{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:43Z","timestamp":1791928783158,"version":"4.3.4"},"reference-count":43,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"9","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,7,9]]},"DOI":"10.1167\/iovs.62.9.17","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T21:49:58Z","timestamp":1625867398000},"page":"17","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of the Effect of a Novel\n                    <i>\u03b23<\/i>\n                    -Adrenergic Agonist on Choroidal Vascularity"],"prefix":"10.1167","volume":"62","author":[{"given":"Murat","family":"Topcuoglu","sequence":"first","affiliation":[{"name":"Alaaddin Keykubat University Education and Research Hospital, Department of Urology, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Aslan","sequence":"additional","affiliation":[{"name":"Alaaddin Keykubat University Education and Research Hospital, Department of Ophthalmology, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"4922","key":"bib1","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1126\/science.2570461","article-title":"Molecular characterization of the human beta 3-adrenergic receptor","volume":"245","author":"Emorine","year":"1989","journal-title":"Science"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3390\/cells8040357","article-title":"Everything you always wanted to know about \u00df3-AR * (* but were afraid to ask)","volume":"8","author":"Schena","year":"2019","journal-title":"Cells"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1002\/ejhf.2017.19.issue-4","article-title":"Cardiac beta3-adrenergic receptors in the clinical arena: the end of the beginning","volume":"19","author":"Balligand","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.2337\/db18-0462","article-title":"Regulation of human adipose tissue activation, gallbladder size, and bile acid metabolism by a \u00df3-adrenergic receptor agonist","volume":"67","author":"Baskin","year":"2018","journal-title":"Diabetes"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00210-013-0835-6","article-title":"\u00df3-adrenoceptors: a drug target in ophthalmology","volume":"386","author":"Gericke","year":"2013","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/S0014-5793(98)00631-0","article-title":"Beta3-adrenergic relaxation of bovine iris sphincter","volume":"429","author":"Geyer","year":"1998","journal-title":"FEBS Lett"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"20681","DOI":"10.1074\/jbc.M300368200","article-title":"Beta 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation","volume":"278","author":"Steinle","year":"2003","journal-title":"J Biol Chem"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.exer.2004.08.015","article-title":"Beta 3-adrenergic receptors mediate choroidal endothelial cell invasion, proliferation, and cell elongation","volume":"80","author":"Steinle","year":"2005","journal-title":"Exp Eye Res"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1124\/jpet.106.115840","article-title":"Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function","volume":"321","author":"Takasu","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1002\/nau.22609","article-title":"Do we need a new definition of the overactive bladder syndrome? ICI-RS 2013","volume":"33","author":"Drake","year":"2014","journal-title":"Neurourol Urodyn"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1111\/ijcp.2013.67.issue-7","article-title":"Mirabegron for the treatment of overactive bladder: a prespecified pooled efficacy analysis and pooled safety analysis of three randomised, double-blind, placebo-controlled, phase III studies","volume":"67","author":"Nitti","year":"2013","journal-title":"Int J Clin Pract"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.biocel.2009.10.006","article-title":"Proliferative retinopathies: angiogenesis that blinds","volume":"42","author":"Sapieha","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"196","DOI":"10.5301\/ejo.5000860","article-title":"Choroidal thickness and visual prognosis in type 1 lesion due to neovascular age-related macular degeneration","volume":"27","author":"Hern\u00e1ndez-Mart\u00ednez","year":"2017","journal-title":"Eur J Ophthalmol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.ajo.2014.01.019","article-title":"Subfoveal choroidal thickness as a potential predictor of visual outcome and treatment response after intravitreal ranibizumab injections for typical exudative age-related macular degeneration","volume":"157","author":"Kang","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"2968","DOI":"10.1167\/iovs.12-9691","article-title":"Propranolol inhibition of \u00df-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy","volume":"53","author":"Chen","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.ajo.2008.05.032","article-title":"Enhanced depth imaging spectral-domain optical coherence tomography","volume":"146","author":"Spaide","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1016\/j.ophtha.2013.01.066","article-title":"Analysis of choroidal morphologic features and vasculature in healthy eyes using spectral-domain optical coherence tomography","volume":"120","author":"Branchini","year":"2013","journal-title":"Ophthalmology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"issue":"6","key":"bib19","doi-asserted-by":"publisher","first-page":"3893","DOI":"10.1167\/iovs.14-14447","article-title":"Choroidal structure in normal eyes and after photodynamic therapy determined by binarization of optical coherence tomographic images","volume":"55","author":"Sonoda","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/S0161-6420(13)38012-9","article-title":"Grading diabetic retinopathy from stereoscopic color fundus photographs\u2013an extension of the modified Airlie House classification","volume":"98","author":"ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group","year":"1991","journal-title":"Ophthalmology"},{"issue":"Pt 2","key":"bib21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/eye.1990.43","article-title":"Control of retinal and choroidal blood flow","volume":"4","author":"Bill","year":"1990","journal-title":"Eye (Lond)"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.preteyeres.2017.12.001","article-title":"Neural control of choroidal blood flow","volume":"64","author":"Reiner","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.3390\/molecules23051191","article-title":"Structure-activity relationships based on 3D-QSAR CoMFA\/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human \u00df3-adrenergic receptor and anti-obesity and anti-diabetic profiles","volume":"23","author":"Lorca","year":"2018","journal-title":"Molecules"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S0165-6147(96)80011-3","article-title":"Function and regulation of the beta 3-adrenoceptor","volume":"17","author":"Strosberg","year":"1996","journal-title":"Trends Pharmacol Sci"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/0165-6147(94)90118-X","article-title":"The human beta 3-adrenoceptor: the search for a physiological function","volume":"15","author":"Emorine","year":"1994","journal-title":"Trends Pharmacol Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/B978-0-12-381298-8.00011-3","article-title":"\u00df(3)-Adrenoceptor agonists and (antagonists as) inverse agonists history, perspective, constitutive activity, and stereospecific binding","volume":"484","author":"Grazia Perrone","year":"2010","journal-title":"Methods Enzymol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1124\/jpet.107.125757","article-title":"GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog","volume":"323","author":"Hicks","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.eururo.2012.05.053","article-title":"A multicenter, double-blind, randomized, placebo-controlled trial of the \u00df3-adrenoceptor agonist solabegron for overactive bladder","volume":"62","author":"Ohlstein","year":"2012","journal-title":"Eur Urol"},{"issue":"1-3","key":"bib29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2011.01.061","article-title":"Desirable properties of \u00df3-adrenoceptor agonists: implications for the selection of drug development candidates","volume":"657","author":"Michel","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.3390\/cancers12061415","article-title":"Current therapies and new targets to fight melanoma: a promising role for the \u00df3-adrenoreceptor","volume":"12","author":"Filippi","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"9","key":"bib31","doi-asserted-by":"publisher","first-page":"e006753","DOI":"10.1161\/CIRCHEARTFAILURE.119.006753","article-title":"Targeting cardiac myocyte Na+-K+ pump function with \u00df3 adrenergic agonist in rabbit model of severe congestive heart failure","volume":"13","author":"Fry","year":"2020","journal-title":"Circ Heart Fail"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.ajo.2011.03.008","article-title":"Analysis of choroidal thickness in age-related macular degeneration using spectral-domain optical coherence tomography","volume":"152","author":"Manjunath","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1097\/ICU.0b013e3282fb7c33","article-title":"Polypoidal choroidal vasculopathy and treatments","volume":"19","author":"Gomi","year":"2008","journal-title":"Curr Opin Ophthalmol"},{"key":"bib34","first-page":"385","article-title":"Foveolar choroidal blood flow in age-related macular degeneration","volume":"39","author":"Grunwald","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3109\/09286580903450346","article-title":"Prevalence of visual impairment in the adult Japanese population by cause and severity and future projections","volume":"17","author":"Yamada","year":"2010","journal-title":"Ophthalmic Epidemiol"},{"key":"bib36","article-title":"Pachychoroid spectrum disease [published online ahead of print November 30, 2020]","author":"Borooah","journal-title":"Acta Ophthalmol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1006\/rtph.1998.1243","article-title":"Binding of drugs to eye melanin is not predictive of ocular toxicity","volume":"28","author":"Leblanc","year":"1998","journal-title":"Regul Toxicol Pharmacol"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1089\/jop.2012.0254","article-title":"Randomized, double-masked, placebo-controlled study to assess the ocular safety of mirabegron in healthy volunteers","volume":"29","author":"Novack","year":"2013","journal-title":"J Ocul Pharmacol Ther"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s00210-011-0682-2","article-title":"Role of \u00df3-adrenoceptors in regulation of retinal vascular tone in rats","volume":"384","author":"Mori","year":"2011","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"4","key":"bib42","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1167\/iovs.11-9408","article-title":"Beta-adrenoreceptor agonism influences retinal responses to hypoxia in a model of retinopathy of prematurity","volume":"53","author":"Dal Monte","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"21090","DOI":"10.1038\/srep21090","article-title":"Choroidal vascularity index as a measure of vascular status of the choroid: measurements in healthy eyes from a population-based study","volume":"6","author":"Agrawal","year":"2016","journal-title":"Sci Rep"},{"key":"bib37","author":"U.S. Food and Drug Administration","year":"2012"},{"key":"bib38","author":"European Medicines Agency."}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2776450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:24Z","timestamp":1791927084000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2776450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,9]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.9.17","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7,9]]}}}