{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:59:56Z","timestamp":1791928796280,"version":"4.3.4"},"reference-count":33,"publisher":"Association for Research in Vision and Ophthalmology (ARVO)","issue":"3","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Invest. Ophthalmol. Vis. Sci."],"published-print":{"date-parts":[[2022,3,9]]},"DOI":"10.1167\/iovs.63.3.6","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T11:30:50Z","timestamp":1646825450000},"page":"6","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of Local Rod and Cone Function in Stargardt Disease"],"prefix":"10.1167","volume":"63","author":[{"given":"Krunoslav","family":"Stingl","sequence":"first","affiliation":[{"name":"University Eye Hospital, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany"},{"name":"Center for Rare Eye Diseases, University of Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carel","family":"Hoyng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Radboud University Medical Centre, 6500HB Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Kempf","sequence":"additional","affiliation":[{"name":"University Eye Hospital, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany"},{"name":"Center for Rare Eye Diseases, University of Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Kohl","sequence":"additional","affiliation":[{"name":"Institute for Ophthalmic Research, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronja","family":"Jung","sequence":"additional","affiliation":[{"name":"University Eye Hospital, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Righetti","sequence":"additional","affiliation":[{"name":"University Eye Hospital, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"K\u00fchlewein","sequence":"additional","affiliation":[{"name":"University Eye Hospital, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany"},{"name":"Institute for Ophthalmic Research, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Pohl","sequence":"additional","affiliation":[{"name":"University Eye Hospital, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Kort\u00fcm","sequence":"additional","affiliation":[{"name":"University Eye Hospital, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Kelbsch","sequence":"additional","affiliation":[{"name":"University Eye Hospital, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany"},{"name":"Pupil research group, University of Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Pupil research group, University of Tuebingen, Tuebingen, Germany"},{"name":"STZ eyetrial at the Center for Ophthalmology, University Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Peters","sequence":"additional","affiliation":[{"name":"Institute for Ophthalmic Research, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany"},{"name":"Pupil research group, University of Tuebingen, Tuebingen, Germany"},{"name":"STZ eyetrial at the Center for Ophthalmology, University Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Stingl","sequence":"additional","affiliation":[{"name":"University Eye Hospital, Center for Ophthalmology, University of Tuebingen, Tuebingen, Germany"},{"name":"Center for Rare Eye Diseases, University of Tuebingen, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the SORAPRAZAN consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27","reference":[{"issue":"1","key":"bib1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/ng0997-122b","article-title":"A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy","volume":"17","author":"Allikmets","year":"1997","journal-title":"Nat Genet"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ajo.2017.12.011","article-title":"Peripheral pigmented retinal lesions in Stargardt disease","volume":"188","author":"Zhao","year":"2018","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"bib3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/0002-9394(67)93339-9","article-title":"Fundus flavimaculatus. Clinical, functional and histopathologic observations","volume":"64","author":"Klien","year":"1967","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"bib4","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1001\/archopht.117.4.504","article-title":"Variation of clinical expression in patients with Stargardt dystrophy and sequence variations in the ABCR gene","volume":"117","author":"Fishman","year":"1999","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"bib5","first-page":"1248","article-title":"Alterations of slow and fast rod ERG signals in patients with molecularly confirmed Stargardt disease type 1","volume":"43","author":"Scholl","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib6","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1167\/iovs.03-1178","article-title":"Dark adaptation of rod photoreceptors in normal subjects, and in patients with Stargardt disease and an ABCA4 mutation","volume":"45","author":"Kang Derwent","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"bib7","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/ceo.v49.5","article-title":"Stargardt disease: multimodal imaging\u2014a review","volume":"49","author":"Heath Jeffery","year":"2021","journal-title":"Clin Exp Ophthalmol"},{"issue":"12","key":"bib8","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1136\/bjo.2007.118356","article-title":"ABCA4 mutations and discordant ABCA4 alleles in patients and siblings with bull's-eye maculopathy","volume":"91","author":"Michaelides","year":"2007","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"bib9","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.ophtha.2014.08.032","article-title":"Early-onset Stargardt disease: phenotypic and genotypic characteristics","volume":"122","author":"Lambertus","year":"2015","journal-title":"Ophthalmology"},{"issue":"1","key":"bib10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ophtha.2017.07.019","article-title":"The rapid-onset chorioretinopathy phenotype of ABCA4 disease","volume":"125","author":"Tanaka","year":"2018","journal-title":"Ophthalmology"},{"issue":"14","key":"bib11","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1093\/hmg\/ddab122","article-title":"Cis-acting modifiers in the ABCA4 locus contribute to the penetrance of the major disease-causing variant in Stargardt disease","volume":"30","author":"Lee","year":"2021","journal-title":"Hum Mol Genet"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"100861","DOI":"10.1016\/j.preteyeres.2020.100861","article-title":"Clinical spectrum, genetic complexity and therapeutic approaches for retinal disease caused by ABCA4 mutations","volume":"79","author":"Cremers","year":"2020","journal-title":"Prog Retin Eye Res"},{"issue":"8","key":"bib13","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1097\/IAE.0000000000000136","article-title":"Multimodal imaging and multifocal electroretinography demonstrate autosomal recessive Stargardt disease may present like occult macular dystrophy","volume":"34","author":"Sisk","year":"2014","journal-title":"Retina"},{"issue":"15","key":"bib14","doi-asserted-by":"publisher","first-page":"4951","DOI":"10.1167\/iovs.19-27100","article-title":"Peripapillary sparing with near infrared autofluorescence correlates with electroretinographic findings in patients with Stargardt disease","volume":"60","author":"Nassisi","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib15","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1097\/00006982-200412000-00013","article-title":"Electroretinographic findings in patients with Stargardt disease and fundus flavimaculatus","volume":"24","author":"Oh","year":"2004","journal-title":"Retina"},{"issue":"2","key":"bib16","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1167\/iovs.11-8415","article-title":"Macular function in macular degenerations: repeatability of microperimetry as a potential outcome measure for ABCA4-associated retinopathy trials","volume":"53","author":"Cideciyan","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"bib17","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1167\/tvst.7.6.10","article-title":"Cross-sectional and longitudinal assessment of retinal sensitivity in patients with childhood-onset Stargardt disease","volume":"7","author":"Tanna","year":"2018","journal-title":"Transl Vis Sci Technol"},{"issue":"1","key":"bib18","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1159\/000488711","article-title":"Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) study: design and baseline characteristics (report no. 1)","volume":"61","author":"Strauss","year":"2019","journal-title":"Ophthalmic Res"},{"issue":"5","key":"bib19","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/tvst.6.5.6","article-title":"Towards treatment of Stargardt disease: workshop organized and sponsored by the Foundation Fighting Blindness","volume":"6","author":"Sears","year":"2017","journal-title":"Transl Vis Sci Technol"},{"issue":"7","key":"bib20","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1167\/tvst.9.7.20","article-title":"Assessment of AAV dual vector safety in the Abca4 (-\/-) mouse model of Stargardt disease","volume":"9","author":"McClements","year":"2020","journal-title":"Transl Vis Sci Technol"},{"issue":"9","key":"bib21","doi-asserted-by":"publisher","first-page":"4621","DOI":"10.3390\/ijms22094621","article-title":"Antisense oligonucleotide-based rescue of aberrant splicing defects caused by 15 pathogenic variants in ABCA4","volume":"22","author":"Tomkiewicz","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"6","key":"bib22","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1515\/bmt-2017-0029","article-title":"Pupillographic campimetry an objective method to measure the visual field","volume":"63","author":"Stingl","year":"2018","journal-title":"Biomed Tech (Berl)"},{"issue":"5","key":"bib23","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1159\/000510888","article-title":"Clinical protocols for the evaluation of rod function","volume":"244","author":"Stingl","year":"2020","journal-title":"Ophthalmologica"},{"key":"bib24","doi-asserted-by":"crossref","DOI":"10.1136\/bjophthalmol-2020-318286","article-title":"Spatial and temporal resolution of the photoreceptors rescue dynamics after treatment with voretigene neparvovec","author":"Stingl","year":"2021 Jan 20","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"bib25","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1167\/tvst.8.6.19","article-title":"Objective measurement of local rod and cone function using gaze-controlled chromatic pupil campimetry in healthy subjects","volume":"8","author":"Kelbsch","year":"2019","journal-title":"Transl Vis Sci Technol"},{"issue":"6","key":"bib26","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1167\/tvst.9.6.5","article-title":"Chromatic pupil campimetry reveals functional defects in exudative age-related macular degeneration with differences related to disease activity","volume":"9","author":"Kelbsch","year":"2020","journal-title":"Transl Vis Sci Technol"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3389\/fneur.2019.00129","article-title":"Standards in pupillography","volume":"10","author":"Kelbsch","year":"2019","journal-title":"Front Neurol"},{"issue":"6","key":"bib28","doi-asserted-by":"publisher","first-page":"3281","DOI":"10.1167\/iovs.10-6538","article-title":"Cone photoreceptor abnormalities correlate with vision loss in patients with Stargardt disease","volume":"52","author":"Chen","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"bib29","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.bbadis.2011.10.007","article-title":"Increased cone sensitivity to ABCA4 deficiency provides insight into macular vision loss in Stargardt's dystrophy","volume":"1822","author":"Conley","year":"2012","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"bib30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1136\/bjophthalmol-2016-308823","article-title":"Stargardt disease: clinical features, molecular genetics, animal models and therapeutic options","volume":"101","author":"Tanna","year":"2017","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"bib31","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1111\/opo.v41.4","article-title":"Evaluation of photoreceptor function in inherited retinal diseases using rod- and cone-enhanced flicker stimuli","volume":"41","author":"Hathibelagal","year":"2021","journal-title":"Ophthalmic Physiol Opt"},{"issue":"2","key":"bib32","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1167\/iovs.16-20505","article-title":"Development of a chromatic pupillography protocol for the first gene therapy trial in patients with CNGA3-linked achromatopsia","volume":"58","author":"Lisowska","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"19","key":"bib33","doi-asserted-by":"publisher","first-page":"5248","DOI":"10.1523\/JNEUROSCI.4483-05.2006","article-title":"Synaptic plasticity in CNGA3(-\/-) mice: cone bipolar cells react on the missing cone input and form ectopic synapses with rods","volume":"26","author":"Haverkamp","year":"2006","journal-title":"J Neurosci"}],"container-title":["Investigative Opthalmology &amp; Visual Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2778648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:31:36Z","timestamp":1791927096000},"score":1,"resource":{"primary":{"URL":"https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2778648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,2]]}},"URL":"https:\/\/doi.org\/10.1167\/iovs.63.3.6","relation":{},"ISSN":["1552-5783"],"issn-type":[{"value":"1552-5783","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,9]]}}}