retinal ganglion cell death in the mice","volume":"791","author":"Sakamoto","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jphs.2016.12.002","article-title":"Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1\/2, and suppressing TNF-alpha expression in mice","volume":"133","author":"Ishimaru","year":"2017","journal-title":"J Pharmacol Sci"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1007\/s11064-019-02948-5","article-title":"Systemic Administration of an Apelin Receptor Agonist Prevents NMDA-Induced Loss of Retinal Neuronal Cells in Mice","volume":"45","author":"Shibagaki","year":"2020","journal-title":"Neurochem Res"},{"key":"bib44","first-page":"85","article-title":"A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q","volume":"12","author":"Pang","year":"2006","journal-title":"Mol Vis"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.mrrev.2005.11.001","article-title":"The role of oxidative stress in glaucoma","volume":"612","author":"Izzotti","year":"2006","journal-title":"Mutat Res"},{"issue":"1","key":"bib46","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.optom.2017.06.002","article-title":"Reactive oxygen species, oxidative stress, glaucoma and hyperbaric oxygen therapy","volume":"11","author":"McMonnies","year":"2018","journal-title":"J Optom"},{"issue":"4","key":"bib47","doi-asserted-by":"publisher","first-page":"BSR20170695","DOI":"10.1042\/BSR20170695","article-title":"Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice","volume":"37","author":"Zeng","year":"2017","journal-title":"Biosci Rep"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"9337","DOI":"10.1007\/s11033-020-05994-3","article-title":"Evaluation of silent information regulator T (SIRT) 1 and Forkhead Box O (FOXO) transcription factor 1 and 3a genes in glaucoma","volume":"47","author":"Yaman","year":"2020","journal-title":"Mol Biol Rep"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cbi.2019.03.021","article-title":"miR-221 promotes lens epithelial cells apoptosis through interacting with SIRT1 and E2F3","volume":"306","author":"Gong","year":"2019","journal-title":"Chem Biol Interact"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"108128","DOI":"10.1016\/j.exer.2020.108128","article-title":"Circular RNA HIPK3 regulates human lens epithelial cell dysfunction by targeting the miR-221-3p\/PI3K\/AKT pathway in age-related cataract","volume":"198","author":"Cui","year":"2020","journal-title":"Exp Eye Res"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1093\/hmg\/ddn201","article-title":"A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex","volume":"17","author":"Mellios","year":"2008","journal-title":"Hum Mol Genet"},{"issue":"2","key":"bib52","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1080\/02713683.2017.1396617","article-title":"Brain-derived neurotrophic factor in patients with primary open-angle glaucoma and age-related cataract","volume":"43","author":"Shpak","year":"2018","journal-title":"Curr Eye Res"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s00417-018-3923-y","article-title":"The effect of trabeculectomy on serum brain-derived neurotrophic factor levels in primary open-angle glaucoma","volume":"256","author":"Uzel","year":"2018","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"3","key":"bib54","doi-asserted-by":"publisher","first-page":"E443","DOI":"10.1152\/ajpendo.00360.2018","article-title":"MiRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy","volume":"316","author":"Shao","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"bib55","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/IJG.0000000000001448","article-title":"Mitochondrial markers in aging and primary open-angle glaucoma","volume":"29","author":"Liu","year":"2020","journal-title":"J Glaucoma"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.mito.2017.05.004","article-title":"Mitochondrial dysfunction in ocular disease: focus on glaucoma","volume":"35","author":"Kamel","year":"2017","journal-title":"Mitochondrion."},{"key":"bib57","first-page":"1162","article-title":"TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients","volume":"21","author":"Ashworth Briggs","year":"2015","journal-title":"Mol Vis"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1471-2415-13-69","article-title":"Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance","volume":"13","author":"Fountoulakis","year":"2013","journal-title":"BMC Ophthalmol"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s12038-017-9709-2","article-title":"MicroRNA-486-5p suppresses TGF-beta2-induced proliferation, invasion and epithelial-mesenchymal transition of lens epithelial cells by targeting Smad2","volume":"42","author":"Liu","year":"2017","journal-title":"J Biosci"},{"issue":"12","key":"bib60","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.3390\/cells8121518","article-title":"Role of fibronectin in primary open angle glaucoma","volume":"8","author":"Faralli","year":"2019","journal-title":"Cells"},{"issue":"13","key":"bib61","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021942118","article-title":"Primary cilia and the reciprocal activation of AKT and SMAD2\/3 regulate stretch-induced autophagy in trabecular meshwork cells","volume":"118","author":"Shim","year":"2021","journal-title":"Proc Natl Acad Sci USA."},{"issue":"2","key":"bib62","doi-asserted-by":"publisher","first-page":"e57850","DOI":"10.1371\/journal.pone.0057850","article-title":"MicroRNA-762 is upregulated in human corneal epithelial cells in response to tear fluid and Pseudomonas aeruginosa antigens and negatively regulates the expression of host defense genes encoding RNase7 and ST2","volume":"8","author":"Mun","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"bib63","doi-asserted-by":"publisher","first-page":"7956","DOI":"10.1074\/jbc.M112.445429","article-title":"MicroRNA-92a negatively regulates Toll-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase","volume":"288","author":"Lai","year":"2013","journal-title":"J Biol Chem"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"3780","DOI":"10.1096\/fsb2.v28.8","article-title":"DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice","volume":"28","author":"Sundermeier","year":"2014","journal-title":"FASEB J"},{"key":"bib65","doi-asserted-by":"crossref","first-page":"100916","DOI":"10.1016\/j.preteyeres.2020.100916","article-title":"Inflammation in glaucoma: from the back to the front of the eye, and beyond","author":"Baudouin","year":"2020","journal-title":"Prog Retin Eye Res"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1002\/jemt.22743","article-title":"Label-free optical detection of age-related and diabetic oxidative damage in human aqueous humors","volume":"79","author":"Woong Moon","year":"2016","journal-title":"Microsc Res Tech"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"118641","DOI":"10.1016\/j.ijpharm.2019.118641","article-title":"Confocal Raman spectroscopy: evaluation of a non-invasive technique for the detection of topically applied ketorolac tromethamine in vitro and in vivo","volume":"570","author":"Bertens","year":"2019","journal-title":"Int J Pharm"},{"issue":"4","key":"bib68","doi-asserted-by":"publisher","first-page":"041106","DOI":"10.1117\/1.NPh.6.4.041106","article-title":"Nonresonant raman spectroscopy of isolated human retina samples complying with laser safety regulations for in vivo measurements","volume":"6","author":"Stiebing","year":"2019","journal-title":"Neurophotonics"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"3659423","DOI":"10.1155\/2017\/3659423","article-title":"Rapid detection and identification of miRNAs by surface-enhanced raman spectroscopy using hollow Au nanoflowers substrates","volume":"2017","author":"Cao","year":"2017","journal-title":"J. Nanomater"},{"key":"bib23","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2013"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:26Z","timestamp":1791927086000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":69,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.7.24","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,22]]}}}