{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:52Z","timestamp":1791928792049,"version":"4.3.4"},"reference-count":70,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"12","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2022,11,15]]},"DOI":"10.1167\/iovs.63.12.22","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T10:31:13Z","timestamp":1668508273000},"page":"22","source":"Crossref","is-referenced-by-count":4,"title":["Retinal Vascular Plexuses Are Unequally Affected in Canine Inherited Retinal Degenerations"],"prefix":"10.1167","volume":"63","author":[{"given":"Ana","family":"Ripolles-Garcia","sequence":"first","affiliation":[{"name":"Division of Experimental Retinal Therapies, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yineng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Experimental Retinal Therapies, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Gray","sequence":"additional","affiliation":[{"name":"Division of Experimental Retinal Therapies, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Shuang","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo D.","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Division of Experimental Retinal Therapies, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Beltran","sequence":"additional","affiliation":[{"name":"Division of Experimental Retinal Therapies, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s00335-011-9361-3","article-title":"Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies","volume":"23","author":"Miyadera","year":"2012","journal-title":"Mamm Genome"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"4211","DOI":"10.1093\/hmg\/ddw254","article-title":"Overlap of abnormal photoreceptor development and progressive degeneration in Leber congenital amaurosis caused by NPHP5 mutation","volume":"25","author":"Downs","year":"2016","journal-title":"Hum Mol Genet"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"3968","DOI":"10.1073\/pnas.90.9.3968","article-title":"Irish setter dogs affected with rod\/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene","volume":"90","author":"Suber","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"6328","DOI":"10.1073\/pnas.082714499","article-title":"Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa","volume":"99","author":"Kijas","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1093\/hmg\/11.9.993","article-title":"Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration","volume":"11","author":"Zhang","year":"2002","journal-title":"Hum Mol Genet"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/tvst.7.4.6","article-title":"Inherited retinal degenerations: current landscape and knowledge gaps","volume":"7","author":"Duncan","year":"2018","journal-title":"Transl Vis Sci Technol"},{"key":"bib7","first-page":"28","article-title":"Decreased retinal blood flow in retinitis pigmentosa","volume":"30","author":"Akyol","year":"1995","journal-title":"Can J Ophthalmol"},{"key":"bib8","first-page":"175","article-title":"Histopathology of the human retina in retinitis pigmentosa","volume":"17","author":"Milam","year":"1998","journal-title":"Prog Retin Eye Res"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S1350-9462(00)00027-6","article-title":"Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease","volume":"20","author":"Yu","year":"2001","journal-title":"Prog Retin Eye Res"},{"key":"bib10","first-page":"H2498","article-title":"Intraretinal oxygen distribution in rats as a function of systemic blood pressure","volume":"267","author":"Yu","year":"1994","journal-title":"Am J Physiol"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.brainres.2017.07.025","article-title":"Retinal metabolism: a comparative look at energetics in the retina","volume":"1672","author":"Country","year":"2017","journal-title":"Brain Res"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.preteyeres.2017.01.003","article-title":"Retinal oxygen: from animals to humans","volume":"58","author":"Linsenmeier","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S1095-6433(01)00530-X","article-title":"A multi-layer model of retinal oxygen supply and consumption helps explain the muted rise in inner retinal PO(2) during systemic hyperoxia","volume":"132","author":"Cringle","year":"2002","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1167\/iovs.05-1284","article-title":"Retinal oxygenation and oxygen metabolism in Abyssinian cats with a hereditary retinal degeneration","volume":"47","author":"Padnick-Silver","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib15","doi-asserted-by":"crossref","first-page":"e1396","DOI":"10.1111\/aos.14828","article-title":"Microvascular and metabolic alterations in retinitis pigmentosa and Stargardt disease","volume":"99","author":"Della Volpe Waizel","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/aos.12359","article-title":"Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa","volume":"92","author":"Eysteinsson","year":"2014","journal-title":"Acta Ophthalmol"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1878-5085-3-17","article-title":"Retinitis pigmentosa and ocular blood flow","volume":"3","author":"Konieczka","year":"2012","journal-title":"The EPMA Journal"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1139\/Y10-036","article-title":"ET-1 plasma levels and ocular blood flow in retinitis pigmentosa","volume":"88","author":"Cellini","year":"2010","journal-title":"Can J Physiol Pharmacol"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1159\/000507961","article-title":"Vascular density and retinal function in patients with retinitis pigmentosa evaluated by swept-source OCT angiography and microperimetry","volume":"244","author":"Corazza","year":"2021","journal-title":"Ophthalmologica"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ajo.2019.02.034","article-title":"Projection-resolved optical coherence tomographic angiography of retinal plexuses in retinitis pigmentosa","volume":"204","author":"Hagag","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1136\/bjophthalmol-2016-308925","article-title":"Vessel density analysis in patients with retinitis pigmentosa by means of optical coherence tomography angiography","volume":"101","author":"Battaglia Parodi","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1097\/IAE.000000000000190","article-title":"Optical coherence tomography angiography in patients with retinitis pigmentosa","volume":"39","author":"Alnawaiseh","year":"2019","journal-title":"Retina"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnana.2018.00055","article-title":"Retinal vascular degeneration in the transgenic P23H Rat Model of Retinitis Pigmentosa","volume":"12","author":"Fern\u00e1ndez-S\u00e1nchez","year":"2018","journal-title":"Front Neuroanat"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"170","DOI":"10.4103\/JOCO.JOCO_99_20","article-title":"Multimodal imaging in retinitis pigmentosa: correlations among microvascular changes, macular function and retinal structure","volume":"32","author":"Falfoul","year":"2020","journal-title":"J Curr Ophthalmol"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnana.2021.785249","article-title":"Characterization of the canine retinal vasculature with optical coherence tomography angiography: comparisons with histology and fluorescein angiography","volume":"15","author":"Ripolles-Garcia","year":"2021","journal-title":"Front Neuroanat"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"100878","DOI":"10.1016\/j.preteyeres.2020.100878","article-title":"Plexus-specific retinal vascular anatomy and pathologies as seen by projection-resolved optical coherence tomographic angiography","volume":"80","author":"Hormel","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1007\/s00417-017-3633-x","article-title":"Retinal and choroidal vascular features in patients with retinitis pigmentosa imaged by OCT based microangiography","volume":"255","author":"Rezaei","year":"2017","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"e90390","DOI":"10.1371\/journal.pone.0090390","article-title":"Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations","volume":"9","author":"Beltran","year":"2014","journal-title":"PLoS One"},{"key":"bib29","doi-asserted-by":"crossref","DOI":"10.1111\/vop.12973","article-title":"Non-invasive optical coherence tomography angiography: A comparison with fluorescein and indocyanine green angiography in normal adult dogs and cats","author":"Occelli","year":"2022","journal-title":"Vet Ophthalmol"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.3390\/jcm8122078","article-title":"Optical coherence tomography angiography imaging in inherited retinal diseases","volume":"8","author":"Ong","year":"2019","journal-title":"J Clin Med"},{"key":"bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-31488-1","article-title":"Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography","volume":"8","author":"Jauregui","year":"2018","journal-title":"Sci Rep"},{"key":"bib32","first-page":"1","article-title":"Widefield Swept Source OCTA in Retinitis Pigmentosa","volume":"10","author":"Mastropasqua","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1167\/tvst.7.6.42","article-title":"Comparative Optical Coherence Tomography Angiography of Wild-Type and rd10 Mouse Retinas","volume":"7","author":"Kim","year":"2018","journal-title":"Transl Vis Sci Technol"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1080\/08820538.2021.1985527","article-title":"Optical coherence tomography angiography in patients with cone dystrophy","volume":"37","author":"Yilmaz","year":"2022","journal-title":"Semin Ophthalmol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.2147\/OPTH.S254909","article-title":"Quantification of macular microvascular changes in retinitis pigmentosa using optical coherence tomography angiography","volume":"14","author":"AttaAllah","year":"2020","journal-title":"Clin Ophthalmol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"189","DOI":"10.4103\/joco.joco_20_21","article-title":"Retinal vascular abnormalities in different types of inherited retinal dystrophies assessed by optical coherence tomography angiography","volume":"33","author":"Sabbaghi","year":"2021","journal-title":"J Curr Ophthalmol"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"46396","DOI":"10.1038\/srep46396","article-title":"Optical coherence tomography angiography to estimate retinal blood flow in eyes with retinitis pigmentosa","volume":"7","author":"Sugahara","year":"2017","journal-title":"Sci Rep"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"e636","DOI":"10.1111\/aos.2018.96.issue-5","article-title":"Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity","volume":"96","author":"Takagi","year":"2018","journal-title":"Acta Ophthalmol"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"6360","DOI":"10.1167\/iovs.16-20544","article-title":"Macular features in retinitis pigmentosa: correlations among ganglion cell complex thickness, capillary density, and macular function","volume":"57","author":"Toto","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1016\/j.ymthe.2021.03.021","article-title":"Gene therapy reforms photoreceptor structure and restores vision in NPHP5-associated Leber congenital amaurosis","volume":"29","author":"Aguirre","year":"2021","journal-title":"Mol Ther"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"E8547","DOI":"10.1073\/pnas.1805055115","article-title":"Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector","volume":"115","author":"Cideciyan","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.exer.2016.04.006","article-title":"Assessment of visual function and retinal structure following acute light exposure in the light sensitive T4R rhodopsin mutant dog","volume":"146","author":"Iwabe","year":"2016","journal-title":"Exp Eye Res"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"e27385","DOI":"10.1371\/journal.pone.0027385","article-title":"A computational tool for quantitative analysis of vascular networks","volume":"6","author":"Zudaire","year":"2011","journal-title":"PLoS One"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/cellbio.1990.6.issue-1","article-title":"Cell biology of von Willebrand factor","volume":"6","author":"Wagner","year":"1990","journal-title":"Ann Rev Cell Biol"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0014-4835(88)90014-0","article-title":"Immunocytochemical localization of laminin, type IV collagen and fibronectin in rat retinal vessels","volume":"47","author":"Essner","year":"1988","journal-title":"Exp Eye Res"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1167\/iovs.05-0845","article-title":"A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa","volume":"47","author":"Beltran","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"e24074","DOI":"10.1371\/journal.pone.0024074","article-title":"Photoreceptor cell death, proliferation and formation of hybrid rod\/S-cone photoreceptors in the degenerating STK38L mutant retina","volume":"6","author":"Berta","year":"2011","journal-title":"PLoS One"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/S0161-6420(95)30953-0","article-title":"Histopathology of bone spicule pigmentation in retinitis pigmentosa","volume":"102","author":"Li","year":"1995","journal-title":"Ophthalmology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.3390\/jcm8091425","article-title":"Vascular patterns in retinitis pigmentosa on swept-source optical coherence tomography angiography","volume":"8","author":"Arrigo","year":"2019","journal-title":"J Clin Med"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"e59","DOI":"10.1111\/aos.13475","article-title":"Optical coherence tomography angiography of the macular microvasculature changes in retinitis pigmentosa","volume":"96","author":"Koyanagi","year":"2018","journal-title":"Acta Ophthalmol"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1097\/IAE.000000000000190","article-title":"Optical coherence tomography angiography in patients with retinitis pigmentosa","volume":"39","author":"Alnawaiseh","year":"2019","journal-title":"Retina"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"17866","DOI":"10.1038\/s41598-018-36279-2","article-title":"Repeatability and reproducibility of quantification of superficial peri-papillary capillaries by four different optical coherence tomography angiography devices","volume":"8","author":"Lei","year":"2018","journal-title":"Sci Rep"},{"key":"bib55","first-page":"1784","article-title":"A quantitative comparison of five optical coherence tomography angiography systems in clinical performance","volume":"11","author":"Li","year":"2018","journal-title":"Int J Ophthalmol"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"e0177059","DOI":"10.1371\/journal.pone.0177059","article-title":"OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices","volume":"12","author":"Munk","year":"2017","journal-title":"PLoS One"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1001\/archopht.1992.01080230134038","article-title":"Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa","volume":"110","author":"Stone","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.1167\/iovs.09-4945","article-title":"A comparison of visual field sensitivity to photoreceptor thickness in retinitis pigmentosa","volume":"51","author":"Rangaswamy","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.preteyeres.2018.03.005","article-title":"Non-syndromic retinitis pigmentosa","volume":"66","author":"Verbakel","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.oret.2017.07.022","article-title":"OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia","volume":"2","author":"Hagag","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1002\/(ISSN)1096-9861","article-title":"Vascular atrophy in the retinal degenerative rd mouse","volume":"254","author":"Blanks","year":"1986","journal-title":"J Comp Neurol"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/genes11101120","article-title":"Mechanisms of photoreceptor death in retinitis pigmentosa","volume":"11","author":"Newton","year":"2020","journal-title":"Genes (Basel)"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1076\/ceyr.27.3.183.16053","article-title":"Evolving neurovascular relationships in the RCS rat with age","volume":"27","author":"Wang","year":"2003","journal-title":"Curr Eye Res"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3389\/fncel.2015.00484","article-title":"Astrocytes and M\u00fcller cell alterations during retinal degeneration in a transgenic rat model of retinitis pigmentosa","volume":"9","author":"Fern\u00e1ndez-S\u00e1nchez","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1136\/bjo.22.10.613","article-title":"Hereditary degeneration of the rat retina","volume":"22","author":"Bourne","year":"1938","journal-title":"Br J Ophthalmol"},{"key":"bib66","first-page":"537","article-title":"Progressive optic axon dystrophy and vascular changes in RD mice","volume":"41","author":"Wang","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/0014-4835(79)90112-X","article-title":"Retinal vessels of canine eyes at different ages\u2014a qualitative and quantitative study","volume":"28","author":"Slatter","year":"1979","journal-title":"Exp Eye Res"},{"issue":"Suppl","key":"bib68","first-page":"60","article-title":"Evidence for tissue oxygen demand as the major factor causing autoregulation","volume":"15","author":"Guyton","year":"1964","journal-title":"Circ Res"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.preteyeres.2008.02.002","article-title":"Regulation of retinal blood flow in health and disease","volume":"27","author":"Pournaras","year":"2008","journal-title":"Prog Retin Eye Res"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.18240\/ijo","article-title":"In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review","volume":"14","author":"Lu","year":"2021","journal-title":"Int J Ophthalmol"},{"key":"bib46","article-title":"R: A language and environment for statistical computing.","volume-title":"Vienna, Austria: R Foundation for Statistical Computing;","author":"Team","year":"2018"},{"key":"bib47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-3-319-24277-4_9","volume-title":"ggplot2: elegant graphics for data analysis","author":"Wickham","year":"2016"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2783854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:33Z","timestamp":1791927093000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2783854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,15]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,11,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.63.12.22","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,15]]}}}