{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:35Z","timestamp":1791928775537,"version":"4.3.4"},"reference-count":34,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"9","license":[{"start":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:00:00Z","timestamp":1625616000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2021,7,7]]},"DOI":"10.1167\/iovs.62.9.8","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T15:58:02Z","timestamp":1625673482000},"page":"8","source":"Crossref","is-referenced-by-count":7,"title":["Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis"],"prefix":"10.1167","volume":"62","author":[{"given":"Bo Young","family":"Chun","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu, Korea"},{"name":"Brain Science & Engineering Institute, School of Medicine, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Heon","family":"Kim","sequence":"additional","affiliation":[{"name":"Brain Science & Engineering Institute, School of Medicine, Kyungpook National University, Daegu, Korea"},{"name":"Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn-Kwan","family":"Jung","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Seok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Fatima Research Institute, Fatima Hospital, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Yonezawa","sequence":"additional","affiliation":[{"name":"Gradulate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoungho","family":"Suk","sequence":"additional","affiliation":[{"name":"Brain Science & Engineering Institute, School of Medicine, Kyungpook National University, Daegu, Korea"},{"name":"Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"6","key":"bib1","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.ajo.2005.01.031","article-title":"Evolving management of optic neuritis and multiple sclerosis","volume":"139","author":"Arnold","year":"2005","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"bib2","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1001\/archopht.121.7.944","article-title":"High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis: experience of the optic neuritis treatment trial","volume":"121","author":"Beck","year":"2003","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0002-9394(03)00862-6","article-title":"Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial","volume":"137","author":"Beck","year":"2004","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"bib4","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.exer.2008.05.017","article-title":"Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis","volume":"87","author":"Shindler","year":"2008","journal-title":"Exp Eye Res"},{"issue":"11","key":"bib5","doi-asserted-by":"publisher","first-page":"6964","DOI":"10.1167\/iovs.12-10559","article-title":"Visual functional and histopathological correlation in experimental autoimmune optic neuritis","volume":"53","author":"Matsunaga","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0002-9440(10)64537-3","article-title":"Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions","volume":"157","author":"Korrnek","year":"2000","journal-title":"Am J Pathol"},{"issue":"9","key":"bib7","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1056\/NEJMra052130","article-title":"Multiple sclerosis- the plaque and its pathogenesis","volume":"354","author":"Frohman","year":"2006","journal-title":"N Engl J Med"},{"issue":"5","key":"bib8","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.2353\/ajpath.2007.060783","article-title":"Microglial recruitment, activation, and proliferation in response to primary demyelination","volume":"170","author":"Remington","year":"2007","journal-title":"Am J Pathol"},{"issue":"3","key":"bib9","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/(ISSN)1097-4547","article-title":"Microglial cell activation and proliferation precedes the onset of CNS autoimmunity","volume":"81","author":"Ponomarev","year":"2005","journal-title":"J Neurosci Res"},{"issue":"2","key":"bib10","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","article-title":"The blood-brain barrier in health and chronic neurodegenerative disorders","volume":"57","author":"Zlokovic","year":"2008","journal-title":"Neuron"},{"issue":"1-2","key":"bib11","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.jneuroim.2010.08.011","article-title":"Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE","volume":"229","author":"Bennett","year":"2010","journal-title":"J Neuroimmunol"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1146\/annurev-pathol-011811-132443","article-title":"Pathology of demyelinating diseases","volume":"7","author":"Popescu","year":"2012","journal-title":"Annu Rev Pathol"},{"issue":"5","key":"bib13","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.4049\/jimmunol.1400401","article-title":"Neurophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases","volume":"193","author":"Aube","year":"2014","journal-title":"J Immunol"},{"issue":"Pt 9","key":"bib14","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1093\/brain\/awv203","article-title":"Permeability of the blood-brain barrier predicts conversion from optic neuritis to multiple scleritis","volume":"138","author":"Cramer","year":"2015","journal-title":"Brain"},{"issue":"9","key":"bib15","first-page":"3456","article-title":"Reversals of blood-brain barrier disruption by catalase: a serial magnetic resonance imaging study of experimental optic neuritis","volume":"35","author":"Guy","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"bib16","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1002\/(ISSN)1098-1136","article-title":"Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet","volume":"44","author":"Yonezawa","year":"2003","journal-title":"Glia"},{"issue":"6","key":"bib18","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s00281-015-0516-2","article-title":"Glial regulation of the blood-brain barrier in health and disease","volume":"37","author":"Broux","year":"2015","journal-title":"Semin Immunopathol"},{"issue":"2","key":"bib19","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/(ISSN)1098-1136","article-title":"Glial cell influence on the human blood-brain barrier","volume":"36","author":"Prat","year":"2001","journal-title":"Glia"},{"issue":"2","key":"bib20","doi-asserted-by":"publisher","first-page":"324","DOI":"10.21037\/apm","article-title":"Impact of blood-brain barrier disruption on newly diagnosed neuromyelitis optica spectrum disorder symptoms and prognosis","volume":"9","author":"Liang","year":"2020","journal-title":"Ann Palliat Med"},{"issue":"3","key":"bib21","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/jcp.v216:3","article-title":"DICAM, a novel dual immunoglobulin domain containing cell adhesion molecule interacts with av\u00df3 integrin","volume":"216","author":"Jung","year":"2008","journal-title":"J Cell Physiol"},{"issue":"5","key":"bib22","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1093\/ibd\/izy373","article-title":"DICAM attenuates experimental colitis via stabilizing junctional complex in mucosal barrier","volume":"25","author":"Han","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"bib23","first-page":"294046","article-title":"Analysis of the pathogenesis of experimental autoimmune optic neuritis","volume":"2011","author":"Kesuka","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1167\/iovs.15-16851","article-title":"Pathological involvement of astrocyte-derived lipocalin-2 in the demyelinating optic neuritis","volume":"56","author":"Chun","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib25","first-page":"332","article-title":"Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL\/6 mice","volume":"22","author":"Larabee","year":"2016","journal-title":"Mol Vis"},{"issue":"1","key":"bib26","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.neures.2006.05.013","article-title":"Statistical parametric mapping of immunopositive cell density","volume":"56","author":"Wada","year":"2006","journal-title":"Neurosci Res"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/978-1-61779-452-0","article-title":"Isolation and culture of spinal cord astrocytes","volume":"814","author":"Kerstetter","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"7428","key":"bib28","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nature11603","article-title":"Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability","volume":"492","author":"Zhu","year":"2012","journal-title":"Nature"},{"issue":"8","key":"bib29","doi-asserted-by":"publisher","first-page":"5574","DOI":"10.4049\/jimmunol.177.8.5574","article-title":"IL-1\u00df regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program","volume":"177","author":"Argaw","year":"2006","journal-title":"J Immunol"},{"issue":"7","key":"bib30","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1084\/jem.20060285","article-title":"A crucial role for interlukin-1 in the induction of IL-17 producing T cells that mediate autoimmune encephalomyelitis","volume":"203","author":"Sutton","year":"2006","journal-title":"J Exp Med"},{"issue":"3","key":"bib31","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.coi.2007.04.005","article-title":"Differentiation and function of Th17 T cells","volume":"19","author":"Stockinger","year":"2007","journal-title":"Curr Opin Immunol"},{"issue":"5","key":"bib32","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.humimm.2020.02.009","article-title":"The action of Th17 cells on blood brain barrier in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"81","author":"Balasa","year":"2020","journal-title":"Hum Immunol"},{"issue":"5","key":"bib33","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/S0002-9440(10)63438-4","article-title":"Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain","volume":"165","author":"Ferrati","year":"2004","journal-title":"Am J Pathol"},{"issue":"6","key":"bib34","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1046\/j.1468-1331.2001.00327.x","article-title":"Chemokines CXCL10 and CCL2: differential involvement in intrathecal inflammation in multiple sclerosis","volume":"8","author":"Sorensen","year":"2001","journal-title":"Eur J Neurol"},{"key":"bib17","first-page":"344","volume-title":"The Fine Structure of the Nervous System, Neurons and Their Supporting Cells","author":"Peters","year":"1991"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2776438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:29Z","timestamp":1791927089000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2776438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,7]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.62.9.8","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7,7]]}}}