{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:52:45Z","timestamp":1793213565197,"version":"4.5.0"},"reference-count":29,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"9","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,7,16]]},"DOI":"10.1167\/iovs.62.9.25","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T11:31:18Z","timestamp":1626435078000},"page":"25","source":"Crossref","is-referenced-by-count":18,"title":["Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Damage Via miR-138\/ROBO4 Axis"],"prefix":"10.1167","volume":"62","author":[{"given":"Xiaoling","family":"Shi","sequence":"first","affiliation":[{"name":"Institute of Brain Diseases and Cognition, Medical College of Xiamen University, Xiamen, Fujian, China"},{"name":"Affiliated Xiamen Eye Center, Medical College of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuo","family":"Dong","sequence":"additional","affiliation":[{"name":"Affiliated Xiamen Eye Center, Medical College of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Institute of Brain Diseases and Cognition, Medical College of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanhua","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Brain Diseases and Cognition, Medical College of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Brain Diseases and Cognition, Medical College of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/s41419-020-2522-0","article-title":"PKCtheta-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization","volume":"11","author":"Kumar","year":"2020","journal-title":"Cell Death Dis"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1002\/(ISSN)1097-0177","article-title":"Hyperoxia inhibits several critical aspects of vascular development","volume":"236","author":"Uno","year":"2007","journal-title":"Dev Dyn"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.biopha.2016.10.015","article-title":"Madecassic Acid protects against hypoxia-induced oxidative stress in retinal microvascular endothelial cells via ROS-mediated endoplasmic reticulum stress","volume":"84","author":"Yang","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"6974","DOI":"10.3892\/mmr.2017.7475","article-title":"FK506 suppresses hypoxia induced inflammation and protects tight junction function via the CaNNFATc1 signaling pathway in retinal microvascular epithelial cells","volume":"16","author":"Hu","year":"2017","journal-title":"Mol Med Rep"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"512","DOI":"10.2174\/1389200221666200610172105","article-title":"Salidroside - Can it be a Multifunctional Drug?","volume":"21","author":"Magani","year":"2020","journal-title":"Curr Drug Metab"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"109552","DOI":"10.1016\/j.biopha.2019.109552","article-title":"Anti-inflammatory effects of Rhodiola rosea L.: A review","volume":"121","author":"Pu","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"976","DOI":"10.3389\/fphar.2020.00976","article-title":"Traditional Tibetan medicine in cancer therapy by targeting apoptosis pathways","volume":"11","author":"Tang","year":"2020","journal-title":"Front Pharmacol"},{"key":"bib8","doi-asserted-by":"crossref","first-page":"9568647","DOI":"10.1155\/2020\/9568647","article-title":"Antioxidant Effects of Salidroside in the Cardiovascular System","volume":"2020","author":"Sun","year":"2020","journal-title":"Evid Based Complement Alternat Med"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.biopha.2018.04.184","article-title":"Salidroside protects hypoxia-induced injury by up-regulation of miR-210 in rat neural stem cells","volume":"103","author":"Yan","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.bbrc.2020.06.036","article-title":"Salidroside alleviated hypoxia-induced liver injury by inhibiting endoplasmic reticulum stress-mediated apoptosis via IRE1alpha\/JNK pathway","volume":"529","author":"Xiong","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"bib11","first-page":"2363","article-title":"Salidroside prevents hydroperoxide-induced oxidative stress and apoptosis in retinal pigment epithelium cells","volume":"16","author":"Yin","year":"2018","journal-title":"Exp Ther Med"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1080\/15476286.2019.1637696","article-title":"Salidroside alleviates high-glucose-induced injury in retinal pigment epithelial cell line ARPE-19 by down-regulation of miR-138","volume":"16","author":"Qian","year":"2019","journal-title":"RNA Biol"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4331\/wjbc.v5.i1.1","article-title":"MicroRNA signature and function in retinal neovascularization","volume":"5","author":"Agrawal","year":"2014","journal-title":"World J Biol Chem"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.exer.2019.01.006","article-title":"Impact of angiogenic activation and inhibition on miRNA profiles of human retinal endothelial cells","volume":"181","author":"Walz","year":"2019","journal-title":"Exp Eye Res"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"e78684","DOI":"10.1371\/journal.pone.0078684","article-title":"MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1","volume":"8","author":"Sen","year":"2013","journal-title":"PLoS One"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"13517","DOI":"10.1038\/ncomms13517","article-title":"The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization","volume":"7","author":"Zhang","year":"2016","journal-title":"Nat Commun"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.gene.2017.03.027","article-title":"Transcription factor SP1 mediates hyperglycemia-induced upregulation of roundabout4 in retinal microvascular endothelial cells","volume":"616","author":"Xie","year":"2017","journal-title":"Gene"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.gene.2016.03.047","article-title":"Validation of RT-qPCR reference genes and determination of Robo4 expression levels in human retinal endothelial cells under hypoxia and\/or hyperglycemia","volume":"585","author":"Xie","year":"2016","journal-title":"Gene"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"D92","DOI":"10.1093\/nar\/gkt1248","article-title":"starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"bib21","first-page":"1655","article-title":"MicroRNA-21 mediates the protective effects of salidroside against hypoxia\/reoxygenation-induced myocardial oxidative stress and inflammatory response","volume":"19","author":"Liu","year":"2020","journal-title":"Exp Ther Med"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s10753-019-01121-y","article-title":"Salidroside restores an anti-inflammatory endothelial phenotype by selectively inhibiting endothelial complement after oxidative stress","volume":"43","author":"Wang","year":"2020","journal-title":"Inflammation"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"172797","DOI":"10.1016\/j.ejphar.2019.172797","article-title":"Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK\/NF-kappaB\/NLRP3 signaling pathway in AGEs-induced HUVECs","volume":"867","author":"Hu","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"bib24","first-page":"2279","article-title":"Salidroside attenuates oxidized low density lipoprotein induced endothelial cell injury via promotion of the AMPK\/SIRT1 pathway","volume":"43","author":"Zhao","year":"2019","journal-title":"Int J Mol Med"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s00011-019-01268-2","article-title":"MiR-138-5p exacerbates hypoxia\/reperfusion-induced heart injury through the inactivation of SIRT1-PGC-1alpha","volume":"68","author":"Wang","year":"2019","journal-title":"Inflamm Res"},{"key":"bib26","first-page":"132","article-title":"The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation","author":"Shirakura","year":"2019","journal-title":"J Cell Sci"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1073\/pnas.0403198102","article-title":"Microvascular patterning is controlled by fine-tuning the Akt signal","volume":"102","author":"Sun","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1161\/01.RES.0000121103.03275.EC","article-title":"Phosphatidylinositol 3-kinase\/Akt regulates angiotensin II-induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and suppression of caspase-3 activity","volume":"94","author":"Ohashi","year":"2004","journal-title":"Circ Res"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"107886","DOI":"10.1016\/j.exer.2019.107886","article-title":"Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K\/Akt\/VEGF signaling pathway in diabetic retinopathy","volume":"190","author":"Lu","year":"2020","journal-title":"Exp Eye Res"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2776480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:26Z","timestamp":1791927086000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2776480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.9.25","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7,16]]}}}