{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:54Z","timestamp":1791928794011,"version":"4.3.4"},"reference-count":77,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"7","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,6,23]]},"DOI":"10.1167\/iovs.62.7.26","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T11:32:16Z","timestamp":1624447936000},"page":"26","source":"Crossref","is-referenced-by-count":27,"title":["Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration"],"prefix":"10.1167","volume":"62","author":[{"given":"John T.","family":"Demirs","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura A.","family":"Crowley","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Twarog","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Poor","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis S.","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaddeus P.","family":"Dryja","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha-Mei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.molimm.2015.02.032","article-title":"Age-related macular degeneration and the role of the complement system","volume":"67","author":"McHarg","year":"2015","journal-title":"Mol Immunol"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40246-016-0079-x","article-title":"AMD and the alternative complement pathway: genetics and functional implications","volume":"10","author":"Tan","year":"2016","journal-title":"Hum Genomics"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.ophtha.2018.03.034","article-title":"Genome-wide association studies identify disease mechanisms in age-related macular degeneration","volume":"125","author":"Wright","year":"2018","journal-title":"Ophthalmology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"7227","DOI":"10.1073\/pnas.0501536102","article-title":"A common haplotype in the complement regulatory gene factor H (HF1\/CFH) predisposes individuals to age-related macular degeneration","volume":"102","author":"Hageman","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.preteyeres.2009.11.003","article-title":"The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited","volume":"29","author":"Anderson","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"bib6","first-page":"443","article-title":"Immunohistological study of subretinal membranes in age-related macular degeneration","volume":"36","author":"Baudouin","year":"1992","journal-title":"Jpn J Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/gim.2015.70","article-title":"Age-related macular degeneration: genome-wide association studies to translation","volume":"18","author":"Black","year":"2016","journal-title":"Genet Med"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/ng.3448","article-title":"A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants","volume":"48","author":"Fritsche","year":"2016","journal-title":"Nat Genet"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1089\/gtmb.2018.0110","article-title":"Association between complement factor C2\/C3\/CFB\/CFH polymorphisms and age-related macular degeneration: a meta-analysis","volume":"22","author":"Lu","year":"2018","journal-title":"Genet Test Mol Biomarkers"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"Klein","year":"2005","journal-title":"Science"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1126\/science.1110189","article-title":"Complement factor H polymorphism and age-related macular degeneration","volume":"308","author":"Edwards","year":"2005","journal-title":"Science"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1126\/science.1110359","article-title":"Complement factor H variant increases the risk of age-related macular degeneration","volume":"308","author":"Haines","year":"2005","journal-title":"Science"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1086\/431426","article-title":"Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration","volume":"77","author":"Zareparsi","year":"2005","journal-title":"Am J Hum Genet"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/ejhg.2008.140","article-title":"Variation near complement factor I is associated with risk of advanced AMD","volume":"17","author":"Fagerness","year":"2009","journal-title":"Eur J Hum Genet"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/ng1750","article-title":"Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration","volume":"38","author":"Gold","year":"2006","journal-title":"Nat Genet"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1093\/hmg\/ddm146","article-title":"Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration","volume":"16","author":"Spencer","year":"2007","journal-title":"Hum Mol Genet"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1038\/ng2131","article-title":"Variation in complement factor 3 is associated with risk of age-related macular degeneration","volume":"39","author":"Maller","year":"2007","journal-title":"Nat Genet"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/ng.2741","article-title":"Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration","volume":"45","author":"Seddon","year":"2013","journal-title":"Nat Genet"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1167\/iovs.11-8425","article-title":"C9-R95X polymorphism in patients with neovascular age-related macular degeneration","volume":"53","author":"Nishiguchi","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/ng1890","article-title":"A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration","volume":"38","author":"Hughes","year":"2006","journal-title":"Nat Genet"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1080\/07853890601097030","article-title":"Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications","volume":"38","author":"Hageman","year":"2006","journal-title":"Ann Med"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1086\/377701","article-title":"Age-related macular degeneration\u2013a genome scan in extended families","volume":"73","author":"Majewski","year":"2003","journal-title":"Am J Hum Genet"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1086\/422476","article-title":"Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions","volume":"75","author":"Weeks","year":"2004","journal-title":"Am J Hum Genet"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"e2593","DOI":"10.1371\/journal.pone.0002593","article-title":"Systemic complement activation in age-related macular degeneration","volume":"3","author":"Scholl","year":"2008","journal-title":"PLoS One"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.ophtha.2011.07.056","article-title":"Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration","volume":"119","author":"Smailhodzic","year":"2012","journal-title":"Ophthalmology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1093\/hmg\/ddp472","article-title":"Genetic control of the alternative pathway of complement in humans and age-related macular degeneration","volume":"19","author":"Hecker","year":"2010","journal-title":"Hum Mol Genet"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1001\/archopht.125.4.515","article-title":"Estimation of systemic complement C3 activity in age-related macular degeneration","volume":"125","author":"Sivaprasad","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"5818","DOI":"10.1167\/iovs.09-3928","article-title":"Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes","volume":"50","author":"Reynolds","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"8828","DOI":"10.1167\/iovs.11-7933","article-title":"Complement factor D in age-related macular degeneration","volume":"52","author":"Stanton","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"26568","DOI":"10.1038\/srep26568","article-title":"A novel complotype combination associates with age-related macular degeneration and high complement activation levels in vivo","volume":"6","author":"Paun","year":"2016","journal-title":"Sci Rep"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/eye.2016.328","article-title":"Local complement activation in aqueous humor in patients with age-related macular degeneration","volume":"31","author":"Schick","year":"2017","journal-title":"Eye"},{"key":"bib32","first-page":"79","article-title":"Association of age-related macular degeneration with complement activation products, smoking, and single nucleotide polymorphisms in South Carolinians of European and African descent","volume":"25","author":"Rohrer","year":"2019","journal-title":"Mol Vis"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1177\/1120672119857896","article-title":"Systemic activation of the complement system in patients with advanced age-related macular degeneration","volume":"30","author":"Lynch","year":"2020","journal-title":"Eur J Ophthalmol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1442-9071.2011.02581.x","article-title":"Therapeutic targeting of the complement system in age-related macular degeneration: a review","volume":"40","author":"Troutbeck","year":"2012","journal-title":"Clin Experiment Ophthalmol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.ejpb.2015.02.020","article-title":"Antibody therapies and their challenges in the treatment of age-related macular degeneration","volume":"95","author":"Volz","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1136\/bjophthalmol-2015-306972","article-title":"Current therapeutic developments in atrophic age-related macular degeneration","volume":"100","author":"Hanus","year":"2016","journal-title":"Br J Ophthalmol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ejphar.2016.03.001","article-title":"Targeting the complement system for the management of retinal inflammatory and degenerative diseases","volume":"787","author":"Xu","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1001\/jamaophthalmol.2018.1544","article-title":"Efficacy and safety of lampalizumab for geographic atrophy due to age-related macular degeneration: Chroma and Spectri phase 3 randomized clinical trials","volume":"136","author":"Holz","year":"2018","journal-title":"JAMA Ophthalmol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neurobiolaging.2016.12.017","article-title":"A review of human diseases caused or exacerbated by aberrant complement activation","volume":"52","author":"McGeer","year":"2017","journal-title":"Neurobiol Aging"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/nrneph.2016.70","article-title":"Complement in disease: a defence system turning offensive","volume":"12","author":"Ricklin","year":"2016","journal-title":"Nat Rev Nephrol"},{"issue":"Pt 2","key":"bib41","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/eye.1997.47","article-title":"Regulation of ocular immune responses","volume":"11","author":"Streilein","year":"1997","journal-title":"Eye (Lond)"},{"key":"bib42","first-page":"4195","article-title":"Complement regulatory activity of normal human intraocular fluid is mediated by MCP, DAF, and CD59","volume":"41","author":"Sohn","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib43","first-page":"357","article-title":"Immunohistochemical localization of complement regulatory proteins in the human retina","volume":"27","author":"Fett","year":"2012","journal-title":"Histol Histopathol"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/path.4128","article-title":"Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration","volume":"229","author":"Ebrahimi","year":"2013","journal-title":"J Pathol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"4902","DOI":"10.1038\/s41467-019-12780-8","article-title":"Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration","volume":"10","author":"Menon","year":"2019","journal-title":"Nat Commun"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1016\/j.celrep.2019.10.084","article-title":"Cell-type-specific complement expression in the healthy and diseased retina","volume":"29","author":"Pauly","year":"2019","journal-title":"Cell Rep"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"e3000365","DOI":"10.1371\/journal.pbio.3000365","article-title":"Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis","volume":"17","author":"Hu","year":"2019","journal-title":"PLoS Biol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"24100","DOI":"10.1073\/pnas.1914143116","article-title":"Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration","volume":"116","author":"Voigt","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib49","article-title":"Cell types of the human retina and its organoids at single-cell resolution: developmental convergence, transcriptomic identity, and disease map","author":"Cowan","year":"2019","journal-title":"BioRxiv"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.celrep.2019.12.082","article-title":"Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration","volume":"30","author":"Orozco","year":"2020","journal-title":"Cell Rep"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"4484","DOI":"10.1167\/iovs.04-0342","article-title":"The Minnesota Grading System of eye bank eyes for age-related macular degeneration","volume":"45","author":"Olsen","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.ophtha.2012.10.036","article-title":"Clinical classification of age-related macular degeneration","volume":"120","author":"Ferris","year":"2013","journal-title":"Ophthalmology"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1136\/bjo.60.5.324","article-title":"Ageing and degeneration in the macular region: a clinico-pathological study","volume":"60","author":"Sarks","year":"1976","journal-title":"Br J Ophthalmol"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1167\/iovs.17-22605","article-title":"Induction of ocular complement activation by inflammatory stimuli and intraocular inhibition of complement factor D in animal models","volume":"59","author":"Crowley","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1167\/iovs.10-6476","article-title":"Choriocapillaris vascular dropout related to density of drusen in human eyes with early age-related macular degeneration","volume":"52","author":"Mullins","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib56","first-page":"1986","article-title":"Quantifying changes in RPE and choroidal vasculature in eyes with age-related macular degeneration","volume":"43","author":"McLeod","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"4982","DOI":"10.1167\/iovs.09-3639","article-title":"Relationship between RPE and choriocapillaris in age-related macular degeneration","volume":"50","author":"McLeod","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"7348","DOI":"10.1038\/s41598-018-25557-8","article-title":"Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy","volume":"8","author":"Katschke","year":"2018","journal-title":"Sci Rep"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.preteyeres.2017.06.002","article-title":"On phagocytes and macular degeneration","volume":"61","author":"Guillonneau","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12974-017-0814-9","article-title":"Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain","volume":"14","author":"Fonseca","year":"2017","journal-title":"J Neuroinflammation"},{"key":"bib62","first-page":"1588","article-title":"Complement gene expression and regulation in mouse retina and retinal pigment epithelium\/choroid","volume":"17","author":"Luo","year":"2011","journal-title":"Mol Vis"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"30192","DOI":"10.1074\/jbc.M110.103986","article-title":"Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina","volume":"285","author":"Clark","year":"2010","journal-title":"J Biol Chem"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"3473","DOI":"10.1167\/iovs.08-3202","article-title":"Expression and modulation of RPE cell membrane complement regulatory proteins","volume":"50","author":"Yang","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/ng.2640","article-title":"A functional variant in the CFI gene confers a high risk of age-related macular degeneration","volume":"45","author":"van de Ven","year":"2013","journal-title":"Nat Genet"},{"key":"bib67","first-page":"3861","article-title":"Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels","volume":"24","author":"Kavanagh","year":"2015","journal-title":"Hum Mol Genet"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1093\/hmg\/ddaa114","article-title":"Effect of rare coding variants in the CFI gene on Factor I expression levels","volume":"29","author":"de Jong","year":"2020","journal-title":"Hum Mol Genet"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1167\/iovs.61.6.18","article-title":"Rare genetic variants in complement factor I lead to low FI plasma levels resulting in increased risk of age-related macular degeneration","volume":"61","author":"Hallam","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1038\/s41433-019-0501-4","article-title":"Early local activation of complement in aqueous humour of patients with age-related macular degeneration","volume":"33","author":"Altay","year":"2019","journal-title":"Eye (Lond)"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"6628","DOI":"10.1167\/iovs.12-9587","article-title":"Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration","volume":"53","author":"Loyet","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1006\/exer.2001.1094","article-title":"Complement activation and inflammatory processes in Drusen formation and age related macular degeneration","volume":"73","author":"Johnson","year":"2001","journal-title":"Exp Eye Res"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0002-9394(02)01624-0","article-title":"A role for local inflammation in the formation of drusen in the aging eye","volume":"134","author":"Anderson","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"4870","DOI":"10.1167\/iovs.15-17009","article-title":"Assessment of proteins associated with complement activation and inflammation in maculae of human donors homozygous risk at chromosome 1 CFH-to-F13B","volume":"56","author":"Keenan","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.ophtha.2013.09.044","article-title":"Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE study","volume":"121","author":"Yehoshua","year":"2014","journal-title":"Ophthalmology"},{"key":"bib76","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ophtha.2019.07.011","article-title":"Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial","volume":"127","author":"Liao","year":"2020","journal-title":"Ophthalmology"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/nrneph.2010.85","article-title":"C3 glomerulopathy: a new classification","volume":"6","author":"Fakhouri","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"bib58","first-page":"240","volume-title":"The Complement FactsBook","author":"Morley","year":"1999"},{"key":"bib63","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-809324-5.01301-8","article-title":"Anatomy and Regulation of the Optic Nerve Blood Flow","volume-title":"Reference Module in Neuroscience and Biobehavioral Psychology","author":"Ehrlich","year":"2017"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:26Z","timestamp":1791927086000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2772726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,23]]},"references-count":77,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.7.26","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,23]]}}}