{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:59Z","timestamp":1791928799161,"version":"4.3.4"},"reference-count":50,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"2","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2022,2,4]]},"DOI":"10.1167\/iovs.63.2.11","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T12:11:48Z","timestamp":1643976708000},"page":"11","source":"Crossref","is-referenced-by-count":29,"title":["Impact of Next Generation Sequencing in Unraveling the Genetics of 1036 Spanish Families With Inherited Macular Dystrophies"],"prefix":"10.1167","volume":"63","author":[{"given":"Marta","family":"Del Pozo-Valero","sequence":"first","affiliation":[{"name":"Department of Genetics, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Riveiro-Alvarez","sequence":"additional","affiliation":[{"name":"Department of Genetics, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Martin-Merida","sequence":"additional","affiliation":[{"name":"Department of Genetics, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Blanco-Kelly","sequence":"additional","affiliation":[{"name":"Department of Genetics, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saoud","family":"Swafiri","sequence":"additional","affiliation":[{"name":"Department of Genetics, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Lorda-Sanchez","sequence":"additional","affiliation":[{"name":"Department of Genetics, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Trujillo-Tiebas","sequence":"additional","affiliation":[{"name":"Department of Genetics, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Carre\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Jimenez-Rolando","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Garcia-Sandoval","sequence":"additional","affiliation":[{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain"},{"name":"Department of Ophthalmology, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Corton","sequence":"additional","affiliation":[{"name":"Department of Genetics, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Avila-Fernandez","sequence":"additional","affiliation":[{"name":"Department of Genetics, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ayuso","sequence":"additional","affiliation":[{"name":"Department of Genetics, Instituto de Investigaci\u00f3n Sanitaria\u2013Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Madrid, Spain"},{"name":"Center for Biomedical Network Research on Rare Diseases (CIBERER), ISCIII, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1136\/jmg.40.9.641","article-title":"The genetics of inherited macular dystrophies","volume":"40","author":"Michaelides","year":"2003","journal-title":"J Med Genet"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1136\/bjophthalmol-2016-308823","article-title":"Stargardt disease: Clinical features, molecular genetics, animal models and therapeutic options","volume":"101","author":"Tanna","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/sj.ejhg.5200447","article-title":"Mutations in the VMD2 gene are associated with juvenile-onset vitelliform macular dystrophy (Best disease) and adult vitelliform macular dystrophy but not age-related macular degeneration","volume":"8","author":"Kr\u00e4mer","year":"2000","journal-title":"Eur J Hum Genet"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ajhg.2007.08.004","article-title":"Biallelic mutation of BEST1 causes a distinct retinopathy in humans","volume":"82","author":"Burgess","year":"2008","journal-title":"Am J Hum Genet"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1136\/bjophthalmol-2019-315086","article-title":"Macular dystrophies: Clinical and imaging features, molecular genetics and therapeutic options","volume":"104","author":"Rahman","year":"2020","journal-title":"Br J Ophthalmol"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1136\/bjo.46.11.678","article-title":"X-linked hereditary retinoschisis","volume":"46","author":"Forsius","year":"1962","journal-title":"Br J Ophthalmol"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.preteyeres.2013.11.001","article-title":"Macular dystrophies mimicking age-related macular degeneration","volume":"39","author":"Saksens","year":"2014","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib8","doi-asserted-by":"publisher","first-page":"4824","DOI":"10.1038\/s41598-018-22096-0","article-title":"Clinical and genetic characteristics of 251 consecutive patients with macular and cone\/cone-rod dystrophy","volume":"8","author":"Birtel","year":"2018","journal-title":"Sci Rep"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1007\/BF01961301","article-title":"\u00dcber famili\u00e4re, progressive Degeneration in der Maculagegend des Auges","volume":"71","author":"Stargardt","year":"1909","journal-title":"Albr von Graefes Arch f\u00fcr Ophthalmol"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/ng0397-236","article-title":"A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy","volume":"15","author":"Allikmets","year":"1997","journal-title":"Nat Genet"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/hmg\/7.3.355","article-title":"Autosomal recessive retinitis pigmentosa and cone-rod dystrophy caused by splice site mutations in the Stargardt's disease gene ABCR","volume":"7","author":"Cremers","year":"1998","journal-title":"Hum Mol Genet"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1167\/iovs.13-13391","article-title":"Generalized choriocapillaris dystrophy, a distinct phenotype in the spectrum of ABCA4-associated retinopathies","volume":"55","author":"Bertelsen","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.preteyeres.2018.03.005","article-title":"Non-syndromic retinitis pigmentosa","volume":"66","author":"Verbakel","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ophtha.2017.07.019","article-title":"The rapid-onset chorioretinopathy phenotype of ABCA4 disease","volume":"125","author":"Tanaka","year":"2018","journal-title":"Ophthalmology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/ng0198-11","article-title":"Retinitis pigmentosa caused by a homozygous mutation in the Stargardt disease gene ABCR","volume":"18","author":"Mart\u00ednez-Mir","year":"1998","journal-title":"Nat Genet"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"100861","DOI":"10.1016\/j.preteyeres.2020.100861","article-title":"Clinical spectrum, genetic complexity and therapeutic approaches for retinal disease caused by ABCA4 mutations","volume":"79","author":"Cremers","year":"2020","journal-title":"Prog Retin Eye Res"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1002\/humu.v40.10","article-title":"Cost-effective molecular inversion probe-based ABCA4 sequencing reveals deep-intronic variants in Stargardt disease","volume":"40","author":"Khan","year":"2019","journal-title":"Hum Mutat"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1002\/humu.v40.12","article-title":"Identification of splice defects due to noncanonical splice site or deep-intronic variants in ABCA4","volume":"40","author":"Fadaie","year":"2019","journal-title":"Hum Mutat"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1101\/gr.226621.117","article-title":"ABCA4 midigenes reveal the full splice spectrum of all reported noncanonical splice site variants in Stargardt disease","volume":"28","author":"Sangermano","year":"2018","journal-title":"Genome Res"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1038\/s41436-018-0414-9","article-title":"Deep-intronic ABCA4 variants explain missing heritability in Stargardt disease and allow correction of splice defects by antisense oligonucleotides","volume":"21","author":"Sangermano","year":"2019","journal-title":"Genet Med"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1038\/s41436-018-0420-y","article-title":"ABCA4-associated disease as a model for missing heritability in autosomal recessive disorders: novel noncoding splice, cis-regulatory, structural, and recurrent hypomorphic variants","volume":"21","author":"Bauwens","year":"2019","journal-title":"Genet Med"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1038\/s41436-020-0787-4","article-title":"Resolving the dark matter of ABCA4 for 1054 Stargardt disease probands through integrated genomics and transcriptomics","volume":"22","author":"Khan","year":"2020","journal-title":"Genet Med"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.preteyeres.2017.03.003","article-title":"Unravelling the genetics of inherited retinal dystrophies: Past, present and future","volume":"59","author":"Broadgate","year":"2017","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"bib24","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1038\/s41598-021-81093-y","article-title":"Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications","volume":"11","author":"Perea-Romero","year":"2021","journal-title":"Sci Rep"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"6206","DOI":"10.1167\/iovs.10-5743","article-title":"Further associations between mutations and polymorphisms in the ABCA4 gene: Clinical implication of allelic variants and their role as protector\/risk factors","volume":"52","author":"Aguirre-Lamban","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1136\/bjo.2008.145193","article-title":"Molecular analysis of the ABCA4 gene for reliable detection of allelic variations in Spanish patients: Identification of 21 novel variants","volume":"93","author":"Aguirre-Lamban","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1136\/bjo.2008.148155","article-title":"Frequency of ABCA4 mutations in 278 Spanish controls: An insight into the prevalence of autosomal recessive Stargardt disease","volume":"93","author":"Riveiro-Alvarez","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1016\/j.ophtha.2013.04.002","article-title":"Outcome of ABCA4 disease-associated alleles in autosomal recessive retinal dystrophies: Retrospective analysis in 420 Spanish families","volume":"120","author":"Riveiro-Alvarez","year":"2013","journal-title":"Ophthalmology"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"6797","DOI":"10.1093\/hmg\/ddu396","article-title":"Analysis of the ABCA4 genomic locus in Stargardt disease","volume":"23","author":"Zernant","year":"2014","journal-title":"Hum Mol Genet"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.ophtha.2019.03.018","article-title":"Genomic landscape of sporadic retinitis pigmentosa","volume":"126","author":"Martin-Merida","year":"2019","journal-title":"Ophthalmology"},{"issue":"6","key":"bib31","doi-asserted-by":"publisher","first-page":"e65574","DOI":"10.1371\/journal.pone.0065574","article-title":"Exome sequencing of index patients with retinal dystrophies as a tool for molecular diagnosis","volume":"8","author":"Corton","year":"2013","journal-title":"PLoS One"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1001\/jamaophthalmol.2014.4266","article-title":"New mutations in the RAB28 gene in 2 Spanish families with cone-rod dystrophy","volume":"133","author":"Riveiro-\u00c1lvarez","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1167\/iovs.18-23854","article-title":"Toward the mutational landscape of autosomal dominant retinitis pigmentosa: A comprehensive analysis of 258 Spanish families","volume":"59","author":"Martin-Merida","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ajo.2019.05.014","article-title":"Expanded phenotypic spectrum of retinopathies associated with autosomal recessive and dominant mutations in PROM1","volume":"207","author":"Del Pozo-Valero","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ajo.2020.06.027","article-title":"Genotype-phenotype correlations in a Spanish cohort of 506 families with bi-allelic ABCA4 pathogenic variants","volume":"219","author":"Del Pozo-Valero","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"5136","DOI":"10.1093\/hmg\/ddt367","article-title":"Non-exomic and synonymous variants in ABCA4 are an important cause of Stargardt disease","volume":"22","author":"Braun","year":"2013","journal-title":"Hum Mol Genet"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.ajhg.2014.04.003","article-title":"Biallelic variants in TTLL5, encoding a tubulin glutamylase, cause retinal dystrophy","volume":"94","author":"Sergouniotis","year":"2014","journal-title":"Am J Hum Genet"},{"issue":"10","key":"bib39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/gm488","article-title":"Genetic architecture of retinal and macular degenerative diseases: The promise and challenges of next-generation sequencing","volume":"5","author":"Ratnapriya","year":"2013","journal-title":"Genome Med"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1167\/iovs.14-16178","article-title":"Targeted next-generation sequencing improves the diagnosis of autosomal dominant retinitis pigmentosa in Spanish patients","volume":"56","author":"Fernandez-San Jose","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"19531","DOI":"10.1038\/srep19531","article-title":"Panel-based NGS reveals novel pathogenic mutations in autosomal recessive retinitis pigmentosa","volume":"6","author":"Perez-Carro","year":"2016","journal-title":"Sci Rep"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"2710","DOI":"10.1073\/pnas.1913179117","article-title":"Worldwide carrier frequency and genetic prevalence of autosomal recessive inherited retinal diseases","volume":"117","author":"Hanany","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.preteyeres.2008.01.002","article-title":"The spectrum of retinal dystrophies caused by mutations in the peripherin\/RDS gene","volume":"27","author":"Boon","year":"2008","journal-title":"Prog Retin Eye Res"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1038\/s41436-019-0495-0","article-title":"A case\u2013control collapsing analysis identifies retinal dystrophy genes associated with ophthalmic disease in patients with no pathogenic ABCA4 variants","volume":"21","author":"Wolock","year":"2019","journal-title":"Genet Med"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.ajhg.2011.11.004","article-title":"Biallelic mutations in PLA2G5, encoding group v phospholipase A 2, cause benign fleck retina","volume":"89","author":"Sergouniotis","year":"2011","journal-title":"Am J Hum Genet"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/0002-9394(62)94874-2","article-title":"Retinitis punctata albescens. A functional evaluation of an unusual case","volume":"53","author":"Krill","year":"1962","journal-title":"Am J Ophthalmol"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1136\/bjo.64.9.652","article-title":"Benign familial fleck retina","volume":"64","author":"Sabel Aish","year":"1980","journal-title":"Br J Ophthalmol"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1146\/biochem.2008.77.issue-1","article-title":"Biochemistry and physiology of mammalian secreted phospholipases A 2","volume":"77","author":"Lambeau","year":"2008","journal-title":"Annu Rev Biochem"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.ajhg.2020.09.002","article-title":"Structural variants create new topological-associated domains and ectopic retinal enhancer-gene contact in dominant retinitis pigmentosa","volume":"107","author":"de Bruijn","year":"2020","journal-title":"Am J Hum Genet"},{"key":"bib42","first-page":"215","article-title":"Scaling new heights in the genetic diagnosis of inherited retinal dystrophies","volume-title":"Adv Exp Med Biol","author":"Gonz\u00e0lez-Duarte","year":"2019"}],"container-title":["Investigative Opthalmology & Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2778354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:30Z","timestamp":1791927090000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2778354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,4]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.63.2.11","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,4]]}}}