{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:31Z","timestamp":1791928771443,"version":"4.3.4"},"reference-count":70,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"13","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2022,12,19]]},"DOI":"10.1167\/iovs.63.13.18","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T11:31:48Z","timestamp":1671449508000},"page":"18","source":"Crossref","is-referenced-by-count":8,"title":["Different Murine High-Risk Corneal Transplant Settings Vary Significantly in Their (Lymph)angiogenic and Inflammatory Cell Signatures"],"prefix":"10.1167","volume":"63","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfrun","family":"Sch\u00f6nberg","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Bassett","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Hadrian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Hos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bock","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Cursiefen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.09.030","article-title":"In vitro 3D corneal tissue model with epithelium, stroma, and innervation","volume":"112","author":"Wang","year":"2017","journal-title":"Biomaterials"},{"issue":"11","key":"bib2","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/nri1224","article-title":"Ocular immune privilege: Therapeutic opportunities from an experiment of nature","volume":"3","author":"Streilein","year":"2003","journal-title":"Nat Rev Immunol"},{"issue":"30","key":"bib3","doi-asserted-by":"publisher","first-page":"11405","DOI":"10.1073\/pnas.0506112103","article-title":"Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision","volume":"103","author":"Cursiefen","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ajo.2018.01.018","article-title":"Trends in corneal transplantation from 2001 to 2016 in Germany: A report of the DOG-section cornea and its keratoplasty registry","volume":"188","author":"Flockerzi","year":"2018","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"bib5","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1097\/TP.0000000000001281","article-title":"Changing indications in penetrating keratoplasty: A systematic review of 34 years of global reporting","volume":"101","author":"Matthaei","year":"2017","journal-title":"Transplantation"},{"issue":"6","key":"bib6","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1097\/01.tp.0000185197.37824.35","article-title":"How effective is penetrating corneal transplantation? Factors influencing long-term outcome in multivariate analysis","volume":"81","author":"Williams","year":"2006","journal-title":"Transplantation"},{"issue":"9","key":"bib7","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1016\/S0161-6420(94)31138-9","article-title":"Risk factors for corneal graft failure and rejection in the collaborative corneal transplantation studies. Collaborative Corneal Transplantation Studies Research Group","volume":"101","author":"Maguire","year":"1994","journal-title":"Ophthalmology"},{"issue":"7","key":"bib8","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/j.ophtha.2010.01.039","article-title":"Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: An evidence-based meta-analysis","volume":"117","author":"Bachmann","year":"2010","journal-title":"Ophthalmology"},{"issue":"6","key":"bib9","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.survophthal.2016.12.010","article-title":"Management of high-risk corneal transplantation","volume":"62","author":"Di Zazzo","year":"2017","journal-title":"Surv Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"108152","DOI":"10.1016\/j.exer.2020.108152","article-title":"Animal models of high-risk corneal transplantation: A comprehensive review","volume":"198","author":"Singh","year":"2020","journal-title":"Exp Eye Res"},{"issue":"6","key":"bib11","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/j.ajo.2005.07.024","article-title":"The impact of corneal allograft rejection on the long-term outcome of corneal transplantation","volume":"140","author":"Coster","year":"2005","journal-title":"Am J Ophthalmol"},{"issue":"8","key":"bib12","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nm1078","article-title":"Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity","volume":"10","author":"Chen","year":"2004","journal-title":"Nat Med"},{"issue":"1","key":"bib13","doi-asserted-by":"publisher","first-page":"7227","DOI":"10.1038\/s41598-017-07806-4","article-title":"Transient ingrowth of lymphatic vessels into the physiologically avascular cornea regulates corneal edema and transparency","volume":"7","author":"Hos","year":"2017","journal-title":"Sci Rep"},{"issue":"86","key":"bib14","first-page":"51159","article-title":"An alkali-burn injury model of corneal neovascularization in the mouse","author":"Anderson","year":"2014","journal-title":"J Vis Exp"},{"key":"bib15","first-page":"2013","article-title":"Corneal allograft rejection: Immunopathogenesis to therapeutics","volume":"11","author":"Qazi","year":"2013","journal-title":"J Clin Cell Immunol"},{"issue":"7","key":"bib16","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1172\/JCI20465","article-title":"VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment","volume":"113","author":"Cursiefen","year":"2004","journal-title":"J Clin Invest"},{"issue":"8","key":"bib17","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1167\/iovs.03-1380","article-title":"Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival","volume":"45","author":"Cursiefen","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib18","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.3390\/ijms23052574","article-title":"Characterization of recruited mononuclear phagocytes following corneal chemical injury","volume":"23","author":"Lamy","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"6","key":"bib19","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1167\/iovs.06-0570","article-title":"Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis","volume":"48","author":"Bock","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"bib20","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ajpath.2015.09.012","article-title":"IL-10 indirectly regulates corneal lymphangiogenesis and resolution of inflammation via macrophages","volume":"186","author":"Hos","year":"2016","journal-title":"Am J Pathol"},{"issue":"5","key":"bib21","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.exer.2008.08.007","article-title":"Improved semiautomatic method for morphometry of angiogenesis and lymphangiogenesis in corneal flatmounts","volume":"87","author":"Bock","year":"2008","journal-title":"Exp Eye Res"},{"issue":"5","key":"bib22","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.3390\/jcm9051270","article-title":"Topical VEGF-C\/D inhibition prevents lymphatic vessel ingrowth into cornea but does not improve corneal graft survival","volume":"9","author":"Salabarria","year":"2020","journal-title":"J Clin Med"},{"issue":"9","key":"bib23","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1111\/ajt.v19.9","article-title":"Local VEGF-A blockade modulates the microenvironment of the corneal graft bed","volume":"19","author":"Salabarria","year":"2019","journal-title":"Am J Transplant"},{"issue":"2","key":"bib24","doi-asserted-by":"publisher","first-page":"535","DOI":"10.4049\/jimmunol.0903180","article-title":"Cutting edge: Lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation","volume":"184","author":"Dietrich","year":"2010","journal-title":"J Immunol"},{"issue":"3","key":"bib25","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00441-017-2785-7","article-title":"Neutrophils in tissue injury and repair","volume":"371","author":"Wang","year":"2018","journal-title":"Cell Tissue Res"},{"issue":"4","key":"bib26","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.jtos.2020.06.006","article-title":"Epithelium-derived IL-33 activates mast cells to initiate neutrophil recruitment following corneal injury","volume":"18","author":"Elbasiony","year":"2020","journal-title":"Ocular Surf"},{"issue":"1","key":"bib27","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/s41598-018-36526-6","article-title":"Phase-specific functions of macrophages determine injury-mediated corneal hem- and lymphangiogenesis","volume":"9","author":"Kiesewetter","year":"2019","journal-title":"Sci Rep"},{"issue":"2","key":"bib28","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1167\/iovs.02-0838","article-title":"The corneal stroma is endowed with a significant number of resident dendritic cells","volume":"44","author":"Hamrah","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"759","DOI":"10.3389\/fimmu.2019.00759","article-title":"ALCAM mediates DC migration through afferent lymphatics and promotes allospecific immune reactions","volume":"10","author":"Willrodt","year":"2019","journal-title":"Front Immunol"},{"issue":"2","key":"bib30","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/ajt.v22.2","article-title":"Pre-incubation of corneal donor tissue with sCD83 improves graft survival via the induction of alternatively activated macrophages and tolerogenic dendritic cells","volume":"22","author":"Peckert-Maier","year":"2022","journal-title":"Am J Transplant"},{"issue":"3","key":"bib31","first-page":"2734","article-title":"Prevalence of corneal vascularization in a general eye service population.","volume":"37","author":"Colby","year":"1996","journal-title":"Invest Ophthalmol Vis Sci."},{"issue":"3","key":"bib32","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0039-6257(98)00035-6","article-title":"Ocular neovascularization: An epidemiologic review","volume":"43","author":"Lee","year":"1998","journal-title":"Surv Ophthalmol"},{"issue":"7","key":"bib33","first-page":"2127","article-title":"Lymphatic vessels in vascularized human corneas: Immunohistochemical investigation using LYVE-1 and podoplanin","volume":"43","author":"Cursiefen","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib34","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1097\/00003226-200210000-00003","article-title":"Corneal neovascularization after nonmechanical versus mechanical corneal trephination for non-high-risk keratoplasty","volume":"21","author":"Cursiefen","year":"2002","journal-title":"Cornea"},{"issue":"3","key":"bib35","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1097\/00003226-200304000-00021","article-title":"Corneal lymphangiogenesis: Evidence, mechanisms, and implications for corneal transplant immunology","volume":"22","author":"Cursiefen","year":"2003","journal-title":"Cornea"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/978-3-7091-1646-3","article-title":"Lymphatic vessels in the development of tissue and organ rejection","volume":"214","author":"Hos","year":"2014","journal-title":"Adv Anat Embryol Cell Biol"},{"issue":"1","key":"bib37","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/08820530500509358","article-title":"Angiogenesis and lymphangiogenesis-implications for corneal immunity","volume":"21","author":"Dana","year":"2006","journal-title":"Semin Ophthalmol"},{"issue":"1","key":"bib38","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1001\/jama.2011.931","article-title":"Ocular disease: Mechanisms and management","volume":"306","author":"Perlman","year":"2011","journal-title":"JAMA"},{"issue":"2","key":"bib39","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1189\/jlb.1102544","article-title":"Corneal immunity is mediated by heterogeneous population of antigen-presenting cells","volume":"74","author":"Hamrah","year":"2003","journal-title":"J Leukoc Biol"},{"issue":"7","key":"bib40","first-page":"2264","article-title":"Identification of a novel macrophage population in the normal mouse corneal stroma","volume":"43","author":"Brissette-Storkus","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib41","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.3390\/ijms18061257","article-title":"Wound-healing studies in cornea and skin: Parallels, differences and opportunities","volume":"18","author":"Bukowiecki","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"12","key":"bib42","first-page":"2795","article-title":"Proinflammatory chemokine induction in keratocytes and inflammatory cell infiltration into the cornea","volume":"42","author":"Hong","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"bib43","doi-asserted-by":"publisher","first-page":"8549","DOI":"10.1167\/iovs.11-7956","article-title":"Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing","volume":"52","author":"Ebihara","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib44","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1076\/ceyr.16.7.670.5057","article-title":"Cytokine expression in the alkali-burned cornea","volume":"16","author":"Sotozono","year":"1997","journal-title":"Curr Eye Res"},{"issue":"5","key":"bib45","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1167\/iovs.05-1193","article-title":"Two waves of neutrophil emigration in response to corneal epithelial abrasion: Distinct adhesion molecule requirements","volume":"47","author":"Li","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib46","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1001\/archopht.116.11.1470","article-title":"Inflammatory response in the early stages of wound healing after excimer laser keratectomy","volume":"116","author":"O'Brien","year":"1998","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"bib47","first-page":"987","article-title":"Proinflammatory cytokines induce RANTES and MCP-1 synthesis in human corneal keratocytes but not in corneal epithelial cells. Beta-chemokine synthesis in corneal cells","volume":"37","author":"Tran","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"Suppl 2","key":"bib48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13223-018-0278-1","article-title":"An introduction to immunology and immunopathology","volume":"14","author":"Marshall","year":"2018","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"1","key":"bib49","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1167\/iovs.16-20019","article-title":"Immune cells on the corneal endothelium of an allogeneic corneal transplantation rabbit model","volume":"58","author":"Koudouna","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib50","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1167\/iovs.08-2993","article-title":"MHC-matched corneal allograft rejection in an IFN-gamma\/IL-17-independent manner in C57BL\/6 mice","volume":"50","author":"Yamada","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"bib51","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/ajt.13940","article-title":"The role of neutrophils in transplanted organs","volume":"17","author":"Scozzi","year":"2017","journal-title":"Am J Transplant"},{"issue":"6673","key":"bib52","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"issue":"3","key":"bib53","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.4049\/jimmunol.180.3.1353","article-title":"Cross presentation of antigen on MHC class II via the draining lymph node after corneal transplantation in mice","volume":"180","author":"Kuffov\u00e1","year":"2008","journal-title":"J Immunol"},{"issue":"1","key":"bib54","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S0161-6420(89)32949-6","article-title":"Leukocytes in the graft bed associated with corneal graft failure. Analysis by immunohistology and actuarial graft survival","volume":"96","author":"Williams","year":"1989","journal-title":"Ophthalmology"},{"issue":"2","key":"bib55","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/j.1365-2249.1997.279-ce1171.x","article-title":"Identification and characterization of cells infiltrating the graft and aqueous humour in rat corneal allograft rejection","volume":"107","author":"Larkin","year":"1997","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"bib56","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/BF02173536","article-title":"Composition of cellular infiltrates in rejected human corneal allografts","volume":"222","author":"Pepose","year":"1985","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"2","key":"bib57","first-page":"386","article-title":"Cytotoxic T cells play no essential role in acute rejection of orthotopic corneal allografts in mice","volume":"42","author":"Yamada","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"bib58","first-page":"3341","article-title":"The role of cytotoxic T lymphocytes in corneal allograft rejection","volume":"41","author":"Hegde","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"bib59","first-page":"1530","article-title":"T-cell mediated responses in a murine model of orthotopic corneal transplantation","volume":"36","author":"Joo","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib60","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.4049\/jimmunol.150.5.1727","article-title":"Impaired cell-mediated immunity in mice bearing healthy orthotopic corneal allografts","volume":"150","author":"Sonoda","year":"1993","journal-title":"J Immunol"},{"issue":"1","key":"bib61","doi-asserted-by":"publisher","first-page":"20891","DOI":"10.1038\/s41598-021-99805-9","article-title":"Keratoconus patients exhibit a distinct ocular surface immune cell and inflammatory profile","volume":"11","author":"D'Souza","year":"2021","journal-title":"Sci Rep"},{"issue":"7","key":"bib62","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1097\/00007890-199910150-00011","article-title":"Detection of minor alloantigen-specific cytotoxic T cells after rejection of murine orthotopic corneal allografts: Evidence that graft antigens are recognized exclusively via the \u201cindirect pathway\u201d","volume":"68","author":"Sano","year":"1999","journal-title":"Transplantation"},{"issue":"6","key":"bib63","first-page":"1130","article-title":"Murine orthotopic corneal transplantation in high-risk eyes. Rejection is dictated primarily by weak rather than strong alloantigens","volume":"38","author":"Sano","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib64","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1097\/00003226-200205000-00014","article-title":"Draining lymph nodes play an essential role in alloimmunity generated in response to high-risk corneal transplantation","volume":"21","author":"Yamagami","year":"2002","journal-title":"Cornea"},{"issue":"6","key":"bib65","first-page":"1293","article-title":"The critical role of lymph nodes in corneal alloimmunization and graft rejection","volume":"42","author":"Yamagami","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"bib66","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.smim.2011.04.002","article-title":"Costimulatory pathways in transplantation","volume":"23","author":"Pilat","year":"2011","journal-title":"Semin Immunol"},{"issue":"1","key":"bib67","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00417-010-1442-6","article-title":"Features of corneal neovascularization and lymphangiogenesis induced by different etiological factors in mice","volume":"249","author":"Shi","year":"2011","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"3","key":"bib68","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/s41433-019-0517-9","article-title":"Literature review and suggested protocol for prevention and treatment of corneal graft rejection","volume":"34","author":"Azevedo Magalhaes","year":"2020","journal-title":"Eye (London, England)"},{"issue":"12","key":"bib69","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1097\/ICO.0000000000002736","article-title":"Cutting edge: Novel treatment options targeting corneal neovascularization to improve high-risk corneal graft survival","volume":"40","author":"Cursiefen","year":"2021","journal-title":"Cornea"},{"issue":"3","key":"bib70","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000501374","article-title":"Unmet needs in ophthalmology: A European Vision Institute-consensus roadmap 2019-2025","volume":"62","author":"Cursiefen","year":"2019","journal-title":"Ophthalm Res"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:32Z","timestamp":1791927092000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2785224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,19]]},"references-count":70,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.63.13.18","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12,19]]}}}